Influence of Dietary Magnesium on the Amplitude of Wave V of the Auditory Brainstem Response

1989 ◽  
Vol 101 (5) ◽  
pp. 537-541 ◽  
Author(s):  
Michael J. Cevette ◽  
Kay B. Franz ◽  
Robert H. Brey ◽  
Martin S. Robinette
Keyword(s):  
Auditory Brainstem Response ◽  
Auditory Brainstem ◽  
Diet Group ◽  
Auditory Brainstem Responses ◽  
Low Magnesium ◽  
Intramuscular Injections ◽  
Dietary Magnesium ◽  
Before And After ◽  
Brainstem Response ◽  
Brainstem Function

Thirty-six weanling guinea pigs were fed either a low (600 ppm) or normal (3000 ppm) diet of magnesium for 8 weeks. One half of each diet group received intramuscular injections of magnesium-depleting drugs, furosemide and gentamicin. The other half were controls and received equal intramuscular injections of saline. Auditory brainstem responses were obtained from all animals before and after 8 weeks of treatment of diet and drugs to examine the effects of treatment upon hearing and auditory brainstem function. A three-way analysis of variance of dietary magnesium, by drug and by sex, showed no significant differences in auditory brainstem wave V thresholds, wave V latencies, or interpeak wave I-V latencies between the control and experimental groups. The low magnesium diet group, which received drugs, had significantly greater wave V auditory brainstem response amplitudes. Results can be explained on the basis of magnesium influencing the uptake of calcium into both the hair cells and associated brainstem pathways.

Auditory Testing and Bilirubin

PEDIATRICS ◽  
1986 ◽  
Vol 77 (6) ◽  
pp. 928-928
Author(s):  
STEVEN M. SHAPIRO ◽  
KURT B. HECOX
Keyword(s):  
Auditory Brainstem Response ◽  
Auditory Brainstem ◽  
Brainstem Response ◽  
Brainstem Function ◽  
Unbound Bilirubin ◽  
Bilirubin Toxicity

To the Editor.— Nakamura et al (Pediatrics 1985;75:703-708) provide a useful correlation of the auditory brainstem response (ABR) with unbound bilirubin levels. However, their findings of normal I-V interwave intervals despite increased wave I latencies are surprising in light of other reports of increased interwave intervals in neonates with hyperbilirubinemia. Their suggestion that with bilirubin toxicity alone "brainstem function probably is not involved" contradicts other studies of hyperbilirubinemic neonates that have found central (brainstem), in addition to peripheral, auditory brainstem response abnormalities.

scholarly journals The Binaural Interaction Component of the Auditory Brainstem Response Under Precedence Effect Conditions

2020 ◽  
Vol 24 ◽  
pp. 233121652094613
Author(s):  
Kelly Dean ◽  
John H. Grose
Keyword(s):  
Auditory Brainstem Response ◽  
Interaural Time Difference ◽  
Auditory Brainstem ◽  
Auditory Brainstem Responses ◽  
Precedence Effect ◽  
Binaural Processing ◽  
Binaural Interaction ◽  
Brainstem Response ◽  
Echo Suppression ◽  
Interaction Component

The purpose of this study was to measure the binaural interaction component (BIC) derived from click-evoked auditory brainstem responses (ABRs) using stimuli configured to elicit the Precedence Effect. The hypothesis was that the contribution of binaural processing to echo suppression can be evidenced by a diminished or absent BIC associated with the echo. Ten normal-hearing young adults provided ABRs generated by sequences of click pairs. Results showed that BICs elicited by diotic clicks in isolation were obliterated when those diotic clicks were preceded by a click pair having an interaural time difference of 400 µs and where the interclick interval was 8.4 ms. The presence of the leading click pair increased the latency of the ABR generated by the lagging diotic click pair but did not decrease its amplitude. The results were interpreted as indicating a contribution of binaural processing at the level of the brainstem to echo suppression, at least for the conditions tested here.

