Single cell protein

1981 ◽  
Vol 10 (8) ◽  
pp. 403-408 ◽  
Author(s):  
D G Waterworth
Keyword(s):  
Single Cell ◽  
Large Scale ◽  
Agricultural Research ◽  
Continuous Fermentation ◽  
Single Cell Protein ◽  
Cell Protein ◽  
Scale Production ◽  
Forage Crops ◽  
Large Scale Production ◽  
Research World

Whilst agricultural research world-wide pursues yield improvement in food and forage crops in an attempt to keep pace with growing demand, alternative ‘non-crop’ protein sources have also been sought. Bacteria and yeasts have been shown to have the characteristics necessary for large-scale production of what has come to be known as single-cell protein. ICI's ‘Pruteen’, using a unique continuous fermentation system, compares favourably with conventional protein feedstuffs.

scholarly journals Effect of Mixing on Microorganism Growth in Loop Bioreactors

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
A. M. Al Taweel ◽  
Q. Shah ◽  
B. Aufderheide
Keyword(s):  
Large Scale ◽  
Critical Role ◽  
Single Cell Protein ◽  
Cell Protein ◽  
Scale Production ◽  
Reactor Model ◽  
Forced Circulation ◽  
Capital Costs ◽  
Large Scale Production ◽  
The Impact

The impact of mixing on the promotion of microorganism growth rate has been analyzed using a multiphase forced-circulation pipe-loop reactor model capable of identifying conditions under which it is possible to convert natural gas into Single-Cell Protein. The impact of mixing in the interphase mass transfer was found to exert a critical role in determining the overall productivity of the bioreactor, particularly at the high cell loadings needed to reduce the capital costs associated with the large-scale production needed for the production of relatively low-value SCP in a sustainable manner.

Single cell protein

1980 ◽  
Vol 290 (1040) ◽  
pp. 341-354 ◽  
Keyword(s):  
Single Cell ◽  
Large Scale ◽  
Single Cell Protein ◽  
Raw Material ◽  
Cell Protein ◽  
Pressure Cycle ◽  
Amino Acid Requirements ◽  
Business Size ◽  
Optimization And Control ◽  
And Control

The following topics are covered in this paper: the European feedstuff business, size, shape and source; the protein and amino acid requirements of the principal target species; the place of single cell protein (s.c.p.); the raw material options and the technical challenge of large scale s.c.p. manufacture; fermentation of s.c.p., its stoichiometry, mass and heat transfer requirements; static and dynamic optimization and control; the pressure cycle fermenter; the principle of sterility and the engineering design constraints; the nutritional performance of I.C.I.’s ‘Pruteen’ and the future for s.c.p.

Single Cell Protein (Scp) Production from Marine Lactobacillus spp.

2020 ◽  
Author(s):  
A. Rathipriya ◽  
B. Kannan ◽  
A. Dhinakaran ◽  
A. Hema
Keyword(s):  
Single Cell ◽  
Tamil Nadu ◽  
Fish Meal ◽  
Standard Procedure ◽  
Single Cell Protein ◽  
Lactobacillus Fermentum ◽  
Diffusion Method ◽  
Cell Protein ◽  
Scale Production ◽  
Single Strain

Background: The Single Cell Protein (SCP) production technologies arose as a promising way to solve the problem of protein shortage in worldwide, which mainly used in human foods or animal feeds. For future success, the animal proteins are expensive protein source in fish feeds and there has been considerable interest in replacing all or part of the fish meal in aquaculture feeds with SCPs. Collectively, studies indicated that SCPs were suitable ingredients for farmed fishes. The Lactobacillus fermentum strain used in this study was surprising to note a single strain contains 20 amino acids. In this study the strain used and seemed to be ideal in the above respects. Further research on industrial scale production of SCP using this strain using cheaper sources (or) sewage is warranted. Methods: In this field – laboratory investigation during 2015-2016, the soil samples were collected from the Velar estuary, Tamil Nadu. About 25 colonies were selected and inoculated in to MRS broth. The completed preparation was observed under microscope for motility of the bacterium. Different biochemical characteristics test analyzed by using standard protocol. The antimicrobial effects were determined by the agar diffusion method. Finally the biochemical parameters were analyzed by using standard procedure. Result: Our investigation is evident that, the strain very well can be used a probiotic for human and animal nutrition. The isolated strains were found to be non-motile and non-spore farming. Lactobacillus fermentum contains 60-80% of protein, 7-8% of carbohydrate, 2-3% of lipid and 8-9% of nucleic acid contents. The Lactobacillus fermentum strain used in this study showed a high level of inhibitory activity against all the pathogens tested. SCP cannot compete with soya, alfalfa or fish meal. Mushroom production from lignocellulosics seems to be one economical and promising use for SCP.

scholarly journals Highly Multiplexed Single-Cell Protein Profiling with Large-Scale Convertible DNA-Antibody Barcoded Arrays

2018 ◽  
Vol 5 (9) ◽  
pp. 1800672 ◽  
Author(s):  
Peng Zhao ◽  
Sirsendu Bhowmick ◽  
Jianchao Yu ◽  
Jun Wang
Keyword(s):  
Single Cell ◽  
Large Scale ◽  
Single Cell Protein ◽  
Protein Profiling ◽  
Cell Protein

scholarly journals Spheroid Fabrication Using Concave Microwells Enhances the Differentiation Efficacy and Function of Insulin-Producing Cells via Cytoskeletal Changes

Cells ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 2551
Author(s):  
Yu Na Lee ◽  
Hye Jin Yi ◽  
Hanse Goh ◽  
Ji Yoon Park ◽  
Sarah Ferber ◽  
...  
Keyword(s):  
Single Cell ◽  
Large Scale ◽  
Diabetic Mouse ◽  
Scale Production ◽  
Pancreatic Islet Transplantation ◽  
Glucose Levels ◽  
Insulin Producing Cells ◽  
Large Scale Production ◽  
And Function

Pancreatic islet transplantation is the fundamental treatment for insulin-dependent diabetes; however, donor shortage is a major hurdle in its use as a standard treatment. Accordingly, differentiated insulin-producing cells (DIPCs) are being developed as a new islet source. Differentiation efficiency could be enhanced if the spheroid structure of the natural islets could be recapitulated. Here, we fabricated DIPC spheroids using concave microwells, which enabled large-scale production of spheroids of the desired size. We prepared DIPCs from human liver cells by trans-differentiation using transcription factor gene transduction. Islet-related gene expression and insulin secretion levels were higher in spheroids compared to those in single-cell DIPCs, whereas actin–myosin interactions significantly decreased. We verified actin–myosin-dependent insulin expression in single-cell DIPCs by using actin–myosin interaction inhibitors. Upon transplanting cells into the kidney capsule of diabetic mouse, blood glucose levels decreased to 200 mg/dL in spheroid-transplanted mice but not in single cell-transplanted mice. Spheroid-transplanted mice showed high engraftment efficiency in in vivo fluorescence imaging. These results demonstrated that spheroids fabricated using concave microwells enhanced the engraftment and functions of DIPCs via actin–myosin-mediated cytoskeletal changes. Our strategy potentially extends the clinical application of DIPCs for improved differentiation, glycemic control, and transplantation efficiency of islets.

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