scholarly journals Regulatory Forum Opinion Piece*: Effective Brain Trimming for Regulatory-type Nonclinical Toxicity Studies

2017 ◽  
Vol 46 (2) ◽  
pp. 115-120 ◽  
Author(s):  
Brad Bolon
Keyword(s):  
Best Practices ◽  
Chemical Structure ◽  
Best Practice ◽  
Toxicity Testing ◽  
Clinical Findings ◽  
Anatomic Landmarks ◽  
Analytical Strategy ◽  
Practice Recommendations ◽  
Longitudinal Orientation ◽  
Regulatory Type

Regulatory guidances for nonclinical toxicity testing require brain evaluation but do not require a specific analytical strategy. The Society of Toxicologic Pathology (STP) has produced “best practice” recommendations for brain sampling and processing in general toxicity (GT) studies in adult rodents and nonrodents as well as developmental neurotoxicity (DNT) studies in rodents. This article explains acceptable brain trimming strategies as described in these 2 STP documents. Figures in the DNT and GT “best practices” illustrate coronal brain trimming at specific levels as defined by discrete external and internal anatomic landmarks. However, the text of both “best practice” papers states that institutions may choose different brain trimming levels or other planes (e.g., a longitudinal orientation) as long as key structures are sampled and trimming is consistent among individuals across the study. The STP-recommended number of brain levels to evaluate (7 or 8 coronal sections for GT and DNT studies, respectively) may need to be increased if neurotoxicity is considered possible or likely based on in-life clinical findings or other risk factors (chemical structure, known mode of action, etc.).

scholarly journals Concussion Management Plans' Compliance with NCAA Requirements: Preliminary Evidence Suggesting Possible Improvement

2017 ◽  
Vol 45 (2) ◽  
pp. 231-237
Author(s):  
Christine M. Baugh ◽  
Emily Kroshus ◽  
Kaitlyn I. Perry ◽  
Alexandra P. Bourlas
Keyword(s):  
Best Practices ◽  
Best Practice ◽  
National Collegiate Athletic Association ◽  
Preliminary Evidence ◽  
Concussion Management ◽  
Practice Recommendations ◽  
Management Plans ◽  
Baseline Examination

This study examined the extent to which concussion management plans at National Collegiate Athletic Association (NCAA) member schools were in line with NCAA Concussion Policy and best practice recommendations in absence of any process to ensure compliance. Most schools' concussion management plans were in compliance with 3 (60%) or 4 (25.6%) of the NCAA's 4 required components. Annual athlete education and acknowledgement was the requirement least often included, representing an area for improvement. Further, schools tended to more often include best practices that were more medically-oriented (e.g., including baseline examination), compared to best practices that were less medical in nature (e.g., avoiding flagrant head hits).

Approaches and Best Practices in Web Service Style, XML Data Binding and Validation – Implications to Securing Web Services

2008 ◽  
pp. 318-344 ◽  
Author(s):  
Asif Akram ◽  
David Meredith
Keyword(s):  
Best Practices ◽  
Web Services ◽  
Web Service ◽  
Best Practice ◽  
Xml Data ◽  
Application Security ◽  
Practice Recommendations ◽  
Data Binding ◽  
Data Typing

This chapter shows how the WSDL interface style (RPC / Document), strength of data typing and approach to data binding and validation have important implications on application security (and interoperability). This is because some (common) bad-practices and poor implementation choices can render a service vulnerable to the consequences of propagating loosely bound or poorly constrained data. The chosen Web service style and strength of data typing dictate how SOAP messages are constructed and serialized, and to what extent SOAP messages can be constrained and secured during validation. The chosen approach to binding and validation dictates how and where the SOAP-body and SOAP-header (which includes the security constructs) are handled in the application, and also determines the reliability of message parsing. The authors show how these Web service styles and implementation choices must be carefully considered and applied correctly by providing implementation examples and best practice recommendations.

scholarly journals Volcano observatory best practices (VOBP) workshops - a summary of findings and best-practice recommendations

2019 ◽  
Vol 8 (1) ◽  
Author(s):  
John Pallister ◽  
Paolo Papale ◽  
John Eichelberger ◽  
Chris Newhall ◽  
Charles Mandeville ◽  
...  
Keyword(s):  
Best Practices ◽  
Best Practice ◽  
Practice Recommendations ◽  
Volcano Observatory

Before It Is Too Late: Implementation Strategies of an Efficient Opioid and Pain Stewardship Program

2019 ◽  
pp. 001857871988232
Author(s):  
Oscar Santalo
Keyword(s):  
Best Practices ◽  
Best Practice ◽  
Substance Misuse ◽  
Implementation Strategies ◽  
Practice Recommendations ◽  
Drug Diversion ◽  
Stewardship Program ◽  
History Information ◽  
Dosing Strategies ◽  
Information Recognition