Newborn Hearing Screening with Combined Otoacoustic Emissions and Auditory Brainstem Responses

2004 ◽  
Vol 15 (06) ◽  
pp. 414-425 ◽  
Author(s):  
James W. Hall ◽  
Steven D. Smith ◽  
Gerald R. Popelka
Keyword(s):  
Auditory Brainstem Response ◽  
Otoacoustic Emissions ◽  
Auditory Brainstem ◽  
Hearing Screening ◽  
Auditory Neuropathy ◽  
Diagnostic Evaluation ◽  
Auditory Brainstem Responses ◽  
Conductive Loss ◽  
Brainstem Response ◽  
Screening Measures

Accurate assessment of neonatal hearing screening performance is impossible without knowledge of the true status of hearing, a prohibitive requirement that necessitates a complete diagnostic evaluation on all babies screened. The purpose of this study was to circumvent this limitation by integrating two types of screening measures obtained near simultaneously on every baby. Peripheral auditory function was defined by otoacoustic emission results. A complete diagnostic evaluation was performed on every baby who received a "Refer" outcome for auditory brainstem response screening. The integrated results for auditory brainstem response screening in an unselected group of 300 newborns estimated sensitivity at 100%, specificity at 99.7%, overall referral rate at 2.0%, and a positive predictive value of 83.3%. Conductive loss associated with amniotic fluid in the middle ear can persist several weeks after birth; conductive loss can produce a "Refer" outcome for auditory brainstem response screening; and auditory neuropathy can be detected with screening measures. Prevalence results were consistent with the published literature. The implications of this study are that otoacoustic emissions and auditory brainstem measures provide much more information than either alone and that both are needed for a comprehensive hearing screening program.

scholarly journals Auditory Brainstem Response: reference-values for age

CoDAS ◽  
2014 ◽  
Vol 26 (2) ◽  
pp. 117-121 ◽  
Author(s):  
Luana Araujo Cruz Rosa ◽  
Marcia Rumi Suzuki ◽  
Rosanna Giaffredo Angrisani ◽  
Marisa Frassom Azevedo
Keyword(s):  
Reference Values ◽  
Auditory Brainstem Response ◽  
Auditory Brainstem ◽  
Auditory Brainstem Responses ◽  
Age Group ◽  
Group Methods ◽  
Brainstem Response ◽  
Term Newborns ◽  
Absolute Latency ◽  
Preterm Newborns

PURPOSE: To study the absolute latencies of waves I , III and V and interpeak I-III , III-V and I-V of Auditory brainstem responses obtained in preterm newborns in relation to post-conceptual age, term newborns and six months of age infants, establishing reference values for each age group. METHODS: Retrospective study realized through the analysis of tests performed on 80 infants divided into four groups, being the group one composed per newborns assessed between 35 and 36 weeks post-conceptual age; group two by newborns assessed between 37 and 38 weeks; group three with newborns reviewed between 39 to 40 weeks; and group four with infants evaluated with six months. RESULTS: The wave I absolute latency in the group one was 1.81 ms, decreasing to 1.79 ms in groups two and three, and to 1.70 ms in group four. The wave III latency in group one was 4.74 ms, decreasing to 4.62 ms in group two, to 4.56 ms in the group three and to 4.37 ms in the group four. The wave V latency in group one was 7.14 ms, in the group two it was 7.05 ms, in the group three 6.90 ms; and in the group four it was 6.50 ms. Interpeak latencies were also decreased in all groups. CONCLUSION: The latencies studied decreased with the increasing age and were similar values with the international literature.

Chirp-Evoked Auditory Brainstem Response in Children: A Review

2015 ◽  
Vol 24 (4) ◽  
pp. 573-583 ◽  
Author(s):  
Gabriel Anne Bargen
Keyword(s):  
Auditory Brainstem Response ◽  
Pediatric Population ◽  
Auditory Brainstem ◽  
Normal Hearing ◽  
Auditory Brainstem Responses ◽  
Test Time ◽  
Future Research ◽  
Inclusion Criteria ◽  
Qualitative Synthesis ◽  
Brainstem Response

Purpose The aim of this study was to assess the use of the chirp stimulus to record auditory brainstem responses in the pediatric population via a traditional review. Method An electronic search of the literature and a hand search of the literature were conducted. Studies that utilized chirp stimuli within the pediatric population that met all of the inclusion criteria were included in this review. Qualitative synthesis and interpretation of the data were completed. Results Seven studies that met the inclusion criteria were included in the review. Chirp stimuli produce auditory brainstem response (ABR) waveform amplitudes in children similar to those in adults when presented at moderate to low frequency levels. Latency data from chirp stimuli are not consistent when stimulus presentation rates are altered. Test–retest reliability when using the chirp stimulus was found to be good, as were sensitivity and specificity of chirp-evoked ABRs utilized in a newborn hearing screening protocol. Conclusion Reviewed studies indicated that when presented at 60 dB nHL or lower, broadband chirp–generated ABRs have larger amplitudes than click-generated ABRs in children with normal hearing. Utilization of chirp stimuli decreases test time because waveforms are easier to detect with increased synchronization. Further research should focus on correlating chirp thresholds with behavioral hearing thresholds. Given the variance of results in these select studies, future research should also evaluate latency findings and focus on developing normative data for infants with hearing impairment and normal hearing.

