Long-term function of Hydrofit as hemostatic sealant: abridged republication*

2020 ◽  
pp. 021849232096233
Author(s):  
Hiromichi Sonoda ◽  
Tomoki Ushijima ◽  
Yasuhisa Oishi ◽  
Hideki Tatewaki ◽  
Yoshihisa Tanoue ◽  
...  
Keyword(s):  
Chemical Change ◽  
Suture Line ◽  
Ascending Aorta ◽  
Aortic Graft ◽  
Blood Products ◽  
Graft Replacement ◽  
Water Contact ◽  
Long Period ◽  
Anastomosis Site

The newly-designed hemostatic sealant, Hydrofit, was developed in Japan and consists of a urethane-based polymer without blood products. By applying Hydrofit gel to an anastomosis site on the aorta, water contact initiates a chemical change in the forming elastomer which adheres rapidly and tightly. We experienced an extirpation of Hydrofit gel that had been applied 4 years and 8 months previously in a 42-year-old female who underwent aortic valve replacement and graft replacement of the ascending aorta. The Hydrofit left around the aortic graft suture line was without infection and functioned very well as an elastic sealant for a long period.

The “Auto-sliding Graft” Aortic Wrapping Technique

2018 ◽  
Vol 67 (05) ◽  
pp. 393-394 ◽  
Author(s):  
Francisco Estevez-Cid ◽  
Jose María Herrera-Norena ◽  
Carlos Velasco-García de Sierra
Keyword(s):  
At Risk ◽  
Protective Effect ◽  
Simple Technique ◽  
Circulatory Arrest ◽  
Suture Line ◽  
Ascending Aorta ◽  
Aortic Dilatation ◽  
Aortic Graft ◽  
Patients At Risk ◽  
Wrapping Technique

AbstractWe describe the “auto-sliding graft” technique, a different anastomotic option for reconstructive prosthetic procedures on the ascending aorta especially in patients at risk of circulatory arrest with mild aortic dilatation. This simple technique provides not only an important hemostatic reinforcement for the distal aortic graft anastomosis but also a protective effect on the native ascending aorta beyond the suture line.

scholarly journals An evaluation of the long-term patency of the aortocoronary bypass graft anastomosed to a vascular prosthesis

2020 ◽  
Vol 58 (4) ◽  
pp. 832-838
Author(s):  
Ai Kawamura ◽  
Daisuke Yoshioka ◽  
Koichi Toda ◽  
Ryoto Sakaniwa ◽  
Shigeru Miyagawa ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Aortic Aneurysm ◽  
Thoracic Aortic Aneurysm ◽  
Vascular Prosthesis ◽  
Ascending Aorta ◽  
Graft Occlusion ◽  
Proximal Anastomosis ◽  
Left Circumflex Artery ◽  
Anastomosis Site

Abstract OBJECTIVES Although concomitant surgery for coronary artery disease (CAD) and thoracic aortic aneurysm is performed often, the long-term patency of the coronary artery bypass grafting (CABG) anastomosed to a vascular prosthesis has not been fully investigated. Here, we explored the long-term patency of the graft in comparison with the proximal anastomosis site on the native ascending aorta or vascular prosthesis. METHODS A total of 84 patients with concomitant CABG who underwent surgery for thoracic aortic aneurysm at 3 Osaka Cardiovascular Research Group institutes were retrospectively investigated for this study. The patency of 109 aortocoronary bypasses using saphenous vein grafts was evaluated with computed tomography angiography or coronary angiography, comparing the grafts anastomosed on the vascular prosthesis (group P, n = 75) to those anastomosed on the native ascending aorta (group N, n = 34). RESULTS During 45.9 ± 39.7 months follow-up, significantly worse patency of the grafts in group P was revealed when compared with those in group N (100% vs 77.6% in 12 months, 100% vs 52.7% in 36 months and 100% vs 31.6% in 57 months, log rank P < 0.001). The poor patency of the grafts was confirmed in each target lesions (left anterior descending artery: P = 0.050, right coronary artery: P = 0.045, left circumflex artery: P = 0.051) and regardless of the severities of the target coronary vessels (severe stenosis: P = 0.013, mild-to-moderate stenosis: P = 0.029). Furthermore, an analysis of graft occlusion risk factors using the univariate Cox proportional hazards model revealed that the proximal anastomosis site on the vascular prosthesis was the sole risk factor for graft occlusion (P < 0.001). CONCLUSIONS In the simultaneous surgery for CAD and thoracic aortic aneurysm, CABG design from vascular prosthesis to coronary artery should be avoided if possible, although further studies are warranted.

A Simple Method of Creating LVAD Outflow Tract Aortic Anastomosis

2005 ◽  
Vol 6 (1) ◽  
pp. 53 ◽  
Author(s):  
Eugene L. Kukuy ◽  
Daniel J. Goldstein ◽  
Vivek Rao ◽  
Niloo M. Edwards ◽  
Yoshifumi Naka
Keyword(s):  
Postoperative Bleeding ◽  
Left Ventricular ◽  
Ascending Aorta ◽  
Outflow Tract ◽  
Assist Device ◽  
Simple Method ◽  
Ventricular Assist ◽  
Anastomosis Site ◽  
Left Ventricular Assist ◽  
Aortic Anastomosis

Left ventricular assist device (LVAD) implantation is frequently complicated by intraoperative and postoperative bleeding, particularly at the aortic anastomosis site. Many modifications of the anastomosis have been attempted. We describe a simple method to anastomose the LVAD outflow tract to the ascending aorta with minimal bleeding and a short anastomosis time.

