Adoption of Computerized Tomography Quantitative Imaging Data in the Evaluation of Severe Acute Pancreatitis by Pleural Effusion

2020 ◽  
Vol 10 (9) ◽  
pp. 2096-2100
Author(s):  
Jun Wang ◽  
Dongmei Wang ◽  
Mei Qiu ◽  
Jing Lou ◽  
Rong Fang ◽  
...  
Keyword(s):  
Renal Failure ◽  
Acute Pancreatitis ◽  
Acute Renal Failure ◽  
Pleural Effusion ◽  
Computerized Tomography ◽  
Severe Acute Pancreatitis ◽  
Pancreatic Pseudocyst ◽  
Hypovolemic Shock ◽  
Control Group ◽  
Early Assessment

In order to study the pleural effusion (PE) in Severe acute pancreatitis (SAP) in patients with the clinical value of diagnosis, in this study, 78 patients with SAP who were included in Shandong Jinan Municipal Hospital of Traditional Chinese Medicine from January 31, 2017 to December 30, 2019 were selected as the experimental group (EG) and 78 patients with mild acute pancreatitis (MAP) as the control group (CG). The PE was diagnosed by computerized tomography (CT) imaging technology, and the patients with PE in the two groups were divided into small group, medium group and large group according to the volume of PE. The concurrent symptoms of SAP were recorded, and the relation between the occurrence of PE and the complications of SAP was analyzed by a multivariate Logistic regression model (LRM). It was concluded that the concurrent rate of PE in the EG was greatly higher than that in the CG, and the number of cases in the medium and multiple groups was also greatly higher than that in the CG (P < 0.05). There were statistically significant differences (SSD) in acute renal failure, hypovolemic shock and pancreatic pseudocyst in the PE small amount group, medium amount group and large amount group (P < 0.05). The complications of SAP in patients with acute renal failure, hypovolemic shock and pancreatic pseudocyst were positively correlated with age and PE (P < 0.05), which showed that CT could present the PE more directly, which was beneficial to the diagnosis of SAP. In addition, the increased amount of PE indicated the aggravation of SAP and the occurrence of concurrent symptoms, which is helpful for early assessment of patients’ condition and prediction of poor prognosis as an independent indicator to evaluate the early stage of SAP.

Acute Renal Failure Complicating Severe Acute Pancreatitis

Renal Failure ◽  
1996 ◽  
Vol 18 (4) ◽  
pp. 621-628 ◽  
Author(s):  
Petar Kes ◽  
Željko VuČIČEviĆ ◽  
Iva RatkoviĆ-GusiĆ ◽  
Antun Fotivec
Keyword(s):  
Renal Failure ◽  
Acute Pancreatitis ◽  
Acute Renal Failure ◽  
Severe Acute Pancreatitis

ACUTE RENAL FAILURE IN SEVERE ACUTE PANCREATITIS (LITERATURE REVIEW)

2018 ◽  
Vol 1 ◽  
pp. 57-64
Author(s):  
O.Kh. Khalidov ◽  
◽  
D.A. Gudkov ◽  
V.S. Fomin ◽  
◽  
...  
Keyword(s):  
Renal Failure ◽  
Acute Pancreatitis ◽  
Acute Renal Failure ◽  
Literature Review ◽  
Severe Acute Pancreatitis

Risk factors and outcome of acute renal failure in patients with severe acute pancreatitis

2010 ◽  
Vol 25 (2) ◽  
pp. 225-229 ◽  
Author(s):  
Hao Li ◽  
Zhaoxin Qian ◽  
Zhiling Liu ◽  
Xiaoliang Liu ◽  
Xiaotong Han ◽  
...  
Keyword(s):  
Risk Factors ◽  
Renal Failure ◽  
Acute Pancreatitis ◽  
Acute Renal Failure ◽  
Severe Acute Pancreatitis

Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells (huMSCs) Carrying MicroRNA-342 Relieve Protect Severe Acute Pancreatitis Injury (SAP)

2021 ◽  
Vol 11 (9) ◽  
pp. 1838-1843
Author(s):  
Xiaohong Zhou ◽  
Xuzhong Hao ◽  
Feifei He
Keyword(s):  
Stem Cells ◽  
Acute Pancreatitis ◽  
Mesenchymal Stem Cells ◽  
Umbilical Cord ◽  
Severe Acute Pancreatitis ◽  
Pancreatic Tissue ◽  
Inflammatory Factors ◽  
Control Group ◽  
Human Umbilical Cord Blood ◽  
Human Umbilical Cord