Neurophysiological aspects of brainstem processing of speech stimuli in audiometric-normal geriatric population

2016 ◽  
Vol 131 (3) ◽  
pp. 239-244 ◽  
Author(s):  
M S Ansari ◽  
R Rangasayee ◽  
M A H Ansari
Keyword(s):  
Speech Perception ◽  
Auditory Brainstem Response ◽  
Clinical Decision Making ◽  
Speech Sound ◽  
Auditory Brainstem ◽  
Normal Hearing ◽  
Auditory Brainstem Responses ◽  
Spectral Amplitude ◽  
Brainstem Response ◽  
Noisy Conditions

AbstractObjective:Poor auditory speech perception in geriatrics is attributable to neural de-synchronisation due to structural and degenerative changes of ageing auditory pathways. The speech-evoked auditory brainstem response may be useful for detecting alterations that cause loss of speech discrimination. Therefore, this study aimed to compare the speech-evoked auditory brainstem response in adult and geriatric populations with normal hearing.Methods:The auditory brainstem responses to click sounds and to a 40 ms speech sound (the Hindi phoneme |da|) were compared in 25 young adults and 25 geriatric people with normal hearing. The latencies and amplitudes of transient peaks representing neural responses to the onset, offset and sustained portions of the speech stimulus in quiet and noisy conditions were recorded.Results:The older group had significantly smaller amplitudes and longer latencies for the onset and offset responses to |da| in noisy conditions. Stimulus-to-response times were longer and the spectral amplitude of the sustained portion of the stimulus was reduced. The overall stimulus level caused significant shifts in latency across the entire speech-evoked auditory brainstem response in the older group.Conclusion:The reduction in neural speech processing in older adults suggests diminished subcortical responsiveness to acoustically dynamic spectral cues. However, further investigations are needed to encode temporal cues at the brainstem level and determine their relationship to speech perception for developing a routine tool for clinical decision-making.

Electrically Induced Auditory Brainstem Response as a Clinical Tool in Estimating Nerve Survival

1984 ◽  
Vol 93 (4_suppl) ◽  
pp. 97-100 ◽  
Author(s):  
F. Blair Simmons ◽  
Tom Meyers ◽  
Hugh S. Lusted ◽  
Clough Shelton
Keyword(s):  
Auditory Brainstem Response ◽  
Ganglion Cells ◽  
Round Window ◽  
Auditory Brainstem ◽  
Auditory Brainstem Responses ◽  
Scala Tympani ◽  
Clinical Tool ◽  
Large Populations ◽  
Brainstem Response ◽  
Better Than

Nerve survival estimates in totally deaf ears of cats and humans can be easily obtained by auditory brainstem responses to electrical stimulation at the round window. In humans, electrically induced auditory brainstem responses require considerably more current than concurrently observed perceptual thresholds and “maximum loudnesses,” and there is much variability from patient to patient. In cats, in which we also compared efficacy of stimulation sites, preliminary data analysis suggests that the scala tympani is clearly much more efficient than the round window, and the round window better than the promontory in ears with large populations of ganglion cells. In ears with no or nearly no ganglion cells, scala tympani and round window stimulations are about equal.

Ototoxic Effect of Ultrastop Antifog Solution Applied to the Guinea Pig Middle Ear

2014 ◽  
Vol 151 (5) ◽  
pp. 840-844 ◽  
Author(s):  
Kazuhiro Nomura ◽  
Hidetoshi Oshima ◽  
Daisuke Yamauchi ◽  
Hiroshi Hidaka ◽  
Tetsuaki Kawase ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Middle Ear ◽  
Auditory Brainstem Response ◽  
Treated Group ◽  
Auditory Brainstem ◽  
University Hospital ◽  
Auditory Brainstem Responses ◽  
Response Threshold ◽  
Middle Ear Surgery ◽  
Brainstem Response