Hospital pharmacies may not have the necessary resources, tools, or policies in place to implement a valuable opioid stewardship program. Meanwhile, the number of opioid prescriptions and medication use has increased nationwide. The overuse of opioids is due to the challenging nature of pain management, drug diversion prevention, and opioid abuse, as well as difficulty in recognizing and implementing best practices regarding opioid stewardship. The purpose of this review is to describe the components and executional strategy of an effective opioid and pain stewardship program. Opioid and pain stewardship programs can help identify opportunities for better adherence to best practice recommendations such as standardization of opioid dosing strategies, prescription of multimodal and opioid-sparing regimens, identification of substance misuse, review of patient history information, recognition of pain as a disease state, and increased dispensing of opioid reversal medications.

scholarly journals Assessment of Evidence-Based Health and Safety Policies on Sudden Death and Concussion Management in Secondary School Athletics: A Benchmark Study

2018 ◽  
Vol 53 (8) ◽  
pp. 756-767 ◽  
Author(s):  
William M. Adams ◽  
Samantha E. Scarneo ◽  
Douglas J. Casa
Keyword(s):  
Best Practices ◽  
Sudden Death ◽  
Secondary School ◽  
Best Practice ◽  
Health And Safety ◽  
State Level ◽  
Heat Acclimatization ◽  
Automated External Defibrillators ◽  
Concussion Management ◽  
Practice Recommendations

Context: Implementation of best-practice health and safety policies has been shown to be effective at reducing the risk of sudden death in sport; however, little is known about the extent to which these policies are required within secondary school athletics.Objective: To examine best-practice health and safety policies pertaining to the leading causes of sudden death and to concussion management in sport mandated at the state level for secondary school athletics.Design: Descriptive observational study.Setting: State high school athletic associations (SHSAAs), state departments of education, and enacted legislation.Patients or Other Participants: United States (including the District of Columbia) SHSAAs.Main Outcome Measure(s): A review of SHSAA health and safety policies for the 2016–2017 academic year, state department of education policies, and enacted legislation was undertaken to assess the polices related to the leading causes of sudden death and concussion management in sport. Current best-practice recommendations used to assess health and safety policies were specific to emergency action plans, automated external defibrillators, heat acclimatization, environmental monitoring and modification, and concussion management. The total number of best-practice recommendations required for each SHSAA's member schools for the aforementioned areas was quantified and presented as total number and percentage of recommendations required.Results: Four of 51 SHSAA member schools were required to follow best practices for emergency action plans, 7 of 51 for access to automated external defibrillators, 8 of 51 for heat acclimatization, and 3 of 51 for management of concussion.Conclusions: At the time of this study, SHSAA member schools were not required to follow all best-practice recommendations for preventing the leading causes of sudden death and for concussion management in sport. Continued advocacy for the development and implementation of best practices at the state level to be required of all secondary schools is needed to appropriately serve the health and well-being of our young student-athletes.

Unilateral Hearing Loss in Young Children: Developing Best Practices with Limited Evidence

2014 ◽  
Vol 24 (2) ◽  
pp. 64-73 ◽  
Author(s):  
Sarah McKay
Keyword(s):  
Young Children ◽  
Best Practices ◽  
Best Practice ◽  
Scientific Evidence ◽  
Unilateral Hearing Loss ◽  
Clinical Expertise ◽  
Limited Evidence ◽  
Substantial Evidence ◽  
Practice Recommendations ◽  
Professional Perspectives

Substantial evidence exists to highlight the difficulties that children with UHL can experience. Unfortunately, the research regarding effective intervention for this population of children remains limited, particularly for young children. Professional perspectives vary widely regarding best choices and timing of interventions. As a result, clinicians are currently in a position of integrating the available scientific evidence with their clinical expertise to develop “best practice” recommendations for the management of their patients.

scholarly journals Quantitative research in tourism and hospitality: an agenda for best-practice recommendations

2019 ◽  
Vol 31 (7) ◽  
pp. 2776-2787 ◽  
Author(s):  
A. George Assaf ◽  
Mike G. Tsionas
Keyword(s):  
Best Practices ◽  
Quantitative Research ◽  
Design Methodology ◽  
Best Practice ◽  
Original Research ◽  
Content Type ◽  
Practice Recommendations ◽  
Main Observation ◽  
Areas Of Concern ◽  
Tourism And Hospitality

Purpose This paper aims to serve as an important guide for more rigorous quantitative research in tourism and hospitality. Design/methodology/approach This paper relies on comments from several methodological experts in the field, as well as the authors’ main observation of the literature. Findings This paper identifies ten important areas of concern. In each of these areas, the authors provide recommendations for best practices. Research limitations/implications There are certainly other issues and concerns that are not covered in this paper. However, the issues addressed can be applied or generalized to most methodological contexts. Originality/value This paper does not present results from original research but provides interesting and comprehensive recommendations for more rigorous quantitative research.

