scholarly journals Imaging angiogenesis using 68Ga-NOTA-PRGD2 positron emission tomography/computed tomography in patients with severe intracranial atherosclerotic disease

2017 ◽  
Vol 37 (10) ◽  
pp. 3401-3408 ◽  
Author(s):  
Shi Shu ◽  
Li Zhang ◽  
Yi Cheng Zhu ◽  
Fang Li ◽  
Li Ying Cui ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Positron Emission Tomography ◽  
Emission Tomography ◽  
Time Interval ◽  
Arterial Lesion ◽  
Event Time ◽  
Intracranial Atherosclerotic Disease ◽  
Positron Emission ◽  
Recent Group ◽  
The Brain

Angiogenesis is a critical compensation route, which has been demonstrated in the brain following ischemic stroke; however, few studies have investigated angiogenesis in chronic intracranial atherosclerosis disease (ICAD). We used 68Ga-NOTA-PRGD2 positron emission tomography/computed tomography based imaging to detect angiogenesis in chronic ICAD and to explore the factors that may have affected it. A total of 21 participants with unilateral severe chronic ICAD were included in the study. Of the 21 participants, 19 were men; the mean (SD) age was 52 (15) years. In 18 participants, we observed elevated 68Ga-NOTA-PRGD2 uptake in the peri-infarct, subcortical, and periventricular regions of the lesioned side, with a higher 68Ga-NOTA-PRGD2 SUVmax compared to that in the contralateral hemisphere (0.15 vs. 0.06, p=0.001). The 18F-FDG PET SUVmax was significantly lower on the lesioned side (11.28 vs. 13.92, p=0.001). Subgroup analyses revealed that the recent group (<6 months) had a higher lesion-to-contralateral region ratio SUVmax than the remote group (>6 months) (6.73 vs. 2.36, p<0.05). Our results provide molecular imaging evidence of angiogenesis in patients with severe chronic ICAD. Furthermore, the extent of angiogenesis in chronic ICAD may be affected by the post-qualified event time interval, and not by infarction itself or the severity of the arterial lesion.

scholarly journals Segmentation of brain biomedical images to compute the volume of gliomas

2019 ◽  
Vol 28 ◽  
pp. 01016
Author(s):  
Estera Kot ◽  
Krzysztof Siwek
Keyword(s):  
Computed Tomography ◽  
Positron Emission Tomography ◽  
Active Contour ◽  
Treatment Plan ◽  
Computer Software ◽  
Current Treatment ◽  
Emission Tomography ◽  
Positron Emission ◽  
The Brain ◽  
Visual Results

The paper presents an algorithm of segmentation of brain imaging examination results − computed tomography (CT) and positron emission tomography (PET) − to identify, compute, and visualize the brain tumors. Computer software was developed in the MATLAB environment using active contour methods: Edge and Chan-Vese. A review of the current treatment plan for patients with diagnosed glioblastoma multiforme was included to emphasize the significance of the solved problem. The work presents executed steps in the algorithm with a detailed description of thresholding process. Visual results of tumors were performed and presented.

scholarly journals THE BIGGEST MYSTERIES OF NATURE — THE UNIVERSE AND THE BRAIN

Osvitolohiya ◽  
2020 ◽  
pp. 6-12
Author(s):  
Blashyak Vladislav
Keyword(s):  
Magnetic Resonance Imaging ◽  
Computed Tomography ◽  
Positron Emission Tomography ◽  
Magnetic Resonance ◽  
Emission Tomography ◽  
Resonance Imaging ◽  
Positron Emission ◽  
The Brain ◽  
The Universe

In the article, which is the result of scientific research in recent decades, the professor points to the value of revolutionary inventions that play a huge role in the development of research, in the evolution of the universe and the brain. One such invention is the telescope. As for the brain, the introduction of research tools such as computed tomography (1972), MRI (magnetic resonance imaging), followed by EEG (electroencephalography), PET (positron emission tomography), MEG (magnetoencephalography) and more recent inventions for tracking of the eyes condition. Such discoveries in science have made the researcher wonder: does knowledge about the brain really allow us to make learning more effective? The scientist provides a classification of children according to their age psychological periods and the work of neurons in the brain. It is indicated that at the age of 4–5 years the network of neurons is best developed. The period of a rebellious teenager is characterized by the maturation of the brain, or the processes of strengthening between neurons. The author speaks about the importance of knowledge in the achievements of neuroeducation in order to understand the strange and most unexpected statements of our students. The article calls for monitoring the results of the latest research on the universe and on our brains. The author is convinced that in the process of teaching educators are able to make certain changes in the brains of their students.

The Potential Value of Hybrid Positron Emission Tomography/Dual-Source Computed Tomography Imaging in Coronary Bypass Surgery

2011 ◽  
Vol 14 (5) ◽  
pp. 283 ◽  
Author(s):  
Andre Plass ◽  
Maximilian Y. Emmert ◽  
Oliver Gaemperli ◽  
Hatem Alkadhi ◽  
Philipp Kaufmann ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Positron Emission Tomography ◽  
Coronary Artery ◽  
Coronary Angiography ◽  
Myocardial Perfusion ◽  
Predictive Value ◽  
Bypass Surgery ◽  
Emission Tomography ◽  
Positron Emission ◽  
Pet Ct

<p><b>Background:</b> We evaluated how comprehensive assessment of coronary artery lesions and their hemodynamic relevance by means of hybrid positron emission tomography (PET) and computed tomography (CT) imaging would affect decision-making in coronary artery bypass surgery (CABG), compared with using invasive coronary angiography (ICA) alone.</p><p><b>Methods:</b> After undergoing ICA, 27 patients (21 men and 6 women; mean SD age, 66 � 10 years) planned for cardiac surgery were scheduled for myocardial perfusion stress/rest evaluation with [13N]ammonia PET and CT coronary angiography. Only ICA was available to the surgeon. Postoperatively, the performed CABG was compared with the hypothetical strategy based on hybrid PET/CT findings (regional coronary flow reserve [CFR], myocardial perfusion defects). Procedures included CABG (n = 18) alone, CABG combined with valve replacement (n = 6), and CABG combined with isolated valve replacement (n = 3). A total of 56 bypass grafts (28 venous and 28 arterial) and 66 distal anastomoses were placed.</p><p><b>Results:</b> CT evaluation showed 93% concordance (66/71) with ICA regarding significant stenoses, with sensitivity, specificity, positive predictive value, and negative predictive value of 93.1%, 98.7%, 94.4%, and 98.4%, respectively. In the PET scan, 16 patients had 1 ischemic region, and 12 patients had 1 scar region, including 5 patients who presented with mixed conditions (scar and ischemia). One patient had a completely normal myocardium. Compared with the performed surgery, PET/CT fusion evaluation showed that of the performed anastomoses, 48% had documented ischemia (with a CFR <2 in 86%), 38% were nonischemic (although a CFR value <2 was found in 78%), and 14% had scar tissue (fixed perfusion defect).</p><p><b>Conclusions:</b> Although <50% of bypasses were placed to areas with myocardial ischemia, the CFR was low in the majority of nonischemic regions, a finding that may have important prognostic relevance. PET/CT fusion imaging could potentially influence planning for CABG and provide incremental prognostic information.</p>

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