Objectives Recent advances in endoscopic technology have allowed its application to middle ear surgery. An antifog agent is necessary for endoscopy because moisture and blood may obscure visibility. Ultrastop is one of the most commonly used antifog agents. The current study examined the ototoxic effect of topical application of Ultrastop in the guinea pig ear. Study Design A preliminary experimental animal study. Setting University hospital. Subjects and Methods Eighteen male Hartley guinea pigs (weight, 480-620 g) were divided into 3 groups to be treated with Ultrastop, gentamicin (50 mg/mL, positive control), or saline solution (negative control). After auditory brainstem responses were measured, topical solutions of 0.2 mL were applied through a small hole made at the tympanic bulla. Posttreatment auditory brainstem responses were obtained 14 days after the treatment. The extent of middle ear damage was investigated and scored. Results The saline-treated group showed no deterioration in auditory brainstem response threshold. The Ultrastop-treated and gentamicin-treated groups showed severe deterioration in auditory brainstem response threshold. Middle ear examination revealed extensive changes in the Ultrastop-treated group and medium changes in the gentamicin-treated group. Conclusion Ultrastop applied topically to the guinea pig middle ear caused significant middle ear inflammation and hearing impairment.

Cochlear implantation in auditory neuropathy spectrum disorders: role of transtympanic electrically evoked auditory brainstem responses and serial neural response telemetry

2021 ◽  
pp. 1-8
Author(s):  
S N Dutt ◽  
A Kumar ◽  
A A Mittal ◽  
S Vadlamani ◽  
S K Gaur
Keyword(s):  
Cochlear Implantation ◽  
Auditory Brainstem Response ◽  
Auditory Brainstem ◽  
Neural Response ◽  
Auditory Neuropathy ◽  
Auditory Brainstem Responses ◽  
Auditory Neuropathy Spectrum Disorder ◽  
Neural Response Telemetry ◽  
Brainstem Response ◽  
Response Testing

Abstract Objective To evaluate the utility of pre-operative transtympanic electrically evoked auditory brainstem responses and post-operative neural response telemetry in auditory neuropathy spectrum disorder patients. Methods Four auditory neuropathy spectrum disorder patients who had undergone cochlear implantation and used it for more than one year were studied. All four patients underwent pre-operative transtympanic electrically evoked auditory brainstem response testing, intra-operative and post-operative (at 3, 6 and 12 months after switch-on) neural response telemetry, and out-patient cochlear implant electrically evoked auditory brainstem response testing (at 12 months). Results Patients with better waveforms on transtympanic electrically evoked auditory brainstem response testing showed superior performance after one year of implant use. Neural response telemetry and electrically evoked auditory brainstem response measures improved in all patients. Conclusion Inferences related to cochlear implantation outcomes can be based on the waveform of transtympanic electrically evoked auditory brainstem responses. Robust transtympanic electrically evoked auditory brainstem responses suggest better performance. Improvements in electrically evoked auditory brainstem responses and neural response telemetry over time indicate that electrical stimulation is favourable in auditory neuropathy spectrum disorder patients. These measures provide an objective way to monitor changes and progress in auditory pathways following cochlear implantation.

Correlation between speech-evoked auditory brainstem responses and transient evoked otoacoustic emissions

2011 ◽  
Vol 125 (9) ◽  
pp. 911-916 ◽  
Author(s):  
B Rana ◽  
A Barman
Keyword(s):  
Auditory Brainstem Response ◽  
Otoacoustic Emissions ◽  
Otoacoustic Emission ◽  
Auditory Brainstem ◽  
Auditory Brainstem Responses ◽  
Transient Evoked Otoacoustic Emissions ◽  
Global Emission ◽  
Transient Evoked Otoacoustic Emission ◽  
Cochlear Processing ◽  
Brainstem Response

AbstractObjective:To investigate the correlation between cochlear processing and brainstem processing.Method:Transient evoked otoacoustic emissions and speech-evoked auditory brainstem responses were recorded in 40 ears of normal-hearing individuals aged 18 to 23 years. Correlation analyses compared transient evoked otoacoustic emission parameters with speech-evoked auditory brainstem response parameters.Results:There was a significant correlation between speech-evoked auditory brainstem response wave V latency and transient evoked otoacoustic emission global emission strength; there were no other significant correlations between the two tests.Conclusion:Tests for transient evoked otoacoustic emissions and speech-evoked auditory brainstem responses provide unique and functionally independent information about the integrity and sensitivity of the auditory system. Therefore, combining both tests will provide a more sensitive clinical battery with which to identify the location of different disorders (e.g. language-based learning impairments and hearing impairments).

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