Research of Molecule Logic Circuit Based on DNA Strand Displacement Reaction

Because of its outstanding advantages, DNA strand displacement (DSD) reaction has been widely used for signals processing and molecular logic circuit constructing. Two digital logic circuits are constructed in this paper. One is the encoder circuit with four inputs and two outputs, and the other is the decoder circuit with two inputs and four outputs. Of particular interest to us is the multicolor fluorescent gold nanoprobe detection part, where a gold nanoparticle is modified with multicolor fluorophores which exploits the ultrahigh quenching ability of gold nanoparticles (AuNPs). Finally, the circuits can be programmed and simulated with the software Visual DSD. The simulated results based on DSD show that the molecular circuits constructed in this paper is reliable and effective, which has wide prospects in logical circuits and nano-electronics study.

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8-Bit Adder and Subtractor with Domain Label Based on DNA Strand Displacement

Molecules ◽

10.3390/molecules23112989 ◽

2018 ◽

Vol 23 (11) ◽

pp. 2989 ◽

Cited By ~ 2

Author(s):

Weixuan Han ◽

Changjun Zhou

Keyword(s):

Dna Computing ◽

Logic Gates ◽

Logic Circuits ◽

Calculation Model ◽

Strand Displacement ◽

High Concentration ◽

Low Concentration ◽

Molecular Logic ◽

Dna Strand Displacement ◽

Dna Strand

DNA strand displacement, which plays a fundamental role in DNA computing, has been widely applied to many biological computing problems, including biological logic circuits. However, there are many biological cascade logic circuits with domain labels based on DNA strand displacement that have not yet been designed. Thus, in this paper, cascade 8-bit adder/subtractor with a domain label is designed based on DNA strand displacement; domain t and domain f represent signal 1 and signal 0, respectively, instead of domain t and domain f are applied to representing signal 1 and signal 0 respectively instead of high concentration and low concentration high concentration and low concentration. Basic logic gates, an amplification gate, a fan-out gate and a reporter gate are correspondingly reconstructed as domain label gates. The simulation results of Visual DSD show the feasibility and accuracy of the logic calculation model of the adder/subtractor designed in this paper. It is a useful exploration that may expand the application of the molecular logic circuit.

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Molecular Logic Gate Based on DNA Strand Displacement Reaction

Journal of Nanoelectronics and Optoelectronics ◽

10.1166/jno.2021.3037 ◽

2021 ◽

Vol 16 (6) ◽

pp. 974-977

Author(s):

Jingjing Ma

Keyword(s):

Logic Gate ◽

Logic Gates ◽

Displacement Reaction ◽

Strand Displacement ◽

Molecular Logic ◽

Molecular Logic Gates ◽

Dna Strand Displacement ◽

Dna Strand ◽

Biochemical Experiment ◽

Strand Displacement Reaction

In this paper, I construct an XOR logic gate based on DNA strand displacement reaction, and verify our design through corresponding biochemical experiment. I designed several different DNA strands. Based on two basic DNA strand displacement reaction mechanisms, by adding different input strands and taking the signal of FAM fluorescent group as the output, the XOR logic gate is realized. The result shows that DNA strand displacement technology has important application value in DNA computing, especially in the construction of DNA molecular logic gates.

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