Chondrosarcoma of the Larynx: Presentation of a Case and Review of the Literature

2008 ◽  
Vol 94 (6) ◽  
pp. 864-868 ◽  
Author(s):  
Santino Rizzo ◽  
Francesco Strinati ◽  
Fabrizio Longari ◽  
Cristina Bizzotti ◽  
Guido Altissimi ◽  
...  
Keyword(s):  
Cricoid Cartilage ◽  
Upper Respiratory Tract ◽  
Laryngeal Function ◽  
Slow Growth Rate ◽  
Good State ◽  
Low Degree ◽  
Degree Of Malignancy ◽  
Frequent Site ◽  
Upper Respiratory

Chondrosarcoma of the larynx is a rare tumor of the upper respiratory tract that originates from cartilaginous tissue. The cricoid cartilage is the most frequent site of onset at the larynx. The diagnosis is not always easy, given the tumor's slow growth rate, the aspecificity of the symptoms, and the low degree of malignancy with which most cases present and which often causes it to be mistaken for a chondroma. A case is presented of a 61-year-old woman with a chondrosarcoma of the larynx, grade 2, originating from the cricoid cartilage and measuring about 3 cm in diameter. The patient underwent extirpation of the tumor together with the cricoid cartilage, with a successive thyrotracheal anastomosis because she refused a total laryngectomy, which would have been the indicated intervention on the basis of the extent and grade of the neoplasm. At 6 years from surgery, the patient is in a good state of health with good laryngeal function and without recurrence of the disease. This fact confirms that the surgical approach to chondrosarcoma of the larynx can in most cases be conservative, reserving demolitive surgery for the more aggressive forms, for tumors of greater extent, and for recurrences. In fact, good laryngeal function and therefore a good quality of life can be maintained even for long periods of time.

Nasal disease and quality of life in athletes

2018 ◽  
Vol 132 (9) ◽  
pp. 812-815
Author(s):  
A C Walker ◽  
P Surda ◽  
M Rossiter ◽  
S A Little
Keyword(s):  
Quality Of Life ◽  
Respiratory Tract ◽  
Respiratory Tract Infections ◽  
Upper Respiratory Tract Infections ◽  
Upper Respiratory Tract ◽  
Nasal Symptoms ◽  
Nasal Disease ◽  
Upper Respiratory ◽  
Tract Infections

AbstractObjectivesNasal disease imposes a significant disease burden upon the individual in the general population, but is relatively under studied in athletes. This study sought to define the frequency of nasal symptoms in the active population, and to quantify the impact of these symptoms on quality of life and on the frequency of upper respiratory tract infections.ResultsA total of 296 participants completed the study (246 athletes and 50 sedentary controls). Nasal symptoms were significantly more frequent in the active group than in the sedentary controls (70 per cent vs 52 per cent). Upper respiratory tract infections were significantly more common in athletes with regular nasal symptoms than in athletes without nasal symptoms. Quality-of-life scores, as measured by the 22-item Sino-Nasal Outcome Test, were significantly worse in athletes with regular nasal symptoms.ConclusionThis study suggests that regular exercise is associated with a significant increase in the prevalence of troubling nasal symptoms, and nasal symptoms in athletes are associated with increased susceptibility to upper respiratory tract infections. Quality of life was negatively affected, confirming the importance of nasal health to athlete welfare.

Self-Esteem, Extraversion, Neuroticism and Health As Predictors of Quality of Life

Human Affairs ◽  
2015 ◽  
Vol 25 (4) ◽  
Author(s):  
Gabriela Mikulášková ◽  
Peter Babinčák
Keyword(s):  
Quality Of Life ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Self Esteem ◽  
Upper Respiratory Tract ◽  
Respiratory Tract Disease ◽  
Stepwise Method ◽  
Upper Respiratory ◽  
Tract Disease

AbstractThe study verified self-esteem, extraversion, neuroticism and health as predictors of subjectively-assessed quality of life. The sample included 109 adolescents (69 healthy adolescents and 40 adolescents with upper respiratory tract disease). The research tools used were WHOQOL-BREF (WHO, 1998), Rosenberg´s self-esteem scale (Rosenberg, 1965) and NEO-FFI personality questionnaire (Hřebíčková et al., 2002). The results were processed using the multiple linear regression analysis stepwise method. Health was not found to be a predictor of subjectively-assessed quality of life in the research sample. Self-esteem was found to be a predictor of psychological (48% of variance) and environmental (25% of variance) quality of life. Neuroticism was confirmed as a predictor only for physical quality of life (8% of variance). Extraversion was established as a universal predictor for all the aspects of quality of life measured: physical (20% of variance), psychological (8% of variance) and environmental (10% of variance).

