Biogenic Silver Nanoparticles from Nothapodytes foetida Kills Human Cancer Cells In Vitro Through Inhibition of Cell Proliferation and Induction of Apoptosis

2017 ◽  
Vol 11 (5) ◽  
pp. 416-427 ◽  
Author(s):  
Kailas D. Datkhile ◽  
Pratik P. Durgavale ◽  
Madhavi N. Patil
Keyword(s):  
Cell Proliferation ◽  
Silver Nanoparticles ◽  
Cancer Cells ◽  
Human Cancer ◽  
Human Cancer Cells ◽  
Biogenic Silver Nanoparticles ◽  
Nothapodytes Foetida ◽  
Induction Of Apoptosis

scholarly journals Induction of apoptosis by in vitro and in vivo plant extracts derived from Menyanthes trifoliata L. in human cancer cells

2019 ◽  
Vol 71 (1) ◽  
pp. 165-180 ◽  
Author(s):  
Tomasz Kowalczyk ◽  
Przemysław Sitarek ◽  
Ewa Skała ◽  
Monika Toma ◽  
Marzena Wielanek ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Plant Extracts ◽  
Human Cancer ◽  
Human Cancer Cells ◽  
Induction Of Apoptosis ◽  
Menyanthes Trifoliata

Antioxidant and In Vitro Anticancer Effect of 2-Pyrrolidinone Rich Fraction of Brassica oleracea var. capitata Through Induction of Apoptosis in Human Cancer Cells

2013 ◽  
Vol 27 (11) ◽  
pp. 1664-1670 ◽  
Author(s):  
Ramar Thangam ◽  
Veeraperumal Suresh ◽  
Mayan Rajkumar ◽  
Jally Damien Vincent ◽  
Palani Gunasekaran ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Brassica Oleracea ◽  
Human Cancer ◽  
Anticancer Effect ◽  
Human Cancer Cells ◽  
Induction Of Apoptosis

Low power ultrasound inhibits cell proliferation and invasion of human cancer cells in vitro

2012 ◽  
Vol 1 (2) ◽  
pp. 51 ◽  
Author(s):  
Etienne Mfoumou ◽  
Sivakumar Narayanswamy ◽  
Ion Stiharu ◽  
Ala-Eddin Al Moustafa
Keyword(s):  
Cell Proliferation ◽  
Low Power ◽  
Cancer Cells ◽  
Human Cancer ◽  
Power Ultrasound ◽  
Human Cancer Cells ◽  
Proliferation And Invasion

scholarly journals Raltitrexed-Modified Gold and Silver Nanoparticles for Targeted Cancer Therapy: Cytotoxicity Behavior In Vitro on A549 and HCT-116 Human Cancer Cells

Materials ◽  
2021 ◽  
Vol 14 (3) ◽  
pp. 534
Author(s):  
Jeroni Morey ◽  
Pere Llinás ◽  
Alberto Bueno-Costa ◽  
Alberto J. León ◽  
M. Nieves Piña
Keyword(s):  
Silver Nanoparticles ◽  
Cancer Cells ◽  
Human Lung ◽  
Human Cancer ◽  
Covalent Bonding ◽  
Targeted Cancer Therapy ◽  
Gold And Silver Nanoparticles ◽  
Human Cancer Cells ◽  
Hct 116

Two different raltitrexed gold and silver nanoparticles for the delivery of an antitumoral drug into cancer cells were synthesized and characterized. A cysteine linker was used for the covalent bonding of raltitrexed to the surface of nanoparticles. To evaluate the efficacy of the antifolate-derivative nanoparticles, their cytotoxicity was assayed in vitro with A549 human lung adenocarcinoma and HCT-116 colorectal carcinoma human cells. Modified nanoparticles are a biocompatible material, and administration of silver raltitrexed nanoparticles strongly inhibited the viability of the cancer cells; gold raltitrexed nanoparticles do not show any type of cytotoxic effect. The results suggest that silver raltitrexed nanoparticles could be a potential delivery system for certain cancer cells.

scholarly journals A New Smoothened Antagonist Bearing the Purine Scaffold Shows Antitumour Activity In Vitro and In Vivo

2021 ◽  
Vol 22 (16) ◽  
pp. 8372
Author(s):  
Ana María Zárate ◽  
Christian Espinosa-Bustos ◽  
Simón Guerrero ◽  
Angélica Fierro ◽  
Felipe Oyarzún-Ampuero ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Antitumour Activity ◽  
Anticancer Compounds ◽  
Human Cancer Cells ◽  
Cycle Arrest ◽  
Apoptosis Inducer ◽  
Purine Ring

The Smoothened (SMO) receptor is the most druggable target in the Hedgehog (HH) pathway for anticancer compounds. However, SMO antagonists such as vismodegib rapidly develop drug resistance. In this study, new SMO antagonists having the versatile purine ring as a scaffold were designed, synthesised, and biologically tested to provide an insight to their mechanism of action. Compound 4s was the most active and the best inhibitor of cell growth and selectively cytotoxic to cancer cells. 4s induced cell cycle arrest, apoptosis, a reduction in colony formation and downregulation of PTCH and GLI1 expression. BODIPY-cyclopamine displacement assays confirmed 4s is a SMO antagonist. In vivo, 4s strongly inhibited tumour relapse and metastasis of melanoma cells in mice. In vitro, 4s was more efficient than vismodegib to induce apoptosis in human cancer cells and that might be attributed to its dual ability to function as a SMO antagonist and apoptosis inducer.

Rhodium(i) N-heterocyclic carbene complexes: synthesis and cytotoxic properties

2021 ◽  
Vol 45 (11) ◽  
pp. 5176-5183
Author(s):  
Ichraf Slimani ◽  
Serap Şahin-Bölükbaşı ◽  
Mustafa Ulu ◽  
Enes Evren ◽  
Nevin Gürbüz ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Mtt Assay ◽  
Incubation Time ◽  
Human Cancer ◽  
Cytotoxic Activities ◽  
Carbene Complexes ◽  
Human Cancer Cells ◽  
Benzimidazolium Salts ◽  
Ht 29

A series of benzimidazolium salts and their [RhCl(NHC)(COD)] complexes were synthesized. All compounds were screened for in vitro cytotoxic activities against a panel of human cancer cells (HT-29 colon, Ishikawa endometrial, U-87 glioblastoma) using the MTT assay for 48 h incubation time.

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