scholarly journals Spontaneous expression of the interleukin 2 receptor gene and presence of functional interleukin 2 receptors on T lymphocytes in the blood of individuals with active pulmonary sarcoidosis.

1988 ◽  
Vol 82 (3) ◽  
pp. 775-781 ◽  
Author(s):  
K Konishi ◽  
D R Moller ◽  
C Saltini ◽  
M Kirby ◽  
R G Crystal
Keyword(s):  
T Lymphocytes ◽  
Receptor Gene ◽  
Interleukin 2 ◽  
Pulmonary Sarcoidosis ◽  
Interleukin 2 Receptor ◽  
Spontaneous Expression

Interleukin-2 Receptor Gene Expression by Bronchoalveolar Lavage Lymphocytes in Pulmonary Sarcoidosis

1989 ◽  
Vol 140 (1) ◽  
pp. 82-88 ◽  
Author(s):  
Joachim Müller-Quernheim ◽  
Martin Krönke ◽  
Jànos Strausz ◽  
Michael Schykowski ◽  
Rudolf Ferlinz
Keyword(s):  
Gene Expression ◽  
Bronchoalveolar Lavage ◽  
Receptor Gene ◽  
Interleukin 2 ◽  
Pulmonary Sarcoidosis ◽  
Interleukin 2 Receptor ◽  
Receptor Gene Expression

scholarly journals Interleukin 2 receptor gene expression in normal human T lymphocytes.

1985 ◽  
Vol 82 (18) ◽  
pp. 6281-6285 ◽  
Author(s):  
W. J. Leonard ◽  
M. Kronke ◽  
N. J. Peffer ◽  
J. M. Depper ◽  
W. C. Greene
Keyword(s):  
Gene Expression ◽  
T Lymphocytes ◽  
Receptor Gene ◽  
Interleukin 2 ◽  
Interleukin 2 Receptor ◽  
Human T Lymphocytes ◽  
Normal Human ◽  
Receptor Gene Expression

Activation of interleukin-2 receptor gene by Forskolin and cyclic AMP analogues

1987 ◽  
Vol 143 (2) ◽  
pp. 753-760 ◽  
Author(s):  
Shuh Narumiya ◽  
Masakazu Hirata ◽  
Tsunehisa Nanba ◽  
Toshio Nikaido ◽  
Yoshihisa Taniguchi ◽  
...  
Keyword(s):  
Cyclic Amp ◽  
Receptor Gene ◽  
Interleukin 2 ◽  
Interleukin 2 Receptor

scholarly journals Further Analysis of Interleukin-2 Receptor Subunit Expression on the Different Human Peripheral Blood Mononuclear Cell Subsets

Blood ◽  
1998 ◽  
Vol 91 (1) ◽  
pp. 165-172 ◽  
Author(s):  
Denis David ◽  
Lynda Bani ◽  
Jean-Louis Moreau ◽  
Christophe Demaison ◽  
Karine Sun ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Peripheral Blood Mononuclear Cell ◽  
Mononuclear Cell ◽  
Peripheral Blood ◽  
Human Peripheral Blood ◽  
Interleukin 2 ◽  
Constitutive Expression ◽  
Variable Intensity ◽  
Peripheral Blood Mononuclear ◽  
Interleukin 2 Receptor

We have investigated the expression of the three components of the interleukin-2 receptor (IL-2Rα, IL-2Rβ, and IL-2Rγ) on the surface of the various peripheral blood mononuclear cell (PBMC) subsets by flow cytometry analysis. The PBMC were immediately isolated (ficoll) from blood collected on heparin as anticoagulant. The three IL-2R components are absent or only marginally detectable on CD4 T lymphocytes. No expression of the IL-2R chains is found for the B lymphocytes. In most donors, the three chains are not detectable on CD8 T lymphocytes, but for a few of them, IL-2Rβ or IL-2Rγ are clearly expressed. CD56 high (IL-2Rα+) and CD56 low (IL-2Rα−) natural killer (NK) cells express IL-2Rβ, but not IL-2Rγ. IL-2Rγ is expressed by monocytes of all donors although with variable intensity. When blood is collected on other anticoagulants or when cells are isolated 1 day after collection, IL-2Rα, IL-2Rβ, and IL-2Rγ are largely expressed on the surface of most PBMC. This observation provides a possible explanation for divergent data previously reported on IL-2R expression. Finally, we show that IL-2Rγ, which is not detectable on the cell surface of lymphocytes, is nevertheless expressed and stored as an intracellular component. This result is in agreement with the constitutive expression of the IL-2Rγ gene and suggests a specific regulatory mechanism for IL-2Rγ membrane translocation.

Sign in / Sign up

Export Citation Format

Share Document