Pulmonary Homografts for Aortic Valve Replacement: Long-term Comparison with Aortic Grafts

2011 ◽  
Vol 14 (4) ◽  
pp. 237 ◽  
Author(s):  
Ferdinand Vogt ◽  
Anke Kowert ◽  
Andres Beiras-Fernandez ◽  
Martin Oberhoffer ◽  
Ingo Kaczmarek ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Aortic Valve Replacement ◽  
Valve Replacement ◽  
Survival Rates ◽  
Long Term Results ◽  
Rank Test ◽  
Aortic Graft ◽  
Valve Prostheses ◽  
Retrospective Comparative Study

<p><b>Objective:</b> The use of homografts for aortic valve replacement (AVR) is an alternative to mechanical or biological valve prostheses, especially in younger patients. This retrospective comparative study evaluated our single-center long-term results, with a focus on the different origins of the homografts.</p><p><b>Methods:</b> Since 1992, 366 adult patients have undergone AVR with homografts at our center. We compared 320 homografts of aortic origin and 46 homografts of pulmonary origin. The grafts were implanted via either a subcoronary technique or the root replacement technique. We performed a multivariate analysis to identify independent factors that influence survival. Freedom from reintervention and survival rates were calculated as cumulative events according to the Kaplan-Meier method, and differences were tested with the log-rank test.</p><p><b>Results:</b> Overall mortality within 1 year was 6.5% (21/320) in the aortic graft group and 17.4% (8/46) in the pulmonary graft group. In the pulmonary graft group, 4 patients died from valve-related complications, 1 patient died after additional heterotopic heart transplantation, and 1 patient who entered with a primary higher risk died from a prosthesis infection. Two patients died from non-valve-related causes. During the long-term follow-up, the 15-year survival rate was 79.9% for patients in the aortic graft group and 68.7% for patients in the pulmonary graft group (<i>P</i> = .049). The rate of freedom from reoperation was 77.7% in the aortic graft group and 57.4% in the pulmonary graft group (<i>P</i> < .001). The reasons for homograft explantation were graft infections (aortic graft group, 5.0%; pulmonary graft group, 6.5%) and degeneration (aortic graft group, 7.5%; pulmonary graft group, 32.6%).</p><p><b>Conclusion:</b> Our study demonstrated superior rates of survival and freedom from reintervention after AVR with aortic homografts. Implantation with a pulmonary graft was associated with a higher risk of redo surgery, owing to earlier degenerative alterations.</p>

Long-Term Stable Metal Organic Framework (MOF) Based Mixed Matrix Membranes for Ultrafiltration

2020 ◽  
Author(s):  
Muayad Al-shaeli ◽  
Stefan J. D. Smith ◽  
Shanxue Jiang ◽  
Huanting Wang ◽  
Kaisong Zhang ◽  
...  
Keyword(s):  
Contact Angle ◽  
Water Contact Angle ◽  
Mixed Matrix Membranes ◽  
Recovery Ratio ◽  
Mixed Matrix ◽  
Water Contact ◽  
Membrane Performance ◽  
Metal Organic ◽  
Matrix Membranes

<p>In this study, novel <a>mixed matrix polyethersulfone (PES) membranes</a> were synthesized by using two different kinds of metal organic frameworks (MOFs), namely UiO-66 and UiO-66-NH<sub>2</sub>. The composite membranes were characterised by SEM, EDX, FTIR, PXRD, water contact angle, porosity, pore size, etc. Membrane performance was investigated by water permeation flux, flux recovery ratio, fouling resistance and anti-fouling performance. The stability test was also conducted for the prepared mixed matrix membranes. A higher reduction in the water contact angle was observed after adding both MOFs to the PES and sulfonated PES membranes compared to pristine PES membranes. An enhancement in membrane performance was observed by embedding the MOF into PES membrane matrix, which may be attributed to the super-hydrophilic porous structure of UiO-66-NH<sub>2</sub> nanoparticles and hydrophilic structure of UiO-66 nanoparticles that could accelerate the exchange rate between solvent and non-solvent during the phase inversion process. By adding the MOFs into PES matrix, the flux recovery ratio was increased greatly (more than 99% for most mixed matrix membranes). The mixed matrix membranes showed higher resistance to protein adsorption compared to pristine PES membranes. After immersing the membranes in water for 3 months, 6 months and 12 months, both MOFs were stable and retained their structure. This study indicates that UiO-66 and UiO-66-NH<sub>2</sub> are great candidates for designing long-term stable mixed matrix membranes with higher anti-fouling performance.</p>

scholarly journals Heterogeneous Scarring Effects of Full-Year Nonemployment

2017 ◽  
Vol 107 (5) ◽  
pp. 369-373 ◽  
Author(s):  
Fatih Guvenen ◽  
Fatih Karahan ◽  
Serdar Ozkan ◽  
Jae Song
Keyword(s):  
Social Security ◽  
Low Income ◽  
Social Security Administration ◽  
Earnings Distribution ◽  
Employment Effects ◽  
Long Period ◽  
Earnings Losses ◽  
The Social ◽  
Scarring Effects

Drawing on administrative data from the Social Security Administration, we find that individuals that go through a long period of non-employment suffer large and long-term earnings losses (around 35-40 percent) compared to individuals with similar age and previous earnings histories. Importantly, these differences depend on past earnings, and are largest at the bottom and top of the earnings distribution. Focusing on workers that are employed 10 years after a period of long-term non-employment, we find much smaller earnings losses (8-10 percent). Furthermore, the large earnings losses of low-income individuals are almost entirely due to employment effects.

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