Haemolysis during cardiopulmonary bypass: how to reduce the free haemoglobin by managing the suctioned blood separately

Perfusion ◽  
2001 ◽  
Vol 16 (6) ◽  
pp. 519-524 ◽  
Author(s):  
A Pierangeli ◽  
V Masieri ◽  
F Bruzzi ◽  
E De Toni ◽  
G Grillone ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Control Group ◽  
Study Group ◽  
Artery Bypass Graft ◽  
Operative Field ◽  
Free Plasma Haemoglobin ◽  
Free Plasma

During cardiopulmonary bypass (CPB) the collection of the patient’s blood from the operating area is of fundamental importance. This blood is collected in the cardiotomy reservoir using field suckers and can be managed in different ways. It can be filtered in the cardiotomy reservoir and redirected to the venous reservoir, then oxygenated and returned to the patient, or it can be managed separately: collected in the cardiotomy reservoir, treated at the end of the operation and only after this, returned to the patient. The aim of this study is to determine in vivo the effect of a separate management of the suction blood from the operative field, using the Avant D903 oxygenator (Dideco, Mirandola, Italy). Twenty-one patients undergoing coronary artery bypass graft surgery with CPB were selected and put into two groups at random. In the control group ( n 10) the suction blood in the cardiotomy reservoir was filtered and immediately redirected into the venous reservoir, oxygenated and returned to the patient. In the study group ( n 11) the suctioned blood was collected in the D903 Avant’s (Dideco) cardiotomy reservoir and returned to the patient only after having been washed at the end of the operation, using a Compact Advanced (Dideco), as required. Clinical data demonstrated that while in the study group it was possible to keep the free plasma haemoglobin (FPH) concentrations the same as at the beginning, in the control group there was a significant increase in FPH from 5.0 3.5 mg/dl (baseline) to 37 16.7 mg/dl (120 min after CPB).

The Effect of Discharge Information Calendar on Healthy Lifestyle Behaviors of Patients after Coronary Artery Bypass Graft Surgery

2021 ◽  
Author(s):  
Merve Afacan ◽  
Seher Ünver
Keyword(s):  
Coronary Artery ◽  
Healthy Lifestyle ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Control Group ◽  
Study Group ◽  
Lifestyle Behaviors ◽  
Artery Bypass Graft ◽  
Cabg Surgery ◽  
Healthy Lifestyle Behaviors

Objectives: To evaluate the effect of discharge information calendar on healthy lifestyle behaviors (HLB) of patients who underwent coronary artery bypass graft (CABG) surgery. Patients and Methods: This randomized controlled study was carried out on 68 patients (study group=33; control group=35) who underwent CABG surgery between 10.11.2017-10.10.2018. Data were collected from the patient information form and HLB Scale-II. The patients were visited by the researcher one day before their discharge and verbal information was given about the HLB. Discharge information calendar that is designed as a desktop calendar and includes 14 main headings on HLB was used to inform the patients in the study group. HLB of the patients were evaluated at the day before discharge, 2nd and 6th weeks following discharge. Results: The mean scale scores obtained from the 2nd and 6th weeks of the study group were significantly higher compared with the control group (p<0.001). Conclusion: The information provided using discharge information calendar to the patients after CABG surgery are effective in gaining HLB for the patients. It is recommended to use visual and written materials (such as the discharging information calendar) to inform patients and help patients to remember the information during the post-discharge period.

The effect of melatonin on interleukins 22 and 13 in patients undergoing coronary artery bypass graft surgery with cardiopulmonary bypass: A Clinical Trial

2020 ◽  
Author(s):  
Reza Jouybar ◽  
Mansour Jannati ◽  
Saeed Khademi
Keyword(s):  
Cardiopulmonary Bypass ◽  
Coronary Artery ◽  
Coronary Artery Bypass Graft ◽  
Coronary Artery Bypass ◽  
Artery Bypass ◽  
Bypass Graft ◽  
The Body ◽  
Control Group ◽  
Artery Bypass Graft ◽  
Significant Difference

Abstract Objective: Coronary artery bypass graft surgery with cardiopulmonary bypass (CABG) is one treatment for patients with coronary artery disease. After CABG, a series of inflammatory processes occur which affect other organs of the body and even cause severe organ damage and subsequently a worse prognosis. The purpose of this study was to evaluate the effect of pre-surgically administered melatonin on interleukins 22 and 13 in patients undergoing CABG.Results: In this study, 22 patients were evaluated, 10 patients (45.5%) in the Melatonin group, and 12 patients (54.5%) in the control group. The mean level of IL-22 at all time-points in T2, T3, and T4 was significantly lower in the Melatonin group (P <0.05). There was also a significant increase in IL-22 in both groups at T4 compared to T1. There was no significant difference between the two groups in IL-13 at any time, but the Melatonin group at T2 had a significant decrease in IL-13 compared to T1. This study showed that preoperative melatonin administration could prevent the increase of IL-22 but not IL-13.

scholarly journals Effect of Propofol Infusion on the Endocrine Response to Cardiac Surgery

