Comparison of Diazepam and Flurazepam in the Treatment of Insomnia in General Practice

1979 ◽  
Vol 7 (5) ◽  
pp. 401-403 ◽  
Author(s):  
Ian MacPhail ◽  
W Alasdair Ogilvie ◽  
C R Purvis
Keyword(s):  
General Practice ◽  
Side Effects ◽  
Sleep Disturbance ◽  
Crossover Study ◽  
Double Blind ◽  
Blind Crossover Study ◽  
Double Blind Crossover Study

In a double-blind crossover study in general practice, flurazepam was shown to be significantly better (p<0.001) than diazepam in treating sleep disturbance. Fewer patients reported side-effects on flurazepam.

scholarly journals Comparison of Patient-Controlled Epidural Analgesia with Patient-Controlled Intravenous Analgesia Using Pethidine or Fentanyl

1997 ◽  
Vol 25 (2) ◽  
pp. 126-132 ◽  
Author(s):  
W. D. Ngan Kee ◽  
K. K. Lam ◽  
P. P. Chen ◽  
T. Gin
Keyword(s):  
Side Effects ◽  
Caesarean Section ◽  
Epidural Analgesia ◽  
Crossover Study ◽  
Double Blind ◽  
Pain Scores ◽  
Intravenous Analgesia ◽  
Fentanyl Consumption ◽  
Blind Crossover Study ◽  
Double Blind Crossover Study

We compared patient-controlled epidural analgesia (PCEA) with patient-controlled intravenous analgesia (PCIA) using pethidine or fentanyl in a randomized, double-blind crossover study of 80 patients after caesarean section. Patients received pethidine by PCEA or PCIA, or fentanyl by PCEA or PCIA, with a crossover of the route of administration at 12h. For pethidine, pain scores were lower with PCEA vs PCIA from 4 to 16 h (P<0.05). Pethidine consumption was lower with PCEA vs PCIA from 12 to 24 h (P=0.0005). Patients preferred PCEA to PCIA (P=0.015). For fentanyl, pain scores were lower with PCEA vs PCIA at 12 h (P=0.045). Fentanyl consumption was lower with PCEA vs PCIA from 0 to 12 h (P=0.0007). Patients had similar preference for PCEA and PCIA. Pain scores and side-effects were similar between drugs. Plasma pethidine was similar between groups. Plasma fentanyl was higher with PCIA vs PCEA at 12 h (P=0.002). PCEA has advantages over PCIA and pethidine may be the preferred drug.

A Double-Blind Crossover Study of Two Cyclobenzaprine Regimens in Primary Fibromyalgia Syndrome

1993 ◽  
Vol 21 (2) ◽  
pp. 74-80 ◽  
Author(s):  
S Santandrea ◽  
F Montrone ◽  
P Sarzi-Puttini ◽  
L Boccassini ◽  
I Caruso
Keyword(s):  
Side Effects ◽  
Crossover Study ◽  
Fibromyalgia Syndrome ◽  
Double Blind ◽  
Primary Fibromyalgia ◽  
Significant Difference ◽  
Irritable Bowel ◽  
Primary Fibromyalgia Syndrome ◽  
Blind Crossover Study ◽  
Double Blind Crossover Study

In a double-blind crossover study, the efficacy and tolerability of oral cyclobenzaprine administered in two different regimens were compared in 40 patients affected by primary fibromyalgia syndrome. The patients were randomly divided into two groups. Each group of 20 patients was treated for 15 days with either a single dose of 10 mg/day cyclobenzaprine at bedtime or 30 mg/day cyclobenzaprine in three equal doses daily. Following treatment there was a 15-day washout period before the groups were crossed over to the other treatment. Both regimens resulted in a significant decline in the number of tender points; significant improvements were also reported in the quality of sleep, anxiety, fatigue, irritable bowel syndrome and stiffness. There was no significant difference in efficacy between the two therapeutic regimens at any stage during the trial. The frequency of reported side-effects was significantly greater ( P < 0.001) when patients received 30 mg/day cyclobenzaprine (26 patients, 84%) than when they received 10 mg/day (10 patients, 27%). A dose of 10 mg cyclobenzaprine at bedtime significantly improved the symptomatology of patients affected by primary fibromyalgia syndrome. The higher dose did not further reduce these symptoms but did result in a higher incidence of side-effects.

