Fluorescence Turn-On Detection of Ascorbic Acid Using a Self-Assembled Lanthanide Polymer Nanoparticle

2019 ◽  
Vol 74 (3) ◽  
pp. 275-284
Author(s):  
Hui-Hui Zeng ◽  
Fang Liu ◽  
Long-Ke Hu ◽  
Jie Deng ◽  
Yue-Ping Xie ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Coordination Polymer ◽  
Fluorescence Probe ◽  
Signal To Noise Ratio ◽  
Polymer Nanoparticles ◽  
Sensing Systems ◽  
Sensing Platforms ◽  
Lanthanide Coordination Polymer ◽  
Fluorescence Turn On

Ascorbic acid (AA), or vitamin C, is an important reactive biological molecule in vivo, and an abnormal level of AA is associated with many diseases. Therefore, the rapid, sensitive, and selective detection of AA levels is of significance in cases of medical assay and diagnosis. Compared with other nanoparticles, lanthanide coordination polymer nanoparticles (Ln-CPs) have been demonstrated as the excellent biomolecule sensing platforms due to their unique optical properties and intrinsic porosities. In this work, the cerium coordination polymer nanoparticles ATP-Ce-Tris were synthesized in a simple and quick way. The synthesized ATP-Ce-Tris nanoparticle shows the characteristic peak of Ce3+ located at 365 nm, which is corresponding to the 4f→5d transition of Ce3+. In the presence of Fe3+, the fluorescence of ATP-Ce-Tris quenched, and the following added ascorbic acid (AA) makes it restoring effectively. Based on this, we constructed a fluorescence probe with excellent sensitivity for AA sensing in a wide linear relationship from 0.05 to 500 μM. The detection limit was as low as 18 nM (signal-to-noise ratio of three), which is one or two orders of magnitude lower than those of reported sensors. The proposed sensing systems also exhibits excellent sensitivity for AA detection in human serum sample, exploiting a valuable platform for AA analysis in clinic diagnostic and drug screening.

A turn on fluorescent sensor based on lanthanide coordination polymer nanoparticles for the detection of mercury(ii) in biological fluids

RSC Advances ◽  
2016 ◽  
Vol 6 (22) ◽  
pp. 17811-17817 ◽  
Author(s):  
Qian Li ◽  
Chengjuan Wang ◽  
Hongliang Tan ◽  
Gonge Tang ◽  
Jie Gao ◽  
...  
Keyword(s):  
Coordination Polymer ◽  
Fluorescent Sensor ◽  
Biological Fluids ◽  
Polymer Nanoparticles ◽  
Turn On ◽  
Lanthanide Coordination Polymer

Im-quenched fluorescence of Eu/IPA CPNPs can be recovered upon the addition of Hg2+ through the formation of a Hg/Im complex.

Fluorescence assay for alkaline phosphatase activity based on energy transfer from terbium to europium in lanthanide coordination polymer nanoparticles

2018 ◽  
Vol 6 (37) ◽  
pp. 6008-6015 ◽  
Author(s):  
Fengyi Wang ◽  
Xuan Hu ◽  
Jing Hu ◽  
Qianqian Peng ◽  
Baozhan Zheng ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Energy Transfer ◽  
Coordination Polymer ◽  
Phosphatase Activity ◽  
Alkaline Phosphatase Activity ◽  
Fluorescence Assay ◽  
Polymer Nanoparticles ◽  
Lanthanide Coordination Polymer

An effective fluorescence assay alkaline phosphatase (ALP) method was developed by using bimetallic lanthanide coordination polymer nanoparticles (Tb-GMP-Eu CPNs).

scholarly journals Angularly Resolved Deep Brain Fluorescence Imaging Using a Single Optical Fiber

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Israel J. De La Rosa ◽  
Mehdi Azimipour ◽  
Patrick K. Cullen ◽  
Fred J. Helmstetter ◽  
Ramin Pashaie
Keyword(s):  
Optical Fiber ◽  
Pulse Compression ◽  
Fluorescence Probe ◽  
Signal To Noise Ratio ◽  
Fluorescence Emission ◽  
Compression Technique ◽  
Excitation Light ◽  
New Device ◽  
Deep Brain

In this article, we report the development of a minimally invasive fiber optic based fluorescence probe which can reach deep brain objects and measure the intensity and spatial distribution of fluorescence signals in the tissue. In this design, the brain is scanned by a single penetrating side-firing optical fiber which delivers excitation light pulses to the tissue at different depths and orientations and simultaneously collects samples of fluorescence emission signals. Signal-to-noise ratio of the measurements is improved by adapting the pulse compression technique and the theory of optimal filters. Effects of each design parameter on the overall performance of the scanner, including the spatial resolution and speed of scanning, are analyzed and experimentally measured. In vivo experiments show that the new device, despite the simplicity of the design, provides valuable information particularly useful in optogenetic stimulation experiments where the exact position of the fiber tip and the radiation orientation can change the outcome of a test.

Functionalized lanthanide coordination polymer nanoparticles for selective sensing of hydrogen peroxide in biological fluids

The Analyst ◽  
2014 ◽  
Vol 139 (21) ◽  
pp. 5516-5522 ◽  
Author(s):  
Hongliang Tan ◽  
Chanjiao Ma ◽  
Qian Li ◽  
Li Wang ◽  
Fugang Xu ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Coordination Polymer ◽  
Biological Fluids ◽  
Polymer Nanoparticles ◽  
Lanthanide Coordination Polymer

The fluorescence of Phe/Tb CPNPs functionalized with CPBA (Phe/Tb-CPBA CPNPs) was selectively quenched upon the addition of H2O2.

A visual and reversible assay for temperature using thioflavin T-doped lanthanide/nucleotide coordination polymers

The Analyst ◽  
2016 ◽  
Vol 141 (8) ◽  
pp. 2347-2350 ◽  
Author(s):  
Yan-Yun Li ◽  
Xiao-Qin Jiang ◽  
Min Zhang ◽  
Guoyue Shi
Keyword(s):  
Coordination Polymer ◽  
Coordination Polymers ◽  
Thioflavin T ◽  
Polymer Nanoparticles ◽  
Lanthanide Coordination Polymer ◽  
One Step

A convenient one-step approach has been developed to make thermo-sensitive lanthanide coordination polymer nanoparticles (LCPNs) doped with thioflavin T.

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