The Politics of Postgenomic Reproduction: Exploring Pregnant Narratives from within a Clinical Trial

2021 ◽  
pp. 016224392110667
Author(s):  
Natali Valdez

There are more large-scale pregnancy trials that implement lifestyle interventions than ever before; yet, there is a dearth of information on pregnant peoples’ experiences in such trials. Contemporary lifestyle pregnancy trials draw on epigenetics and DOHaD research to design and justify prenatal interventions on the material environment to reduce health risks in future generations. This article draws on ethnographic data from a prenatal trial in the United Kingdom and focuses specifically on the experiences of pregnant participants during the intervention phase. In this article, I develop the politics of postgenomic reproduction as a feminist and critical race framework to examine the complex and mercurial stakes of contemporary pregnancy trials. I argue that narratives of control and responsibility in epigenetic models are echoed and preceded by participants’ own embodied experience. The pregnant narratives show at once how their bodies are exposed to unpredictable and uncontrollable environmental exposures and that they are required to respond as if they have absolute control and responsibility. Attending to trial participants’ narratives from a feminist and critical race framework reveals how individualized lifestyle interventions are deeply political and racial, and carry implications for how pregnancy trials influence postgenomic reproduction.

Author(s):  
Dan-Yu Lin ◽  
Donglin Zeng ◽  
Peter B Gilbert

Abstract Large-scale deployment of safe and durably effective vaccines can curtail the COVID-19 pandemic.1−3 However, the high vaccine efficacy (VE) reported by ongoing phase 3 placebo-controlled clinical trials is based on a median follow-up time of only about two months4−5 and thus does not pertain to long-term efficacy. To evaluate the duration of pro- tection while allowing trial participants timely access to efficacious vaccine, investigators can sequentially cross participants over from the placebo arm to the vaccine arm according to priority groups. Here, we show how to estimate potentially time-varying placebo-controlled VE in this type of staggered vaccination of participants. In addition, we compare the per- formance of blinded and unblinded crossover designs in estimating long-term VE.


Author(s):  
William Edelglass

Buddhism is a vast and heterogeneous set of traditions embedded in many different environments over more than two millennia. Still, there have been some similar practices across Buddhist cultures that contributed to the construction of local Buddhist environments. These practices included innumerable stories placing prominent Buddhist figures, including the historical Buddha, in particular places. Many of these stories concerned the conversion of local serpent spirits, dragons, and other beings associated with a local place who then themselves became Buddhist and were said to protect Buddhism in their locales. Events in the stories as well as relics and landscape features were marked by pillars, reliquary shrines (stupas), caves, temples, or monasteries that often became the focus of pilgrimage or considered particularly auspicious places for Buddhist practice, where one could encounter buddhas and bodhisattvas. Through ritual practices such as pilgrimage, circumambulation, and offerings, Buddhists engaged environments and their local spirits. Landscapes were transformed into Buddhist sites that were mapped and made meaningful according to Buddhist stories and cosmology. Farmers, herders, traders, and others in Buddhist cultures whose livelihood depended on their environments engaged the spirits of the land, whose blessings they needed for their own good. Just as they transformed the meaning of local environments, Buddhists also transformed the material environment. In addition to building monasteries, stupas, and other religious structures, Buddhist monastics developed administrative and engineering expertise that enabled large-scale irrigation systems. As Buddhism spread through Asia, it brought agricultural technologies that created the watery landscapes enabling rice production and increasing the agricultural surplus that made possible large monasteries and urbanization. In the last decades of the 20th century and the first decades of the 21st, eco-Buddhist scholars and practitioners have found resources in Buddhist traditions to construct a Buddhist environmental ethic. Some have argued that concepts such as dependent origination, the ethics of loving-kindness and compassion, and other ideas from classical Buddhist traditions suggest that Buddhism has always been particularly attuned to the environment. Critics have charged that eco-Buddhists are distorting Buddhist traditions by claiming that premodern traditions were responding to contemporary environmental concerns. Moreover, they argue, Buddhist ideas such as dependent origination, or its more environmentally resonant interpretation as “interdependence,” do not in fact provide a satisfying grounding for an environmental ethic. Partly in response to such critics, much scholarly work on Buddhism and the environment became more focused on concrete phenomena, informed by a variety of disciplines, including anthropology, archaeology, place studies, art history, pilgrimage studies, and the study of activism. Instead of focusing primarily on universal concepts found in ancient texts, scholars are just as likely to look at how local communities have drawn on Buddhist ontology, ethics, cosmology, symbolism, and rituals to develop Buddhist responses to local environmental needs, developing contemporary Buddhist environmentalisms.