An Analgesic Comparison of Floctafenine (Idarac) and Dihydrocodeine in Post-Operative Pain

1975 ◽  
Vol 3 (3) ◽  
pp. 172-175 ◽  
Author(s):  
S Lipton ◽  
M Conway ◽  
F Ali Akbar
Keyword(s):  
Side Effects ◽  
Pain Relief ◽  
Crossover Study ◽  
Analgesic Drug ◽  
Double Blind ◽  
Post Operative Pain ◽  
Blind Crossover Study ◽  
Double Blind Crossover Study

A double-blind crossover study comparing floctafenine 200 mg, a new analgesic drug, and dihydrocodeine 60 mg, was performed on 72 patients suffering from post-operative pain. Degree of pain relief by floctafenine was similar to that of dihydrocodeine but the relief afforded by the former was of longer duration. Side-effects associated with dihydrocodeine were statistically higher than those associated with floctafenine. Floctafenine was demonstrated to be an effective analgesic with an insignificant incidence of untoward side-effects.

Double-blind crossover study of the antiemetic efficacy of high-dose dexamethasone versus high-dose metoclopramide.

1984 ◽  
Vol 2 (5) ◽  
pp. 466-471 ◽  
Author(s):  
M S Aapro ◽  
P M Plezia ◽  
D S Alberts ◽  
V Graham ◽  
S E Jones ◽  
...  
Keyword(s):  
Side Effects ◽  
Crossover Study ◽  
Nausea And Vomiting ◽  
High Dose ◽  
Severe Nausea ◽  
Double Blind ◽  
Antiemetic Efficacy ◽  
High Dose Dexamethasone ◽  
Blind Crossover Study ◽  
Double Blind Crossover Study

Nausea and vomiting remain common and debilitating side effects of therapy with many anticancer drugs. Recent reports have shown that both metoclopramide and dexamethasone are effective drugs for the treatment of severe nausea and vomiting caused by cis-platinum. A double-blind crossover study comparing the antiemetic properties of high-dose oral and intravenous regimens of metoclopramide and dexamethasone in outpatients was carried out. Standardized patient questionnaires and interviews were used to evaluate response. Dexamethasone and metoclopramide protected against more than five episodes of emesis in 48% and 40% of patients, respectively. Nausea persisted for less than six hours in 45% of patients on dexamethasone and in 37% on metoclopramide. The antiemetic efficacy of both regimens was retained through repeated courses of chemotherapy. Side effects were minimal with dexamethasone; however, 33% of patients experienced unacceptable extrapyramidal side effects to metoclopramide. Patient preference was significantly in favor of dexamethasone: 70% of patients chose to continue dexamethasone compared to 22% who preferred metoclopramide and 8% who chose other antiemetics. Dexamethasone was the preferred antiemetic in this patient population due to minimal side effects.

Inhibition of Spontaneous Platelet Aggregation by Sulfinpyrazone

1979 ◽  
Vol 42 (02) ◽  
pp. 621-625 ◽  
Author(s):  
G G Nenci ◽  
G Agnelli ◽  
M Berrettini ◽  
P Parise ◽  
E Ballatori
Keyword(s):  
Platelet Aggregation ◽  
Crossover Study ◽  
Double Blind ◽  
Platelet Aggregability ◽  
Initiation Of Therapy ◽  
Spontaneous Platelet Aggregation ◽  
Blind Crossover Study ◽  
Double Blind Crossover Study

SummaryIn a randomized double-blind crossover study in 16 patients with enhanced in vitro spontaneous platelet aggregation, sulfinpyrazone proved to be effective in normalizing platelet aggregability within 4 days after initiation of therapy.

Sign in / Sign up

Export Citation Format

Share Document