Is a tailored strategy using proton beam radiotherapy for reirradiation advantageous for elderly women? A case report

2021 ◽  
pp. 030089162110079
Author(s):  
Amelia Barcellini ◽  
Antonino Ditto ◽  
Alfredo Mirandola ◽  
Marianna Roccio ◽  
Sara Imparato ◽  
...  
Keyword(s):  
Case Report ◽  
Proton Beam ◽  
Elderly Women ◽  
Treatment Time ◽  
Endometrial Adenocarcinoma ◽  
Complete Response ◽  
Overall Treatment Time ◽  
Proton Beam Radiotherapy ◽  
Good Local Control ◽  
History Of

Background: The management of primary or recurrent vaginal tumours in an aging population is challenging for gynecologic and radiation oncologists. In patients unsuited for surgery and already irradiated on the pelvis, proton beam radiotherapy may be worthwhile due to its ballistic advantages. Case report: We report the case of an 80-year-old woman with a squamous cell carcinoma of the vagina after a history of pelvic radiation and vaginal brachytherapy delivered for a previous endometrial adenocarcinoma. She received proton beam radiotherapy with a complete response after 12 months and mild toxicity. Conclusions: The complexity of reirradiation management in the frail and elderly population requires attention. Efforts should be focused on maintaining autonomy and quality of life in order to improve adherence and clinical compliance to the treatment. In the era of the tailored approach, hadrontherapy can play an important role to minimize toxicity, obtain good local control, and reduce the overall treatment time.

Diagnosis of Metastatic Breast Cancer—A Case Report Using Molecular Cancer Classification

2011 ◽  
Vol 07 (02) ◽  
pp. 116
Author(s):  
Yogesh Gandhi ◽  
Sunil Gandhi ◽  
◽  
Keyword(s):  
Breast Cancer ◽  
Case Report ◽  
Effective Treatment ◽  
Cancer Diagnosis ◽  
Treatment Options ◽  
Metastatic Breast ◽  
Complete Response ◽  
Molecular Profiling ◽  
History Of

An accurate cancer diagnosis is critical as it can direct the use of site-directed, and potentially more effective, treatment options for specific types of cancer. A differential or uncertain diagnosis could prevent cancer patients from receiving optimal treatment, thus affecting their overall prognosis. Advances in molecular technology have led to the development of molecular cancer classifiers that can direct or confirm the diagnosis of metastatic cancers which would otherwise be considered uncertain or unknown. This case report describes the role of molecular diagnostics in the evaluation of a patient with a large pancreatic mass and a history of breast cancer. Results from a 92-gene molecular profiling assay (CancerTYPE ID®) predicted that this new mass was breast cancer. This diagnosis allowed for effective treatment and complete response in this patient.

Complete Response of a Mutated BRCA2 Metastatic Clear Cell Endometrial Adenocarcinoma to the Poly (ADP ribose) Polymerase (PARP) Inhibitor Olaparib

2022 ◽  
Vol 2 (1) ◽  
pp. 84-86
Author(s):  
DIMITRI ANZELLINI ◽  
GIANLUCA ARCANGELI ◽  
SERGIO DEL BIANCO
Keyword(s):  
Endometrial Cancer ◽  
Case Report ◽  
Clear Cell ◽  
Early Stage ◽  
Parp Inhibitor ◽  
Endometrial Adenocarcinoma ◽  
Abnormal Uterine Bleeding ◽  
Complete Response ◽  
Developed Countries ◽  
Primary Therapy

Background: Cancer of the endometrium is the most common gynecologic malignancy in developed countries and the second most common in developing countries. Endometrioid tumors tend to have a favorable prognosis and typically present at an early stage with abnormal uterine bleeding. Clear cell carcinoma as well as serous endometrial carcinoma are associated with a poorer prognosis. Patients with metastatic endometrial cancer are treated with systemic therapy either following surgery or as primary therapy. As far as second-line chemotherapy is concerned, there are no general agreements on the chemotherapy to be used. Furthermore, to the best of knowledge, there are no studies on the use of poly (ADP ribose) polymerase (PARP) inhibitors in endometrial cancer even in BRCA mutated tumors. Case Report: We here present the case report of an 81-year-old woman with a mutated BRCA2 metastatic clear cell endometrial adenocarcinoma that showed an excellent clinical and radiological response to the PARP inhibitor olaparib. Conclusion: Olaparib could be successfully used in this patient setting.

Horizontal maxillary ridge augmentation with ridge split procedure and simultaneous implant placement: A case report

2021 ◽  
Vol 9 (1) ◽  
pp. 32-35
Author(s):  
Vaibhav Jain ◽  
Abir Sarkar ◽  
Pramod K Chahar ◽  
Vishvnathe Udayshankar
Keyword(s):  
Case Report ◽  
Treatment Time ◽  
Clinical Situation ◽  
Overall Treatment Time ◽  
Endosseous Implants ◽  
Ridge Augmentation ◽  
Implant Placement ◽  
Augmentation Techniques ◽  
Immediate Implant ◽  
Ridge Split

Treatment of edentulous maxillary anterior region with horizontal ridge atrophy presents a clinical situation in which the placement of endosseous implants might be complex or sometimes impossible without a ridge augmentation procedure. This case report presents management of horizontally deficient maxillary anterior ridge with ridge split procedure using piezotome and simultaneous implant placement. In contrast to other ridge augmentation techniques, ridge splitting allows for immediate implant placement following surgery reducing the overall treatment time and eradicates the possible morbidity from a second surgical site.

scholarly journals Surgical Management of Multiple Dental Anomalies in an Adolescent: A Case Report

2020 ◽  
pp. 1-3
Author(s):  
Michaela DeSeta ◽  
Michaela DeSeta ◽  
Nabina Bhujel ◽  
Jerry Kwok
Keyword(s):  
Case Report ◽  
Surgical Management ◽  
Multidisciplinary Approach ◽  
Treatment Time ◽  
Treatment Options ◽  
Permanent Tooth ◽  
Functional Improvement ◽  
Dental Anomalies ◽  
Overall Treatment Time ◽  
Impacted Teeth

Introduction: Unerupted or impacted teeth are commonly seen in young adolescents, whilst transposition of teeth is fairly uncommon. Paediatric patients presenting with an impacted or missing permanent tooth can complicate what may otherwise be a straightforward transition to the permanent dentition. In patients with multiple impacted teeth or transposition of teeth, the complexity of the case is increased further. Case Report: We present a case of impaction and transposition in an adolescent, managed by surgical technique only, using autotransplantation and corticotomy. This technique permitted rapid positional changes of the teeth to give an immediate aesthetic and functional improvement, with less reliance on longterm patient compliance. Conclusion: This report discusses the complexity of different treatment options that could have been undertaken. A multidisciplinary approach gave more treatment options to the patient, and total surgical management had many clinical advantages, along with a huge reduction in overall treatment time.

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