West Nile Virus

2002 ◽  
Vol 37 (6) ◽  
pp. 676-682 ◽  
Author(s):  
Steven P. Gelone

Several infectious agents have emerged over the past two decades as a result of population migration and enhanced world travel. The introduction of arthropodborne infections to formerly unaffected geographic areas has occurred in the western hemisphere at an alarming rate. In 1999, the West Nile virus (WNV) first appeared in North America in Queens, New York and spread rapidly to infect bird and mosquito populations along the Atlantic and Gulf coasts. Significant human morbidity and mortality has been associated with the virus, with several patients deaths from encephalitis. Specific antiviral therapy is currently unavailable, but recommendations for a national plan to control and prevent the spread of this vector-borne disease have been made by the Centers for Disease Control and Prevention. Educating the public about how WNV is transmitted, how to best protect one's self, and what signs and symptoms are consistent with this infection are extremely important. Pharmacists, who have more patient interactions per unit time than any other health care provider group, are in an excellent position to play a pivotal role in this educational effort.

2010 ◽  
Vol 15 (10) ◽  
Author(s):  
P Reiter

The appearance of West Nile virus in New York in 1999 and the unprecedented panzootic that followed, have stimulated a major research effort in the western hemisphere and a new interest in the presence of this virus in the Old World. This review considers current understanding of the natural history of this pathogen, with particular regard to transmission in Europe.


2008 ◽  
Vol 9 (1) ◽  
pp. 71-86 ◽  
Author(s):  
Bradley J. Blitvich

AbstractWest Nile virus (WNV) is a flavivirus that is maintained in a bird–mosquito transmission cycle. Humans, horses and other non-avian vertebrates are usually incidental hosts, but evidence is accumulating that this might not always be the case. Historically, WNV has been associated with asymptomatic infections and sporadic disease outbreaks in humans and horses in Africa, Europe, Asia and Australia. However, since 1994, the virus has caused frequent outbreaks of severe neuroinvasive disease in humans and horses in Europe and the Mediterranean Basin. In 1999, WNV underwent a dramatic expansion of its geographic range, and was reported for the first time in the Western Hemisphere during an outbreak of human and equine encephalitis in New York City. The outbreak was accompanied by extensive and unprecedented avian mortality. Since then, WNV has dispersed across the Western Hemisphere and is now found throughout the USA, Canada, Mexico and the Caribbean, and parts of Central and South America. WNV has been responsible for >27,000 human cases, >25,000 equine cases and hundreds of thousands of avian deaths in the USA but, surprisingly, there have been only sparse reports of WNV disease in vertebrates in the Caribbean and Latin America. This review summarizes our current understanding of WNV with particular emphasis on its transmission dynamics and changing epidemiology.


Public Health ◽  
2016 ◽  
Vol 131 ◽  
pp. 63-70 ◽  
Author(s):  
A. Kolimenakis ◽  
K. Bithas ◽  
C. Richardson ◽  
D. Latinopoulos ◽  
A. Baka ◽  
...  

2011 ◽  
Vol 139 (6) ◽  
pp. 807-817 ◽  
Author(s):  
K. O. MURRAY ◽  
C. WALKER ◽  
E. GOULD

SUMMARYWest Nile virus (WNV) is now endemic in the USA. After the widespread surge of virus activity across the USA, research has flourished, and our knowledge base has significantly expanded over the past 10 years since WNV was first recognized in New York City. This article provides a review of the virology of WNV, history, epidemiology, clinical features, pathology of infection, the innate and adaptive immune response, host risk factors for developing severe disease, clinical sequelae following severe disease, chronic infection, and the future of prevention.


2006 ◽  
Vol 54 (11-12) ◽  
pp. 395-402
Author(s):  
J. Li

Since the outbreak of vector-borne West Nile virus in New York City in 1999, the disease has spread across United States and Canada, resulting in the use of larvicides such as methoprene at catch basins for widespread urban mosquito control. Although the manufacturer has recommended a methoprene dosage for catch basin application, the effect of rainfall on this dosage is not known. A field study on the fate of methoprene pellets and ingots was conducted during the summer of 2004 at three catch basins in the City of Toronto, Canada. Water samples from each catch basin were collected daily and during rain storms and analyzed for methoprene concentration using gas chromatography mass spectrometry. It was found that: (1) the methoprene concentration at the catch basin sump fell below the minimum lethal concentration most of the time; (2) rainfall events greater than 25 mm flushed methoprene pellets out of the catch basin; (3) the higher the sump water depth, the higher the residual methoprene concentration at the catch basin sump; and (4) rainfall flushed methoprene from the catch basins into the storm sewer outfall at concentrations much lower than the detrimental level which might cause ecosystem damage.


2013 ◽  
Vol 165 ◽  
pp. 79-85 ◽  
Author(s):  
A. Marm Kilpatrick ◽  
Ryan J. Peters ◽  
Alan P. Dupuis ◽  
Matthew J. Jones ◽  
Peter Daszak ◽  
...  

2004 ◽  
Vol 112 (11) ◽  
pp. 1183-1187 ◽  
Author(s):  
Adam M. Karpati ◽  
Mary C. Perrin ◽  
Tom Matte ◽  
Jessica Leighton ◽  
Joel Schwartz ◽  
...  

2001 ◽  
Vol 7 (4) ◽  
pp. 643-649 ◽  
Author(s):  
Dennis J. White ◽  
Laura D. Kramer ◽  
P. Bryon Backenson ◽  
Gary Lukacik ◽  
Geraldine Johnson ◽  
...  

2006 ◽  
Vol 6 (2) ◽  
pp. 128-139 ◽  
Author(s):  
John H. Rappole ◽  
Bradley W. Compton ◽  
Peter Leimgruber ◽  
Jamie Robertson ◽  
David I. King ◽  
...  

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