Nano-Sized Micelles of Block Copolymers of Methoxy Poly(ethylene glycol)-Poly(ε-caprolactone)-Graft-2-Hydroxyethyl Cellulose for Doxorubicin Delivery

2008 ◽  
Vol 8 (5) ◽  
pp. 2362-2368 ◽  
Author(s):  
Ming-Fa Hsieh ◽  
Nguyen Van Cuong ◽  
Chao-Hsuan Chen ◽  
Yung Tsung Chen ◽  
Jui-Ming Yeh
Keyword(s):  
Block Copolymers ◽  
Ethylene Glycol ◽  
Water Soluble ◽  
Hydroxyethyl Cellulose ◽  
Drug Resistant ◽  
Wild Type ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Mcf 7 ◽  
Resistant Cells

The amphiphilic block copolymers methoxy poly(ethylene glycol)-poly(ε-caprolactone) was grafted to 2-hydroxyethyl cellulose to produce the water-soluble copolymers. Doxorubicin loaded nanoparticles were prepared by dialysis method and the sizes of nanoparticles were determined by dynamic light scattering in solution and atomic force microscopes. As results the sizes were detected in a range of 197.4 to 340.7 nm. The in-vitro release of Dox was studied in phosphate and acetate buffered solution at 37 °C. The results showed that 43 and 53% of Dox remained after an incubation period of 7 days. The cytotoxicity of Dox loaded micelles was investigated in two different human MCF-7/wild type and MCF-7/Adriamycin drug resistant cells lines. The Dox-loaded micelles showed reduced cytotoxicity compared to free Dox in MCF-7/wild type and MCF-7/Adriamycin drug resistant cells.

Influence of racemization on stereocomplex-induced gelation of water-soluble polylactide-poly(ethylene glycol) block copolymers

2010 ◽  
pp. n/a-n/a ◽  
Author(s):  
Helene Nouailhas ◽  
Feng Li ◽  
Abdelsalm El Ghzaoui ◽  
Suming Li ◽  
Jean Coudane
Keyword(s):  
Block Copolymers ◽  
Ethylene Glycol ◽  
Water Soluble ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Synthesis of Poly(ethylene glycol) Block Copolymers as Potential Water-Soluble Drug Carriers

1995 ◽  
Vol 60 (10) ◽  
pp. 1765-1780 ◽  
Author(s):  
Michal Pechar ◽  
Jiří Strohalm ◽  
Karel Ulbrich
Keyword(s):  
Block Copolymers ◽  
Ethylene Glycol ◽  
Glutamic Acid ◽  
Drug Carrier ◽  
Drug Carriers ◽  
Water Soluble ◽  
Poly Ethylene Glycol ◽  
Water Soluble Drug ◽  
Poly Ethylene ◽  
The Relationship

The synthesis of a model water-soluble drug carrier based on poly(ethylene glycol) (PEG) block copolymers is described. In the copolymers, two blocks of PEG are linked by a biodegradable oligopeptide or amino acid linkage containing the glutamic acid residue. 4-Nitroaniline as a drug model is attached to the γ-carboxyl group of glutamic acid of the polymer carrier via an enzymatically degradable oligopeptide spacer. The oligopeptides used were potential substrates for chymotrypsin. The relationship between the structure of oligopeptides linking two PEG blocks and the rate of chymotrypsin-catalyzed polymer chain degradation as well as the relationship between the structure of the spacer and kinetics of drug model release from the carrier after incubation in chymotrypsin solution is discussed in detail. The results showed that by modifying the structure of oligopeptides in the polymer construct, changes in the rates of both polymer degradation and the drug model release can be achieved in a very broad range.

scholarly journals Intracellular Trafficking of Polyamidoamine–Poly(ethylene glycol) Block Copolymers in DNA Delivery

2011 ◽  
Vol 22 (8) ◽  
pp. 1519-1525 ◽  
Author(s):  
Daniel K. Bonner ◽  
Cheuk Leung ◽  
Jane Chen-Liang ◽  
Loice Chingozha ◽  
Robert Langer ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Ethylene Glycol ◽  
Intracellular Trafficking ◽  
Dna Delivery ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

In vivo and in vitro degradation of poly(ether ester) block copolymers based on poly(ethylene glycol) and poly(butylene terephthalate)

Biomaterials ◽  
2004 ◽  
Vol 25 (2) ◽  
pp. 247-258 ◽  
Author(s):  
A.A. Deschamps ◽  
A.A. van Apeldoorn ◽  
H. Hayen ◽  
J.D. de Bruijn ◽  
U. Karst ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
In Vitro Degradation ◽  
Butylene Terephthalate ◽  
Poly Ethylene ◽  
Ether Ester

Water-soluble polyesters from long chain alkylesters of citric acid and poly(ethylene glycol)

2007 ◽  
Vol 43 (4) ◽  
pp. 1288-1301 ◽  
Author(s):  
Fabienne Barroso-Bujans ◽  
Ricardo Martínez ◽  
Mehrdad Yazdani-Pedram ◽  
Pedro Ortiz ◽  
Holger Frey
Keyword(s):  
Citric Acid ◽  
Ethylene Glycol ◽  
Water Soluble ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Long Chain
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