Volumetric analysis of intravoxel incoherent motion imaging for assessment of solitary pulmonary lesions

2017 ◽  
Vol 58 (12) ◽  
pp. 1448-1456 ◽  
Author(s):  
Mei Yuan ◽  
Yan Zhong ◽  
Yu-Dong Zhang ◽  
Tong-Fu Yu ◽  
Hai Li ◽  
...  
Keyword(s):  
Diffusion Coefficient ◽  
Diagnostic Accuracy ◽  
Diagnostic Performance ◽  
Region Of Interest ◽  
Volumetric Analysis ◽  
Intravoxel Incoherent Motion ◽  
Fast Diffusion ◽  
Pulmonary Lesions ◽  
Perfusion Fraction ◽  
Single Section

Background Differentiating between malignant and benign solitary pulmonary lesions (SPLs) is challenging. Purpose To determine diagnostic performance of intravoxel incoherent motion-based diffusion-weighted imaging (DW-IVIM) in distinguishing malignant from benign SPLs, using histogram analysis derived whole-tumor and single-section region of interest (ROI). Material and Methods This retrospective study received institutional review board approval. A total of 129 patients with diagnosed SPLs underwent DW-IVIM and apparent diffusion coefficient (ADC). ADC, slow diffusion coefficient (D), fast diffusion coefficient (D*), and perfusion fraction (f) were calculated separately by outlining whole-tumor and single-section ROI. Inter-observer reliability was assessed by inter-class correlation coefficient (ICC). ADC and DW-IVIM parameters were analyzed using independent-sample T-test. Receiver operating characteristic (ROC) analysis was constructed to determine diagnostic performance. Multiple logistic regression was performed to identify independent factors associated with malignant SPLs. Results There were 48 benign SPLs found in 35 patients and 94 patients with lung cancer (LC). ICC for whole-tumor ROI (range, 0.89–0.95) was higher than that for single-section ROI (range, 0.61–0.71). Mean ADC and D were significantly lower in the malignant group. ADC and D 10th showed significantly higher AUC values than did mean ADC and D. D showed significantly higher diagnostic accuracy in mean, 10th, and 25th percentiles than ADC values (all Ps < 0.05). D 10th was found to be an independent factor in discriminating LCs with an odds ratio of –1.217. Conclusion Volumetric analysis had higher reproducibility and diagnostic accuracy than did single-section. Further, compared to ADC, D value differentiated benign SPLs from LCs more accurately.

scholarly journals Early detection treatment response for head and neck carcinomas using intravoxel incoherent motion-magnetic resonance imaging: a meta-analysis

2020 ◽  
pp. 20190507
Author(s):  
Qingxu Song ◽  
Fang Li ◽  
Xin Chen ◽  
Jianbo Wang ◽  
Hong Liu ◽  
...  
Keyword(s):  
Diffusion Coefficient ◽  
Apparent Diffusion Coefficient ◽  
Diagnostic Accuracy ◽  
Head And Neck ◽  
Treatment Response ◽  
Meta Analysis ◽  
Intravoxel Incoherent Motion ◽  
Perfusion Fraction ◽  
Apparent Diffusion ◽  
Pre Treatment

Objectives: To evaluate the diagnostic accuracy of intravoxel incoherent motion-MRI (IVIM-MRI) for predicting the treatment response in head and neck squamous cell carcinomas (HNSCC) patients. Methods: A comprehensive literature search was performed to identify original articles on diagnostic performance of IVIM in predicting treatment response in HNSCC patients receiving chemoradiotherapy. The IVIM parameters studied were diffusion coefficient (D), pseudodiffusion coefficient (D*), perfusion fraction (f), and apparent diffusion coefficient. Summary estimates of diagnostic accuracy were obtained by using a random-effects model. Of 65 studies screened, 8 studies with 347 patients were finally included. Results: The pooled sensitivities and specificities were 76% [95% confidence interval (CI) 69–82%] and 81% (95% CI 70–89%) for pre-treatment D, and 70% (95% CI 58–80%) and 82% (95% CI 66–92%) for △D, respectively. In addition, the sensitivities and specificities ranged from 41.7 to 94% and 67 to 100% for pre-treatment f, and from 55.7 to 76.5% and 72.2 to 93.3% for pre-treatment apparent diffusion coefficient, respectively. Conclusions: The diffusion-related coefficients pre-treatment D and △D demonstrated good accuracy in predicting early treatment response in HNSCC patients. However, because of the variability in reference test and other limitations of included literature, further investigation is needed before implementing any IVIM strategy into clinical practice.

