Paranoid Symptoms Associated with Triazolam

1985 ◽  
Vol 30 (6) ◽  
pp. 462-463 ◽  
Author(s):  
B. Schogt ◽  
D. Conn
Keyword(s):  
Paranoid Symptoms

scholarly journals A Study of HLA-Linked Genes in a Monosymptomatic Psychotic Disorder in an Indian Bengali Population

2005 ◽  
Vol 50 (5) ◽  
pp. 269-274 ◽  
Author(s):  
Monojit Debnath ◽  
Sujit K Das ◽  
Nirmal K Bera ◽  
Chitta R Nayak ◽  
Tapas K Chaudhuri
Keyword(s):  
Human Leukocyte ◽  
Delusional Disorder ◽  
Control Group ◽  
Typing Method ◽  
Hla Genes ◽  
Healthy Donors ◽  
Serological Typing ◽  
Molecular Typing Method ◽  
Paranoid Symptoms ◽  
Nested Case Control

Objective: The etiology of delusional disorder is imperfectly understood. Involvement of biological factors has long been suspected. We examined the incidence of class I human leukocyte antigens (HLAs) in patients with delusional disorder to understand the role of HLA genes and explore a possible immunogenetic etiology for delusional disorder. Methods: We used a nested case–control study design. Psychiatric reference data were available for 27 500 patients registered between 1998 and 2003. Initially, we enrolled 150 patients with delusional disorder from the India-born Bengali population, using DSM-IV diagnostic criteria. After longitudinal follow-up, 80 patients were found to have only delusional disorder, while the remaining 70 patients represented different illnesses with paranoid symptoms and were excluded. We performed serological typing on all 150 patients and applied the polymerase chain reaction–based high-resolution molecular typing method to the 80 patients with delusional disorder. Eighty healthy donors of the same ethnic background, matched for age, sex, and other socioeconomic variables, formed the control group. Results: Some of the HLA alleles were associated with delusional disorder, and the gene HLA-A*03 was found to be significantly more frequent. This gene may influence patients' susceptibility to delusional disorder. Conclusion: The study reveals important associations between HLA genes and delusional disorder. This preliminary observation may help our understanding of this disorder's genetic basis.

Emotion regulation as a moderator of the interplay between self-reported and physiological stress and paranoia

2018 ◽  
Vol 49 ◽  
pp. 43-49 ◽  
Author(s):  
Katarina Krkovic ◽  
Stephanie Krink ◽  
Tania M. Lincoln
Keyword(s):  
Heart Rate ◽  
Emotion Regulation ◽  
Sampling Method ◽  
Physiological Stress ◽  
Cognitive Emotion Regulation ◽  
Daily Stress ◽  
Physiological Indicators ◽  
Moderating Factors ◽  
Paranoid Symptoms

AbstractExperience sampling method (ESM) studies have found an association between daily stress and paranoid symptoms, but it is uncertain whether these findings generalize to physiological indicators of stress. Moreover, the temporality of the association and its moderating factors require further research. Here, we investigate whether physiological and self-rated daily stress predict subsequent paranoid symptoms and analyze the role of emotion regulation as a putative moderator. We applied ESM during 24 h to repeatedly assess heart rate, self-rated stress, and subclinical paranoia in a sample of 67 psychosis-prone individuals as measured with Community Assessment for Psychotic Experiences (CAPE). Adaptive and maladaptive emotion regulation was assessed at baseline with the Emotion Regulation Skills Questionnaire (ERSQ-ES) and the Cognitive Emotion Regulation Questionnaire (CERQ). Linear mixed models were used to analyze the data. Heart rate (b = 0.004, p < 0.05) and self-rated stress (b = 0.238, p < 0.001) predicted subsequent paranoia. The reverse effect, paranoia as a predictor of subsequent heart rate (b = 0.230, p = 0.615) or self-rated stress (b = –0.009, p = 0.751) was non-significant. Maladaptive emotion regulation was a significant predictor of paranoia (b = 0.740, p < 0.01) and moderated the path from self-rated stress to paranoia (b = 0.188, p < 0.05) but not the path from heart rate to paranoia (b = 0.005, p = 0.09). Our findings suggest a one-way temporal link between daily stress and paranoia and highlight the importance of emotion regulation as a vulnerability factor relevant to this process.

Theory of mind impairments in schizophrenia: symptomatology, severity and specificity

2001 ◽  
Vol 31 (2) ◽  
pp. 207-220 ◽  
Author(s):  
GRAHAM J. PICKUP ◽  
CHRISTOPHER D. FRITH
Keyword(s):  
Theory Of Mind ◽  
Matched Control ◽  
Single Case ◽  
Mental States ◽  
Second Order ◽  
Problem Solving Skills ◽  
Weak Evidence ◽  
Schizophrenic Patients ◽  
Paranoid Symptoms ◽  
Low Iq

