scholarly journals Coenzyme Q10 Inhibits Glutamate Excitotoxicity and Oxidative Stress–Mediated Mitochondrial Alteration in a Mouse Model of Glaucoma

2014 ◽  
Vol 55 (2) ◽  
pp. 993 ◽  
Author(s):  
Dongwook Lee ◽  
Myoung Sup Shim ◽  
Keun-Young Kim ◽  
You Hyun Noh ◽  
Heemin Kim ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mouse Model ◽  
Coenzyme Q10 ◽  
Glutamate Excitotoxicity ◽  
Mitochondrial Alteration ◽  
And Oxidative Stress

A multifunctional compound ebselen reverses memory impairment, apoptosis and oxidative stress in a mouse model of sporadic Alzheimer's disease

2019 ◽  
Vol 109 ◽  
pp. 107-117 ◽  
Author(s):  
Franciele Martini ◽  
Suzan Gonçalves Rosa ◽  
Isabella Pregardier Klann ◽  
Bruna Cruz Weber Fulco ◽  
Fabiano Barbosa Carvalho ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Memory Impairment ◽  
Sporadic Alzheimer’S Disease ◽  
And Oxidative Stress

scholarly journals Coenzyme Q10, Ageing and the Nervous System: An Overview

Antioxidants ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 2
Author(s):  
David Mantle ◽  
Robert A. Heaton ◽  
Iain P. Hargreaves
Keyword(s):  
Oxidative Stress ◽  
Coenzyme Q10 ◽  
Neurological Disorders ◽  
Neurological Disease ◽  
Age Related ◽  
Increased Risk ◽  
Potential Therapeutic Role ◽  
Ageing Brain ◽  
And Oxidative Stress

The ageing brain is characterised by changes at the physical, histological, biochemical and physiological levels. This ageing process is associated with an increased risk of developing a number of neurological disorders, notably Alzheimer’s disease and Parkinson’s disease. There is evidence that mitochondrial dysfunction and oxidative stress play a key role in the pathogenesis of such disorders. In this article, we review the potential therapeutic role in these age-related neurological disorders of supplementary coenzyme Q10, a vitamin-like substance of vital importance for normal mitochondrial function and as an antioxidant. This review is concerned primarily with studies in humans rather than in vitro studies or studies in animal models of neurological disease. In particular, the reasons why the outcomes of clinical trials supplementing coenzyme Q10 in these neurological disorders is discussed.

Presymptomatic Alterations in Energy Metabolism and Oxidative Stress in the APP23 Mouse Model of Alzheimer Disease

2012 ◽  
Vol 11 (6) ◽  
pp. 3295-3304 ◽  
Author(s):  
Daniela Hartl ◽  
Victoria Schuldt ◽  
Stephanie Forler ◽  
Claus Zabel ◽  
Joachim Klose ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Energy Metabolism ◽  
Alzheimer Disease ◽  
Mouse Model ◽  
App23 Mouse ◽  
And Oxidative Stress

scholarly journals Pharmacological and genetic reappraisals of protease and oxidative stress pathways in a mouse model of obstructive lung diseases

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Tsuyoshi Shuto ◽  
Shunsuke Kamei ◽  
Hirofumi Nohara ◽  
Haruka Fujikawa ◽  
Yukihiro Tasaki ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mouse Model ◽  
Lung Diseases ◽  
Obstructive Lung Diseases ◽  
And Oxidative Stress

Comicronized PEA and Rutin reduces inflammation and oxidative stress in a mouse model of vascular injury

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Alessio Filippo peritore ◽  
Daniela Impellizzeri ◽  
Enrico Gugliandolo ◽  
Rosalba Siracusa ◽  
Roberta Fusco ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mouse Model ◽  
Vascular Injury ◽  
And Oxidative Stress

scholarly journals Age-related cognitive impairment is associated with long-term neuroinflammation and oxidative stress in a mouse model of episodic systemic inflammation

2018 ◽  
Vol 15 (1) ◽  
Author(s):  
Joana Costa d’Avila ◽  
Luciana Domett Siqueira ◽  
Aurélien Mazeraud ◽  
Estefania Pereira Azevedo ◽  
Debora Foguel ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cognitive Impairment ◽  
Mouse Model ◽  
Systemic Inflammation ◽  
Age Related ◽  
And Oxidative Stress
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