The Combined Masseter Muscle/Intraoral Cheek Transposition (IOCT) Flap for Primary Reconstruction of the Dorsal Oral Cavity

1992 ◽  
Vol 106 (4) ◽  
pp. 326-331 ◽  
Author(s):  
Joachim Zöller ◽  
Heinz Maier ◽  
Achim Herrmann
Keyword(s):  
High Risk ◽  
Oral Cavity ◽  
Masseter Muscle ◽  
Operating Time ◽  
Tumor Resection ◽  
Muscle Flap ◽  
Reconstruction Method ◽  
Primary Reconstruction ◽  
Functional Reconstruction ◽  
Risk Patients

A method for primary reconstruction of the dorsal oral cavity after tumor resection of T2 or small T3 tumors is presented. By combination of the masseter muscle flap with a cranial pedicled intraoral cheek transposition (IOCT) flap, a reconstruction of the defects with two layers of tissue is possible. This easy and functional reconstruction method is especially useful for high-risk patients because of the markedly reduced operating time.

scholarly journals Pterygoid Muscle Transposition for Reconstruction of Small Posterior Defect Along with Primary Closure Following Surgery for Oral Cancers: A Novel Technique

2010 ◽  
Vol 1 (3) ◽  
pp. 187-188
Author(s):  
Sandeep Lerra
Keyword(s):  
Oral Cavity ◽  
Primary Closure ◽  
Primary Repair ◽  
Operation Time ◽  
Primary Reconstruction ◽  
Muscle Transposition ◽  
Oral Cancers ◽  
Floor Of Mouth ◽  
Risk Patients ◽  
Novel Method

Abstract A novel method for the primary reconstruction of the defect in the posterior oral cavity following excision of retromolar trigone (RMT) is described. It uses a combination of lateral pterygoid flap along with primary closure of the residual floor of mouth mucosa and buccal mucosa for primary repair of the defect. This is a functionally satisfactory and simple reconstructive procedure with a shorter operation time and hence can be used for reconstruction in high-risk patients. To the best of our knowledge, this technique of primary repair of posterior oral cavity has not been described in literature.

scholarly journals Efficacy of Whole-Ventricular Radiotherapy in Patients Undergoing Maximal Tumor Resection for Glioblastomas Involving the Ventricle

2021 ◽  
Vol 11 ◽  
Author(s):  
Kyung Hwan Kim ◽  
Jihwan Yoo ◽  
Nalee Kim ◽  
Ju Hyung Moon ◽  
Hwa Kyung Byun ◽  
...  
Keyword(s):  
High Risk ◽  
Failure Rate ◽  
Recursive Partitioning ◽  
Methylation Status ◽  
Tumor Resection ◽  
Matched Cohort ◽  
Prospective Evaluation ◽  
Mgmt Methylation ◽  
Tumor Spread ◽  
Risk Patients

Background and PurposePatients with glioblastoma (GBM) involving the ventricles are at high risk of ventricle opening during surgery and potential ventricular tumor spread. We evaluated the effectiveness of whole-ventricular radiotherapy (WVRT) in reducing intraventricular seeding in patients with GBM and identified patients who could benefit from this approach.Methods and MaterialsWe retrospectively reviewed the data of 382 patients with GBM who underwent surgical resection and temozolomide-based chemoradiotherapy. Propensity score matching was performed to compensate for imbalances in characteristics between patients who did [WVRT (+); n=59] and did not [WVRT (–); n=323] receive WVRT. Local, outfield, intraventricular, and leptomeningeal failure rates were compared.ResultsAll patients in the WVRT (+) group had tumor ventricular involvement and ventricle opening during surgery. In the matched cohort, the WVRT (+) group exhibited a significantly lower 2-year intraventricular failure rate than the WVRT (–) group (2.1% vs. 11.8%; P=0.045), with no difference in other outcomes. Recursive partitioning analysis stratified the patients in the WVRT (–) group at higher intraventricular failure risk (2-year survival, 14.2%) due to tumor ventricular involvement, MGMT unmethylation, and ventricle opening. WVRT reduced the intraventricular failure rate only in high-risk patients (0% vs. 14.2%; P=0.054) or those with MGMT-unmethylated GBM in the matched cohort (0% vs. 17.3%; P=0.036).ConclusionsWVRT reduced the intraventricular failure rate in patients with tumor ventricular involvement and ventricle opening during surgery. The MGMT-methylation status may further stratify patients who could benefit from WVRT. Further prospective evaluation of WVRT in GBM is warranted.