Intravoxel incoherent motion diffusion-weighted imaging assessment of microvascular characteristics in the murine embryonal rhabdomyosarcoma model

2019 ◽  
Vol 61 (2) ◽  
pp. 260-266
Author(s):  
Yuan Yuan ◽  
Dewei Zeng ◽  
Yu Zhang ◽  
Juan Tao ◽  
Yajie Liu ◽  
...  
Keyword(s):  
Diffusion Coefficient ◽  
Microvessel Density ◽  
Diffusion Weighted Imaging ◽  
Embryonal Rhabdomyosarcoma ◽  
Intravoxel Incoherent Motion ◽  
Microvascular Blood Flow ◽  
Vegf Expression ◽  
Perfusion Fraction ◽  
Diffusion Weighted ◽  
D Value

Background Intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) can distinguish the false diffusion generated by microvascular blood flow from the true water molecule diffusion. Purpose To investigate the correlation between IVIM-DWI parameters and angiogenic markers such as the microvessel density and vascular endothelial growth factor (VEGF) expression in the murine embryonal rhabdomyosarcoma model. Material and Methods The murine embryonal rhabdomyosarcoma model was produced by subcutaneously injecting 107 human embryonal rhabdomyosarcoma cells into the right back of nude mice. The apparent diffusion coefficient (ADC), pseudo-diffusion coefficient (D*), true diffusion coefficient (D), and perfusion fraction (f) were obtained from 22 mice models using IVIM-DWI with b-values of 0, 50, 100, 150, 200, 400, 600, 800, 1000, and 1200 s/mm2. The microvessel density and VEGF expression were obtained by histologic examination. We then compared the correlation between IVIM-DWI parameters and microvessel density and VEGF expression. Results The average ADC, D*, D, and f values were 1.05 ± 0.27 × 10−3 mm2/s, 6.19 ± 1.78 × 10−3 mm2/s, 0.69 ± 0.09 ×10−3 mm2/s, and 17.68 ± 8.41 (%), respectively. There was moderate positive correlation between D* value and microvessel density and VEGF expression (r = 0.484, P = 0.023; r = 0.511, P = 0.015). However, there was no significant correlation between ADC, D, and f values and microvessel density and VEGF expression. Conclusion The D* value from IVIM-DWI may be used to evaluate tumor angiogenesis in the murine embryonal rhabdomyosarcoma model.

scholarly journals The Value of Intravoxel Incoherent Motion (IVIM) Magnetic Resonance Imaging in the Evaluation of the Osteosarcoma Response to Preoperative Neoadjuvant Chemotherapy in Teens

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Houdong Zuo
Keyword(s):  
Magnetic Resonance Imaging ◽  
Diffusion Coefficient ◽  
Magnetic Resonance ◽  
Neoadjuvant Chemotherapy ◽  
Roc Curves ◽  
Intravoxel Incoherent Motion ◽  
Imaging Biomarkers ◽  
Fast Diffusion ◽  
Resonance Imaging ◽  
Before And After

Purpose. To investigate the value of intravoxel incoherent motion (IVIM) magnetic resonance imaging in the evaluation of the osteosarcoma (OS) response to preoperative neoadjuvant chemotherapy (NAC) in teens. Methods. Eighteen consecutive osteosarcoma patients (12 males and 6 females) diagnosed by histopathology were enrolled. All enrolled patients received NAC and underwent MRI examinations before and after 2 cycles of NAC. The volume (V), apparent diffusion coefficient (ADC), (slow) diffusion coefficient (D), pseudo-perfusion (fast) diffusion coefficient (D⁎or D star), and perfusion fractions (f) of the OS before and after NAC were measured and analysed. The sensitivity and the specificity of the ADC, D, D⁎ and f values and the correlation between changes in volume (ΔV) and the IVIM-derived parameters (ΔADC, ΔD, ΔD⁎ and Δf) were also calculated and analysed. Paired Student’s t-tests, receiver operating characteristic (ROC) curves, and Spearman correlation analyses were used. Results. The mean volume of the OS after NAC decreased significantly (61.55±9.3 cm3 vs 40.26±4.1 cm3) (P<0.05). After NAC, the ADC (1.21±0.09 × 10-3 mm2/s vs 1.73±0.11 × 10-3 mm2/s) and D (1.14±0.09 × 10-3 mm2/s vs 1.63±0.1 × 10-3 mm2/s) values increased and f (28.58±1.37% vs 20.93±1.16%) values decreased significantly (P<0.05), while D⁎ (9.17±0.98 × 10-3 mm2/s vs 8.94±0.13 × 10-3 mm2/s) values changed slightly (P>0.05). The AUC values of ADC (0.938) and D (0.943) were higher than those of D⁎ (0.574) and f (0.765). The sensitivity and specificity of ADC (0.778, 1) and D (0.944, 0.833) values were superior to those of D⁎ (0.278, 0.722) and f (0.5, 0.944) values. No significant correlations were found between the ΔV and ΔADC, ΔD, ΔD⁎ and Δf values (P>0.05). Conclusion. IVIM-derived parameters ADC and D have the potential to be imaging biomarkers for evaluation of the therapeutic response to NAC in OS patients.

