scholarly journals Expression Profiling of Nonpolar Lipids in Meibum From Patients With Dry Eye: A Pilot Study

2017 ◽  
Vol 58 (4) ◽  
pp. 2266 ◽  
Author(s):  
Jianzhong Chen ◽  
Jeremy K. Keirsey ◽  
Kari B. Green ◽  
Kelly K. Nichols
Keyword(s):  
Pilot Study ◽  
Dry Eye ◽  
Expression Profiling ◽  
Nonpolar Lipids

scholarly journals Topical TRPM8 Agonist for Relieving Neuropathic Ocular Pain in Patients with Dry Eye: A Pilot Study

2021 ◽  
Vol 10 (2) ◽  
pp. 250
Author(s):  
Hyeon Jeong Yoon ◽  
Jonghwa Kim ◽  
Jee Myung Yang ◽  
Edward T. Wei ◽  
Seong Jin Kim ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Pilot Study ◽  
Pain Intensity ◽  
Dry Eye ◽  
Associated Factors ◽  
Treatment Result ◽  
Ocular Pain ◽  
Eye Pain ◽  
Validated Questionnaire

Background: Activation of TRPM8, a cold-sensing receptor located on the cornea and eyelid, has the potential to relieve the neuropathic ocular pain (NOP) in dry eye (DE) by inhibiting other aberrant nociceptive inputs. We aimed to investigate the effect of a topical TRPM8 agonist, cryosim-3 (C3), on relieving DE-associated NOP. Methods: We conducted a prospective pilot study of 15 patients with DE-associated NOP. These patients applied topical C3 to their eyelid, 4 times/day for 1 month. The patients underwent clinical examinations. They also completed the Ocular Pain Assessment Survey (OPAS), which is a validated questionnaire for NOP, at baseline, 1 week, and 1 month after treatment. Result: At 1 week, the OPAS scores of eye pain intensity, quality of life (driving/watching TV, general activity, sleep, and enjoying life/relations with other people), and associated factors (burning sensation, light sensitivity, and tearing) improved. The total OPAS scores of eye pain intensity, quality of life, and associated factors remained improved at 1 month. The Schirmer test scores also improved at 1 month. Conclusion: TRPM8 agonist (C3) could be a novel agent for treating patients with DE-associated NOP who are unresponsive to conventional treatments.

scholarly journals Gene Expression Profiling as an Adjunctive Measure to Guide the Management of Indeterminate, High-Risk Choroidal Melanocytic Lesions: A Pilot Study

2018 ◽  
Vol 5 (2) ◽  
pp. 102-109
Author(s):  
Ezekiel Weis ◽  
Kelsey Roelofs ◽  
Matthew Larocque ◽  
Albert Murtha
Keyword(s):  
Gene Expression ◽  
Pilot Study ◽  
High Risk ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Melanocytic Lesions

scholarly journals Efficacy and safety of glycyrrhizin 2.5% eye drops in the treatment of moderate dry eye disease: results from a prospective, open-label pilot study

2018 ◽  
Vol Volume 12 ◽  
pp. 2629-2636 ◽  
Author(s):  
Carole Burillon ◽  
Frédéric Chiambaretta ◽  
Pierre-Jean Pisella
Keyword(s):  
Pilot Study ◽  
Dry Eye ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Eye Drops ◽  
Efficacy And Safety ◽  
Open Label

A randomized pilot study to investigate the effect of opioids on immunomarkers using gene expression profiling during surgery

Pain ◽  
2019 ◽  
Vol 160 (12) ◽  
pp. 2691-2698 ◽  
Author(s):  
Theresa Wodehouse ◽  
Mary Demopoulos ◽  
Robert Petty ◽  
Farideh Miraki-Moud ◽  
Alla Belhaj ◽  
...  
Keyword(s):  
Gene Expression ◽  
Pilot Study ◽  
Gene Expression Profiling ◽  
Expression Profiling

Differential expression profiling of circulation microRNAs in PTC patients with non- 131 I and 131 I-avid lungs metastases: a pilot study

2015 ◽  
Vol 42 (5) ◽  
pp. 499-504 ◽  
Author(s):  
Zhong-Ling Qiu ◽  
Chen-Tian Shen ◽  
Hong-Jun Song ◽  
Wei-Jun Wei ◽  
Quan-Yong Luo
Keyword(s):  
Pilot Study ◽  
Differential Expression ◽  
Expression Profiling ◽  
Differential Expression Profiling

Personalized gene expression profiling-guided (MAGE) therapy in heavily treated metastatic breast cancer (MBC): A pilot study.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. e22071-e22071
Author(s):  
Manuel Sureda ◽  
Joseba Rebollo ◽  
Elena Ma Martínez ◽  
Francisco J. Fernández-Morejón ◽  
Vicente Munoz ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Metastatic Breast Cancer ◽  
Pilot Study ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Metastatic Breast

Dry eye symptoms and plasma hormone levels - A pilot study

2013 ◽  
Vol 36 ◽  
pp. e7-e8
Author(s):  
Fiona Stapleton ◽  
Ulrike Hampel ◽  
Noor Badarudin ◽  
Isabelle Jalbert ◽  
Michele Madigan ◽  
...  
Keyword(s):  
Pilot Study ◽  
Dry Eye ◽  
Hormone Levels ◽  
Eye Symptoms ◽  
Plasma Hormone ◽  
Dry Eye Symptoms

scholarly journals Prevalence of dry eye in college students at Uparwara community in Raipur

2019 ◽  
Vol 6 (9) ◽  
pp. 3768
Author(s):  
Andrea Kolla ◽  
Devesh Dahariya ◽  
Male Shiva Ram ◽  
Varaprasad Kolla
Keyword(s):  
College Students ◽  
Risk Factor ◽  
Pilot Study ◽  
Dry Eye ◽  
Electronic Devices ◽  
Questionnaire Study ◽  
Age Group ◽  
Declaration Of Helsinki ◽  
Eye Symptoms ◽  
Dry Eye Symptoms

Background: The study aims to investigate the prevalence of dry eye in college students in the Uparwara community.Methods: This pilot study was conducted tenure to declaration of Helsinki rules with n=240 (males 200 and females 40) with in the age group of 18-25 years, OSDI questionnaire was used to assess the prevalence among the college students of Uparwara community at Raipur.Results: Data from 240 subjects were analyzed with a mean age group of 19.41±0.70 mean±SD. This OSDI questionnaire study with subscales for dry eye symptoms were measured in both the genders males 213 (89%), females 27 (11%). The percentage distributions among the subjects showed that 116 (48.3%) participants reported dry eye symptoms and 124 (51.6%) was normal.Conclusions: This study emphasized on the prolonged usage of VDT and electronic devices i.e., >4 hours as a compliance factor for dry eye, our data suggest that VDT usage less than 4 hours also can be a risk factor for dry eye since all our 116 participants with dry eye symptoms are VDT users and interestingly 78% (90) of them are <4 hours VDT users but still have dry eye symptoms.

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