1995 ◽  
Vol 23 (5) ◽  
pp. 543-547 ◽  
Author(s):  
A. Ng ◽  
S. S. W. Tan ◽  
H. S. Lee ◽  
S. L. Chew
Keyword(s):  
Cardiac Surgery ◽  
Cardiopulmonary Bypass ◽  
Coronary Artery ◽  
Stress Response ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Blood Levels ◽  
Study Group ◽  
Artery Bypass Graft ◽  
Endocrine Response

The effect of propofol infusion on the stress response was studied in patients undergoing coronary artery bypass graft (CABG). Ten patients received propofol infusion during cardiopulmonary bypass (CPB) and ten controls received diazepam. Blood levels of Cortisol, adrenaline and noradrenaline were sampled. There was a significant reduction in all three hormones (P<0.05) in the study group. In addition, the amount of sodium nitroprusside used during CPB was significantly reduced (P<0.05).

Acute and Chronic Changes in Platelet Volume and Count After Cardiopulmonary Bypass Induced Thrombocytopenia in Man

1987 ◽  
Vol 57 (01) ◽  
pp. 55-58 ◽  
Author(s):  
J F Martin ◽  
T D Daniel ◽  
E A Trowbridge
Keyword(s):  
Platelet Count ◽  
Mean Platelet Volume ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Control Group ◽  
Artery Bypass Graft ◽  
Platelet Volume ◽  
Young Males ◽  
The Mean

SummaryPatients undergoing surgery for coronary artery bypass graft or heart valve replacement had their platelet count and mean volume measured pre-operatively, immediately post-operatively and serially for up to 48 days after the surgical procedure. The mean pre-operative platelet count of 1.95 ± 0.11 × 1011/1 (n = 26) fell significantly to 1.35 ± 0.09 × 1011/1 immediately post-operatively (p <0.001) (n = 22), without a significant alteration in the mean platelet volume. The average platelet count rose to a maximum of 5.07 ± 0.66 × 1011/1 between days 14 and 17 after surgery while the average mean platelet volume fell from preparative and post-operative values of 7.25 ± 0.14 and 7.20 ± 0.14 fl respectively to a minimum of 6.16 ± 0.16 fl by day 20. Seven patients were followed for 32 days or longer after the operation. By this time they had achieved steady state thrombopoiesis and their average platelet count was 2.44 ± 0.33 × 1011/1, significantly higher than the pre-operative value (p <0.05), while their average mean platelet volume was 6.63 ± 0.21 fl, significantly lower than before surgery (p <0.001). The pre-operative values for the platelet volume and counts of these patients were significantly different from a control group of 32 young males, while the chronic post-operative values were not. These long term changes in platelet volume and count may reflect changes in the thrombopoietic control system secondary to the corrective surgery.

Capnography and Pulse Oximetry Improve Fast Track Extubation in Patients Undergoing Coronary Artery Bypass Graft Surgery: A Randomized Clinical Trial

2021 ◽  
Author(s):  
Seyed Tayeb Moradian ◽  
Fatemah Beitollahi ◽  
Mohammad Saeid Ghiasi ◽  
Amir vahedian-azimi
Keyword(s):  
Clinical Trial ◽  
Pulse Oximetry ◽  
Fast Track ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Intervention Group ◽  
Control Group ◽  
Artery Bypass Graft ◽  
Cabg Surgery ◽  
Non Invasive

Abstract Background Use of capnography as a non-invasive method during the weaning process for fast track extubation (FTE) is controversial. We conducted the present study to determine whether pulse oximetry and capnography could be utilized as alternatives to arterial blood gas (ABG) measurements in patients under mechanical ventilation (MV) following coronary artery bypass graft (CABG) surgery. Methods In this randomized clinical trial, 70 patients, who were candidates for CABG surgery, were randomly assigned into two equal groups (n = 35); the intervention group and the control group. In the intervention group, the ventilator management and weaning from MV was done using Etco2 from capnography and SpO2 from pulse oximetry. Meanwhile, in the control group, weaning was done based on ABG analysis. The length of intensive care unit (ICU) stay, time to extubation, number of manual ventilator setting changes, and alarms were compared between the groups. Results The end-tidal carbon dioxide (ETCO2) levels in the intervention group were completely similar to the partial pressure of carbon dioxide (PaCo2) in the control group (39.5 ± 3.1 vs. 39.4 ± 4.32, P > 0.05). The mean extubation times were significantly shorter in the intervention group compared to those in the control patients (212.2 ± 80.6 vs. 342.7 ± 110.7, P < 0.001). Moreover, the number of changes in the manual ventilator setting and the number of alarms were lower in the intervention group (P < 0.05). However, the differences in the length of stay in ICU between the two groups were not significant (P = 0.219). Conclusion According to our results, the use of non-invasive monitors, including capnography and pulse oximetry, is emphasized in order to utilize FTE after CABG surgery. Furthermore, it is a safe and valuable monitor that could be a good alternative for ABG in this population. Nevertheless, further studies with larger sample sizes and on different disease states and populations are required to assess the accuracy of our findings. Trial registration: IRCT, IRCT201701016778N6, Registered 3 March 2017, https://www.irct.ir/trial/7192

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