scholarly journals Inhibition of Choroidal and Corneal Pathologic Neovascularization byPlgf1-deGene Transfer

2012 ◽  
Vol 53 (13) ◽  
pp. 7989 ◽  
Author(s):  
Valeria Tarallo ◽  
Sasha Bogdanovich ◽  
Yoshio Hirano ◽  
Laura Tudisco ◽  
Lorena Zentilin ◽  
...  
Keyword(s):  
Pathologic Neovascularization

Pathologic Neovascularization in Cartilage Tumors

2002 ◽  
Vol 397 ◽  
pp. 76-82 ◽  
Author(s):  
Richard L. McGough ◽  
Bassam I. Aswad ◽  
Richard M. Terek
Keyword(s):  
Cartilage Tumors ◽  
Pathologic Neovascularization

scholarly journals Nrf2 in ischemic neurons promotes retinal vascular regeneration through regulation of semaphorin 6A

2015 ◽  
Vol 112 (50) ◽  
pp. E6927-E6936 ◽  
Author(s):  
Yanhong Wei ◽  
Junsong Gong ◽  
Zhenhua Xu ◽  
Rajesh K. Thimmulappa ◽  
Katherine L. Mitchell ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Ganglion Cells ◽  
Tissue Injury ◽  
Hypoxia Inducible Factor ◽  
Conditional Knockout ◽  
Cellular Damage ◽  
Related Factor ◽  
Cns Diseases ◽  
Vascular Regeneration ◽  
Pathologic Neovascularization

Delayed revascularization of ischemic neural tissue is a major impediment to preservation of function in central nervous system (CNS) diseases including stroke and ischemic retinopathies. Therapeutic strategies allowing rapid revascularization are greatly needed to reduce ischemia-induced cellular damage and suppress harmful pathologic neovascularization. However, key mechanisms governing vascular recovery in ischemic CNS, including regulatory molecules governing the transition from tissue injury to tissue repair, are largely unknown. NF-E2-related factor 2 (Nrf2) is a major stress-response transcription factor well known for its cell-intrinsic cytoprotective function. However, its role in cell–cell crosstalk is less appreciated. Here we report that Nrf2 is highly activated in ischemic retina and promotes revascularization by modulating neurons in their paracrine regulation of endothelial cells. Global Nrf2 deficiency strongly suppresses retinal revascularization and increases pathologic neovascularization in a mouse model of ischemic retinopathy. Conditional knockout studies demonstrate a major role for neuronal Nrf2 in vascular regrowth into avascular retina. Deletion of neuronal Nrf2 results in semaphorin 6A (Sema6A) induction in hypoxic/ischemic retinal ganglion cells in a hypoxia-inducible factor-1 alpha (HIF-1α)-dependent fashion. Sema6A expression increases in avascular inner retina and colocalizes with Nrf2 in human fetal eyes. Extracellular Sema6A leads to dose-dependent suppression of the migratory phenotype of endothelial cells through activation of Notch signaling. Lentiviral-mediated delivery of Sema6A small hairpin RNA (shRNA) abrogates the defective retinal revascularization in Nrf2-deficient mice. Importantly, pharmacologic Nrf2 activation promotes reparative angiogenesis and suppresses pathologic neovascularization. Our findings reveal a unique function of Nrf2 in reprogramming ischemic tissue toward neurovascular repair via Sema6A regulation, providing a potential therapeutic strategy for ischemic retinal and CNS diseases.

scholarly journals Lack of netrin-4 modulates pathologic neovascularization in the eye

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Norbert Kociok ◽  
Sergio Crespo-Garcia ◽  
Yong Liang ◽  
Sabrina V. Klein ◽  
Christina Nürnberg ◽  
...  
Keyword(s):  
Pathologic Neovascularization

scholarly journals Propranolol Inhibition of β-Adrenergic Receptor Does Not Suppress Pathologic Neovascularization in Oxygen-Induced Retinopathy

2012 ◽  
Vol 53 (6) ◽  
pp. 2968 ◽  
Author(s):  
Jing Chen ◽  
Jean-Sebastian Joyal ◽  
Colman J. Hatton ◽  
Aimee M. Juan ◽  
Dorothy T. Pei ◽  
...  
Keyword(s):  
Adrenergic Receptor ◽  
Oxygen Induced Retinopathy ◽  
Pathologic Neovascularization

Angiopoietin 2 expression in the retina: upregulation during physiologic and pathologic neovascularization

2000 ◽  
Vol 184 (3) ◽  
pp. 275-284 ◽  
Author(s):  
Sean F. Hackett ◽  
Hiroaki Ozaki ◽  
Rupert W. Strauss ◽  
Karl Wahlin ◽  
Chitra Suri ◽  
...  
Keyword(s):  
Angiopoietin 2 ◽  
Pathologic Neovascularization

scholarly journals The NLRP3 Inflammasome May Contribute to Pathologic Neovascularization in the Advanced Stages of Diabetic Retinopathy

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Shyam S. Chaurasia ◽  
Rayne R. Lim ◽  
Bhav H. Parikh ◽  
Yeo Sia Wey ◽  
Bo Bo Tun ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Nlrp3 Inflammasome ◽  
Advanced Stages ◽  
Pathologic Neovascularization

Anti-angiogenic effect of bare titanium dioxide nanoparticles on pathologic neovascularization without unbearable toxicity

2014 ◽  
Vol 10 (5) ◽  
pp. e1109-e1117 ◽  
Author(s):  
Dong Hyun Jo ◽  
Jin Hyoung Kim ◽  
Jin Gyeong Son ◽  
Nam Woong Song ◽  
Yong-Il Kim ◽  
...  
Keyword(s):  
Titanium Dioxide ◽  
Titanium Dioxide Nanoparticles ◽  
Angiogenic Effect ◽  
Bare Titanium ◽  
Pathologic Neovascularization

scholarly journals Etiopathogenesis in Retinopathy of Prematurity

2018 ◽  
pp. 5-12
Keyword(s):  
Oxidative Stress ◽  
Vascular Endothelial Growth Factor ◽  
Retinopathy Of Prematurity ◽  
Vascular Endothelial ◽  
Retinal Tissue ◽  
Oxygen Induced Retinopathy ◽  
Weight Suppression ◽  
Exogenous Factors ◽  
Endothelial Growth Factor ◽  
Pathologic Neovascularization

Retinopathy of prematurity is a potentially blinding disease associated with low gestational age and birth weight. Suppression of growth factors due to hyperoxia and loss of maternal-fetal interaction cause impaired development of retinal vascularization. Subsequently, an increase in metabolic demands and inadequate vascularization lead to hypoxia that triggers the pathologic neovascularization process, which may lead to a retinal detachment in retinal tissue. Vascular endothelial growth factor (VEGF) has a key role in both physiologic and pathologic vascularization. Based upon in animal models of oxygen-induced retinopathy (OIR) exogenous factors like oxygen levels, oxidative stress, inflammation and cytokines, several signaling pathways and receptors have been linked to the pathogenesis of retinopathy of prematurity.

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