Antibiotic-induced black hairy tongue: two case reports and a review of the literature

Black hairy tongue (BHT) is characterized by a discolored, hairy tongue. We herein report two cases of BHT associated with antibacterial agents and review previous cases. In Case 1, a 17-year-old girl with a central neurocytoma was administered intravenous piperacillin–tazobactam for postoperative infection, and BHT developed 12 days later. Her symptoms resolved 8 days after she discontinued the piperacillin–tazobactam and brushed her tongue three times daily. In Case 2, a 65-year-old man was administered intravenous piperacillin–tazobactam and levofloxacin to treat multidrug-resistant Pseudomonas aeruginosa, and BHT developed 15 days later. The piperacillin–tazobactam was discontinued and the patient brushed his tongue, and the discoloration gradually subsided thereafter. However, the BHT reappeared after linezolid treatment. The patient had adverse drug reactions to both the piperacillin–tazobactam and linezolid treatments. The BHT might have been related to antibiotic use in both cases. We identified 19 cases of antibiotic-related BHT in a literature search, but none were related to piperacillin–tazobactam use. In all cases, symptoms resolved after discontinuation of the drug and brushing of the tongue. BHT may be a rare adverse effect of antibiotics. Treatment strategies include removal of the causative agents, mechanical debridement, and good oral hygiene.

Download Full-text

Treatment for postoperative infection of pathological femoral fracture after radiotherapy: two case reports and review of the literature

Archives of Orthopaedic and Trauma Surgery ◽

10.1007/s00402-020-03493-5 ◽

2020 ◽

Author(s):

Minami Matsuhashi ◽

Taichi Saito ◽

Tomoyuki Noda ◽

Takenori Uehara ◽

Yasunori Shimamura ◽

...

Keyword(s):

Femoral Fracture ◽

Postoperative Infection ◽

Case Reports ◽

Review Of The Literature

Download Full-text

Central Neurocytoma: 2 Case Reports and Review of the Literature

Acta Neurochirurgica ◽

10.1007/s007010070014 ◽

2000 ◽

Vol 142 (12) ◽

pp. 1417-1422 ◽

Cited By ~ 11

Author(s):

Ph. Metellus ◽

J. R. Alliez ◽

F. Dodero ◽

J. Hassoun ◽

B. Alliez

Keyword(s):

Case Reports ◽

Central Neurocytoma ◽

Review Of The Literature

Download Full-text

Multidrug-Resistant Tuberculosis during Pregnancy: Two Case Reports and Review of the Literature

Case Reports in Obstetrics and Gynecology ◽

10.1155/2016/1536281 ◽

2016 ◽

Vol 2016 ◽

pp. 1-4 ◽

Cited By ~ 4

Author(s):

Minakshi Rohilla ◽

Bharti Joshi ◽

Vanita Jain ◽

Jasvinder Kalra ◽

G. R. V. Prasad

Keyword(s):

Case Reports ◽

Multidrug Resistant ◽

Reproductive Age ◽

Second Line ◽

Review Of The Literature ◽

Health Crisis ◽

Resistant Tuberculosis ◽

Multidrug Resistant Tuberculosis ◽

Antituberculosis Treatment ◽

Mdr Tb

Multidrug-resistant tuberculosis (MDR-TB) is identified from the time of introduction of antituberculosis treatment and is a known worldwide public health crisis affecting women of reproductive age group. Management issues raised by pregnant women with MDR tuberculosis are challenging due to the limited clinical experience available with the use of second line drugs. We hereby report two cases of MDR-TB during pregnancy: one patient was on second line drugs, while another one was evaluated and diagnosed to have MDR-TB in last trimester. At 6 months of follow-up both mothers and babies are doing well. The approach to such cases along with review of the literature is discussed.

Download Full-text

Effect of Synergistic Action of Bovine Lactoferrin with Antibiotics on Drug Resistant Bacterial Pathogens

Medicina ◽

10.3390/medicina57040343 ◽

2021 ◽

Vol 57 (4) ◽

pp. 343

Author(s):

Mohammed S. Al-Mogbel ◽

Godfred A. Menezes ◽

Mohamed T. Elabbasy ◽

Manal M. Alkhulaifi ◽

Ashfaque Hossain ◽

...

Keyword(s):

