Ewing's Sarcoma of Bone and Soft Tissues

1989 ◽  
Vol 98 (5) ◽  
pp. 400-402 ◽  
Author(s):  
Nour Sneige ◽  
John G. Batsakis
Keyword(s):  
Soft Tissue ◽  
Soft Tissues ◽  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma ◽  
Combined Modality Treatment ◽  
High Grade ◽  
Facial Bones ◽  
Grade Malignancy ◽  
High Grade Malignancy ◽  
Tissue Origin

Ewing's sarcoma is a distinctive clinical and pathologic entity that may be intraosseous or of soft-tissue origin. In the facial bones, the incidence of the sarcoma is estimated at 2.5% of all Ewing's sarcoma of bone. The soft tissues of the head and neck account for 11% of extraskeletal sites of the neoplasm. Combined modality treatment has modified its high-grade malignancy.

Low-grade malignant perineurioma of the paravertebral column, transforming into a high-grade malignancy

1999 ◽  
Vol 49 (9) ◽  
pp. 820-825 ◽  
Author(s):  
Shino Karaki ◽  
Joji Mochida ◽  
Yoon Hwan Lee ◽  
Kazuhiro Nishimura ◽  
Yutaka Tsutsumi
Keyword(s):  
Low Grade ◽  
High Grade ◽  
Grade Malignancy ◽  
High Grade Malignancy

scholarly journals RESECTION OF ESOPHAGEAL GASTROINTESTINAL STROMAL TUMOR WITH HIGH-GRADE MALIGNANCY-A CASE REPORT-

2006 ◽  
Vol 67 (7) ◽  
pp. 1541-1545 ◽  
Author(s):  
Hisashi ISHIKURA ◽  
Hiroshi OKITSU ◽  
Akihiro SAKATA ◽  
Masashi ISHIKAWA ◽  
Jyunnichi SEIKE ◽  
...  
Keyword(s):  
Case Report ◽  
Gastrointestinal Stromal Tumor ◽  
Stromal Tumor ◽  
High Grade ◽  
Grade Malignancy ◽  
High Grade Malignancy

scholarly journals Musculoskeletal oncology: patient triage and management during the COVID-19 pandemic

2020 ◽  
Vol 27 (5) ◽  
Author(s):  
N. Olshinka ◽  
S. Mottard
Keyword(s):  
Surgical Oncology ◽  
Low Grade ◽  
High Grade ◽  
Oncology Patient ◽  
Exposure Risks ◽  
Grade Malignancy ◽  
Oncology Centre ◽  
Sarcoma Treatment ◽  
Musculoskeletal Oncology ◽  
High Grade Malignancy

Sarcoma treatment during the covid-19 pandemic is a new challenge. This patient population is often immunocom­promised and potentially more susceptible to viral complications.    Government guidelines highlight the need to minimize patient exposure to unnecessary hospital visits. However, those guidelines lack practical recommendations on ways to manage triage and diagnosis expressly for new cancer patients. Furthermore, there are no reports on the efficiency of the guidelines.    One of the main issues in treating musculoskeletal tumours is the complexity and variability of presentation. We offer a triage model, used in a quaternary-referral musculoskeletal oncology centre, that allows us to maintain an open pathway for referral of new patients while minimizing exposure risks. A multidisciplinary approach and analysis of existing investigations allow for a pre-clinic evaluation.    The model identifies 3 groups of patients: Patients with suspected high-grade malignancy, or benign cases with aggressive features, both in need of further evaluation in the clinic and prompt treatment Patients with low-grade malignancy, and benign cases whose treatment is not urgent, that are managed, during the pandemic by telemedicine, with reassurance and information about their illness Patients who can be managed by their local medical professionals    In comparison to a pre-pandemic period, that approach resulted in a higher ratio of malignant-to-benign con­ditions for new patients seen in the clinic (3:4 vs. 1:3 respectively), thus using available resources more efficiently and prioritizing patients with suspected high-grade malignancy.    We believe that this triage system could be applied in other surgical oncology fields during a pandemic.

scholarly journals Pediatric patient with diagnosis of extra osseous Ewing’s sarcoma of the tongue: case report

2018 ◽  
Vol 66 (4) ◽  
pp. 399-403
Author(s):  
Neira CHAPARRO ◽  
Amaurys DIAZ ◽  
Luis HERRERA ◽  
Rafael PINEDA ◽  
Betty PEROZO ◽  
...  
Keyword(s):  
Pediatric Patient ◽  
Soft Tissues ◽  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma ◽  
Malignant Neoplasm ◽  
Histopathological Study ◽  
Histopathological Diagnosis ◽  
Unusual Behavior ◽  
Volume Increase ◽  
Tumoral Lesion

