Gender-Specific Vocal Dysfunctions in Parkinson's Disease: Electroglottographic and Acoustic Analyses

1995 ◽  
Vol 104 (3) ◽  
pp. 197-202 ◽  
Author(s):  
Ingo Hertrich ◽  
Hermann Ackermann
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Spectral Energy Distribution ◽  
Low Frequency ◽  
Spectral Energy ◽  
Vowel Production ◽  
Men And Women ◽  
Abrupt Shifts ◽  
Glottal Source ◽  
Gender Specific

Electroglottographic (EGG) and acoustic recordings were obtained during sustained vowel production in men and women suffering from Parkinson's disease (PD). The computed EGG spectrograms allowed us to differentiate various kinds of phonatory disturbances: intervals with subharmonic energy (“low-frequency segments”), “noise-like regions,” and abrupt shifts of fundamental frequency (F0). Female PD subjects presented with a significantly increased portion of subharmonic segments and with significantly more abrupt F0 shifts as compared to both controls and male PD subjects. Presumably, these alterations in spectral energy distribution reflect different oscillatory modes of the glottal source. Thus, PD seems to have a differential impact on phonation in men and women. Conceivably, these gender-specific vocal dysfunctions are determined by the well-known sexual dimorphism of laryngeal size.

scholarly journals The challenging SED of AP Librae

2011 ◽  
Vol 7 (S284) ◽  
pp. 411-413 ◽  
Author(s):  
David Sanchez ◽  
Berrie Giebels ◽  
Pascal Fortin ◽  
Keyword(s):  
Spectral Energy Distribution ◽  
Broad Band ◽  
Low Frequency ◽  
Theoretical Models ◽  
Intermediate Frequency ◽  
High Energy ◽  
Spectral Energy ◽  
Broad Band Emission ◽  
Band Emission ◽  
Bl Lac

AbstractMatching the broad-band emission of active galaxies with the predictions of theoretical models can be used to derive constraints on the properties of the emitting region and to probe the physical processes involved. AP Librae is the third low frequency peaked BL Lac (LBL) detected at very high energy (VHE, E>100GeV) by an Atmospheric Cherenkov Telescope; most VHE BL Lacs (34 out of 39) belong to the high-frequency and intermediate-frequency BL Lac classes (HBL and IBL). LBL objects tend to have a higher luminosity with lower peak frequencies than HBLs or IBLs. The characterization of their time-averaged spectral energy distribution is challenging for emission models such as synchrotron self-Compton (SSC) models.

scholarly journals Far-infrared photometry of OJ 287 with the Herschel Space Observatory

2018 ◽  
Vol 610 ◽  
pp. A74
Author(s):  
Mark Kidger ◽  
Staszek Zola ◽  
Mauri Valtonen ◽  
Anne Lähteenmäki ◽  
Emilia Järvelä ◽  
...  
Keyword(s):  
Energy Distribution ◽  
Light Curve ◽  
Spectral Index ◽  
Spectral Energy Distribution ◽  
Low Frequency ◽  
Far Infrared ◽  
Small Degree ◽  
Spectral Energy ◽  
Space Observatory ◽  
Near Ir

Context. The blazar OJ 287 has shown a ≈12 year quasi-periodicity over more than a century, in addition to the common properties of violent variability in all frequency ranges. It is the strongest known candidate to have a binary singularity in its central engine. Aim. We aim to better understand the different emission components by searching for correlated variability in the flux over four decades of frequency measurements. Methods. We combined data at frequencies from the millimetric to the visible to characterise the multifrequency light curve in April and May 2010. This includes the only photometric observations of OJ 287 made with the Herschel Space Observatory: five epochs of data obtained over 33 days at 250, 350, and 500 μm with Herschel-SPIRE. Results. Although we find that the variability at 37 GHz on timescales of a few weeks correlates with the visible to near-IR spectral energy distribution, there is a small degree of reddening in the continuum at lower flux levels that is revealed by the decreasing rate of decline in the light curve at lower frequencies. However, we see no clear evidence that a rapid flare detected in the light curve during our monitoring in the visible to near-IR light curve is seen either in the Herschel data or at 37 GHz, suggesting a low-frequency cut-off in the spectrum of such flares. Conclusions.We see only marginal evidence of variability in the observations with Herschel over a month, although this may be principally due to the poor sampling. The spectral energy distribution between 37 GHz and the visible can be characterised by two components of approximately constant spectral index: a visible to far-IR component of spectral index α = −0.95, and a far-IR to millimetric spectral index of α = −0.43. There is no evidence of an excess of emission that would be consistent with the 60 μmdust bump found in many active galactic nuclei.

scholarly journals The Effects of Levodopa and Deep Brain Stimulation on Subthalamic Local Field Low-Frequency Oscillations in Parkinson's Disease

Neurosignals ◽  
2013 ◽  
Vol 21 (1-2) ◽  
pp. 89-98 ◽  
Author(s):  
Gaia Giannicola ◽  
Manuela Rosa ◽  
Sara Marceglia ◽  
Emma Scelzo ◽  
Lorenzo Rossi ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Local Field ◽  
Brain Stimulation ◽  
Low Frequency ◽  
Low Frequency Oscillations ◽  
Deep Brain

scholarly journals Myocardial123I-MIBG Uptake and Cardiovascular Autonomic Function in Parkinson’s Disease