Antibacterial Agents ◽

Synergistic Effects ◽

Bacterial Pathogens ◽

Treatment Strategies ◽

Multidrug Resistant ◽

Bovine Lactoferrin ◽

Drug Resistant ◽

Therapeutic Choice ◽

Life Saving ◽

Mucosal Secretions

Background and Objectives: The multidrug resistant (MDR) bacterial pathogenic infection is one of the chief worldwide public health threat to humanity. The development of novel antibiotics against MDR Gram negative bacteria has reduced over the last half century. Research is in progress regarding the treatment strategies that could be engaged in combination with antibiotics to extend the duration of these life-saving antibacterial agents. The current study was therefore planned to assess the synergistic effects of bovine lactoferrin (bLF) in combination with different antibiotics that are conventionally used. This synergism would provide a newer therapeutic choice against MDR pathogens. LF is present in mucosal secretions, vastly in milk. LF is considered an important constituent in host defense. In previous reports, LF has been co-administered as a combination antibiotic therapy. Materials and Methods: This study included synergistic (LF + appropriate antibiotic) exposure against 147 locally encountered bacterial pathogens, which were completely characterized strains. The anti-biofilm effects and the outcome of bLF on minimum inhibitory concentrations (MICs) of antibacterials on clinical MDR bacterial pathogens were determined by standard techniques. Results: In our study, synergism of bLF with antibacterial agents were reproducible and found to be significant. LF on its own had an important effect of inhibiting the biofilm production of some significant bacterial pathogens. Conclusion: The results of this study provides useful data on the antibacterial potential of the combination of LF with antibiotics against drug resistant pathogens.

Download Full-text

Central neurocytoma: two case reports and review of the literature

Neurosurgical Review ◽

10.1007/s10143-006-0041-9 ◽

2006 ◽

Vol 29 (4) ◽

pp. 339-347 ◽

Cited By ~ 15

Author(s):

Antonio De Tommasi ◽

Pietro Ivo D’Urso ◽

Claudio De Tommasi ◽

Francesca Sanguedolce ◽

Antonia Cimmino ◽

...

Keyword(s):

Case Reports ◽

Central Neurocytoma ◽

Review Of The Literature

Download Full-text

Central Neurocytoma: Case Report and Review of the Literature

Skull Base ◽

10.1055/s-2007-984273 ◽

2007 ◽

Vol 17 (S 1) ◽

Author(s):

Chun-Lin Chen

Keyword(s):

Case Report ◽

Central Neurocytoma ◽

Review Of The Literature

Download Full-text

Recent Advances in Treatment of Childhood Obesity

Current Drug Metabolism ◽

10.2174/1389200221666200817112311 ◽

2020 ◽

Vol 21 (14) ◽

pp. 1072-1078

Author(s):

Walter Milano ◽

Paola Ambrosio ◽

Francesca Carizzone ◽

Walter Di Munzio ◽

Valeria De Biasio ◽

...

Keyword(s):

Public Health ◽

Physical Activity ◽

Bariatric Surgery ◽

Childhood Obesity ◽

Treatment Strategies ◽

Lifestyle Changes ◽

Family Context ◽

Review Of The Literature ◽

Biological Factors ◽

The Family

: Childhood obesity has assumed epidemic proportions and is currently one of the most widespread public health problems. Many are the factors involved in the pathogenesis of excess weight with interactions between genetic, environmental and biological factors and therefore, also the therapeutic approach must be multidisciplinary and multidimensional. In this review of the literature, we report the contiguity of childhood obesity with eating disorders and the importance of involving the family context in order to induce stable lifestyle changes, both in relation to dietary and nutritional habits, but also in increasing physical activity. Finally, among the therapeutic options, although for selected cases, pharmacotherapy and bariatric surgery can be used as treatment strategies.

Download Full-text

Linezolid Induced Skin Reactions in a Multi Drug Resistant Infective Endocarditis Patient: A Rare Case

Current Drug Safety ◽

10.2174/1574886315666200516175053 ◽

2020 ◽

Vol 15 (3) ◽

pp. 222-226 ◽

Cited By ~ 1

Author(s):

Asha K. Rajan ◽

Ananth Kashyap ◽

Manik Chhabra ◽

Muhammed Rashid

Keyword(s):

Case Report ◽

Infective Endocarditis ◽

Rare Case ◽

Case Reports ◽

Multidrug Resistant ◽

The Body ◽

Prior History ◽

Skin Reactions ◽

Rare Case Report ◽

Multiple Drugs

Rationale: Linezolid (LNZ) induced Cutaneous Adverse Drug Reactions (CADRs) have rare atypical presentation. Till date, there are very few published case reports on LNZ induced CADRs among the multidrug-resistant patients suffering from Infective Endocarditis (MDR IE). Here, we present a rare case report of LNZ induced CARs in a MDR IE patient. Case report: A 24-year-old female patient was admitted to the hospital with chief complaints of fever (101°C) associated with rigors, chills, and shortness of breath (grade IV) for the past 4 days. She was diagnosed with MDR IE, having a prior history of rheumatic heart disease. She was prescribed LNZ 600mg IV BD for MDR IE, against Staphylococcus coagulase-negative. The patient experienced flares of cutaneous reactions with multiple hyper-pigmented maculopapular lesions all over the body after one week of LNZ therapy. Upon causality assessment, she was found to be suffering from LNZ induced CADRs. LNZ dose was tapered gradually and discontinued. The patient was prescribed corticosteroids along with other supportive care. Her reactions completely subsided and infection got controlled following 1 month of therapy. Conclusion: Healthcare professionals should be vigilant for rare CADRs, while monitoring the patients on LNZ therapy especially in MDR patients as they are exposed to multiple drugs. Moreover, strengthened spontaneous reporting is required for better quantification.

Download Full-text