Open versus laparoscopic retroperitoneal lymph node dissection (RPLND) in clinical stage I nonseminomatous germ-cell tumors (NSGCTs): Two contemporary series from a single institution

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. 5084-5084
Author(s):  
N. Nicolai ◽  
D. Biasoni ◽  
J. Piedra Aguilera ◽  
A. Necchi ◽  
L. Piva ◽  
...  
Keyword(s):  
High Risk ◽  
Clinical Stage ◽  
Operating Time ◽  
Case Series ◽  
Median Number ◽  
Low Risk ◽  
Stage I ◽  
Nodal Metastases ◽  
Risk Patients

5084 Background: Primary RPLND is our choice for clinical stage I (CSI) NSGCTs. Open RPLND (O-RPLND) has been our standard policy since 1985, while laparoscopic RPLND (L-RPLND) has been introduced since the late-1990s. Methods: Between June 2003-March 2008, 150 consecutive CSI NSGCT patients (pts) have been submitted to O-RPLND (n = 91) or L-RPLND (n = 59). Pts with high risk disease (vascular invasion/embryonal carcinoma > 90% in the primary tumor) were more frequently offered O-RPLND, while pts with low risk disease (none of the 2 above) were usually considered for L-RPLND. We reviewed our data focusing on: complications, operating time (OT), hospital stay (HS), number of removed nodes, occurrence of nodal metastases as well as of metastasis during follow-up and global need of chemotherapy (CT). Results: O-RPLND (91). 59/91 (64.8%) were high-risk patients. Median OT was 140 min (IQR 110–150). Five (5.5%) complications occurred: 4 lymphorrea and 1 hemorrhage. Median HS was 6 days (IQR 5–7). Nodal metastases were found in 24 (26.4%) pts. Median number of removed nodes was 20 (IQR 14–25). L-RPLND (59). 54/59 (91.2%) were low-risk patients. Median OT was 210 min (IQR 180–240). Ten (16.9%) complications occurred: 5 required conversions to open procedure due to intraoperative bleeding (4) or technical impossibility to conclude the procedure (1). Median HS was 4 days (IQR 4–5). Nodal metastases were found in 5 (8.5%) pts: 2 of them received immediate adjuvant CT. Median number of removed nodes was 14 (IQR 11–20). OT and HS were significantly better in O-RPLND and L-RPLND series, respectively (p.0001 at Mann Whitney test). After a median follow-up of 15.1 months (1–52), distant metastases were observed in 10 (0.7%) pts: 7/91 (7.7%) following O-RPLND and 1/59 (1.7%) following L-RPLND. CT was administered to 7 (7.7%) pts following O-RPLND and to 3 (5.1%) pts following L-RPLND. Conclusions: In this large case-series, no excess of recurrences but a higher rate of complications were recorded in L-RPLND pts. O-RPLND had a significant better OT while HS was shorter in L-RPLND series. Both procedures are still being applied: pts are currently offered one of the 2 modalities after counseling. No significant financial relationships to disclose.

scholarly journals MBCL-48. OUTCOMES OF TREATMENT BASED ON THE ST. JUDE MEDULLOBLASTOMA-96 REGIMEN FOR JAPANESE CHILDREN WITH MEDULLOBLASTOMA

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii398-iii398
Author(s):  
Junya Fujimura ◽  
Tomonari Suzuki ◽  
Yuko Watanabe ◽  
Hidetaka Niizuma ◽  
Ryuta Saito ◽  
...  
Keyword(s):  
High Risk ◽  
Medical Center ◽  
Therapeutic Option ◽  
Tumor Resection ◽  
University Hospital ◽  
High Dose ◽  
High Risk Patients ◽  
Pediatric Medulloblastoma ◽  
Risk Patients ◽  
Standard Risk

Abstract Medulloblastoma is a type of malignant embryonal tumor in childhood that is considered to require multiagent chemotherapy followed by radical resection and craniospinal irradiation (CSI). However, the outcomes of chemotherapy for this tumor in Japan are unclear. Here, we performed a multicenter retrospective study to determine the prognosis of pediatric medulloblastoma patients in Japan treated with the St. Jude medulloblastoma-96 (SJMB96) regimen. Thirty patients with newly diagnosed medulloblastoma received treatment with the SJMB96 regimen at Juntendo University Hospital in Tokyo (n=10), Saitama Medical University International Medical Center in Saitama (n=10), and Tohoku University Hospital in Miyagi (n=10) from 2011 to 2018. All patients underwent tumor resection and CSI, with radiation doses of 23.4Gy for standard-risk patients (n=11) and 39.6Gy for high-risk patients (n=19). Six weeks after radiation therapy, patients received four cycles of high-dose chemotherapy with autologous peripheral blood stem cell transplantation according to the SJMB96 regimen. We found that 5-year overall survival was 80.8% among standard-risk patients and 74.2% among high-risk patients. No treatment-related deaths occurred. Eight patients who experienced recurrence died within 80 months of diagnosis. As these treatment outcomes are comparable to those previously reported outside of Japan, our findings indicate that this regimen is a therapeutic option for medulloblastoma patients in Japan.

Combination of norfloxacin and cisapride in prevention of SBP in high risk patients: A new approach

2001 ◽  
Vol 120 (5) ◽  
pp. A376-A376
Author(s):  
B JEETSANDHU ◽  
R JAIN ◽  
J SINGH ◽  
M JAIN ◽  
J SHARMA ◽  
...  
Keyword(s):  
High Risk ◽  
New Approach ◽  
High Risk Patients ◽  
Risk Patients
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