ABSTRACT Ewing’s sarcoma is a malignant tumor that arises mainly from bone tissue, so that its extra-osseous presentation is not very common and even more unusual, in the soft tissues of the oral cavity. The objective of this case was to describe the clinical characteristics of an extra-osseous Ewing’s Sarcoma of the tongue in a pediatric patient. An 11-year-old male school patient, who attended an oral medicine consultation referring a volume increase in the tongue. Intraorally, a tumoral lesion was observed on the left lateral edge of the tongue, indurated, with the same color of the mucosa with ulcerated areas, well defined edges and symptomatic on palpation, with an approximate size of 2.5 cm. A cervical and maxillofacial MRI was indicated, observing a partially delimited hyperintense and non-infiltrating lesion in the described area. An incisional biopsy was performed with histopathological diagnosis of malignant neoplasm of blue round cells, theCD99 marker was found to be positive in the immunohistochemical study and was key to the definitive diagnosis of this tumor. A thoraco-abdomino-pelvic tomography was requested by the Pediatric Oncology service, as well as biopsy and aspiration of bone marrow, in which no neoplastic infiltrations were evidenced. After four cycles of chemotherapy, total removal of the lesion was performed with a consecutive histopathological study of the surgical piece, indicating free edges of the lesion. Ewing’s sarcoma is a tumor with aggressive behavior, so this case represents a finding of clinical and epidemiological relevance, both due to its extra-osseous appearance and its unusual behavior.

Non Conventional Fractionation in Radiotherapy of the Musculo-Skeletal Sarcomas

1998 ◽  
Vol 84 (2) ◽  
pp. 167-170 ◽  
Author(s):  
Enza Barbieri ◽  
Giovanni Frezza ◽  
Ombretta Martelli ◽  
Stefano Neri ◽  
Mario Mercuri ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Late Effects ◽  
Surgical Complications ◽  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma ◽  
Young Patients ◽  
Soft Tissue Sarcomas ◽  
Treatment Modalities ◽  
Complication Rates ◽  
Bulky Disease

In 1989 we started an accelerated hyperfractionated schedule of radiotherapy (two 1.6 Gy daily fractions) in standard risk localized Ewing's sarcoma of bone, with the aim at reducing late effects in young patients and at improving disease control through a better integration of treatment modalities. From 1991, the same schedule was used in preoperative radiotherapy of adult soft tissue sarcomas of the extremities: the main purpose was to reduce the time to surgery and to evaluate surgical complications in comparison with a previous experience of hypofractionated radiotherapy (one 3 Gy daily fraction). From 1991 to 1997, 76 patients with Ewing's sarcoma and 24 patients with soft tissue sarcoma were treated at our Institution. Results and complication rates are analyzed in comparison with historical data. In Ewing's sarcoma, a correct evaluation of improvement in local control was difficult because of changing treatment policy (bulky disease was not included in the present series). Late effects, as evaluated in patients with a minimum follow-up of 3 years, occurred with similar incidence, but at higher total dose levels in patients treated with accelerated hyperfractionation. In patients with soft tissue sarcomas, incidence of surgical complications is reduced as compared to historical experience. Major problems of wound healing were seen in association with intraoperative brachitherapy boost.

Chemotherapy in the Management of Osteosarcoma and Ewing's Sarcoma

2007 ◽  
Vol 5 (4) ◽  
pp. 449-455 ◽  
Author(s):  
Scott M. Schuetze
Keyword(s):  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma ◽  
Disease Patient ◽  
Bone Sarcoma ◽  
The United States ◽  
High Grade ◽  
Medical Oncologists ◽  
Bone Sarcomas ◽  
Localized Disease ◽  
Relapsed Disease

Sarcomas of bone are rare malignancies diagnosed in fewer than 3000 individuals yearly in the United States. Ewing's sarcoma and most osteosarcoma are high-grade neoplasms and account for approximately one half of bone sarcoma cases. Fewer than 20% of patients presenting with localized Ewing's sarcoma or osteosarcoma are cured with surgery alone. Current management typically involves collaboration among orthopedic oncologists, medical oncologists, musculoskeletal radiologists, sarcoma pathologists, and radiation oncologists. Modern multidisciplinary management of Ewing's sarcoma and osteosarcoma has improved the cure rate of patients with localized disease to more than 50%. Primary chemotherapy for high-grade bone sarcomas often involves intensive, multiagent regimens, and few secondary chemotherapy options are available to treat refractory or relapsed disease. Patient participation in clinical trials of novel therapies for Ewing's sarcoma and osteosarcoma should be strongly encouraged.

L-TYPE AMINO ACID TRANSPORTER 1 EXPRESSION IN PROSTATE CANCER: ASSOCIATION WITH CANCER PROGRESSION AND HIGH-GRADE MALIGNANCY

2008 ◽  
Vol 179 (4S) ◽  
pp. 105-105
Author(s):  
Takefumi Satoh ◽  
Takeshi Sakata ◽  
Isao Okayasu ◽  
Golam Ferdous ◽  
Tomoko Tsuruta ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Amino Acid ◽  
Cancer Progression ◽  
Amino Acid Transporter ◽  
High Grade ◽  
Acid Transporter ◽  
Grade Malignancy ◽  
High Grade Malignancy
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