The Role of Uric Acid in the Acute Myocardial Infarction: A Narrative Review

Angiology ◽  
2021 ◽  
pp. 000331972110125
Author(s):  
Atalay Demiray ◽  
Baris Afsar ◽  
Adrian Covic ◽  
Masanari Kuwabara ◽  
Charles J. Ferro ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Uric Acid ◽  
Adverse Outcomes ◽  
Narrative Review ◽  
Background Information ◽  
Pathophysiological Role ◽  
Artery Disease ◽  
Pathologic Processes

Increased serum uric acid (SUA) levels have been associated with various pathologic processes such as increased oxidative stress, inflammation, and endothelial dysfunction. Thus, it is not surprising that increased SUA is associated with various adverse outcomes including cardiovascular (CV) diseases. Recent epidemiological evidence suggests that increased SUA may be related to acute myocardial infarction (AMI). Accumulating data also showed that elevated UA has pathophysiological role in the development of AMI. However, there are also studies showing that SUA is not related to the risk of AMI. In this narrative review, we summarized the recent literature data regarding SUA and AMI after providing some background information for the association between UA and coronary artery disease. Future studies will show whether decreasing SUA levels is beneficial for outcomes related to AMI and the optimum SUA levels for best outcomes in CV diseases.

scholarly journals Association between Serum Calcium and First Incident Acute Myocardial Infarction: A Cross-Sectional Study

2020 ◽  
Author(s):  
Chi ZHANG ◽  
Bangming CAO ◽  
Xingmei HUANG ◽  
Jian GU ◽  
Ming XIA ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Logistic Regression ◽  
Serum Calcium ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Gender And Age ◽  
Artery Disease

Background: The role of serum calcium in coronary artery disease (CAD) patients with or without first incident acute myocardial infarction has not been studied previously. This study aimed to assess the relationship between serum calcium and first incident acute myocardial infarction. Methods: This cross-sectional study was conducted from Jan 2014 to Dec 2016. All the participants were from our database, described in detail elsewhere including 1609 cases and 3252 controls. Multiple logistic regression was carried out to explore the effect of serum calcium on first incident acute myocardial infarction. Interaction between serum calcium and risk factors were evaluated. Results: Patients with first incident acute myocardial infarction have significantly lower serum calcium concentrations than those without acute myocardial infarction (2.18 (0.21) vs 2.24 (0.19) mmol/L, P<0.0001). After adjusting for sex and age, logistic regression showed that serum calcium was significantly associated with first incident acute myocardial infarction (odds ratio (OR): 1.50, 95% confidence interval (CI): 1.41-1.60). Further adjusted for potential confounders, serum calcium was associated with first incident acute myocardial infarction (OR: 1.32, 95% CI: 1.22-1.42). Moreover, the association still existed when patients were divided into subgroups according to gender and age. A significant interaction was found between serum calcium and diabetes mellitus (DM), lipoprotein (a) (Lp (a)), and serum albumin. Conclusion: Serum calcium was associated with first incident acute myocardial infarction among CAD patients in both sexes and in age categories. This study provides further evidence showing the value of serum calcium levels in clinical practice.

Role of sinus node artery disease in sick sinus syndrome in inferior wall acute myocardial infarction

1991 ◽  
Vol 67 (15) ◽  
pp. 1180-1184 ◽  
Author(s):  
Paolo Alboni ◽  
Gian Franco Baggioni ◽  
Salvatore Scarfò ◽  
Riccardo Cappato ◽  
Gian Franco Percoco ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Sick Sinus Syndrome ◽  
Sinus Node ◽  
Inferior Wall ◽  
Sinus Node Artery ◽  
Artery Disease

Origin and Pathophysiological Role of Increased Plasma Endothelin-1 in Patients with Acute Myocardial Infarction

Angiology ◽  
1995 ◽  
Vol 46 (7) ◽  
pp. 557-565 ◽  
Author(s):  
Koichi Setsuta ◽  
Yoshihiko Seino ◽  
Yoshifumi Tomita ◽  
Jun Nejima ◽  
Teruo Takano ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Endothelin 1 ◽  
Pathophysiological Role

Abstract 433: Coronary Artery Ectasia in Patients with Obstructive Coronary Artery Disease

2015 ◽  
Vol 35 (suppl_1) ◽  
Author(s):  
Shasha Xu ◽  
Jianjun Jiang ◽  
Huanhuan Zhu ◽  
Bing Wang ◽  
Congfeng Fang ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Acute Myocardial Infarction ◽  
Uric Acid ◽  
Coronary Artery ◽  
Angina Pectoris ◽  
Obstructive Coronary Artery Disease ◽  
Coronary Artery Ectasia ◽  
Old Myocardial Infarction ◽  
Artery Disease

Background and Objective: The pathophysiology of isolated coronary artery ectasia (CAE) remains poorly understood although associations between CAE and a broad spectrum of different diseases, especially atherosclerotic coronary artery disease have been reported. This study aimed to investigate the clinical characteristics of CAE and its relationship to obstructive artery disease in the Chinese Population. Methods and Results: This study recruited 3793 consecutive patients who had undergone coronary angiography for suspected coronary artery disease (CAD) between January 2009 and December 2014. The median age of the patients was 63 years (range, 27 to 94 years) and the majority (69.71%) was male. There were 3068 patients with obstructive coronary artery disease, including angina pectoris (n=1611), acute myocardial infarction (n=1265), and old myocardial infarction (n=192). A total of 120 cases (Male, n=93, female, n=27) with a median age of 63 years (range, 28-86) were identified as CAE in patients undergoing coronary angiography. Co-existent CAD was present in 94% of CAE patients, including 56 angina pectoris; 53 acute myocardial infarction; and 4 old myocardial infarction cases. The prevalence of CAE in patients with obstructive coronary artery disease was 3.67%. The frequency of arterial involvement was: right coronary artery (RCA), 63%; left anterior descending artery (LAD), 43%; left circumflex artery (LCX), 38%; and left main artery (LM), 14%. CAE affected only 1 major vessel in 83% of cases, 2 vessels in 12%, and all 3 vessels in 5%. Using multivariate analysis, serum levels of uric acid were independently associated with present of CAE (P<0.001), while other cardiovascular risk factors such age, arterial hypertension, dyslipidemia, smoking, and diabetes mellitus did not show statistically significant associations (P>0.05). Conclusion: The prevalence of CAE in patients with obstructive coronary artery disease was 3.67%. The RCA was the most commonly affected and most patients had single vessel involvement. Increased serum uric acid level may be a potential risk factor for presence of CAE.

scholarly journals PROGNOSTIC ROLE OF SERUM URIC ACID FOLLOWING ACUTE MYOCARDIAL INFARCTION

2016 ◽  
Vol 5 (87) ◽  
pp. 6447-6453
Author(s):  
Peddi Bhaskar ◽  
Rajendra Prasad Parlapally ◽  
Puduri Rajendra Prasad
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Prognostic Role
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