scholarly journals Bone-Derived Serum Enzymes and Bone Density in Perimenopausal Caucasian Women

1993 ◽  
Vol 30 (2) ◽  
pp. 191-194 ◽  
Author(s):  
J D Johnston ◽  
S Koneru ◽  
T Kuwana ◽  
S B Rosalki
Keyword(s):  
Alkaline Phosphatase ◽  
Acid Phosphatase ◽  
Bone Density ◽  
Femoral Neck ◽  
Serum Levels ◽  
Bone Alkaline Phosphatase ◽  
Serum Enzymes ◽  
Tartrate Resistant Acid Phosphatase ◽  
Vertebral Bone ◽  
Caucasian Women

Serum levels of bone-origin alkaline phosphatase and of tartrate-resistant acid phosphatase were measured in Caucasian women aged 41–69 years who had volunteered for bone densitometry. Bone alkaline phosphatase and tartrate-resistant acid phosphatase were inversely correlated with vertebral bone density and with femoral neck bone density. Bone alkaline phosphatase and acid phosphatase were also significantly correlated, consistent with the concept of ‘coupling’ between osteoblast and osteoclast activity.

scholarly journals Bone Alkaline Phosphatase and Tartrate-Resistant Acid Phosphatase: Potential Co-regulators of Bone Mineralization

2017 ◽  
Vol 101 (1) ◽  
pp. 92-101 ◽  
Author(s):  
Cecilia Halling Linder ◽  
Barbro Ek-Rylander ◽  
Michael Krumpel ◽  
Maria Norgård ◽  
Sonoko Narisawa ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Acid Phosphatase ◽  
Bone Mineralization ◽  
Bone Alkaline Phosphatase ◽  
Tartrate Resistant Acid Phosphatase

scholarly journals Serum levels of bone alkaline phosphatase in breast and prostate cancers with bone metastasis

2000 ◽  
Vol 15 (2) ◽  
pp. 110-113 ◽  
Author(s):  
Girija Ramaswamy ◽  
Vasanti R. Rao ◽  
Lakshmi Krishnamoorthy ◽  
G. Ramesh ◽  
R. Gomathy ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Bone Metastasis ◽  
Serum Levels ◽  
Bone Alkaline Phosphatase ◽  
Prostate Cancers

scholarly journals A collagen membrane influences bone turnover marker in vivo after bone augmentation with xenogenic bone

2020 ◽  
Vol 16 (1) ◽  
Author(s):  
Henning Staedt ◽  
Michael Dau ◽  
Eik Schiegnitz ◽  
Daniel G. E. Thiem ◽  
Olga Tagadiuc ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Acid Phosphatase ◽  
Bone Turnover ◽  
Bone Substitute ◽  
Bone Alkaline Phosphatase ◽  
Collagen Membrane ◽  
Bovine Bone ◽  
Total Acid ◽  
Turnover Markers

Abstract Background The aim was to compare early biochemical and histological osseous healing of chronic mandibular defects regenerated with bovine bone substitute with and without collagen membrane in vivo. Methods Eight weeks after formation of a lateral full-thickness perforating bone defect in the mandible of 40 rabbits, bovine bone substitute with (“+”;n = 20) and without (“-”;n = 20) collagen membrane was applied. Blood and bone was collected 24, 72 h, 7, 14 and 21 days after surgery. Total acid phosphatase, bone acid phosphatase, total alkaline phosphatase and bone alkaline phosphatase activities were compared between groups. Formation of new bone was quantified histologically for all time points. Results Twenty-four hours after surgery, bone alkaline phosphatase was significantly elevated in “+” group when compared to “-” (p=0.012). After 72 hours, all bone turnover markers except for total acid phosphatase (p=0.078) where significantly elevated in “+” (all p < 0.05). Fourteen days after surgery, the significant highest values for all bone turnover markers were detected in “-” (all p < 0.05). A significant difference in favor of group “-” could also be detected after 3 weeks in terms of both acid phosphatases (p < 0.05). In histology, no significant differences could be detected. Conclusion Bone regeneration with bovine bone substitute material and collagen membrane shows a significantly earlier bone remodeling activity but does not seem to influence formation of new bone in histological samples.

Serum levels of tartrate-resistant acid phosphatase-5b in breast cancer patients treated with pamidronate

2002 ◽  
Vol 17 (4) ◽  
pp. 253-258 ◽  
Author(s):  
A. Martinetti ◽  
E. Seregni ◽  
C. Ripamonti ◽  
L. Ferrari ◽  
F. De Conno ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Acid Phosphatase ◽  
Cancer Patients ◽  
Serum Levels ◽  
Tartrate Resistant Acid Phosphatase ◽  
Breast Cancer Patients

Bone Density and Mineral Metabolism in Thyroidectomized Patients Treated with Long-Term l-Thyroxine

1994 ◽  
Vol 87 (5) ◽  
pp. 593-597 ◽  
Author(s):  
Sandro Giannini ◽  
Martino Nobile ◽  
Leonardo Sartori ◽  
Pierluigi Binotto ◽  
Matteo Ciuffreda ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Bone Density ◽  
Bone Mass ◽  
Mineral Metabolism ◽  
Menopausal Status ◽  
Bone Alkaline Phosphatase ◽  
Thyroid Stimulating Hormone ◽  
Control Subjects ◽  
And Control

1. A decreased bone mass has been reported in patients with endogenous hyperthyroidism, but the effect on bone density and mineral metabolism of thyroxine administration in thyroidectomized patients is still controversial. To further contribute to this debate, we studied 25 women thyroidectomized for thyroid cancer on long-term treatment with thyroid-stimulating hormone-suppressive doses of L-thyroxine. Twenty-one sex- and age-matched normal subjects were also studied as a control group. 2. The bone density of the spine and serum calcitonin, calcitriol and parathyroid hormone concentrations were not different when the whole patient group was compared with the control subjects, nor when the patients and control subjects were compared according to their menopausal status. However, postmenopausal thyroidectomized patients showed significantly lower bone mass (P < 0.001) than premenopausal patients. 3. L-Thyroxine-treated patients showed significantly higher levels of bone alkaline phosphatase and urine hydroxyproline excretion than control subjects (P < 0.003 and P < 0.001, respectively). These differences were still present when patients and control subjects were analysed according to their menopausal status. However, bone alkaline phosphatase was significantly higher in postmenopausal than in premenopausal women only in L-thyroxine-treated patients (P < 0.05). In postmenopausal L-thyroxine-treated patients a negative correlation between time since menopause and bone mass (P < 0.05) and a positive correlation between bone alkaline phosphatase and hydroxyproline excretion (P < 0.03) were also found. 4. We conclude that long-term thyroid-stimulating hormone-suppressive treatment with L-thyroxine in thyroidectomized women is not associated with a decrease in spinal bone mass nor with calcitonin deficiency, and that L-thyroxine treatment may increase skeletal sensitivity to menopause-related bone loss.

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