Using fresh frozen plasma as an emergency treatment modality for hypertriglyceridaemic acute pancreatitis in a resource-constrained environment: A case report and review of literature

2021 ◽  
pp. 004947552110055
Author(s):  
JJP Buitendag ◽  
ER Theron ◽  
S Variawa ◽  
GV Oosthuizen
Keyword(s):  
Acute Pancreatitis ◽  
Severe Disease ◽  
Serum Triglyceride ◽  
Fresh Frozen Plasma ◽  
Review Of Literature ◽  
Resource Constrained ◽  
Fresh Frozen ◽  
Vascular Accidents ◽  
Frozen Plasma

Hypertriglyceridaemia is associated with severe disease such as coronary disease, cerebral vascular accidents and acute pancreatitis. Severe hypertriglyceridaemia is defined as a serum triglyceride value of >55 mmol/L. Hypertriglyceridaemic acute pancreatitis, often found in pregnancy, has a higher mortality rate than the other causes of acute pancreatitis. The cornerstone of treatment is to lower the triglyceride level as quickly as possible. In a resource-constrained environment, plasma exchange is not a viable option. Therefore, exploring the possible efficacity of directly infusing fresh frozen plasma is applicable to rural emergency medicine and may lead to more definitive research. In our case study, we used fresh frozen plasma to enhance the removal of triglyceride because it contains lipoprotein lipase.

scholarly journals Factor VII Deficiency and Pregnancy: A Case Report and Review of Literature

2021 ◽  
Author(s):  
Minakshi Rohilla ◽  
Rakhi Rai ◽  
Jasmina Ahluwalia ◽  
Pankaj Malhotra ◽  
Vanita Jain
Keyword(s):  
Autosomal Recessive ◽  
English Literature ◽  
Fresh Frozen Plasma ◽  
Factor Vii ◽  
Coagulation Disorder ◽  
Review Of Literature ◽  
Factor Vii Deficiency ◽  
First Case ◽  
Fresh Frozen ◽  
Frozen Plasma

Abstract Inherited factor VII deficiency is an autosomal recessive coagulation disorder with broad range of bleeding manifestations. The association between bleeding and absolute factor VII level is poor. Usually, the bleeding is associated with FVII levels of less than 1% of the normal value. Factor VII deficiency is associated with prolongation of prothrombin time only with normal activated partial thromboplastin time. Approximately 66 pregnant women have been reported with factor VII deficiency so far in English literature. We hereby, report 2 cases along with the review of literature of Factor VII deficiency during pregnancy. Our patients were diagnosed to have factor VII deficiency after deranged coagulogram with factor VII level of < 1% and 17.1% respectively, however could be managed by fresh frozen plasma only in first case and fresh frozen plasma & factor VII concentrate in second case successfully. Coagulogram is a simple, easily available, affordable and lifesaving investigation to detect this deficiency in pregnancy.

Fresh frozen plasma therapy in acute pancreatitis: an experimental study

1988 ◽  
Vol 3 (6) ◽  
pp. 437-447
Author(s):  
Trevor Leese ◽  
Kevin P. West ◽  
David B. Morton ◽  
Peter R. F. Bell
Keyword(s):  
Experimental Study ◽  
Acute Pancreatitis ◽  
Fresh Frozen Plasma ◽  
Plasma Therapy ◽  
Fresh Frozen ◽  
Frozen Plasma

Treatment of acute pancreatitis with fresh frozen plasma

1983 ◽  
Vol 70 (12) ◽  
pp. 710-712 ◽  
Author(s):  
A. Cuschieri ◽  
R. A. B. Wood ◽  
J. R. G. Cumming ◽  
S. E. Meehan ◽  
C. R. Mackie
Keyword(s):  
Acute Pancreatitis ◽  
Fresh Frozen Plasma ◽  
Fresh Frozen ◽  
Frozen Plasma

Multicentre clinical trial of low volume fresh frozen plasma therapy in acute pancreatitis

