Solitary Fibrous Tumor of the External Auditory Canal

Solitary fibrous tumors (SFTs) originating from the external auditory canal are uncommon; only few cases have been reported in the literature. In this article, we report a case of a 35-year-old man who presented with a 6-month history of a gradual swelling in the entrance of the left external auditory meatus associated with hearing loss. The tumor was surgically removed, and histological examination showed spindle-cell proliferation with a collagenous stroma. Immunohistochemically, the tumor cells were positive for CD34 confirming the diagnosis of an SFT. Although SFTs are benign, complications such as relapses and metastasis after excision were reported. Thus, a careful and long follow-up is recommended.

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Malignant solitary fibrous tumor of the thyroid: a case-report and review of the literature

Arquivos Brasileiros de Endocrinologia & Metabologia ◽

10.1590/0004-2730000003230 ◽

2014 ◽

Vol 58 (4) ◽

pp. 402-406 ◽

Cited By ~ 5

Author(s):

Wellington Alves Filho ◽

Renata Regina da Graça Lorencetti Mahmoud ◽

Daniel Marin Ramos ◽

Vergilius José Furtado de Araujo-Filho ◽

Patricia Picciarelli de Lima ◽

...

Keyword(s):

Thyroid Gland ◽

Solitary Fibrous Tumor ◽

Spindle Cell ◽

Spindle Cell Neoplasm ◽

Cellular Atypia ◽

Long Term Follow Up ◽

History Of ◽

Fibrous Tumor

Solitary fibrous tumor (SFT) is an uncommon spindle-cell neoplasm that most often involves the pleura, rarely occurring in extra-thoracic locations. Twenty-six cases of SFT arising in the thyroid gland have been described. We report a case of a 60-year-old woman presenting an 8-month history of enlargement of the neck associated with dysphagia. The patient underwent a right hemithyroidectomy and SFT of the thyroid was diagnosed. Immunohistochemistry showed positivity for CD34 marker, and the high number of mitoses and the presence of cellular atypia suggested that the tumor was malignant. To our knowledge, this is the second case of malignant SFT of the thyroid gland ever reported. Due to the rarity of these tumors, the indication of adjuvant therapy and prognosis are uncertain. Long-term follow-up after surgical resection seems to be advisable.

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Solitary Fibrous Tumor of the Parapharyngeal Space: A Case Report and Review of the Literature

Ear Nose & Throat Journal ◽

10.1177/014556139607501011 ◽

1996 ◽

Vol 75 (10) ◽

pp. 681-684 ◽

Cited By ~ 15

Author(s):

Kunal Gangopadhyay ◽

Khalid Taibah ◽

M. Babu Manohar ◽

Hala Kfoury

Keyword(s):

Case Report ◽

Head And Neck ◽

Solitary Fibrous Tumor ◽

Spindle Cell ◽

Parapharyngeal Space ◽

English Literature ◽

Review Of The Literature ◽

Solitary Fibrous Tumors ◽

Rare Location ◽

Fibrous Tumor

Solitary fibrous tumors are uncommon spindle cell neoplasms generally associated with serosal surfaces, especially the pleura. Recently, these tumors have been documented in a number of extrapleural sites including the head and neck. So far only two cases of parapharyngeal solitary fibrous tumor have been reported in the English literature. Rare location of an uncommon lesion often gives rise to difficulty in diagnosis or to misdiagnosis. In both the previously reported cases, as well as in our case, the diagnosis of solitary fibrous tumor was not made until the excised tumor was subjected to histopathology and immunohistochemistry.

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Solitary Fibrous Tumor of the Kidney. A Propos of a Case

Urologia Journal ◽

10.1177/039156030907600214 ◽

2009 ◽

Vol 76 (2) ◽

pp. 112-114 ◽

Cited By ~ 1

Author(s):

M. Marzi ◽

M. D'Alpaos ◽

P. Piras ◽

A. Paiusco ◽

M.S. Minervini ◽

...

