Prostatic Intraepithelial Neoplasm: Anatomo-Clinical and Follow-Up Trends

1996 ◽  
Vol 63 (2) ◽  
pp. 165-169
Author(s):  
G. Vagliani ◽  
R. Nannini ◽  
A. Bondi ◽  
A. Di Silverio ◽  
M. Fini
Keyword(s):  
Basal Cell ◽  
Prostatic Carcinoma ◽  
Cellular Proliferation ◽  
Cell Layer ◽  
Basal Membrane ◽  
Therapeutic Options ◽  
Basal Cell Layer ◽  
Cytological Atypia ◽  
Prostatic Ducts

Cellular proliferation in the prostatic ducts and acini presents a morphological continuum from benign proliferation without cytological atypia (hyperplasia) to proliferations with different degrees of dysplasia. The term prostatic intraepithelial neoplasm (P.I.N.) indicates the theoretical morphological extremity of that continuum. The criteria for differentiating P.I.N. into three grades are to be found in the cytological and architectural aspect as well as the integrity of the basal cell layer and the basal membrane. Clinically P.I.N. is strongly associated with prostatic carcinoma and diagnosis should be followed by further investigations for a co-existing carcinoma. All the elements (age, severity of P.I.N., P.S.A., D.R.E. and T.R.U.S. characteristics) which may be used for correct follow-up are discussed, as well as possible therapeutic options.

scholarly journals Survivin and Sox9: Potential Stem Cell Markers in Canine Normal, Hyperplastic, and Neoplastic Canine Prostate

2018 ◽  
Vol 56 (2) ◽  
pp. 200-207 ◽  
Author(s):  
Laura Bongiovanni ◽  
Francesca Caposano ◽  
Mariarita Romanucci ◽  
Valeria Grieco ◽  
Daniela Malatesta ◽  
...  
Keyword(s):  
Stem Cell ◽  
Basal Cell ◽  
Prostatic Carcinoma ◽  
Cell Layer ◽  
Prostate Gland ◽  
Stem Cell Marker ◽  
Stem Cell Markers ◽  
Basal Cell Layer ◽  
Normal Prostate ◽  
Cell Markers

Canine prostatic carcinoma is a relevant model for human prostatic carcinoma. Survivin is proposed as a biomarker of malignancy in human prostatic cancer. Sox9 is a stem cell marker required for prostate development and expressed in several adult tissues. The aims of the present study were to evaluate the patterns and expression levels of 2 putative stem cell markers, survivin and Sox9, in canine benign prostatic hyperplasia (BPH) and prostatic carcinoma to investigate their potential as stem cell markers. Immunohistochemistry with specific antibodies was performed on 3 samples of normal prostate gland, 18 samples of canine BPH, and 16 samples of prostatic carcinoma. The basal cell layer of normal and hyperplastic prostatic lobules had nuclear Sox9 immunolabeling and nuclear and rarely cytoplasmic survivin immunostaining, identifying them as potential stem cell markers. Significantly more frequent survivin and Sox9 expression (≥10% of nuclei) was observed in prostatic carcinoma as compared with BPH. The potential coexpression of survivin with Sox9, androgen receptor, and p63 was also investigated in selected BPH and prostatic carcinoma cases with immunofluorescence, and a partial colocalization was observed. Results indicate that Sox9 and survivin could be considered markers of stemness in canine prostate cells. Given its role in proliferation, cells in the basal cell layer with nuclear survivin expression are likely to be transit-amplifying cells that maintain some stem cell proprieties.

scholarly journals Basal cell markers:34BE12 and p63, improving detection of basal cells in atypical prostatic lesions

2019 ◽  
Vol 13 (2) ◽  
pp. 56-58
Author(s):  
Inas A. Rasheed
Keyword(s):  
Basal Cell ◽  
Prostatic Carcinoma ◽  
Cell Layer ◽  
Intraepithelial Neoplasia ◽  
Prostatic Intraepithelial Neoplasia ◽  
Cell Detection ◽  
Basal Cells ◽  
Basal Cell Layer ◽  
Cell Markers ◽  
Malignant Lesions

Background: The diagnosis of prostatic pathology may be of challenging , as some  difficult and suspected, atypical  cases may lack basal cell layer by routine H&E sections . Antibodies against 34BE12(HMW-CK) and p63 aid the diagnosis of such cases , to distinguish benign from  malignant prostatic lesions. Objective: to identify basal cells in atypical prostatic lesions ,and distinguish benign from malignant prostatic lesions. Type of the study:  A retro-spective  study. Methods:  115cases of  paraffin embedded prostatic tissue blocks ,diagnosed as : 76 cases were benign prostatic hyperplasia( BPH) , 9 cases were  high grade –prostatic intraepithelial neoplasia (HG-PIN) , and 30 cases were prostatic carcinoma(PCa) .Sections from each blocks were prepared for immunostaining with 34BE12 and p63. Results : basal cells were detected in cases of BPH , and HG-PIN , and absent  in all cases of prostatic carcinoma ,using basal cell markers . Negative benign glands(>2) were found in 71.6% and 38.2%  for   BPH  and 57.1% and 55.6% for HG-PIN immunostained  with high molecular weight cytokeratin (34BE12) and p63 , respectively, and significantly reduced to 9.0% and 11.1% for BPH and HG-PIN, respectively  with combined using of both markers .Conclusion : Combination of both   basal cell markers (34BE12 , p63) improving basal cell detection in atypical ,suspected prostatic lesions and distinguish benign from malignant lesions.

Histopathological varieties of oral carcinomain situ: Diagnosis aided by immunohistochemistry dealing with the second basal cell layer as the proliferating center of oral mucosal epithelia

2010 ◽  
Vol 60 (3) ◽  
pp. 156-166 ◽  
Author(s):  
Takanori Kobayashi ◽  
Satoshi Maruyama ◽  
Jun Cheng ◽  
Hiroko Ida-Yonemochi ◽  
Minoru Yagi ◽  
...  
Keyword(s):  
Basal Cell ◽  
Cell Layer ◽  
Basal Cell Layer ◽  
Carcinomain Situ

scholarly journals Basal Cell Adenoma of the Upper Lip from Minor Salivary Gland Origin

2008 ◽  
Vol 02 (03) ◽  
pp. 213-216 ◽  
Author(s):  
Eliana Maria Minicucci ◽  
Eloisa Bueno Pires de Eloisa ◽  
Silke Anna Thereza Weber ◽  
Maria Aparecida Custodio Domingues ◽  
Daniel Araki Ribeiro
Keyword(s):  
Salivary Gland ◽  
Basal Cell ◽  
Cell Layer ◽  
Minor Salivary Gland ◽  
Salivary Gland Neoplasm ◽  
Basal Cell Adenoma ◽  
Parotid Glands ◽  
Upper Lip ◽  
Basal Cell Layer ◽  
Cell Adenoma

ABSTRACTBasal cell adenoma is an uncommon benign salivary gland neoplasm, presenting isomorphic basaloid cells witha prominent basal cell layer. Taking into account that basal cell adenomas represent 1% of all salivary gland tumors, being the majority of cases in the parotid glands, the goal of this paper is to report a case of basalcell adenoma of the upper lip arising from minor salivary gland. (Eur J Dent 2008;2:213-216)

Sign in / Sign up

Export Citation Format

Share Document