1987 ◽  
Vol 74 (10) ◽  
pp. 907-911 ◽  
Author(s):  
T. Leese ◽  
M. Holliday ◽  
D. Heath ◽  
A. W. Hall ◽  
P. R. F. Bell
Keyword(s):  
Clinical Trial ◽  
Acute Pancreatitis ◽  
Fresh Frozen Plasma ◽  
Plasma Therapy ◽  
Multicentre Clinical Trial ◽  
Fresh Frozen ◽  
Low Volume ◽  
Frozen Plasma

scholarly journals Management of Massive Blood Transfusion-a case study

Pulse ◽  
2014 ◽  
Vol 5 (1) ◽  
pp. 39-43
Author(s):  
Sufia Khatun Lima ◽  
Monowara Begum ◽  
Anil Kumar Gupta ◽  
Lutful Aziz ◽  
SP Mitra
Keyword(s):  
Blood Transfusion ◽  
Multidisciplinary Approach ◽  
Fresh Frozen Plasma ◽  
General Surgeon ◽  
Blood Products ◽  
Massive Blood Transfusion ◽  
Fresh Frozen ◽  
Transfusion Protocol ◽  
Frozen Plasma

Management of a complicated obstetric patient with profuse bleeding following caesarean section (under GA) required massive blood transfusion was managed properly with multidisciplinary approach in ICU. The involvement of obstetrician, anesthesiologist, intensivist, general surgeon, hematologist & gastroenterologist as a team in a single setup is essential for the management of such patients and the best outcome. The patient received total 117 units of blood products among which 20 units whole blood, 17 units packed red blood cell, 40 units of fresh frozen plasma and 40 units of platelet concentrate. Despite this massive blood transfusion, the patient recovered fully with minimal complications as we follow the near standard blood transfusion protocol. DOI: http://dx.doi.org/10.3329/pulse.v5i1.20189 Pulse Vol.5 January 2011 p.39-43

Factor XIII Deficiency - A Case Report with Review of Literature

JMS SKIMS ◽  
2009 ◽  
Vol 12 (2) ◽  
pp. 53-55
Author(s):  
Javaid Rasool ◽  
Samoon Jeelani ◽  
Sajad Geelani ◽  
Abdul Rashid Lone ◽  
Afaq Ahmad ◽  
...  
Keyword(s):  
Factor Xiii ◽  
Intracranial Haemorrhage ◽  
Neonatal Period ◽  
Fresh Frozen Plasma ◽  
Bleeding Diathesis ◽  
Review Of Literature ◽  
Factor Xiii Deficiency ◽  
Fresh Frozen ◽  
History Of ◽  
Frozen Plasma

Factor XIII deficiency is a rare disorder and these patients present with bleeding diathesis in the neonatal period. An 18 days old male child was brought with the history of umbilical stump bleeding. Two previous siblings had died in the neonatal period of an unknown cause, possibly because of intracranial haemorrhage and another at the age of 6 years of unknown cause. Investigations revealed Factor XIII deficiency. He was put on Fresh Frozen Plasma (FFP) support as he could not afford Fibrogammin and currently receives 6 weekly FFP and is doing well. J Med Sci 2009;12(2):53-55.

Das Smith-Lemli-Opitz-Syndrom

2005 ◽  
Vol 5 (04) ◽  
pp. 178-182
Author(s):  
Wieland Kiess ◽  
Manuela Schulz ◽  
Sabine Liebermann ◽  
Roland Pfäffle ◽  
Peter Bührdel ◽  
...  
Keyword(s):  
Fresh Frozen Plasma ◽  
Therapeutische Möglichkeiten ◽  
Fresh Frozen ◽  
Frozen Plasma

ZusammenfassungDas Smith-Lemli-Opitz-Syndrom wird durch einen Defekt des letzten Schrittes der Cholesterolbiosynthese, den Mangel an 7-Dehydrocholesterolreduktase, verursacht. Die Akkumulation der Metaboliten 7-Dehydrocholesterol und 8-Dehydrocholesterol, die die wichtigsten biochemischen Marker für die Diagnose der Erkrankung darstellen, sowie der Mangel an Cholesterol können zu multiplen kongenitalen Anomalien führen. Die Ursache des Enzymmangels sind Mutationen innerhalb des DHCR7-Gens, welches auf Chromosom 11q13 lokalisiert ist. Therapeutische Möglichkeiten bestehen in der Gabe von Cholesterol und im Notfall Fresh Frozen Plasma (FFP); der therapeutische Nutzen von Statinen befindet sich zurzeit in der klinischen Erprobung.