Keyword(s):

Solitary Fibrous Tumor ◽

Renal Pelvis ◽

Spindle Cell ◽

Left Kidney ◽

Clinical Behavior ◽

Spindle Cell Neoplasm ◽

Solitary Fibrous Tumors ◽

Genital Apparatus ◽

Cell Neoplasm ◽

Fibrous Tumor

Solitary Fibrous Tumors (SFT) are rare spindle cell neoplasm that typically originate from the pleura. However, cases of the SFT are described with origin in other organs, including the urinary and genital apparatus. Within the kidney, except from the renal pelvis, only 19 cases of SFT are described and such rarity of localization makes the histogenesis and the prognosis of the tumor rather unknown. We report the case of a 72-year-old lady who attended our Unit for a mass that was clinically palpable at the level of the left hemiabdomen. The tomodensitographic test indicated a 19cm-diameter mass of likely pertinence of the middle bystender of the left kidney. She had undergone left radical nephrectomy. The histological examination highlighted a solitary fibrous tumor (SFT): the presence of hypercellularity, of cellular pleiomorphism and of a high number of mitosis has led to a histological diagnosis of malignancy for the neoplasm analyzed. The SFT are of rare clinical comparison: this does not allow for a deep knowledge of the lesion histogenesis and prognosis; moreover, the clinical behavior should be more precisely defined.

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A Rare Case of a Solitary Fibrous Tumor of the Spermatic Cord

Case Reports in Pathology ◽

10.1155/2021/9956305 ◽

2021 ◽

Vol 2021 ◽

pp. 1-3

Author(s):

Moyosore Awobajo ◽

Stefanie Hettwer ◽

Sarah Hackman

Keyword(s):

Solitary Fibrous Tumor ◽

Spermatic Cord ◽

Rare Case ◽

Surgical Excision ◽

Mesenchymal Tumors ◽

Solitary Fibrous Tumors ◽

Important Differential Diagnosis ◽

History Of ◽

Scrotal Swelling ◽

Fibrous Tumor

Solitary fibrous tumors (SFTs) are rare mesenchymal tumors, originally identified in the pleura. Even though they have subsequently been described in several extrapleural sites, the incidence of SFTs in the spermatic cord is particularly rare. Here, we report a case of a 27-year-old male that presented with a 3-year history of left scrotal swelling. Computed tomography (CT) and ultrasound demonstrated multiple solid, hypoechoic well-circumscribed masses that were separate from the testis. Surgical excision of the mass led to pathologic diagnosis of a solitary fibrous tumor involving the spermatic cord. Solitary fibrous tumors, although rare, are an important differential diagnosis for urogenital tumors.

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Malignant Gastrointestinal Stromal Tumor Showing Remarkable Whorl Formations

Archives of Pathology & Laboratory Medicine ◽

10.5858/2001-125-0665-mgstsr ◽

2001 ◽

Vol 125 (5) ◽

pp. 665-668

Author(s):

En Yoneda ◽

Kazuhiro Teramura ◽

Shingo Hiruma ◽

Takao Satou ◽

Shigeo Hashimoto

Keyword(s):

Cell Proliferation ◽

Gastrointestinal Stromal Tumor ◽

Tumor Cells ◽

Rare Variant ◽

Ultrastructural Study ◽

Spindle Cell ◽

Stromal Tumor ◽

Spindle Cell Proliferation ◽

Variant Pattern ◽

Histopathologic Findings

Abstract A case of malignant gastrointestinal stromal tumor (GIST) is reported. Histologically, spindle cell proliferation with remarkable whorl formations was predominant in the tumor. Immunohistochemically, the tumor cells were diffusely positive for CD117 (c-Kit) and vimentin and partially positive for CD34. Ultrastructurally, the desmosome-like structures and interdigitations occurred much more frequently in the areas with whorl formations. These organelles were considered to be closely associated with the whorl formations. Various kinds of cellular arrangements are revealed in GISTs, but remarkable whorl formations, such as in our case, are a rare variant pattern. Herein, we discuss the histopathologic differences between this and other tumors showing whorl formations and describe the meaning of this unique arrangement. GISTs are thought to be immature tumors, and, therefore, variations in histopathologic findings are recognized. Finally, the ultrastructural study of GISTs is useful for understanding the mechanisms forming whorl formations and the differentiation or pathogenesis of GISTs.

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Description of a Rare Case of Nodular Fasciitis of the Apical Aspect of the Upper Buccal Sulcus

Case Reports in Dentistry ◽

10.1155/2016/4231683 ◽

2016 ◽

Vol 2016 ◽

pp. 1-4 ◽

Cited By ~ 1

Author(s):

Ana Amélia Souza ◽

Eldon Guttenberg Cariri Neto ◽

Vera Cavalcanti de Araújo ◽

Fabricio Passador-Santos ◽

Maria Teresa de Seixas Alves ◽

...