Obesity Prevention in the Early Care and Education Setting: Successful Initiatives across a Spectrum of Opportunities

2013 ◽  
Vol 41 (S2) ◽  
pp. 8-18 ◽  
Author(s):  
Meredith A. Reynolds ◽  
Caree Jackson Cotwright ◽  
Barbara Polhamus ◽  
Allison Gertel-Rosenberg ◽  
Debbie Chang
Keyword(s):  
Physical Activity ◽  
Best Practices ◽  
Obesity Prevention ◽  
Screen Time ◽  
Best Practice ◽  
Early Care And Education ◽  
Background Information ◽  
Early Care ◽  
Breastfeeding Support ◽  
Practice Recommendations

The Early Care and Education (ECE) track presentations from CDC’s Weight of the Nation (WON) 2012 conference showcased innovative national, state, and community obesity prevention efforts. The track was organized around CDC’s “Spectrum of Opportunities” for obesity prevention in ECE (the Spectrum; Table 1), which outlines a common set of opportunities that can enhance the ECE environment with respect to nutrition, breastfeeding support, physical activity, and screen time — all important areas for obesity prevention targeting young children. Participants discussed the opportunities on the spectrum that had been pursued, the obesity prevention standards and best practices that had been the emphasis of their efforts, and common steps for developing, implementing, and evaluating initiatives. This paper provides background information on why ECE is an important component of any jurisdiction’s obesity prevention efforts, references for the primary national reports offering standards and best practice recommendations, an introduction to the Spectrum, and brief summaries of the WON ECE track presentations.

Establishing best practice recommendations for systemic treatment regimen development and maintenance.

2017 ◽  
Vol 35 (8_suppl) ◽  
pp. 40-40
Author(s):  
Andrea Crespo ◽  
Erin Redwood ◽  
Kathy Vu ◽  
Vishal Kukreti
Keyword(s):  
Best Practices ◽  
Best Practice ◽  
Systemic Treatment ◽  
Careful Analysis ◽  
Patient Harm ◽  
Stakeholder Groups ◽  
Practice Recommendations ◽  
Multidisciplinary Group ◽  
Quality Process ◽  
Computerized Prescriber Order Entry

40 Background: A province-wide review of oncology regimens identified discrepancies in a number of regimens in systemic treatment computerized prescriber order entry (ST CPOE) systems. The potential patient harm from such discrepancies includes unnecessary toxicities and reduced treatment efficacy. The regimen review highlighted the need for a high-quality process to improve the safety of systemic treatment prescribing in Ontario. The objective of this work was to develop recommendations on best practices for the development and maintenance of oncology regimens. Methods: An expert multidisciplinary group of oncology clinicians and administrators was formed to review available literature and leverage their expertise to establish oncology-specific recommendations. These were then circulated to broader stakeholder groups for feedback and consensus. Results: Practical, consensus-based best practice recommendations for ST CPOE and pre-printed order regimen development and maintenance were created. Detailed processes for new regimen development are outlined in the table below. Moreover, broad areas of roles and responsibility, frequency of review, and sign-off were highlighted. This was repeated for regimen changes (not shown). Conclusions: There is a lack of guidance in the literature on best practices for oncology regimen development and maintenance. Careful analysis and application of the expertise of oncology professionals resulted in consensus-based best practice recommendations that will enable the advancement of safe, standardized, systemic treatment prescribing.[Table: see text]

Athletic Trainers’ Methods for Determining Return to Activity for Patients With an Ankle Sprain Part II: Influences of Selected Outcomes

2021 ◽  
pp. 1-6
Author(s):  
Ryan S. McCann ◽  
Ashley M.B. Suttmiller ◽  
Phillip A. Gribble ◽  
Julie M. Cavallario
Keyword(s):  
Best Practices ◽  
Ankle Sprain ◽  
Best Practice ◽  
Athletic Trainers ◽  
Alternative Methods ◽  
Evidence Based ◽  
Ankle Sprains ◽  
Practice Recommendations ◽  
Evaluation Techniques ◽  
Return To Activity

Athletic trainers’ reasons for selecting or avoiding certain evaluation techniques for patients with an ankle sprain are not fully understood. Such information is important to facilitating evidence-based practice and eliminating barriers. The purpose of this qualitative study was to determine what factors influence athletic trainers’ selection or avoidance of specific outcomes used to determine patients’ return to activity readiness following an ankle sprain. Participants cited many factors that facilitate and inhibit their use of best-practice recommendations and alternative methods for evaluating patients with ankle sprains. Athletic trainers’ should continue to promote facilitators and eliminate barriers to the use of best practices.

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