Immunohistochemical Study of Ten Cases of Argyrophilic Carcinoma (Carcinoid) of the Breast
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The significance of argyrophilia in human breast cancer is still a controversial issue. We tested immunohistochemically 10 cases of argyrophilic carcinomas of the breast and found evidence of immunoreactivity with neuroendocrine markers: chromogranin, NSE, gastrin, insulin and bombesin. Argyrophilia was demonstrated in breast cancers of the usual types and was found to be related to the secretory activity of neoplastic cells. Unfortunately, no adequate follow-up data are available to clarify the natural history of argyrophilic breast cancer. A clinical treatment different from that of conventional breast cancer is not at present justified.
1991 ◽
Vol 18
(3)
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pp. 125-140
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1990 ◽
Vol 5
(2)
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pp. 73-76
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