scholarly journals Relationship between serum cystatin-c and coronary lesion severity in coronary artery disease patients with a normal glomerular filtration rate

2021 ◽  
Vol 49 (1) ◽  
pp. 030006052098563
Author(s):  
Junqiang Pan ◽  
Xifeng Sun ◽  
Pengjie Zhang ◽  
Haichao Chen ◽  
Jing Lin
Keyword(s):  
Cystatin C ◽  
Independent Predictor ◽  
Gensini Score ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Coronary Lesion ◽  
Artery Disease ◽  
The Relationship ◽  
Normal Glomerular Filtration Rate ◽  
Lesion Severity

Objective Cardiovascular disease is a major cause of death. This study evaluated the relationship between serum cystatin-c and coronary lesion severity in coronary artery disease (CAD) patients with a normal glomerular filtration rate. Methods Nine hundred and fifty-nine patients were retrospectively included and divided into non-CAD and CAD groups according to coronary angiography results. CAD patients were classified into three groups by Gensini score tertiles. Multivariable logistic regression was used to study the relationship between serum cystatin-c and coronary lesion severity. Results Serum cystatin-c levels were significantly higher in CAD patients than in non-CAD patients. Correlation analysis revealed significant correlations between serum cystatin-c levels with the Gensini score and the number of diseased vessels. The area under the receiver operating characteristic curve of serum cystatin-c was 0.544 and 0.555 for predicting a high Gensini score and three-vessel disease, respectively. Multivariate stepwise regression analysis demonstrated that the serum cystatin-c level was an independent predictor of a high Gensini score [odds ratio (OR) = 2.177, 95% confidence interval (CI) 1.140–3.930] and three-vessel disease (OR = 1.845, 95% CI 0.994–3.424) after adjusting for the conventional CAD risk factors. Conclusions Serum cystatin-c was elevated in CAD patients and may be an independent predictor of CAD severity.

scholarly journals Comparison of estimated GFR equations based on serum cystatin C alone and in combination with serum creatinine in patients with coronary artery disease

2015 ◽  
Vol 15 (7) ◽  
pp. 571-576 ◽  
Author(s):  
Yusuf Cetin Doganer ◽  
Umit Aydogan ◽  
James Edwin Rohrer ◽  
Aydogan Aydogdu ◽  
Tuncer Cayci ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Serum Creatinine ◽  
Cystatin C ◽  
Serum Cystatin C ◽  
Estimated Gfr ◽  
Serum Cystatin ◽  
Artery Disease

SERUM CYSTATIN C-ADIPONECTIN COMPLEX LEVELS PREDICT THE PROGNOSIS OF MALE PATIENTS WITH CORONARY ARTERY DISEASE

2018 ◽  
Vol 71 (11) ◽  
pp. A126
Author(s):  
Tetsuro Matsuoka ◽  
Hiroyasu Yamamoto ◽  
Akane Matsuomoto ◽  
Natsumi Matsuo ◽  
Yukika Mizukami ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Cystatin C ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Male Patients ◽  
Artery Disease

scholarly journals Cystatin C at Admission in the Intensive Care Unit Predicts Mortality among Elderly Patients

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Maria Aparecida Dalboni ◽  
Daniel de Oliveira Beraldo ◽  
Beata Marie Redublo Quinto ◽  
Rosângela Blaya ◽  
Roberto Narciso ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Elderly Patients ◽  
Cystatin C ◽  
Independent Predictor ◽  
Kidney Injury ◽  
Roc Curves ◽  
Serum Levels ◽  
Serum Cystatin C ◽  
Serum Cystatin

Introduction. Cystatin C has been used in the critical care setting to evaluate renal function. Nevertheless, it has also been found to correlate with mortality, but it is not clear whether this association is due to acute kidney injury (AKI) or to other mechanism. Objective. To evaluate whether serum cystatin C at intensive care unit (ICU) entry predicts AKI and mortality in elderly patients. Materials and Methods. It was a prospective study of ICU elderly patients without AKI at admission. We evaluated 400 patients based on normality for serum cystatin C at ICU entry, of whom 234 (58%) were selected and 45 (19%) developed AKI. Results. We observed that higher serum levels of cystatin C did not predict AKI ( versus  mg/L; ). However, it was an independent predictor of mortality, H.R. = 6.16 (95% CI 1.46–26.00; ), in contrast with AKI, which was not associated with death. In the ROC curves, cystatin C also provided a moderate and significant area (0.67; ) compared to AKI (0.47; ) to detect death. Conclusion. We demonstrated that higher cystatin C levels are an independent predictor of mortality in ICU elderly patients and may be used as a marker of poor prognosis.

scholarly journals Significant association between Cystatin C, Gensini score, and Potential biomarker for Increased Risk of coronary artery lesions

2020 ◽  
Author(s):  
jianyuan pan ◽  
Zhenfei Chen ◽  
Gaoliang Zhou ◽  
Jun Feng ◽  
Jing Zhang
Keyword(s):  
Coronary Artery ◽  
Cystatin C ◽  
Elevated Serum ◽  
Healthy Controls ◽  
Gensini Score ◽  
Coronary Artery Lesions ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Potential Biomarker ◽  
Increased Risk

Abstract Objective: Cystatin C (Cys C) has been proposed as a useful biomarker of early impaired kidney function and predictor of mortality risk. The present analysis is to investigate the association of serum Cystatin C with the severity of coronary artery lesions, Gensini score (GS) and the risk of CAD.Methods: 682 CAD patients (230 females, 452 males; mean age 62.6±10.7 years, range from 31 to 86 years) and 135 healthy controls (41 females, 94 males; mean age 58.0±10.3 years, range from 38 to 84 years) were recruited in the current study. ELISA was applied to measure serum Cystatin C levels. Estimated glomerular filtration rate (eGFR) and Gensini score were calculated. Results: Serum TC, LDL-C, UA, Cystatin C and HCY were significantly elevated in CAD patients compared to healthy controls. There were significant differences regarding to Cystatin C, eGFR and Gensini score among different type of CAD patients, of which AMI group had an elevated serum Cystatin C, LDL-C, HCY and Gensini score than the other two groups. When stratified by the quartiles of Cystatin C, we found that age, proportion of male patients and hypertension and diabetes, HCY and Gensini score were increased in Quartile fourth groups than in other quartile groups. Spearman's correlation test revealed positive relationship between Cystatin C, HCY and Gensini score. Multivariate logistic regression analysis revealed that serum Cystatin C level, presence of hypertension and diabetes, HCY, age and male were the risk factors for coronary artery lesions.Conclusions: In summary, our results suggested that Cystatin C is a promising clinical biomarker that provides complementary information to the established risk determinants. The serum Cystatin C level is strongly associated with Gensini score and could be used to evaluate the severity of coronary artery lesions.

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