Quality of life in patients with smell loss due to upper respiratory tract infections

2011 ◽  
Vol 32 (6) ◽  
pp. 504-510 ◽  
Author(s):  
Adolfo Toledano ◽  
Gil Rodríguez ◽  
Ana María Martín ◽  
Tomás Onrubia ◽  
Néstor Galindo
Keyword(s):  
Quality Of Life ◽  
Respiratory Tract ◽  
Respiratory Tract Infections ◽  
Upper Respiratory Tract Infections ◽  
Upper Respiratory Tract ◽  
Upper Respiratory ◽  
Tract Infections ◽  
Smell Loss

scholarly journals Clinical and experimental factors that affect the reported performance characteristics of rapid testing for SARS-CoV-2

2021 ◽  
Author(s):  
Valentin Parvu ◽  
Devin Gary ◽  
Joseph Mann ◽  
Yu-Chih Lin ◽  
Dorsey Mills ◽  
...  
Keyword(s):  
High Sensitivity ◽  
Disease Diagnosis ◽  
Upper Respiratory Tract ◽  
Antigen Test ◽  
Test Sensitivity ◽  
Viral Culture ◽  
Upper Respiratory ◽  
Asymptomatic Individuals ◽  
Design Factors

ABSTRACT Tests that detect the presence of SARS-CoV-2 antigen in clinical specimens from the upper respiratory tract can provide a rapid means of COVID-19 disease diagnosis and help identify individuals that may be infectious and should isolate to prevent SARS-CoV-2 transmission. This systematic review assesses the diagnostic accuracy of SARS-CoV-2 antigen detection in COVID-19 symptomatic and asymptomatic individuals compared to RT-qPCR, and summarizes antigen test sensitivity using meta-regression. In total, 83 studies were included that compared SARS-CoV-2 rapid antigen lateral flow testing (RALFT) to RT-qPCR for SARS-CoV-2. Generally, the quality of the evaluated studies was inconsistent, nevertheless, the overall sensitivity for RALFT was determined to be 75.0% (95% confidence interval [CI]: 71.0-78.0). Additionally, RALFT sensitivity was found to be higher for symptomatic versus asymptomatic individuals and was higher for a symptomatic population within 7 days from symptom onset (DSO) compared to a population with extended days of symptoms. Viral load was found to be the most important factor for determining SARS-CoV-2 antigen test sensitivity. Other design factors, such as specimen storage and anatomical collection type, also affect the performance of RAFLT. RALFT and RT-qPCR testing both achieve high sensitivity when compared to SARS-CoV-2 viral culture.

scholarly journals Oral corticosteroids for post-infectious cough in adults: study protocol for a double-blind randomized placebo-controlled trial in Swiss family practices (OSPIC trial)

Trials ◽  
2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Christoph Merlo ◽  
Stefan Essig ◽  
D. Oana Brancati-Badarau ◽  
Jörg Daniel Leuppi ◽  
Benjamin Speich ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Health Care ◽  
Tract Infection ◽  
Upper Respiratory Tract ◽  
Substantial Impact ◽  
Related Quality ◽  
Oral Corticosteroids ◽  
Upper Respiratory ◽  
Post Infectious

