Sexual Dysfunction Among Egyptian Idiopathic Parkinson’s Disease Patients

2021 ◽  
pp. 089198872110638
Author(s):  
Ahmed M. Elshamy ◽  
Ehab S. Mohamed ◽  
Ayman M. Al-Malt ◽  
Osama A. Ragab
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Sexual Dysfunction ◽  
Rating Scale ◽  
Sexual Experience ◽  
Motor Symptom ◽  
Control Group ◽  
Idiopathic Parkinson’S Disease ◽  
Idiopathic Parkinson's Disease ◽  
And Gender

Background One of the non-motor features of idiopathic Parkinson’s disease (IPD) is sexual dysfunction (SD) which is under-recognized and, consequently, undertreated. This study aimed to evaluate SD in patients with IPD. Patients and methods The study was conducted on 67 IPD patients; 30 healthy subjects with age and gender matching with the patients served as the control group. All participants were subjected to sexual function assessment using the Arabic version of Arizona Sexual Experience Scale (ASEX), Mini-Mental State Examination (MMSE), and Beck Depression Inventory (BDI), while the severity of IPD was assessed using the modified Hoehn and Yahr scoring scale and MDS-Unified Parkinson’s Disease Rating Scale (MDS-UPDRS). Results There were no statistically significant differences between patients with IPD and the control group regarding MMSE, hypertension, diabetes mellitus, or dyslipidemia. However, BDI scores were significantly higher in patients with IPD. The rate of SD among our patients was 64% compared to 30% in the control group. The total score and subscales of ASEX were significantly higher in IPD patients than in controls. SD showed a significant correlation with the severity of the IPD irrespective of other variables, including patient age, sex, disease duration, hypertension, diabetes, dyslipidemia, smoking, and dose of L-dopa. Conclusion SD is a commonly underrated feature in patients with IPD; it should be investigated carefully as it is an important non-motor symptom that correlates with disease severity.

scholarly journals Acoustic and hearing-perceptual voice analysis in individuals with idiopathic Parkinson's disease in "on" and "off" stages

2010 ◽  
Vol 68 (5) ◽  
pp. 706-711 ◽  
Author(s):  
Luiza Lara M Santos ◽  
Larissa Oliveira dos Reis ◽  
Iara Bassi ◽  
Clara Guzella ◽  
Francisco Cardoso ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Acoustic Analysis ◽  
Voice Quality ◽  
Control Group ◽  
Idiopathic Parkinson’S Disease ◽  
Acoustic Parameters ◽  
Perceptual Analysis ◽  
Idiopathic Parkinson's Disease ◽  
Vocal Quality

OBJECTIVE: To evaluate the voice quality of patients with idiopathic Parkinson's disease, at the "on" and "off" moments of the disease. METHOD: Five individuals with Parkinson's disease and five of the control group were assessed. All of them underwent the recording of voice and speech. The acoustic parameters analyzed were: fundamental frequency, jitter, shimmer, harmonic noise proportion and index of tremor, besides performing the hearing-perceptual analysis by means of GRBASI scale. The findings were analyzed using statistics through t test and the level of significance adopted was p<0.05. RESULTS: There was no difference in the acoustic parameters in the three analyzed groups. In the hearing-perceptual analysis, patients with idiopathic Parkinson's disease showed altered voice quality and the ones from the control group, neutral vocal quality. CONCLUSION: Patients with idiopathic Parkinson's disease present rough, breathy and unstable vocal quality in both stages. In the acoustic analysis, there are no differences in the studied parameters.

scholarly journals Blood Dendritic Cell Frequency Declines in Idiopathic Parkinson’s Disease and Is Associated with Motor Symptom Severity

PLoS ONE ◽  
2013 ◽  
Vol 8 (6) ◽  
pp. e65352 ◽  
Author(s):  
Antonio Ciaramella ◽  
Francesca Salani ◽  
Federica Bizzoni ◽  
Francesco E. Pontieri ◽  
Alessandro Stefani ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Dendritic Cell ◽  
Symptom Severity ◽  
Motor Symptom ◽  
Idiopathic Parkinson’S Disease ◽  
Cell Frequency ◽  
Idiopathic Parkinson's Disease ◽  
Blood Dendritic Cell

scholarly journals Cognitive function assessment in idiopathic Parkinson's disease

2007 ◽  
Vol 65 (4a) ◽  
pp. 942-946 ◽  
Author(s):  
Mauro R. Piovezan ◽  
Helio A.G. Teive ◽  
Elcio J. Piovesan ◽  
Maria J. Mader ◽  
Lineu Cesar Werneck
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Function ◽  
Motor Function ◽  
Control Group ◽  
Idiopathic Parkinson’S Disease ◽  
Idiopathic Parkinson's Disease ◽  
Cognitive Disturbances ◽  
Visuospatial Functions ◽  
State Examination