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Akira Katagiri ◽  
Masato Asahina ◽  
Nobuyuki Araki ◽  
Anupama Poudel ◽  
Yoshikatsu Fujinuma ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Autonomic Function ◽  
Low Frequency ◽  
Washout Rate ◽  
Tilt Test ◽  
Mibg Uptake ◽  
Cardiovascular Autonomic Function ◽  
Frequency Power

Introduction. Patients with Parkinson’s disease (PD) showed reduced myocardial123I-MIBG uptake, which may affect autonomic regulation. We investigated correlation between MIBC accumulation and cardiovascular autonomic function in PD.Methods. We performed myocardial MIBG scintigraphy, heart rate variability (HRV) analysis, and the head-up tilt test (HUT) in 50 PD patients (66.4±7.8years; duration5.5±5.9years). Autonomic function tests were also performed in 50 healthy controls (66.5±8.9years). As HRV parameters, a high-frequency power (HF, 0.15–0.4 Hz), a low-frequency power (LF, 0.04–0.15 Hz), and LF/HF ratio were used.Results. Our PD patients had a significant reduction in LF and HF compared with the controls (P=0.005andP=0.01). In HUT, systolic and diastolic blood pressure falls in the PD group were significantly greater than those in the controls (P=0.02andP=0.02). The washout rate of MIBG was negatively correlated with blood pressure changes during HUT.Conclusion. Our PD patients showed reduced HRV, blood pressure dysregulation, and reduced MIBG accumulation, which was correlated with blood pressure dysregulation. Orthostatic hypotension in PD may be mainly caused by sympathetic postganglionic degeneration.

Predictive Factors for Improvement of Gait by Low-Frequency Stimulation in Parkinson's Disease

2014 ◽  
Vol 4 (3) ◽  
pp. 413-420 ◽  
Author(s):  
Agnès Annic ◽  
Caroline Moreau ◽  
Julia Salleron ◽  
David Devos ◽  
Arnaud Delval ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Predictive Factors ◽  
Low Frequency ◽  
Low Frequency Stimulation ◽  
Frequency Stimulation

scholarly journals Levodopa-Responsive Primary Slow Orthostatic Tremor: A Premotor Sign of Parkinson’s Disease?

2020 ◽  
Vol 12 (1) ◽  
pp. 1-6
Author(s):  
Fumihito Yoshii ◽  
Wakoh Takahashi ◽  
Koji Aono
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Surface Electromyography ◽  
Specific Binding ◽  
Low Frequency ◽  
Orthostatic Tremor ◽  
Specific Binding Ratio ◽  
Dopaminergic Medication ◽  
Neurological Signs ◽  
Dat Spect

We present a case of primary orthostatic tremor (OT) responsive to dopaminergic medication. The patient was a 62-year-old woman, who had leg tremor on standing for 2 years. No parkinsonian or other neurological signs were observed. Surface electromyography of the quadriceps muscles showed regular 5–6 Hz muscle discharges. [123I]-FP-CIT DAT-SPECT imaging revealed decreased specific binding ratio values in the striatum compared with age-matched controls. Her leg tremor almost completely disappeared following administration of levodopa 200 mg and pramipexole 0.75 mg. Since her OT with low-frequency discharge was responsive to dopaminergic medication, we speculate that it may be a premotor sign of Parkinson’s disease.

scholarly journals Systematic effects in LOFAR data: A unified calibration strategy

2019 ◽  
Vol 622 ◽  
pp. A5 ◽  
Author(s):  
F. de Gasperin ◽  
T. J. Dijkema ◽  
A. Drabent ◽  
M. Mevius ◽  
D. Rafferty ◽  
...  
Keyword(s):  
Spectral Energy Distribution ◽  
Low Frequency ◽  
Reduction Process ◽  
Spectral Energy ◽  
Ionospheric Scintillation ◽  
Source Population ◽  
Full Data ◽  
Low Frequencies ◽  
Beam Shape ◽  
Systematic Effects

Context. New generation low-frequency telescopes are exploring a new parameter space in terms of depth and resolution. The data taken with these interferometers, for example with the LOw Frequency ARray (LOFAR), are often calibrated in a low signal-to-noise ratio regime and the removal of critical systematic effects is challenging. The process requires an understanding of their origin and properties. Aim. In this paper we describe the major systematic effects inherent to next generation low-frequency telescopes, such as LOFAR. With this knowledge, we introduce a data processing pipeline that is able to isolate and correct these systematic effects. The pipeline will be used to calibrate calibrator observations as the first step of a full data reduction process. Methods. We processed two LOFAR observations of the calibrator 3C 196: the first using the Low Band Antenna (LBA) system at 42–66 MHz and the second using the High Band Antenna (HBA) system at 115–189 MHz. Results. We were able to isolate and correct for the effects of clock drift, polarisation misalignment, ionospheric delay, Faraday rotation, ionospheric scintillation, beam shape, and bandpass. The designed calibration strategy produced the deepest image to date at 54 MHz. The image has been used to confirm that the spectral energy distribution of the average radio source population tends to flatten at low frequencies. Conclusions. We prove that LOFAR systematic effects can be described by a relatively small number of parameters. Furthermore, the identification of these parameters is fundamental to reducing the degrees of freedom when the calibration is carried out on fields that are not dominated by a strong calibrator.

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