To investigate whether exosomes (exo) derived from human umbilical cord mesenchymal stem cells (huMSCs) and microRNA (miRNA)-342 have a protective effect on severe acute pancreatitis (SAP). Human umbilical cord blood was collected to extract huMSC-exo. With sham-operated mice as control group (n = 10), the other mice were induced to SAP model (n = 20), while 10 of the SAP mice received treatment with huMSC-exo. ELISA was performed to determine amylase and TAP level as well as inflammatory factors and HE staining to evaluate pathological changes of pancreatic tissue. The expression of miR-342 and Shh, Ptchl, and Smo in the Hh signal pathway was detected using RT-qPCR. The expression of miR-342 and the mRNA expression of Shh, Ptchl, and Smo was higher than that in model group (p < 0.05). The level of serum amylase, trypsinogen, and IFN-γ,Fasl, and IL-6 was upregulated in pancreas tissues of SAP mice relative to healthy mice, but their levels were decreased upon treatment with huMSC-exo and slightly higher than those of the control group, just not significantly. Collectively, the huMSC-exo may activate the Hh signaling pathway by regulating the expression of miR-342 increasing the expression of Shh, Ptchl, and Smo, and thereby healing of damaged pancreatic tissues in SAP.

scholarly journals Assessment of Prophylactic Carbapenem Antibiotics Administration for Severe Acute Pancreatitis: An Updated Systematic Review and Meta-Analysis

Digestion ◽  
2022 ◽  
pp. 1-9
Author(s):  
Daxin Guo ◽  
Wei Dai ◽  
Jingyi Shen ◽  
Mengting Zhang ◽  
Yetan Shi ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Organ Failure ◽  
Severe Acute Pancreatitis ◽  
Pancreatic Pseudocyst ◽  
Meta Analysis ◽  
Fluid Collection ◽  
Cochrane Library ◽  
Intensive Care Unit Treatment ◽  
Significant Difference ◽  
And Control

<b><i>Background:</i></b> The effectiveness of prophylactic antibiotics in severe acute pancreatitis (SAP) remains a debatable issue. This meta-analysis aimed to determine the efficacy of prophylactic carbapenem antibiotics in SAP. <b><i>Methods:</i></b> This meta-analysis of prophylactic carbapenem antibiotics for SAP was conducted in PubMed, EMBASE, Web of Science, MEDLINE, and Cochrane Library up to February 2021. The related bibliographies were manually searched. The primary outcomes involved infected pancreatic or peripancreatic necrosis, mortality, complications, infections, and organ failure. <b><i>Results:</i></b> Seven articles comprised 5 randomized controlled trials and 2 retrospective observational studies, including 3,864 SAP participants. Prophylactic carbapenem antibiotics in SAP were associated with a statistically significant reduction in the incidence of infections (odds ratio [OR]: 0.27; <i>p</i> = 0.03) and complications (OR: 0.48; <i>p</i> = 0.009). Nevertheless, no statistically significant difference was demonstrated in the incidence of infected pancreatic or peripancreatic necrosis (OR: 0.74; <i>p</i> = 0.24), mortality (OR: 0.69; <i>p</i> = 0.17), extrapancreatic infection (OR: 0.64, <i>p</i> = 0.54), pulmonary infection (OR: 1.23; <i>p</i> = 0.69), blood infection (OR: 0.60; <i>p</i> = 0.35), urinary tract infection (OR: 0.97; <i>p</i> = 0.97), pancreatic pseudocyst (OR: 0.59; <i>p</i> = 0.28), fluid collection (OR: 0.91; <i>p</i> = 0.76), organ failure (OR: 0.63; <i>p</i> = 0.19), acute respiratory distress syndrome (OR: 0.80; <i>p</i> = 0.61), surgical intervention (OR: 0.97; <i>p</i> = 0.93), dialysis (OR: 2.34; <i>p</i> = 0.57), use of respirator or ventilator (OR: 1.90; <i>p</i> = 0.40), intensive care unit treatment (OR: 2.97; <i>p</i> = 0.18), and additional antibiotics (OR: 0.59; <i>p</i> = 0.28) between the experimental and control groups. <b><i>Conclusions:</i></b> It is not recommended to administer routine prophylactic carbapenem antibiotics in SAP.

The Protective Effect of γ-Glutamyl l-Dopa on the Glycerol Treated Rat Model of Acute Renal Failure

1983 ◽  
Vol 65 (2) ◽  
pp. 159-164 ◽  
Author(s):  
I. F. Casson ◽  
D. A. Clayden ◽  
G. F. Cope ◽  
M. R. Lee
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Protective Effect ◽  
Rat Model ◽  
Fold Increase ◽  
Plasma Creatinine ◽  
Control Group ◽  
Creatinine Excretion ◽  
Urine Creatinine ◽  
Before And After

1. γ-Glutamyl l-dopa, a renal pro-drug for dopamine, was administered to rats before and after injection of glycerol, and to a control group which received water in place of glycerol. A third group of rats was given glycerol but no γ-glutamyl l-dopa. 2. The plasma creatinine in rats given γ-glutamyl l-dopa and glycerol was significantly lower than in rats receiving glycerol alone. 3. The fall in urine creatinine excretion, and polyuria, after glycerol was reduced by γ-glutamyl l-dopa and the natriuresis abolished. 4. γ-Glutamyl l-dopa given alone caused a 4000-fold increase in urine dopamine excretion, associated with a natriuresis. 5. The administration of γ-glutamyl l-dopa reduces the severity of renal failure produced by glycerol.

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