Influence of alpha lipoic acid on antioxidant status in D-galactosamine-induced hepatic injury

2008 ◽  
Vol 24 (10) ◽  
pp. 635-642 ◽  
Author(s):  
TS Shanmugarajan ◽  
D Sivaraman ◽  
I Somasundaram ◽  
M Arunsundar ◽  
E Krishnakumar ◽  
...  
Keyword(s):  
Liver Injury ◽  
Lipoic Acid ◽  
Hepatic Injury ◽  
Serum Marker ◽  
Alpha Lipoic Acid ◽  
Suitable Candidate ◽  
Single Intraperitoneal Injection ◽  
Cellular Abnormalities ◽  
Enzymic Antioxidants ◽  
And Oxidative Stress

D-Galactosamine (GalN)-induced liver injury is associated with reactive oxygen species and oxidative stress. In the present study, we evaluated the effect of alpha lipoic acid (ALA) supplementation on acute GalN-induced oxidative liver injury. Hepatotoxicity induced by single intraperitoneal injection of GalN (500 mg/kg body wt) was evident from increase in lipid peroxidation and serum marker enzymes (asparate transaminase, alanine transaminase, alkaline phosphatase, and lactate dehydrogenase). The decreased activities of enzymic antioxidants (superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase) as well as glutathione levels were the salient features observed in GalN-induced hepatotoxicity. Pretreatment with ALA (50 mg/kg body weight for 7 days) significantly precluded these changes and prevents the hepatic injury. Hence, this study clearly exemplified that ALA might be a suitable candidate against GalN-induced cellular abnormalities.

Alpha-lipoic acid defends homocysteine-induced endoplasmic reticulum and oxidative stress in HAECs

2016 ◽  
Vol 80 ◽  
pp. 63-72 ◽  
Author(s):  
Huimin Hu ◽  
Changyuan Wang ◽  
Yue Jin ◽  
Qiang Meng ◽  
Qi Liu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endoplasmic Reticulum ◽  
Lipoic Acid ◽  
Alpha Lipoic Acid ◽  
And Oxidative Stress

scholarly journals Alpha - Lipoic Acid Decreases DNA Damage and Oxidative Stress Induced by Alcohol in the Developing Hippocampus and Cerebellum of Rat

2008 ◽  
Vol 22 (5-6) ◽  
pp. 769-776 ◽  
Author(s):  
Alireza Shirpoor ◽  
Syranush Minassian ◽  
Siamak Salami ◽  
Mohammad Hassan Khadem-Ansari ◽  
Marine Yeghiazaryan
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Lipoic Acid ◽  
Alpha Lipoic Acid ◽  
And Oxidative Stress

Regulation of aging and oxidative stress pathways in aged pancreatic islets using alpha-lipoic acid

2018 ◽  
Vol 449 (1-2) ◽  
pp. 267-276 ◽  
Author(s):  
Navid Nobakht-Haghighi ◽  
Mahban Rahimifard ◽  
Maryam Baeeri ◽  
Mohammad Amin Rezvanfar ◽  
Shermineh Moini Nodeh ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Pancreatic Islets ◽  
Lipoic Acid ◽  
Alpha Lipoic Acid ◽  
And Oxidative Stress

scholarly journals Alpha-lipoic acid ameliorates sodium valproate-induced liver injury in mice

2020 ◽  
Vol 13 (5) ◽  
pp. 963-966
Author(s):  
Chrismawan Ardianto ◽  
Hijrawati Ayu Wardani ◽  
Nurrahmi Nurrahmi ◽  
Mahardian Rahmadi ◽  
Junaidi Khotib
Keyword(s):  
Liver Injury ◽  
Sodium Valproate ◽  
Lipoic Acid ◽  
Histopathological Examination ◽  
Normal Liver ◽  
Inflammatory Cells ◽  
Normal Structure ◽  
Vehicle Group ◽  
Alpha Lipoic Acid ◽  
Liver Structure

Aim: This study examines the effect of alpha-lipoic acid (ALA) on sodium valproate-induced liver injury through histological features of mice liver tissue. Materials and Methods: Mice were divided into three groups; (1) vehicle group, (2) sodium valproate group, and (3) sodium valproate-ALA group. The vehicle group was injected with saline intraperitoneal (i.p.) for 28 days. The sodium valproate group was injected with sodium valproate 300 mg/kg, i.p. daily for 2 weeks, after which the vehicle was administered daily until day 28. The sodium valproate-ALA group was injected with sodium valproate 300 mg/kg daily for 2 weeks before the administration of ALA 100 mg/kg i.p. until day 28. The mice were euthanized, and the liver was extracted for histopathological examination. Results: Histopathological examination of the liver section of the vehicle group showed a normal structure of the liver. Two weeks after the administration of sodium valproate, histopathological examination showed an abnormal structure of the liver, with necrotic appearance and inflammatory cells. Moreover, treatment with ALA after the administration of sodium valproate notably ameliorated hepatic histopathological lesions and the liver structure corresponded to a normal liver structure. Conclusion: ALA ameliorates sodium valproate-induced liver injury in mice.

Sign in / Sign up

Export Citation Format

Share Document