Author(s):  
Deryn Graham ◽  
Ian Benest ◽  
Peter Nicholl

The findings for a case study on improving interaction design for teaching visually impaired students, in an inclusive learning environment, are presented. The crux of the problem is the ability to draw and understand diagrams. The cognitive issues are often underestimated with insufficient attention being given to the use of metaphors, etc. and “one size fits all solutions” are often the norm. The findings of the original seed funded project, which was conducted by three universities in the United Kingdom, have led to design criteria and to an application for a large scale project, to produce generic tools and to enable “multi-modal” teaching and learning, with connotations for the support of people with cognitive as well as physical impairments, especially relevant with respect to an increasingly ageing European population.


2020 ◽  
pp. 233-261
Author(s):  
Chris Heffer

This chapter summarizes the main analytical moves in the TRUST heuristic for analyzing untruthfulness. It then applies the heuristic to three short texts that have been widely called out as lies: Trump’s tweet about large-scale voter fraud just before the 2016 presidential elections; the “Brexit Battle Bus” claim that the United Kingdom sent £350 million per week to the European Union; and Tony Blair’s 2002 statement to Parliament about Iraq possessing weapons of mass destruction. The cases share a common theme: the capacity of untruthful public discourse to undermine democratic legitimacy by, respectively, questioning the integrity of electoral procedures, harming the capacity of voters to make a rational choice, and undermining faith in the rational and responsible deliberation of one’s leaders. The chapter troubles the simple attribution of lying in these cases and shows how a TRUST analysis can lead to a deeper understanding of the types and ethical value of untruthfulness.


2005 ◽  
Vol 21 (2) ◽  
pp. 234-239 ◽  
Author(s):  
Simon Dixon ◽  
Virge James ◽  
Daniel Hind ◽  
Craig J. Currie

Objectives:This study aims to provide the first estimates of the costs and effects of the large scale introduction of autologous transfusion technologies into the United Kingdom National Health Service.Methods:A model was constructed to allow disparate data sources to be combined to produce estimates of the scale, costs, and effects of introducing four interventions. The interventions considered were preparing patients for surgery (PPS) clinics, preoperative autologous donation (PAD), intraoperative cell salvage (ICS), and postoperative cell salvage (PoCS).Results:The key determinants of cost per operation are the anticipated level of reductions in blood use, the mean level of blood use, mean length of stay, and the cost of the technology. The results show the potential for considerable reductions in blood use. The greatest reductions are anticipated to be through the use of PPS and ICS. Vascular surgery, transplant surgery, and cardiothoracic surgery appear to be the specialties that will benefit most from the technologies.Conclusions:Several simplifications were used in the production of these estimates; consequently, caution should be used in their interpretation and use. Despite the drawbacks in the methods used in the study, the model shows the scale of the issue, the importance of gathering better data, and the form that data must take. Such preliminary modeling exercises are essential for rational policy development and to direct future research and discussion among stakeholders.


2017 ◽  
Vol 84 (2_suppl) ◽  
pp. 1-10 ◽  
Author(s):  
Hartmut Porst ◽  
Andrea Burri