Background. Several studies have examined the ability of schizophrenic patients to represent mental states (‘theory of mind'; ToM). There is consensus that some patients have impaired ToM, but there is disagreement about the relation between ToM and symptomatology, and about the severity and specificity of the deficit.Methods. Two first-order and one second-order false belief tests of ToM were given to groups of schizophrenic patients and psychiatric and normal controls. The relation between ToM and symptomatology was explored using regression and symptom subgroup analyses. Severity was investigated by using the same task methodology as in autism research, to enable direct comparison with that disorder. Specificity was investigated using matched control tasks which were as difficult as the ToM tasks, but did not require ToM.Results. Symptom subgroup analysis showed that schizophrenic patients with behavioural signs were impaired relative to controls on ToM, and that remitted patients and a single case with passivity symptoms performed as well as controls. Regression analysis showed that ratings of behavioural signs predicted impaired ToM in schizophrenia. There was weak evidence that a subgroup with paranoid symptoms had ToM impairments, although these were associated with low IQ. Schizophrenic patients only showed ToM deficits on the second-order task. No impairments appeared on the matched control tasks which did not require ToM.Conclusions. There is a clear association between ToM impairment and behavioural signs in schizophrenia. Deficits in paranoid patients are harder to detect with current tasks and may be compensated for by IQ-dependent problem-solving skills. ToM impairments in schizophrenia are less severe than in autism, but are specific and not a reflection of general cognitive deficits.

scholarly journals Details of the Contents of Paranoid Thoughts in Help-Seeking Adolescents with Psychotic-Like Experiences and Continuity with Bullying and Victimization: A Pilot Study

2020 ◽  
Vol 10 (8) ◽  
pp. 122
Author(s):  
Gennaro Catone ◽  
Antonella Gritti ◽  
Katia Russo ◽  
Pia Santangelo ◽  
Raffaella Iuliano ◽  
...  
Keyword(s):  
School Psychologists ◽  
Help Seeking ◽  
Self Report ◽  
Bullying Victimization ◽  
Moderate Correlation ◽  
Psychotic Experiences ◽  
Verbal Bullying ◽  
Paranoid Symptoms ◽  
Social Environmental ◽  
Social Environmental Factors

Background: Psychosis recognizes an interaction between biological and social environmental factors. Adversities are now recognized to be consistently associated with psychotic-like experiences (PLEs). The purpose of this study was to describe the contents of paranoid symptoms and to focus on their relationship with bullying and victimization in help-seeking adolescents. Methods: Help-seeking adolescents who screened positive for PLEs participated in the study. They performed a battery self-report questionnaire for data collection (paranoia: the Specific Psychotic Experiences Questionnaire (SPEQ); the content of paranoid thoughts: the Details of Threat (DoT); bullying victimization: the Multidimensional Peer Victimization Scale (MPVS); depression: the Children’s Depression Inventory (CDI); and anxiety: the Multidimensional Anxiety Scale (MASC)). Results: The participants were 50 adolescents (52% female; mean age: 170 months). The contents of their paranoid symptoms were related to victimization and, in particular, the certainty of threats was correlated with physical (0.394, p < 0.01) and verbal bullying (0.394, p < 0.01), respectively. The powerfulness of the threats correlated with verbal victimization (0.295, p < 0.05). The imminence of the threats was linked to verbal (0.399, p < 0.01) victimization. Hours under threat correlated with verbal (0.415, p < 0.01) victimization. The sureness of the threat had a moderate correlation with physical (0.359, p < 0.05) and verbal (0.443, p < 0.01) victimization, respectively. The awfulness of the threat was linked to social manipulation (0.325, p < 0.05). Conclusions: We described the content of the persecutory symptoms. The powerfulness, imminence, sureness, and awfulness of threats correlated with the level of physical, verbal and social manipulation victimization. Teachers and family must actively monitor early signs of bullying victimization, and school psychologists should promote preventive and therapeutic intervention. From a social psychiatry perspective, the prevention of bullying victimization is necessary.

Chronic Schizophrenic Patients in the Community

1978 ◽  
Vol 132 (3) ◽  
pp. 221-227 ◽  
Author(s):  
A. J. Cheadle ◽  
H. L. Freeman ◽  
J. Korer
Keyword(s):  
Local Population ◽  
Great Majority ◽  
Psychiatric Services ◽  
Drop Out ◽  
Personal Problems ◽  
Never Married ◽  
Schizophrenic Patients ◽  
Paranoid Symptoms ◽  
Long Acting ◽  
State Examination

SummaryA sample of 190 patients, diagnosed as schizophrenic by the same psychiatrist, have been surveyed in an urban community and their clinical and social status assessed. Compared to the local population as a whole, a significantly greater proportion of the men had never married, and although the women had married at approximately the same rate as those in the general population, 25 per cent of them had been divorced by the time of the interview. Assessments of the subjects' clinical condition by the Present State Examination were analysed into four groups of syndromes. Only 27 patients showed schizophrenic or paranoid symptoms, whereas neurotic symptoms were not only prevalent but seemed to cause most of the reported personal problems. Twenty-eight patients were free of symptoms at the time of interview. The great majority of the sample (72 per cent) were being maintained on long-acting neuroleptics. These data will form the baseline to assess a monitoring system, designed to keep the local psychiatric services in touch with schizophrenic patients who might otherwise drop out of treatment.

Paranoid Symptoms in Organic Disease

1964 ◽  
Vol 6 (2) ◽  
pp. 93-100 ◽  
Author(s):  
R. Davidson
Keyword(s):  
Organic Disease ◽  
Paranoid Symptoms
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