The Recovery of Factor VIII from Fresh-Frozen, Indated and Outdated Human Plasma

1976 ◽  
Vol 36 (01) ◽  
pp. 071-077 ◽  
Author(s):  
Daniel E. Whitman ◽  
Mary Ellen Switzer ◽  
Patrick A. McKee
Keyword(s):  
Factor Viii ◽  
Polyacrylamide Gel Electrophoresis ◽  
Sodium Dodecyl ◽  
The United States ◽  
Fresh Frozen Plasma ◽  
Red Cross ◽  
Random Samples ◽  
Fresh Frozen ◽  
Factor Viii Concentrates ◽  
Frozen Plasma

SummaryThe availability of factor VIII concentrates is frequently a limitation in the management of classical hemophilia. Such concentrates are prepared from fresh or fresh-frozen plasma. A significant volume of plasma in the United States becomes “indated”, i. e., in contact with red blood cells for 24 hours at 4°, and is therefore not used to prepare factor VIII concentrates. To evaluate this possible resource, partially purified factor VIII was prepared from random samples of fresh-frozen, indated and outdated plasma. The yield of factor VIII protein and procoagulant activity from indated plasma was about the same as that from fresh-frozen plasma. The yield from outdated plasma was substantially less. After further purification, factor VIII from the three sources gave a single subunit band when reduced and analyzed by sodium dodecyl sulfate polyacrylamide gel electrophoresis. These results indicate that the approximately 287,000 liters of indated plasma processed annually by the American National Red Cross (ANRC) could be used to prepare factor VIII concentrates of good quality. This resource alone could quadruple the supply of factor VIII available for therapy.

Haemophilia in a Female

1971 ◽  
Vol 26 (02) ◽  
pp. 205-210
Author(s):  
J. A McBride ◽  
J Hunter ◽  
Elizabeth Pearse ◽  
Yvette Sultan ◽  
J. P Caen
Keyword(s):  
Fresh Frozen Plasma ◽  
Plasma Fibrinogen ◽  
Fresh Frozen ◽  
Frozen Plasma

SummaryA case of haemophilia in a female is described together with the response of the patient’s level of antihaemophilic factor in the plasma following transfusion of fresh frozen plasma, fibrinogen and cryoprecipitate.

Severe Inherited “Homozygous” Protein C Deficiency in a Newborn Infant

1984 ◽  
Vol 52 (01) ◽  
pp. 053-056 ◽  
Author(s):  
A Estellés ◽  
I Garcia-Plaza ◽  
A Dasí ◽  
J Aznar ◽  
M Duart ◽  
...  
Keyword(s):  
Newborn Infant ◽  
Protein C ◽  
Skin Lesions ◽  
Fresh Frozen Plasma ◽  
Clinical Syndrome ◽  
Assay Method ◽  
Enzyme Linked Immunosorbent Assay ◽  
Protein C Deficiency ◽  
Fresh Frozen ◽  
Frozen Plasma

SummaryA relapsing clinical syndrome of skin lesions and disseminated intravascular coagulation (DIC) that showed remission with the infusion of fresh frozen plasma is described in a newborn infant with homozygous deficiency of protein C antigen.This patient presented since birth a recurrent clinical picture of DIC and ecchymotic skin lesions that resembled typical ecchymosis except for the fact that they showed immediate improvement with the administration of fresh frozen plasma. Using an enzyme linked immunosorbent assay method, the determination of protein C antigen levels in the patient, without ingestion of coumarin drugs, showed very low values (<1%).No other deficiencies in the vitamin-K-dependent factors or in anti thrombin III, antiplasmin, and plasminogen were found. Seven relatives of the infant had heterozygous deficiency in protein C antigen (values between 40-55%), without clinical history of venous thrombosis. The pedigree analysis of this family suggests an autosomal recessive pattern of inheritance for the clinical phenotype, although an autosomal dominant pattern has been postulated until now in other reported families.We conclude that our patient has a homozygous deficiency in protein C and this homozygous state may be compatible with survival beyond the neonatal period.

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