The Use of Liquid Perfluorocarbons for Neonatal Lung Ventilation

1996 ◽  
Vol 19 (5) ◽  
pp. 284-290 ◽  
Author(s):  
Mi. Costantino
Keyword(s):  
Surface Tension ◽  
Gas Exchange ◽  
Lung Ventilation ◽  
Acid Base Balance ◽  
Human Infants ◽  
Severe Respiratory Distress ◽  
Interfacial Surface ◽  
Neonatal Lung ◽  
Base Balance ◽  
Set Up

Over the last years, physiological studies have proved that ventilation with a oxygenated liquid perfluorocarbon (PFC) provides effective gas exchange and acid base balance and improves lung function and recovery Low surface tension and high respiratory gas solubility enable adequate oxygenation and carbon dioxide removal at low insufflation pressure. The elimination of air-liquid interfacial surface tension has recently suggested the adoption of total liquid PFC ventilation as an investigational therapy for severe respiratory distress in human infants. This work is aimed to determine the optimal volumes of PFC to be delivered, the frequency of the ventilatory cycle, the oxygen flow rate and the best circuit set up for neonatal application. The optimisation was obtained through the implementation of a simulation mathematical model of oxygen diffusion in a PFC-ventilated lung and of gas exchange between alveolar environment and pulmonary blood flow. The results show that total liquid ventilation is a valid alternative to traditional gas ventilation, particularly when immature neonates with insufficient or absent production of surfactant are concerned.

Effects of temperature on acid-base balance and ventilation in desert iguanas

1981 ◽  
Vol 51 (2) ◽  
pp. 452-460 ◽  
Author(s):  
P. E. Bickler
Keyword(s):  
Steady State ◽  
Pulmonary Ventilation ◽  
Respiratory Acidosis ◽  
Lung Ventilation ◽  
Acid Base Balance ◽  
Acid Base ◽  
Arterial Ph ◽  
Blood Relative ◽  
Base Balance ◽  
History Of

The effects of constant and changing temperatures on blood acid-base status and pulmonary ventilation were studied in the eurythermal lizard Dipsosaurus dorsalis. Constant temperatures between 18 and 42 degrees C maintained for 24 h or more produced arterial pH changes of -0.0145 U X degrees C-1. Arterial CO2 tension (PCO2) increased from 9.9 to 32 Torr plasma [HCO-3] and total CO2 contents remained constant at near 19 and 22 mM, respectively. Under constant temperature conditions, ventilation-gas exchange ratios (VE/MCO2 and VE/MO2) were inversely related to temperature and can adequately explain the changes in arterial PCO2 and pH. During warming and cooling between 25 and 42 degrees C arterial pH, PCO2 [HCO-3], and respiratory exchange ratios (MCO2/MO2) were similar to steady-state values. Warming and cooling each took about 2 h. During the temperature changes, rapid changes in lung ventilation following steady-state patterns were seen. Blood relative alkalinity changed slightly with steady-state or changing body temperatures, whereas calculated charge on protein histidine imidazole was closely conserved. Cooling to 17-18 degrees C resulted in a transient respiratory acidosis correlated with a decline in the ratio VE/MCO2. After 12-24 h at 17-18 degrees C, pH, PCO2, and VE returned to steady-state values. The importance of thermal history of patterns of acid-base regulation in reptiles is discussed.

scholarly journals Ion Regulation, Acid/Base Balance and Gas Exchange Interactions in Salmon Across Salinities

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
Christian Damsgaard ◽  
Monica McGrath ◽  
Chris M. Wood ◽  
Jeffrey G. Richards ◽  
Colin J. Brauner
Keyword(s):  
Gas Exchange ◽  
Exchange Interactions ◽  
Acid Base Balance ◽  
Acid Base ◽  
Ion Regulation ◽  
Base Balance

Effects of Gas Exchange on Acid-Base Balance

2012 ◽  
Author(s):  
Michael I. Lindinger ◽  
George J.F. Heigenhauser
Keyword(s):  
Gas Exchange ◽  
Acid Base Balance ◽  
Acid Base ◽  
Base Balance

scholarly journals Dermal bone in early tetrapods: a palaeophysiological hypothesis of adaptation for terrestrial acidosis

2012 ◽  
Vol 279 (1740) ◽  
pp. 3035-3040 ◽  
Author(s):  
Christine M. Janis ◽  
Kelly Devlin ◽  
Daniel E. Warren ◽  
Florian Witzmann
Keyword(s):  
Carbon Dioxide ◽  
Lung Ventilation ◽  
Ventilation Mode ◽  
Acid Base Balance ◽  
Dermal Bone ◽  
Base Balance ◽  
Lactate Acidosis ◽  
Early Tetrapods ◽  
Calcified Tissues ◽  
Dermal Bones

The dermal bone sculpture of early, basal tetrapods of the Permo-Carboniferous is unlike the bone surface of any living vertebrate, and its function has long been obscure. Drawing from physiological studies of extant tetrapods, where dermal bone or other calcified tissues aid in regulating acid–base balance relating to hypercapnia (excess blood carbon dioxide) and/or lactate acidosis, we propose a similar function for these sculptured dermal bones in early tetrapods. Unlike the condition in modern reptiles, which experience hypercapnia when submerged in water, these animals would have experienced hypercapnia on land, owing to likely inefficient means of eliminating carbon dioxide. The different patterns of dermal bone sculpture in these tetrapods largely correlates with levels of terrestriality: sculpture is reduced or lost in stem amniotes that likely had the more efficient lung ventilation mode of costal aspiration, and in small-sized stem amphibians that would have been able to use the skin for gas exchange.