Idiopathic Parkinson’s disease (PD) is characterized by reduced nigrostriatal and cortical dopaminergic influence, with changes in movement and, subsequently, behavioral and cognitive disturbances. We studied cognitive impairment in Parkinson’s disease by assessing a group of 30 idiopathic Parkinson’s disease patients with an average age of 64.23 years (PG group) and compared our findings with those for a control group of 30 patients (CG group). All the patients were submitted to the following assessments: motor function, using the UPDRS; staging, using the Hoehn-Yahr scales (PG group only); depression, using the Montgomery-Asberg scale; attention impairment; verbal fluency (FAR and animals); cognitive function, using the Mini Mental State Examination; visuospatial and executive functions; and clock drawing. In addition to altered motor function in PD patients, we found statistically significant differences between PD patients and controls in terms of cognitive function, verbal, executive and visuospatial functions, and attention deficits. Depression was more prevalent in the PG group.

scholarly journals Clustering of Parkinson Subtypes: Strong Influence of D2 Receptor Polymorphism and Gender

2021 ◽  
Author(s):  
Esther Annegret Pelzer ◽  
Sophie Stürmer ◽  
Delia-Lisa Feis ◽  
Corina Melzer ◽  
Frank Schwartz ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
D2 Receptor ◽  
Individual Therapy ◽  
Idiopathic Parkinson’S Disease ◽  
Gender Dimorphism ◽  
Dopaminergic Drugs ◽  
Idiopathic Parkinson's Disease ◽  
And Gender ◽  
Receptor Polymorphism

Abstract Next to motor and non-motor symptoms some more basic features are relevant in idiopathic Parkinson’s disease subtype classification influencing basal ganglia circuitry via dopamine receptor polymorphism and gender dimorphism. By kmeans-clustering algorithm we found an influence of D2 receptor polymorphism and gender on treatment response to dopaminergic drugs -reflected by daily levodopa dosage- opening the door for a more personalized individual therapy in idiopathic Parkinson’s disease.

scholarly journals Immune System and Neuroinflammation in Idiopathic Parkinson’s Disease: Association Analysis of Genetic Variants and miRNAs Interactions

2021 ◽  
Vol 12 ◽  
Author(s):  
Claudia Strafella ◽  
Valerio Caputo ◽  
Andrea Termine ◽  
Francesca Assogna ◽  
Clelia Pellicano ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Immune Response ◽  
Parkinson's Disease ◽  
Target Genes ◽  
Brain Regions ◽  
Control Group ◽  
Idiopathic Parkinson’S Disease ◽  
Novel Treatments ◽  
Idiopathic Parkinson's Disease ◽  
Significant Expression

The present study investigated the association of SNPs involved in the regulation of immune response, cellular degenerative and neuroinflammatory pathways with the susceptibility and progression of idiopathic Parkinson’s Disease (PD). In particular, 342 PD patients were subjected to a genotyping analysis of a panel of 120 SNPs by Open Array Technology. As control group, 503 samples representative of the European general population were utilized. The genetic analysis identified 26 SNPs associated with PD susceptibility. Of them, 12 SNPs were described as significant expression Quantitative Loci (eQTL) variants in different brain regions associated with motor and non-motor PD phenomenology. Moreover, the study highlighted 11 novel susceptibility genes for PD, which may alter multiple signaling pathways critically involved in peripheral immune response, neuroinflammation, neurodegeneration and dopaminergic neurons wiring. The study of miRNA-target genes highlighted a possible role of miR-499a, miR-196a2, and miR-29a in the modulation of multiple neuroinflammatory and neurodegenerative mechanisms underlying PD physiopathology. The study described a network of interconnected genes (APOE, CLU, IL6, IL7R, IL12B, INPP5D, MAPK1, MEF2C, MIF, and TNFSF14), which may act as upstream regulators in the modulation of biological pathways relevant to PD. Intriguingly, IL6 stands out as a master gene regulator since it may indirectly regulate the network of interconnected genes. The study highlighted different genes and miRNAs interactions potentially involved in PD physiopathology, which are worth to be further explored to improve the knowledge of disease and the research of novel treatments strategies.

scholarly journals Objective and subjective analysis of women's voice with idiopathic Parkinson's disease

2012 ◽  
Vol 70 (7) ◽  
pp. 492-496 ◽  
Author(s):  
Riviana Rodrigues das Graças ◽  
Ana Cristina Côrtes Gama ◽  
Francisco Eduardo Costa Cardoso ◽  
Bárbara Pereira Lopes ◽  
Iara Barreto Bassi
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Acoustic Analysis ◽  
Voice Quality ◽  
Control Group ◽  
Idiopathic Parkinson’S Disease ◽  
Subjective Analysis ◽  
Acoustic Measures ◽  
Perceptual Evaluation ◽  
Idiopathic Parkinson's Disease

