scholarly journals Polycythemia vera presenting with pulmonary embolism and splenic infarction: a case report

2022 ◽  
Vol 50 (1) ◽  
pp. 030006052110728
Author(s):  
Ping Huang ◽  
Yuhong Li
Keyword(s):  
Computed Tomography ◽  
Bone Marrow ◽  
Pulmonary Embolism ◽  
Case Report ◽  
Clinical Practice ◽  
Polycythemia Vera ◽  
Bone Marrow Aspiration ◽  
Splenic Infarction ◽  
Chest Tightness ◽  
Aspiration Cytology

Pulmonary embolism and splenic infarction are rare in patients with polycythemia vera. We herein describe a man in his early 60s whose main symptoms were chest tightness, cough, and sputum expectoration. Antibiotics, bronchodilators, and mucoactive agents did not improve his symptoms. Pulmonary artery computed tomography angiography showed pulmonary embolism, and abdominal computed tomography showed multiple hypodense foci in the spleen. Bone marrow aspiration cytology, biopsy, and genetic testing confirmed polycythemia vera. The patient’s symptoms were relieved after treatment with hydroxyurea and rivaroxaban. This case emphasizes that although pulmonary embolism and splenic infarction are relatively rare in patients with polycythemia vera, the possibility of polycythemia vera should be considered in clinical practice.

scholarly journals Pulmonary Embolism and Splenic Infarction Caused by Polycythemia Vera

2021 ◽  
Author(s):  
Ping HUANG ◽  
Yuhong LI
Keyword(s):  
Pulmonary Embolism ◽  
Polycythemia Vera ◽  
Bone Marrow Aspiration ◽  
Splenic Infarction ◽  
Low Molecular Weight ◽  
Chest Tightness ◽  
Aspiration Cytology ◽  
Case Presentation ◽  
Oxygen Inhalation ◽  
Abdomen Ct

Abstract Background: Pulmonary embolism and splenic infarction are rare in patients with embolism caused by polycythemia vera, which is easy to be neglected. Case presentation: We presented a case who was diagnosed with pulmonary embolism and splenic infarction caused by polycythemia vera. The patient’s main symptoms were chest tightness, cough and sputum expectoration. Anti-infection, bronchial relaxation and phlegm treatments did not release his symptoms. Pulmonary artery Computed Tomography Angiography showed pulmonary embolism and the abdomen CT showed multiple low-density changes in the spleen. Bone marrow aspiration cytology, biopsy and genetic testing confirmed polycythemia vera. Symptoms relieved after treatment with low molecular weight heparin, hydroxyurea, diuresis, vasodilation and oxygen inhalation.Conclusions: This case emphasized that patients with polycythemia vera should be considered with the possibility of embolism, and we should give early interventions to minimize or delay the harm caused by its complications.

scholarly journals Idiopathic ovarian vein thrombosis causing pulmonary embolism: case report and literature review

2021 ◽  
Vol 49 (6) ◽  
pp. 030006052110106
Author(s):  
Wenrui Li ◽  
Saisai Cao ◽  
Renming Zhu ◽  
Xueming Chen
Keyword(s):  
Computed Tomography ◽  
Pulmonary Embolism ◽  
Abdominal Pain ◽  
Case Report ◽  
Literature Review ◽  
Ovarian Vein ◽  
Review Of Literature ◽  
Vein Thrombosis ◽  
Medical Disorder ◽  
Ovarian Vein Thrombosis

Ovarian vein thrombosis (OVT) is a rare medical disorder, which is most often found in the immediate postpartum period. OVT is rarely considered idiopathic. We report a case of idiopathic OVT with pulmonary embolism in a 33-year-old woman who presented with abdominal pain. Computed tomography and postoperative pathology confirmed the diagnosis of idiopathic OVT. To date, only 12 cases of idiopathic OVT have been reported. In this case report, we present a summary of these cases and a review of literature regarding management of idiopathic OVT.

scholarly journals Hemophagocytic Lymphohistiocytosis Complicating Erythroleukemia in a Child with Monosomy 7: A Case Report and Review of the Literature

2013 ◽  
Vol 2013 ◽  
pp. 1-3
Author(s):  
Samin Alavi ◽  
Maryam Ebadi ◽  
Alireza Jenabzadeh ◽  
M. T. Arzanian ◽  
Sh. Shamsian
Keyword(s):  
Bone Marrow ◽  
Case Report ◽  
Hemophagocytic Lymphohistiocytosis ◽  
Chromosomal Abnormalities ◽  
Bone Marrow Aspiration ◽  
Review Of The Literature ◽  
Monosomy 7 ◽  
Persistent Fever ◽  
First Case ◽  
Erythroid Precursors