Arterial Blood Gases, Acid-Base Balance, and Lactate and Gas Exchange Variables During Hypoxic Exercise

1989 ◽  
Vol 10 (04) ◽  
pp. 279-285 ◽  
Author(s):  
T. Yoshida ◽  
M. Udo ◽  
M. Chida ◽  
K. Makiguchi ◽  
M. Ichioka ◽  
...  
Keyword(s):  
Gas Exchange ◽  
Blood Gases ◽  
Arterial Blood Gases ◽  
Acid Base Balance ◽  
Acid Base ◽  
Arterial Blood ◽  
Base Balance ◽  
Hypoxic Exercise

ADJUSTMENT OF VENTILATION, INTRAPULMONARY GAS EXCHANGE, AND ACID-BASE BALANCE DURING THE FIRST DAY OF LIFE

PEDIATRICS ◽  
1964 ◽  
Vol 33 (5) ◽  
pp. 682-693
Author(s):  
L. Samuel Prod'hom ◽  
Henry Levison ◽  
Ruth B. Cherry ◽  
James E. Drorbaugh ◽  
John P. Hubbell ◽  
...  
Keyword(s):  
Gas Exchange ◽  
Respiratory Distress ◽  
Respiratory Acidosis ◽  
Acid Base Balance ◽  
Acid Base ◽  
Infants Of Diabetic Mothers ◽  
Arterial Blood ◽  
Physiologic Dead Space ◽  
Base Balance ◽  
Diabetic Mothers

Determinations of blood gases and of acid-base balance were done in umbilical vein and artery blood at birth and in arterial blood at the age of 20 minutes in 20 infants of diabetic mothers. All were born by cesarean section, 18 of them between 36 and 37 weeks gestation. None showed respiratory distress at any time. Ventilation, gaseous metabolism, functional residual capacity, intrapulmonary gas exchange, and acid-base balance were determined at the age of 1, 4, and 24 hours in these 20 infants. The results indicate the following conclusions with regard to infants of diabetic mothers. 1. Adjustment of ventilation to perfusion in the lung appears to be complete at 4 hours of life. 2. Throughout the first 24 hours there is a persistence of an over-all true right to left shunt of approximately 20-25% of the total cardiac output. The exact localization of this shunt is unknown. 3. Acid-base balance in cord blood and in arterial blood during the first day of life in infants of diabetic mothers differs only slightly from that of infants of nondiabetic mothers. At 1 and 4 hours of age there is some persistence of a slight respiratory acidosis. 4. At 24 hours infants of diabetic mothers have the usual low arterial Pco2 of other newborn infants, but a ventilation equivalent of 16.5, which is normal for adults. 5. Although 6 of the 17 infants studied at 4 hours have shown a respiratory rate above 60 without other signs of respiratory distress, these infants with high rates had small tidal volumes, high physiologic dead-space/tidal volume ratios, and relatively little increase in minute volume.

Intensive therapy of multiple fatty embolism of the microvascular bed of vital organs

2021 ◽  
Vol 87 (1) ◽  
pp. 59-62
Author(s):  
M.V. Chepelyanskaya ◽  
◽  
V. V. Unzhakov ◽  
A.S. Doloka ◽  
S.N. Berezutsky ◽  
...  
Keyword(s):  
Intensive Therapy ◽  
Interdisciplinary Approach ◽  
Lung Ventilation ◽  
Fat Embolism ◽  
Multiple Organ ◽  
Acid Base Balance ◽  
Artificial Lung Ventilation ◽  
Base Balance ◽  
Cardiovascular Medications ◽  
Complications And Mortality

The article presents a clinical case of successful treatment of a patient with polytrauma complicated by multiple fatty embolism. Complications were manifested in the form of a syndrome of multiple organ failure: cerebral, cardiovascular and respiratory failure. According to the protocols and recommendations for providing assistance to patients with polytrauma, the tactics of management and intensive therapy were determined, with the obligatory consideration of recommendations for the treatment of patients with fat embolism. The patient underwent neuroprotection, which included one of the modern drugs, such as celex, artificial lung ventilation, maintenance of hemodynamics by cardiovascular medications, correction of the water, electrolyte and acid-base balance with positive dynamics. Despite the difficulties of diagnosis and treatment, a high percentage of disability, complications and mortality, the difficulty of preventing complications, a favorable outcome for patients with associated trauma is possible. An interdisciplinary approach ensures the success of the treatment and rehabilitation of these patients.

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