Abstract Background Cough is a common reason for patients to visit general practices. So-called post-infectious cough is defined as lasting 3 to 8 weeks after an upper respiratory tract infection. It can be disabling in daily activities, with substantial impact on physical and psychosocial health, leading to impaired quality of life and increased health care costs. Recommendations for the management of post-infectious cough in primary care are scarce and incoherent. A systematic review and meta-analysis of randomized clinical trials (RCT) assessing patient-relevant benefits and potential harms of available treatments identified six eligible RCTs assessing different treatment regimens (i.e. inhaled fluticasone propionate, inhaled budesonide, salbutamol plus ipratropium-bromide, montelukast, nociception-opioid-1-receptor agonist, codeine, gelatine). No RCT found clear patient-relevant benefits and most had an unclear or high risk of bias. Post-infectious cough is thought to be mediated by inflammatory processes that are also present in exacerbations of asthma or chronic obstructive pulmonary diseases for which there is strong evidence that oral corticosteroids provide patient-relevant benefit without relevant harm. We therefore plan to conduct the first RCT evaluating the effectiveness of oral corticosteroids for post-infectious cough. Methods We are conducting a triple-blinded randomized-controlled and multicentred superiority trial in primary health care practices in Switzerland. We will include 204 adult patients who consult their general practitioner (GP) for a cough lasting 3 to 8 weeks following an upper respiratory tract infection. Participants will be randomly allocated to either the 5-day treatment with oral corticosteroids or placebo. The primary outcome is cough-related quality of life assessed by the Leicester Cough Questionnaire score 14 days after randomization. Secondary outcomes include cough-related quality of life at several time points, overall cessation of cough and adverse events. Discussion This RCT will provide evidence on whether oral corticosteroids are beneficial and safe in patients with post-infectious cough. Results can have a substantial impact on the well-being and management of these patients in Switzerland and beyond. An evidence-based treatment for this condition may reduce re-consultations with GPs and spending for antitussive drugs, thus possibly having an impact on health care spending. Trial registration ClinicalTrials.gov NCT04232449. Prospectively registered on 18 January 2020.

scholarly journals Ectomesenchymal Chondromyxoid Tumour of the Dorsal Tongue Presenting with Impaired Speech

2016 ◽  
Vol 2016 ◽  
pp. 1-4
Author(s):  
Laura A. Schep ◽  
Martin J. Bullock ◽  
S. Mark Taylor
Keyword(s):  
Respiratory Tract Infections ◽  
Upper Respiratory Tract ◽  
Anterior Dorsal ◽  
Dorsal Tongue ◽  
Upper Respiratory ◽  
Clinical Photograph ◽  
Tract Infections ◽  
Impaired Speech ◽  
Slow Growing

Ectomesenchymal chondromyxoid tumours (ECTs) are rare mesenchymal soft tissue neoplasms that typically present as a slow-growing asymptomatic mass on the anterior dorsum of the tongue. Our patient presented with impaired speech articulation and pain associated with upper respiratory tract infections when the lesion on his dorsal tongue would swell, and he would accidentally bite down on it. Microscopically, ECTs appear as unencapsulated, well-circumscribed proliferations of uniform round to fusiform cells embedded within chondromyxoid matrices. Most cases of ECT have been detected in the third to the sixth decades of life, with no sex preference. ECT may cause a range of symptoms that negatively impact patients’ quality of life, including pain, dysphagia, odynophagia, bleeding, and, in the case of our patient, impairment of speech. We provide a unique preoperative clinical photograph and case description that should help readers in recognizing this neoplasm. Considering the rarity of ECT presenting clinically as well as in the literature, we believe this report will add to our growing understanding of ECT and its management. We report a case of ECT presenting on the anterior dorsal tongue that was successfully surgically resected under local anesthesia with clear margins, accompanied by a review of the pertinent literature.

Malignant fibrous histiocytoma of the larynx

1991 ◽  
Vol 105 (2) ◽  
pp. 130-133 ◽  
Author(s):  
Ricardo Bernáldez ◽  
Manuel Nistal ◽  
Carlos Kaiser ◽  
Javier Gavilán
Keyword(s):  
Respiratory Tract ◽  
Malignant Fibrous Histiocytoma ◽  
Total Laryngectomy ◽  
Normal Tissue ◽  
Fibrous Histiocytoma ◽  
English Literature ◽  
Upper Respiratory Tract ◽  
Mesenchymal Neoplasms ◽  
Degree Of Malignancy ◽  
Upper Respiratory

AbstractMalignant fibrous histiocytomas of the upper respiratory tract are rare, aggressive mesenchymal neoplasms. We report a case of a glottic malignant fibrous histiocytoma of the larynx on a 54 year old man. Only a few have been reported in the English literature. The clinical behaviour and degree of malignancy of these tumours cannot be predicted. Wide, aggressive excision of the tumour with a margin of normal tissue appears to be the treatment of choice. About two years after total laryngectomy the patient is well and free of disease.