scholarly journals Simplified intravoxel incoherent motion diffusion-weighted MRI of liver lesions: feasibility of combined two-colour index maps

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Petra Mürtz ◽  
Narine Mesropyan ◽  
Alois M. Sprinkart ◽  
Wolfgang Block ◽  
Julian A. Luetkens ◽  
...  
Keyword(s):  
Diffusion Coefficient ◽  
Diagnostic Accuracy ◽  
Visual Assessment ◽  
Liver Lesion ◽  
Colour Index ◽  
Intravoxel Incoherent Motion ◽  
Liver Lesions ◽  
Diffusion Weighted ◽  
Cutoff Values ◽  
Index Maps

Abstract Background To evaluate the feasibility of two-colour index maps containing combined diffusion and perfusion information from simplified intravoxel incoherent motion (IVIM) for liver lesion malignancy assessment. Methods Diffusion-weighted data from a respiratory-gated 1.5-T magnetic resonance sequence were analysed in 109 patients with liver lesions. With three b values (0, 50, 800 s/mm2) estimated diffusion coefficient D′, perfusion fraction f′, and apparent diffusion coefficient (ADC) maps were calculated and analysed for regions of interest (ROIs). D′ and f′ cutoff values were determined by differentiating haemangiomas from other lesions and focal nodular hyperplasias from other lesions, respectively. Combined IDf index maps were generated with a voxel value set to 100, if both D′ and f′ voxel values were lower than their cutoff values (1,529.4 × 10-6 mm2/s and 114.4 × 10-3, respectively), otherwise to 0. Moreover, IADC index maps were generated from ADC cutoff value (1,338.5 × 10-6 mm2/s) obtained by differentiating benign from malignant lesions. Discriminatory power was assessed for both IDf and IADC. Index maps were displayed as two-colour overlays to b-800 images and visually assessed within the translucent hyperintense areas. Results For IDf, the same diagnostic accuracy was achieved as for the combined use of parameters D′ and f′ (93.6%). Compared to IADC, IDf showed a higher diagnostic accuracy. Visual judgment of IDf yielded an accuracy (95.4%) similar to that of quantitative analysis (93.6%). Conclusion Voxel-wise combined two-colour index maps IDf provide similar diagnostic accuracy as ROI-based combination of estimated IVIM parameters D′ and f′ and are suitable for visual assessment of liver lesion malignancy.

scholarly journals Non-invasive MR assessment of the microstructure and microcirculation in regional lymph nodes for rectal cancer: a study of intravoxel incoherent motion imaging

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Xinyue Yang ◽  
Yan Chen ◽  
Ziqiang Wen ◽  
Yiyan Liu ◽  
Xiaojuan Xiao ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Diffusion Coefficient ◽  
Lymph Nodes ◽  
Diagnostic Performance ◽  
Interobserver Agreement ◽  
Intravoxel Incoherent Motion ◽  
Short Axis ◽  
Regional Lymph Nodes ◽  
Individual Parameter ◽  
Non Invasive

Abstract Background The aim of this study is to evaluate the microstructure and microcirculation of regional lymph nodes (LNs) in rectal cancer by using non-invasive intravoxel incoherent motion MRI (IVIM-MRI), and to distinguish metastatic from non-metastatic LNs by quantitative parameters. Methods All recruited patients underwent IVIM-MRI (b = 0, 5, 10, 20, 30, 40, 60, 80, 100, 150, 200, 400, 600, 1000, 1500 and 2000 s/mm2) on a 3.0 T MRI system. One hundred sixty-eight regional LNs with a short-axis diameter equal to or greater than 5 mm from 116 patients were evaluated by two radiologists independently, including 78 malignant LNs and 90 benign LNs. The following parameters were assessed: the short-axis diameter (S), long-axis diameter (L), short- to long-axis diameter ratio (S/L), pure diffusion coefficient (D), pseudo-diffusion coefficient (D*), and perfusion factor (f). Intraclass correlation coefficients (ICCs) were calculated to assess the interobserver agreement between two readers. Receiver operating characteristic curves were applied for analyzing statistically significant parameters. Results Interobserver agreement of IVIM-MRI parameters between two readers was excellent (ICCs> 0.75). The metastatic group exhibited higher S, L and D (P < 0.001), but lower f (P < 0.001) than the non-metastatic group. The area under the curve (95% CI, sensitivity, specificity) of the multi-parameter combined equation for D, f and S was 0.811 (0.744~0.868, 62.82%, 87.78%). The diagnostic performance of the multi-parameter model was better than that of an individual parameter (P < 0.05). Conclusion IVIM-MRI parameters provided information about the microstructure and microcirculation of regional LNs in rectal cancer, also improved diagnostic performance in identifying metastatic LNs.

