Medical Treatment of Tinnitus
Medical treatment is presented as the best hope of the various treatment methods available for the management of tinnitus. A test dose of 100 mg lidocaine given rapidly intravenously will give good or partial temporary relief to approximately 80% of patients with tinnitus. More permanent relief can then be achieved by the oral anticonvulsants carbamazepine or primidone but the side effects of these drugs are occasionally too severe to justify their use. Three preliminary clinical studies of the oral amide of lidocaine, tocainide hydrochloride, were conducted and results with 600 mg four times daily are very promising. Further long-term clinical trials with tocainide will be started soon. It would appear that local anesthetics when given intravenously block the multisynaptic slow pathways in tinnitus as well as in chronic pain, with which there are many other similarities. The delay in wave V in the BSER and the sudden sleep induced in patients with a good response to intravenous lidocaine further confirm the site of action of these drugs in the brainstem and reticular formation. Until tocainide is available for general use it is possible to control tinnitus with large doses of intravenous lidocaine, 100 mg given rapidly and 400 mg slowly with EKG monitoring each day for several days, and then at weekly intervals, as in the treatment of clausalgia. Because patients with disabling tinnitus, as with chronic intractable pain, are rigid, insecure, chronically depressed and fatigued, a mood-elevating tranquilizer drug combination such as perphenazine-amitriptyline is of great value in maintaining these patients. While medical treatment is not the final answer it is the best treatment available and it offers a promising direction for further study.