Herein, the first case of childhood erythrophagocytosis following chemotherapy for erythroleukemia in a child with monosomy 7 is reported. A 5-year-old boy presented with anemia, thrombocytopenia, and hepatosplenomegaly in whom erythroleukemia was diagnosed. Prolonged pancytopenia accompanied by persistent fever and huge splenomegaly and hepatomegaly became evident after 2 courses of chemotherapy. On bone marrow aspiration, macrophages phagocytosing erythroid precursors were observed and the diagnosis of HLH was established; additionally, monosomy 7 was detected on bone marrow cytogenetic examination. In conclusion, monosomy 7 can lead to erythrophagocytosis associated with erythroid leukemia and should be considered among the chromosomal abnormalities contributing to the association.

scholarly journals A Case of Pulmonary Embolism and Splenic Infarction after Minocycline Infusion in a Patient with Polycythemia Vera

2021 ◽  
Author(s):  
Makoto Takeuchi ◽  
Takenori Okada ◽  
Kouji Iwato ◽  
Kazuma Kawamoto ◽  
Yuki Ikegami ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Polycythemia Vera ◽  
Splenic Infarction

scholarly journals Enhanced Bone Regeneration With Umbilical Cord Stem Cells: A Case Report And Histomorphometric Analysis

2020 ◽  
Vol 6 (6) ◽  
pp. 1-8
Author(s):  
Dennis Smiler ◽  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Case Report ◽  
Bone Regeneration ◽  
Bone Growth ◽  
Bone Marrow Aspirate ◽  
Bone Marrow Aspiration ◽  
Particulate Material ◽  
Histomorphometric Analysis ◽  
Umbilical Cord Stem Cells

Combining bone-marrow aspirate with xenograft and allograft particulate material has been demonstrated to produce a significant quantity of new bone growth. However, securing 1 to 4 ccs of adult autogenous stem cells by means of bone-marrow aspiration is invasive, and the aspirated stem cells are typically senescent, as the procedure most often is used in aging patients

scholarly journals Circulating and bone marrow myeloid cells containingLeishmaniaamastigotes in a case of advanced canine leishmaniosis

2019 ◽  
Vol 31 (5) ◽  
pp. 726-731
Author(s):  
Ioannis L. Oikonomidis ◽  
Theodora K. Tsouloufi ◽  
Mathios E. Mylonakis ◽  
Dimitra Psalla ◽  
Nectarios Soubasis ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Weight Loss ◽  
Blood Smear ◽  
Bone Marrow Aspiration ◽  
Buffy Coat ◽  
Routine Practice ◽  
Canine Leishmaniosis ◽  
Aspiration Cytology ◽  
Blood Smears ◽  
Leishmania Amastigotes

A 5-y-old male Poodle mix was presented with intermittent vomiting, anorexia, and weight loss. Physical examination revealed emaciation, lethargy, dehydration, hypothermia, respiratory distress, and splenomegaly. Based on clinicopathologic, serologic, and parasitologic findings, diagnoses of severe leishmaniosis and dirofilariasis were made. Extracellular, intraneutrophilic, and intramonocytic Leishmania amastigotes were observed on blood smear and buffy coat smear examination. In blood smears, 0.2% of neutrophils were observed to be infected; in buffy coat smears, 0.5% of neutrophils and 0.1% of monocytes were found to be infected. Leishmania amastigotes were also found engulfed by eosinophils and neutrophil precursors in bone marrow aspiration cytology. The detection of Leishmania amastigotes in blood smears is rare, and the clinical significance is uncertain. In circulating blood, Leishmania amastigotes are primarily found phagocytized by neutrophils. Although debatable, there is growing evidence that neutrophils are used as carriers enabling the “silent entry” of the protozoa into macrophages (“Trojan horse” theory). To date, cytologic screening of blood smears for the diagnosis of canine leishmaniosis is not a routine practice. Clinical pathologists and practitioners should be aware that Leishmania amastigotes may be present in neutrophils and less frequently monocytes during blood smear evaluation; neutrophil precursors and eosinophils may also be parasitized in bone marrow specimens.

scholarly journals A comparative evaluation of bone marrow biopsy and bone marrow aspiration in different haematological condition with special reference to leukaemia and lymphoma

2020 ◽  
Vol 8 (8) ◽  
pp. 2886
Author(s):  
Nidhi Verma ◽  
Priya Gupta ◽  
Amod Kumar Saroj ◽  
Preeti Singh ◽  
Veer Karuna
Keyword(s):  
Bone Marrow ◽  
Diagnostic Accuracy ◽  
Special Reference ◽  
Bone Marrow Biopsy ◽  
Bone Marrow Aspiration ◽  
Clinical History ◽  
Aspiration Cytology ◽  
Medical College ◽  
Cytological Picture ◽  
Haematological Disorders