Intravoxel Incoherent Motion for Differentiating Spinal Metastasis: A Pilot Study

2021 ◽  
Author(s):  
Yuan Li ◽  
Xiaoying Xing ◽  
Enlong Zhang ◽  
Siyuan Qin ◽  
Huishu Yuan ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Diffusion Coefficient ◽  
Regression Model ◽  
Diagnostic Performance ◽  
Logistic Regression Model ◽  
Spinal Metastasis ◽  
Exponential Model ◽  
Intravoxel Incoherent Motion ◽  
Model Parameters ◽  
Tuberculous Spondylitis

Abstract Background: To investigate the value of an intravoxel incoherent motion (IVIM) MRI for discriminating spinal metastasis from tuberculous spondylitis.Methods: This study included 50 patients with spinal metastasis (32 lung cancer, 7 breast cancer, 11 renal cancer), and 20 tuberculous spondylitis. All patients underwent IVIM MRI at 3.0T before treatment. The IVIM parameters including single-index model ( Apparent diffusion coefficient (ADC)-stand), double exponential model (ADCslow，ADCfast and f) and stretched-exponential model parameters (distributed diffusion coefficient (DDC) and α) were acquired. Two radiologists separately measured these parameters for each lesion through drawing region of interest. Receiver operating characteristic (ROC) and the area under the ROC curve analysis was used to evaluate the diagnostic performance. Each parameter was substituted into the Logistic regression model to determine the meaningful parameters, and the combined diagnostic performance was evaluated.Results: The ADCfast and f showed significant differences between spinal metastasis and tuberculous spondylitis. (for all, p < 0.05). The Logistic regression model results showed that ADCfast and f were independent factors affecting the conclusion (P<0.05). The AUC values of ADCfast and f were 0.823 (95%CI:0.719 to 0.927) and 0.876 (95%CI: 0.782 to 0.969), respectively. ADCfast combined with f showed the highest AUC value of 0.925 (95%CI: 0.858 to 0.992). Additional significant differences were found in ADCstand, ADCslow, DDC and α among different metastasis type.Conclusions: IVIM MR imaging may be helpful for differentiating spinal metastasis from tuberculous spondylitis and may be used to detect the origin tumor for those patients who could not identify primary tumors, and provide help for clinical treatment.

Intravoxel incoherent motion magnetic resonance imaging for assessment of chronic pancreatitis with special focus on its early stage

2019 ◽  
Vol 61 (5) ◽  
pp. 579-585 ◽  
Author(s):  
Nobuhiro Fujita ◽  
Akihiro Nishie ◽  
Yoshiki Asayama ◽  
Kousei Ishigami ◽  
Nao Fujimori ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Diffusion Coefficient ◽  
Chronic Pancreatitis ◽  
Magnetic Resonance ◽  
Intravoxel Incoherent Motion ◽  
Control Group ◽  
Imaging Method ◽  
Resonance Imaging ◽  
Perfusion Fraction ◽  
Motion Mri

Background It is clinically necessary to validate a new non-invasive and reliable imaging method to detect early chronic pancreatitis. Intravoxel incoherent motion magnetic resonance imaging (MRI) is useful for quantitative assessment in abdominal solid organs. Purpose To investigate the usefulness of intravoxel incoherent motion MRI parameters in the diagnosis of chronic pancreatitis. Material and Methods Sixty patients with early chronic pancreatitis (n = 44) and chronic pancreatitis (n = 16) were assessed with intravoxel incoherent motion imaging. For comparison, a control group of 71 individuals without chronic pancreatitis was also enrolled. The perfusion fraction (f), pseudo-diffusion coefficient (D*), true diffusion coefficient (D), and apparent diffusion coefficient of pancreatic parenchyma were calculated. These measurements were compared between the three groups. The diagnostic accuracy of imaging parameters was assessed. Results The f values of the early chronic pancreatitis group and the chronic pancreatitis group were significantly lower than those of the control group ( P < 0.001 and P < 0.001, respectively). The D* value of the chronic pancreatitis group was significantly lower than that of the early chronic pancreatitis group ( P = 0.0025). The D values of the early chronic pancreatitis group and the chronic pancreatitis group were significantly higher than those of the control group ( P = 0.001 and P = 0.001, respectively). The perfusion fraction showed the highest diagnostic performance with an Az value of 0.76 for discriminating the control group from the early chronic pancreatitis and chronic pancreatitis groups. Conclusion Intravoxel incoherent motion MRI parameters may reflect the minimal histological changes in early chronic pancreatitis.

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