OBJECTIVE: To compare the voice quality of women with idiopathic Parkinson's disease and those without it. METHODS: An evaluation was performed including 19 female patients diagnosed with idiopathic Parkinson's disease, with an average age of 66 years, and 27 women with an average of 67 years-old in the Control Group. The assessment was performed by computed acoustic analysis and perceptual evaluation. RESULTS: Parkinson's disease patients presented moderate rough and unstable voice quality. The parameters of grade, roughness, and instability had higher scores in Parkinson's disease patients with statistically significant differences. Acoustic measures of Jitter and period perturbation quotient (PPQ) significantly differ between groups. CONCLUSIONS: Parkinson's disease female individuals showed more vocal alterations compared to the Control Group, when both perceptual and acoustic evaluations were analyzed.

scholarly journals Idiopathic Parkinson's disease: vocal and quality of life analysis

2012 ◽  
Vol 70 (9) ◽  
pp. 674-679 ◽  
Author(s):  
Luiza Furtado e Silva ◽  
Ana Cristina Côrtes Gama ◽  
Francisco Eduardo Costa Cardoso ◽  
César Augusto da Conceição Reis ◽  
Iara Barreto Bassi
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Fundamental Frequency ◽  
Control Group ◽  
Idiopathic Parkinson’S Disease ◽  
Self Perception ◽  
Idiopathic Parkinson's Disease ◽  
The Voice

OBJECTIVE: To compare voice and life quality of male patients with idiopathic Parkinson's disease, with individuals without disease (Control Group). METHODS: A cross-sectional study that evaluated the voice of individuals with Parkinson's disease, the group was composed of 27 subjects, aged from 39 to 79 years-old (average 59.96). The Control Group was matched on sex and age. Participants underwent voice recording. Perceptual evaluation was made using GRBASI scale, which considers G as the overall degree of dysphonia, R as roughness, B as breathiness, A as asthenia, S as strain and I as instability. The acoustic parameters analyzed were: fundamental frequency, jitter, shimmer, and harmonic to noise ratio (NHR). For vocal self-perception analysis, we used the Voice Related Quality of Life protocol. RESULTS: Fundamental frequency and jitter presented higher values in the Parkinson's group. NHR values were higher in the Control Group. Perceptual analysis showed a deviation ranging. The vocal disorder self-perception demonstrated a worse impact on quality of life. CONCLUSIONS: Individuals with Parkinson's disease have an altered voice quality and a negative impact on quality of life.

scholarly journals Group Education with Personal Rehabilitation for Idiopathic Parkinson's Disease

2009 ◽  
Vol 36 (1) ◽  
pp. 51-59 ◽  
Author(s):  
Liping Guo ◽  
Yuping Jiang ◽  
Hiroshi Yatsuya ◽  
Yoshitoku Yoshida ◽  
Junichi Sakamoto
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Intervention Group ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Idiopathic Parkinson’S Disease ◽  
Term Care ◽  
Group Education ◽  
Idiopathic Parkinson's Disease ◽  
The Impact

Objective:To evaluate the effect of a group education program with personal rehabilitation for idiopathic Parkinson's disease (IPD).Methods:A single-blind, randomized, controlled clinical trial, with a pre-test/post-test quasi-experimental design. Fortyfour stable, non-demented patients with IPD were randomly assigned to an intervention group (n=23) and control group (n=21). Three group lectures on health education specific to IPD were delivered to the intervention group. The theme of lectures was “Not a lonely journey, as your friend, we—experts specializing in IPD— would love to join with you.” Three domains of the management of IPD were mentioned: “How to manage your routine Meal, Moving and Mood after suffering from IPD” Each lecture was scheduled for 45 minutes (excluding breaks), and designed as an interactive dialogue rather than a traditional lecture. To strengthen the impact of the lectures, relevant information was published on a website: http://www.parkinsonism.cn/. Following the group lecture, individualized and tailored rehabilitation made up of 24 half-hour sessions over eight weeks were provided for the intervention group.Results:The program ran smoothly and IPD patients were satisfied with this program. After only eight weeks, the health-related quality of life (HR-QOL) in the intervention group improved significantly (p<0.001). Patients and their caregivers in this group also reported their mood elevations following the program.Conclusion:Group education combined with personal rehabilitation program appears to be a beneficial and practical intervention, not only complementing the medical treatment for IPD patients but also meeting the growing demand for long-term care.

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