A data-driven principal component analysis-support vector machine approach for breast cancer diagnosis: Comparison and application

2019 ◽  
Vol 42 (7) ◽  
pp. 1301-1312
Author(s):  
Wen Wu ◽  
Shah Faisal

In recent years, with the development of artificial intelligence, data-driven methodologies have been widely studied in fault diagnosis and detection, since an increasing number of complexities of modern complex systems make the mechanism model information difficult to obtain. Especially in people’s health monitoring, it is very difficult to achieve the mechanism model. The existing challenges, such as huge amount of data, high data dimension, large noise interference, and so forth, make the applications of data-driven approaches more suitable. For the sake of solving the problems above, we present principal component analysis-support vector machine (PCA-SVM) method with different kernels to reduce data dimension, and two sets of breast-cancer data are utilized to verify the method. Additionally, support vector machine-recursive feature elimination (SVM-RFE), the original SVM with different kernels, PCA and modified PCA (MPCA) methods are also applied to diagnose malignant cancer in comparison with PCA-SVM. In experiments, PCA-SVM via radial basis function (RBF) kernel shows better performance than other methods, with the two breast cancer datasets obtained from the University of Wisconsin Hospital. Finally, PCA-SVM in this study uses only six principal components and obtains better accuracy (97.19%) than most of the previous studies.

2022 ◽  
pp. 146808742110707
Author(s):  
Aran Mohammad ◽  
Reza Rezaei ◽  
Christopher Hayduk ◽  
Thaddaeus Delebinski ◽  
Saeid Shahpouri ◽  
...  

The development of internal combustion engines is affected by the exhaust gas emissions legislation and the striving to increase performance. This demands for engine-out emission models that can be used for engine optimization for real driving emission controls. The prediction capability of physically and data-driven engine-out emission models is influenced by the system inputs, which are specified by the user and can lead to an improved accuracy with increasing number of inputs. Thereby the occurrence of irrelevant inputs becomes more probable, which have a low functional relation to the emissions and can lead to overfitting. Alternatively, data-driven methods can be used to detect irrelevant and redundant inputs. In this work, thermodynamic states are modeled based on 772 stationary measured test bench data from a commercial vehicle diesel engine. Afterward, 37 measured and modeled variables are led into a data-driven dimensionality reduction. For this purpose, approaches of supervised learning, such as lasso regression and linear support vector machine, and unsupervised learning methods like principal component analysis and factor analysis are applied to select and extract the relevant features. The selected and extracted features are used for regression by the support vector machine and the feedforward neural network to model the NOx, CO, HC, and soot emissions. This enables an evaluation of the modeling accuracy as a result of the dimensionality reduction. Using the methods in this work, the 37 variables are reduced to 25, 22, 11, and 16 inputs for NOx, CO, HC, and soot emission modeling while maintaining the accuracy. The features selected using the lasso algorithm provide more accurate learning of the regression models than the extracted features through principal component analysis and factor analysis. This results in test errors RMSETe for modeling NOx, CO, HC, and soot emissions 19.22 ppm, 6.46 ppm, 1.29 ppm, and 0.06 FSN, respectively.


2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Heping Li ◽  
Yu Ren ◽  
Fan Yu ◽  
Dongliang Song ◽  
Lizhe Zhu ◽  
...  

To facilitate the enhanced reliability of Raman-based tumor detection and analytical methodologies, an ex vivo Raman spectral investigation was conducted to identify distinct compositional information of healthy (H), ductal carcinoma in situ (DCIS), and invasive ductal carcinoma (IDC). Then, principal component analysis-linear discriminant analysis (PCA-LDA) and principal component analysis-support vector machine (PCA-SVM) models were constructed for distinguishing spectral features among different tissue groups. Spectral analysis highlighted differences in levels of unsaturated and saturated lipids, carotenoids, protein, and nucleic acid between healthy and cancerous tissue and variations in the levels of nucleic acid, protein, and phenylalanine between DCIS and IDC. Both classification models were principal component analysis-linear discriminant analysis to be extremely efficient on discriminating tissue pathological types with 99% accuracy for PCA-LDA and 100%, 100%, and 96.7% for PCA-SVM analysis based on linear kernel, polynomial kernel, and radial basis function (RBF), respectively, while PCA-SVM algorithm greatly simplified the complexity of calculation without sacrificing performance. The present study demonstrates that Raman spectroscopy combined with multivariate analysis technology has considerable potential for improving the efficiency and performance of breast cancer diagnosis.


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