Premature ejaculation (PE) is a common complaint of male sexual dysfunction affecting men and their partners and consequently causing significant personal and interpersonal distress. Increased sensitivity of the glans penis and abnormalities of the afferent-efferent reflex pathway within the ejaculatory process are involved in the occurrence of PE. Drugs that either selectively reduce penile sensitization or modify the afferent-efferent reflex are well established therapeutic options for PE. Fortacin™ is the first topical treatment to be officially approved for the treatment of primary PE in adult men, and is mentioned as an experimental aerosol (as TEMPE) in the current European Association of Urology guidelines. It was approved for use in the European Union and launched in the United Kingdom in November 2016. Fortacin™ is a eutectic-like mixture of lidocaine 150 mg/mL and prilocaine 50 mg/mL that meets the requirements of an ideal treatment for PE because it is fast acting (within 5 minutes), has durable effects, can be easily used “on-demand”, and shows minimal side-effects. The metered-dose spray delivery system allows the desensitizing agents to be deposited in a dose-controlled, concentrated film onto the glans penis consequently reducing its sensitivity. This is translated into a delaying of the ejaculatory latency time without adversely affecting the sensation of ejaculation and orgasmic pleasure. The efficacy and safety of Fortacin™ have been proven by means of increased ejaculatory latency, control, and sexual satisfaction in large scale studies demonstrating the significant benefits for both patients and their partners.


2020 ◽  
Vol 19 (S1) ◽  
pp. s98-s119
Author(s):  
Ronald P. Steenblik ◽  
Mark Mateo

AbstractWestern Europe's industrialization was powered largely by coal. Within 15 years after the end of the Second World War, however, governments were subsidizing coal and protecting producers from foreign competition while allowing their industries to contract in a way that avoided large-scale unemployment of miners. The oil-price shocks of 1973–1974 and 1979–1980 gave temporary reprieve to hard-coal production until international oil prices slumped in 1986. This event, combined with ever more stringent environmental regulations and, later, caps on carbon-dioxide emissions, led to the disappearance of subsidized coal mining in one country after another. As of the end of 2019, hard coal was still being mined – in small amounts – in only three Western European countries: Norway, Spain, and the United Kingdom. This paper describes the history of the industry from 1945 through to the present, and the consequences of subsidy policy for trade in hard coal and its substitutes. A common observation is that a reduction in subsidized coal production by a country has not necessarily translated into increased imports of coal on a one-for-one basis.


2020 ◽  
pp. 1097184X2091047 ◽  
Author(s):  
Torunn Wimpelmann ◽  
Aziz Hakimi ◽  
Masooma Saadat

This article explores constructions of gender, masculinity, and class in moral crimes prosecutions, and their legal aftermaths in Afghanistan. It argues that the lack of attention to men in advocacy and research about moral crimes, while reflecting a (geo-) politicized conflation of gender with women, constitute both an empirical and an analytical oversight. The first part of the article discusses the legal grounds for the prosecution of men for “moral crimes” in Afghanistan and presents statistical data that reveals large-scale incarceration of men for pursuing consensual, heterosexual relations, including the non-codified crime of elopement. In the second part, we use ethnographic data to probe into the ways in which the treatment of male elopers are based on specific notions of gender, sexuality, and masculinity. We suggest that the interrelated, yet differentiated, prosecution of male and female elopers in Afghanistan can be usefully understood in terms of a gender regime that places different expectations on men and women. Women’s gender performance is ranked according to (verifiable) chastity, men’s gender performance according to the (legitimate, i.e., honorable) command of resources.


2016 ◽  
Vol 40 (6) ◽  
pp. 499-521 ◽  
Author(s):  
Ian Brittain ◽  
Aaron Beacom

The International Paralympic Committee, U.K. Government, and the Organizing Committee for the London 2012 Olympic and Paralympic Games all contended that the London 2012 Paralympic Games would positively impact the lives of disabled people in the United Kingdom, particularly with regard to changing nondisabled attitudes toward disability. All three have claimed partial success during the course of the 4-year period (Olympiad) separating the London and Rio Paralympic Games. However, this is at odds with the findings of Disabled People’s Organizations (DPOs) and the experiences of disabled individuals. This article considers the claims of both sides against a backdrop of public policies that are targeting large-scale benefit cuts, the media coverage of which actually appears to be hardening attitudes toward anyone on benefits and negating any positive impacts from the Games themselves. It argues that the continued predominance of “ableist” perspectives on disability underpins many of the challenges faced by disabled people. The article adopts a historical perspective on the development of legacy-based foundations upon which the disability sport and Paralympic movements originated. It contends that the gradual move toward an elite “Olympic” sports model of competition has actually served to undermine these foundations.


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