Background: For diagnosis of haematological disorders there are three modalities to examine bone marrow, bone marrow aspiration cytology (BMA), bone marrow imprint (BMI) and bone marrow biopsy (BMB). BMA gives cytological picture; BMI also gives cytological picture but cells are less in number and BMB gives cytological as well as architectural picture. BMA alone may not be sufficient to reach diagnosis therefore the present study was undertaken to compare the above modalities. The study was conducted with the aim to perform cytomorphological evaluation of bone marrow in various haematological disorders with special reference to leukaemia and lymphoma and to compare bone marrow aspiration smears with bone marrow trephine biopsy.Methods: The present study was conducted in department of pathology, LLRM Medical College, Meerut inpatients attending the outpatient department and in-patient department of pediatrics and medicine of SVBP Hospital attached to LLRM Medical College, Meerut, over a period of one year i.e. from March 2018 to May 2019. A detailed clinical history, physical examination and laboratory examination of all the cases was done.Results: Out of 50 cases, maximum number of cases were of anemia 26/50 (52%) followed by leukemia 17/50 (34%), lymphoma 5/50 (10%), multiple myeloma 1/50 (2%), myelofibrosis 1/50 (2%), leishmaniasis 1/50 (2%) and idiopathic thrombocytopenic purpura 1/50(2%). BMA smears were compared with biopsy and concordance and discordance was established. The overall diagnostic accuracy of aspiration was 94%.Conclusions: Bone marrow examination is a safe, quick easy and cost-effective procedure with very less patient discomfort. BMA shows better cellular details when compared to BMI and BMB. BMB is diagnostic investigation in dry tap cases like aplastic anemia, myelofibrosis, myelodysplastic syndrome and metastatic tumors. In present study, concordance between BMA and BMB was seen in majority of the cases and diagnostic accuracy was 94% study concludes that bone marrow aspiration cytology and trephine biopsy complement each other and should be performed simultaneously for complete bone marrow work up and evaluation.

scholarly journals Acute Cerebral Infarction in a patient of Myelodysplastic Syndrome: A Case Report and literature review

2021 ◽  
Author(s):  
Ke-Yang Chen ◽  
Lin-Shuang Tao ◽  
Ni Sun ◽  
Song-Fang Chen ◽  
Bei-Lei Hu
Keyword(s):  
Bone Marrow ◽  
Ischemic Stroke ◽  
Case Report ◽  
Cerebral Infarction ◽  
Myelodysplastic Syndrome ◽  
Bone Marrow Failure ◽  
Bone Marrow Aspiration ◽  
Acute Cerebral Infarction ◽  
Bone Marrow Failure Syndrome ◽  
Inflammatory Processes

Abstract Myelodysplastic syndrome (MDS) is a bone marrow failure syndrome characterized by cytopenia that results in infection and bleeding. However, there are few reports of cerebral infarction in MDS. In this case report we reported a Chinese female patient diagnosed MDS without drugs and an onset of acute cerebral infarction. Imaging examinations showed an ischemic stroke and further bone marrow aspiration identified MDS in the patient. Low dose aspirin and rehydration were used to improve symptom, as well as anti-epileptic drugs and rehabilitation. We also reviewed acute cerebral infarction associated with MDS from a total of three reported cases without drugs for the treatment of MDS. Our data provide further evidence that acute ischemic stroke might be associated with MDS, which may be due to complex chromosomal abnormality and inflammatory processes.

scholarly journals A three-dimensional computed tomography study to determine the ideal method for fluoroscopically-guided bone marrow aspiration from the iliac crest

2020 ◽  
Author(s):  
Ryan S. D'Souza ◽  
Langping Li ◽  
Shuai Leng ◽  
Christine Hunt ◽  
Luke Law ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Bone Marrow ◽  
Iliac Crest ◽  
Three Dimensional ◽  
Safety Margin ◽  
Bone Marrow Aspiration ◽  
New Approach ◽  
Sciatic Notch ◽  
Computed Tomography Images ◽  
Neurovascular Structures

Bone marrow aspiration (BMA) through the iliac crest is potentially unsafe due to the vicinity of neurovascular structures in the greater sciatic notch. Our objective was to investigate the safety of a recently described BMA technique, specifically a trajectory from the posterior superior iliac spine (PSIS) to the anterior inferior iliac spine (AIIS). We conducted a chart review of 260 patients, analyzing three-dimensional reconstructed computed tomography images of the pelvis and sacrum to validate that this new approach offers a wide safety margin from the greater sciatic notch. Analysis of three-dimensional computed tomography scans demonstrated that the PSIS to AIIS trajectory never crossed the greater sciatic notch. The trajectory was noted to be at least one cm away from the greater sciatic notch in all measurements. The new trajectory entered the PSIS at 25.29 ± 4.34° (left side) and 24.93 ± 4.15° (right side) cephalad from the transverse plane, and 24.58 ± 4.99° (left side) and 24.56 ± 4.67° (right side) lateral from the mid-sagittal plane. The area of bone marrow encountered with the new approach was approximately 22.5 cm2. Utilizing the same CT scans, the trajectory from the traditional approach crossed the greater sciatic notch in all scans, highlighting the potential for violating the greater sciatic notch boundary and damaging important neurovascular structures. Statistically significant sex-related differences were identified in needle trajectory angles for both approaches. We conclude that based on this three-dimensional computed tomography study, a trajectory from the PSIS to the AIIS for BMA may offer a wide safety margin from the greater sciatic notch.

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