scholarly journals Knowledge regarding antibiotic use among students of three medical schools in Medellin, Colombia: A cross-sectional study

2019 ◽  
Author(s):  
Luis Felipe Hguita-Gutiérrez ◽  
Valentina Molina ◽  
Jenifer María Acevedo ◽  
Liceth Gómez ◽  
Gustavo Eduardo Roncancio Villamil ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Antibiotic Therapy ◽  
Respiratory Tract Infections ◽  
Upper Respiratory Tract Infections ◽  
Soft Tissue Infections ◽  
Upper Respiratory Tract ◽  
Upper Respiratory ◽  
Tract Infections ◽  
The University

Abstract Background The objective of the present study was to describe the knowledge regarding the antibiotic therapy of students of three medical schools in Medellín, Colombia. Methods The study population comprised medical students who were enrolled in three universities. The instrument contained questions regarding their current academic term, the university, the perceived quality of the education received on antibiotic therapy and bacterial resistance, and specific questions on upper respiratory tract infections, pneumonia, urinary tract infections, and skin and soft tissue infections. The information was analyzed by calculating frequencies and measures of dispersion and central tendency. Knowledge regarding the treatment for each type of infection was compared using the Mann–Whitney U test and the Kruskal–Wallis H test. Results We included 536 medical students, of which 43.5% students consider that the university has not sufficiently trained them to interpret antibiograms and 29.6% students consider that the quality of information received on the subject at their university ranges from regular to poor. The mean score for knowledge regarding antibiotic therapy for upper respiratory tract infections was 44.2 (9.9) on a scale from 0 to 100. The median score with regard to the treatment of pneumonia was 52.9 (14.7), that of urinary tract infection was 58.7 (14.8), and that of skin and soft tissue infections was 63.1 (19.4). The knowledge regarding antibiotic therapy for upper respiratory tract infections, pneumonia, and urinary tract infection does not improve with the academic term, the university, or perceived quality of the education received. Conclusion A large proportion of medical students perceive that the training received from the university is insufficient with regard to antibiotic use and bacterial resistance, which is consistent with the limited knowledge reflected in the selection of antibiotic treatment for respiratory, urinary tract, and skin and soft tissue infections. Overall, the situation was identical among all universities, and it did not significantly increase with the completion of an academic term.

scholarly journals Astragalusin the Prevention of Upper Respiratory Tract Infection in Children with Nephrotic Syndrome: Evidence-Based Clinical Practice

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Chuan Zou ◽  
Guobin Su ◽  
Yuchi Wu ◽  
Fuhua Lu ◽  
Wei Mao ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Cochrane Library ◽  
Upper Respiratory Tract ◽  
Level Of Evidence ◽  
Upper Respiratory Infection ◽  
Evidence Quality ◽  
Answerable Question ◽  
Upper Respiratory ◽  
The Cochrane Library

Aims. To explore whetherAstragalusor its formulations could prevent upper respiratory infection in children with nephrotic syndrome and how best to use it.Methods. We transformed a common clinical question in practice to an answerable question according to the PICO principle. Databases, including the Cochrane Library (Issue 5, 2012), PUBMED (1966–2012.8), CBM (1978–2012.8), VIP (1989–2012.8), and CNKI (1979–2012.8), were searched to identify Cochrane systematic reviews and clinical trials. Then, the quality of and recommendations from the clinical evidence were evaluated using the GRADEpro software.Results. The search yielded 537 papers. Only two studies with high validity were included for synthesis calculations. The results showed thatAstragalusgranules could effectively reduce URTI in children with nephrotic syndrome compared with prednisone treatment alone (23.9% versus 42.9%; RR = 0.56 and 95% CI = 0.33–0.93). The dose ofAstragalusgranules was 2.25 gram (equivalent to 15 gram crudeAstragalus) twice per day, at least for 3–6 months. The level of evidence quality was low, but we still recommended the evidence to the patient according to GRADEpro with the opinion of the expert. Followup showed the incidence of URTI in this child decreased significantly.Conclusions.Astragalusgranules may reduce the incidence of URTI in children with nephrotic syndrome.

Sign in / Sign up

Export Citation Format

Share Document