Keyword(s):

Cell Proliferation ◽

Rare Case ◽

Spindle Cell ◽

Smooth Muscle Actin ◽

Surgical Excision ◽

Nodular Fasciitis ◽

Muscle Actin ◽

Complete Surgical Excision ◽

Histopathologic Diagnosis ◽

Spindle Cell Proliferation

This report describes a rare case of nodular fasciitis (NF) of the oral cavity, discussing the clinical, histological, and immunohistochemical characteristics. Histopathologic diagnosis of this type of lesion can be challenging due to its differential diagnosis, which principally includes sarcoma. The patient presented with a painless, well-defined nodule, reported as increasing in size, located at the apical aspect of the upper left buccal sulcus. Histologically, the lesion revealed spindle cell proliferation arranged in fascicles, while immunohistochemistry demonstrated positivity for smooth muscle actin. Eight months after complete surgical excision, no signs of local recurrence have been observed.

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Fibrous Histiocytoma-like Spindle-Cell Proliferation in the Nipple After Body-Piercing

International Journal of Surgical Pathology ◽

10.1177/106689690601400118 ◽

2006 ◽

Vol 14 (1) ◽

pp. 89-93 ◽

Cited By ~ 4

Author(s):

M. Castillo ◽

A. Sanjuan ◽

N. Perez ◽

G. Zanon ◽

N. Bons ◽

...

Keyword(s):

Cell Proliferation ◽

Spindle Cell ◽

Fibrous Histiocytoma ◽

Body Piercing ◽

Spindle Cell Proliferation

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An Unusual Clinical Presentation of Solitary Fibrous Tumor in the Oral Cavity

Case Reports in Pathology ◽

10.1155/2017/4395049 ◽

2017 ◽

Vol 2017 ◽

pp. 1-5

Author(s):

Everton Freitas de Morais ◽

Deborah Gondim Lambert Moreira ◽

Viviane Alves De Oliveira ◽

Rodrigo Rodrigues Rodrigues ◽

Adriano Rocha Germano ◽

...

Keyword(s):

Oral Cavity ◽

Solitary Fibrous Tumor ◽

Surgical Excision ◽

Excisional Biopsy ◽

Histopathological Analysis ◽

Normal Morphology ◽

S 100 ◽

History Of ◽

Fibrous Tumor

Solitary fibrous tumor is a rare neoplasm of mesenchymal origin that usually affects the pleura. This rarity becomes more relevant in the oral cavity since the clinical features are nonspecific. A 66-year-old female patient presented with a 3-month history of a swelling in the floor of the mouth, measuring 2 cm in greatest diameter, and pain symptomatology. Occlusal and panoramic radiographs showed no bone involvement. Ultrasonography of the submandibular and parotid salivary glands revealed normal morphology, dimensions, and echogenicity. During this exam, a nodular image of low echogenicity measuring about 2.7 × 1.8 cm was detected. An excisional biopsy was performed and histopathological analysis revealed a well-defined tumor-like lesion with alternation between hypercellular areas without a defined pattern and hypocellular areas. On immunohistochemistry, the tumor was positive for CD34 and CD99 and negative forα-SMA, S-100, and bcl-2. Combining the histopathological and immunohistochemical features, the diagnosis was solitary fibrous tumor. The patient is under periodical clinical follow-up and shows no signs of recurrence 7 months after surgical excision of the tumor. The combination of clinical-pathological and immunohistochemical features is necessary for the diagnosis.

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Solitary Fibrous Tumor of the Sigmoid Colon Masquerading as an Adnexal Neoplasm

Case Reports in Pathology ◽

10.1155/2016/4182026 ◽

2016 ◽

Vol 2016 ◽

pp. 1-4 ◽

Cited By ~ 2

Author(s):

Laura Bratton ◽

Rabih Salloum ◽

Wenqing Cao ◽

Aaron R. Huber

Keyword(s):

Sigmoid Colon ◽

Solitary Fibrous Tumor ◽

High Power ◽

Spindle Cell ◽

Cytologic Atypia ◽

Spindle Cell Neoplasm ◽

Solitary Fibrous Tumors ◽

Cell Neoplasm ◽

Mitotic Figures ◽

Fibrous Tumor

Solitary fibrous tumor is a rare, benign spindle cell neoplasm that was first described in the thoracic pleura. This tumor is now known to occur at many extrapleural sites. There are established criteria for the diagnosis of malignant solitary fibrous tumor including ≥4 mitotic figures per 10 high-power fields, increased cellularity, cytologic atypia, infiltrative margins, and/or necrosis. Although all solitary fibrous tumors have the potential to recur or metastasize, those with malignant histologic features tend to behave more aggressively. We report a case of solitary fibrous tumor, with malignant histologic features, in a 21-year-old woman which arose from the serosal surface of the sigmoid colon.

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