Mitochondrial DNA Oxidative Damage Triggering Mitochondrial Dysfunction and Apoptosis in High Glucose-Induced HRECs

2008 ◽  
Vol 49 (9) ◽  
pp. 4203 ◽  
Author(s):  
Lin Xie ◽  
Xiaobo Zhu ◽  
Yiqun Hu ◽  
Tao Li ◽  
Yi Gao ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Oxidative Damage ◽  
Mitochondrial Dysfunction ◽  
High Glucose ◽  
Dna Oxidative Damage

CircTLK1 Modulates Sepsis-Induced Cardiomyocyte Apoptosis via Enhancing PARP1/HMGB1 Axis-Mediated Mitochondrial DNA Oxidative Damage by Sponging miR-17-5p

2020 ◽  
Author(s):  
Yu Qiu ◽  
Ying Yu ◽  
Xiao-Mei Qin ◽  
Tao Jian ◽  
Yan-Fang Tan ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Oxidative Damage ◽  
Cardiomyocyte Apoptosis ◽  
Dna Oxidative Damage

Melatonin protects against MPTP/MPP+-induced mitochondrial DNA oxidative damage in vivo and in vitro

2005 ◽  
Vol 39 (1) ◽  
pp. 34-42 ◽  
Author(s):  
Liu-Ji Chen ◽  
Yan-Qin Gao ◽  
Xue-Jun Li ◽  
Di-Han Shen ◽  
Feng-Yan Sun
Keyword(s):  
Mitochondrial Dna ◽  
Oxidative Damage ◽  
Dna Oxidative Damage

scholarly journals RecQL4 cytoplasmic localization: Implications in mitochondrial DNA oxidative damage repair

2012 ◽  
Vol 44 (11) ◽  
pp. 1942-1951 ◽  
Author(s):  
Zhenfen Chi ◽  
Linghu Nie ◽  
Zhao Peng ◽  
Qiong Yang ◽  
Kuan Yang ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Oxidative Damage ◽  
Cytoplasmic Localization ◽  
Dna Oxidative Damage ◽  
Damage Repair

scholarly journals D-galactose-induced mitochondrial DNA oxidative damage in the auditory cortex of rats

2014 ◽  
Vol 10 (6) ◽  
pp. 2861-2867 ◽  
Author(s):  
ZHENGDE DU ◽  
QIONG YANG ◽  
TAO ZHOU ◽  
LIN LIU ◽  
SHUO LI ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Oxidative Damage ◽  
Auditory Cortex ◽  
Dna Oxidative Damage

scholarly journals Proteomic Profile of Mouse Brain Aging Contributions to Mitochondrial Dysfunction, DNA Oxidative Damage, Loss of Neurotrophic Factor, and Synaptic and Ribosomal Proteins

2020 ◽  
Vol 2020 ◽  
pp. 1-21
Author(s):  
Yingchao Li ◽  
Haitao Yu ◽  
Chongyang Chen ◽  
Shupeng Li ◽  
Zaijun Zhang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cerebral Cortex ◽  
Oxidative Damage ◽  
Mitochondrial Dysfunction ◽  
Neurotrophic Factor ◽  
Ribosomal Proteins ◽  
Aged Mouse ◽  
Tandem Mass ◽  
Aged Mice ◽  
Dna Oxidative Damage

The deleterious effects of aging on the brain remain to be fully elucidated. In the present study, proteomic changes of young (4-month) and aged (16-month) B6129SF2/J male mouse hippocampus and cerebral cortex were investigated by using nano liquid chromatography tandem mass spectrometry (NanoLC-ESI-MS/MS) combined with tandem mass tag (TMT) labeling technology. Compared with the young animals, 390 hippocampal proteins (121 increased and 269 decreased) and 258 cortical proteins (149 increased and 109 decreased) changed significantly in the aged mouse. Bioinformatic analysis indicated that these proteins are mainly involved in mitochondrial functions (FIS1, DRP1), oxidative stress (PRDX6, GSTP1, and GSTM1), synapses (SYT12, GLUR2), ribosome (RPL4, RPS3), cytoskeletal integrity, transcriptional regulation, and GTPase function. The mitochondrial fission-related proteins FIS1 and DRP1 were significantly increased in the hippocampus and cerebral cortex of the aged mice. Further results in the hippocampus showed that ATP content was significantly reduced in aged mice. A neurotrophin brain-derived neurotrophic factor (BNDF), a protein closely related with synaptic plasticity and memory, was also significantly decreased in the hippocampus of the aged mice, with the tendency of synaptic protein markers including complexin-2, synaptophysin, GLUR2, PSD95, NMDAR2A, and NMDAR1. More interestingly, 8-hydroxydeoxyguanosine (8-OHdG), a marker of DNA oxidative damage, increased as shown by immunofluorescence staining. In summary, we demonstrated that aging is associated with systemic changes involving mitochondrial dysfunction, energy reduction, oxidative stress, loss of neurotrophic factor, synaptic proteins, and ribosomal proteins, as well as molecular deficits involved in various physiological/pathological processes.

Nanocatalytic Innate Immunity Activation by Mitochondrial DNA Oxidative Damage for Tumor‐Specific Therapy

2021 ◽  
pp. 2008065
Author(s):  
Han Jiang ◽  
Yuedong Guo ◽  
Chenyang Wei ◽  
Ping Hu ◽  
Jianlin Shi
Keyword(s):  
Innate Immunity ◽  
Mitochondrial Dna ◽  
Oxidative Damage ◽  
Specific Therapy ◽  
Dna Oxidative Damage

Mitochondrial DNA Oxidative Damage Contributes to Cardiomyocyte Ischemia/Reperfusion-Injury in Rats: Cardioprotective Role of Lycopene

2015 ◽  
Vol 230 (9) ◽  
pp. 2128-2141 ◽  
Author(s):  
Rongchuan Yue ◽  
Xuewei Xia ◽  
Jiahui Jiang ◽  
Dezhong Yang ◽  
Yu Han ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Oxidative Damage ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Dna Oxidative Damage

High Glucose Concentrations Induce Oxidative Damage to Mitochondrial DNA in Explanted Vascular Smooth Muscle Cells

2001 ◽  
Vol 226 (5) ◽  
pp. 450-457 ◽  
Author(s):  
Muyao Li ◽  
P. Marlene Absher ◽  
Ping Liang ◽  
James C. Russell ◽  
Burton E. Sobel ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Smooth Muscle ◽  
Oxidative Damage ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
High Glucose ◽  
Muscle Cells

scholarly journals Mitochondrial DNA Oxidative Damage and Repair in Aging and Alzheimer's Disease

2013 ◽  
Vol 18 (18) ◽  
pp. 2444-2457 ◽  
Author(s):  
Renato X. Santos ◽  
Sónia C. Correia ◽  
Xiongwei Zhu ◽  
Mark A. Smith ◽  
Paula I. Moreira ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mitochondrial Dna ◽  
Oxidative Damage ◽  
Dna Oxidative Damage
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