Regional and Distant Metastasis of Oral Squamous Cell Carcinoma in a Male Castrated Llama: A Case Report

2022 ◽  
pp. 089875642110735
Author(s):  
Cileah M. Kretsch ◽  
Katharine M. Simpson ◽  
Jennifer E. Rawlinson ◽  
Hannah Laurence ◽  
Terry R. Spraker
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Surgical Excision ◽  
Tooth Root ◽  
Severe Respiratory Distress ◽  
Left Mandible ◽  
Metastatic Squamous Cell Carcinoma ◽  
History Of

A 19-year-old male castrated llama presented with a 3-year history of tooth root abscesses and an osseous mass on the left mandible. Surgical excision of the affected teeth and mass was performed, and histopathologic review indicated that the mass was an oral squamous cell carcinoma. The patient was admitted to the hospital again 4 months later in severe respiratory distress with submandibular edema, and bicavitary effusion. Necropsy results revealed regional and distant metastatic squamous cell carcinoma.

scholarly journals Oral Squamous Cell Carcinoma Mimicking Medication-Related Osteonecrosis of the Jaws (MRONJ): A Case Series

Oral ◽  
2021 ◽  
Vol 1 (4) ◽  
pp. 326-331
Author(s):  
Rodolfo Mauceri ◽  
Corrado Toro ◽  
Vera Panzarella ◽  
Martina Iurato Carbone ◽  
Vito Rodolico ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Histological Examination ◽  
Squamous Cell ◽  
Malignant Lesion ◽  
Case Series ◽  
Signs And Symptoms ◽  
Osteonecrosis Of The Jaw ◽  
History Of

(1) Background: Medication-related osteonecrosis of the jaw (MRONJ) is a potential adverse drug reaction of antiresorptive and/or antiangiogenic treatment. MRONJ is mostly diagnosed by anamnestic data, clinical examination and radiological findings, with signs and symptoms often unspecific. On the other hand, oral squamous cell carcinoma (OSCC) is characteristic for its pleomorphic appearance (e.g., ulcer, mucous dehiscence, non-healing post-extractive socket). We report three cases where OSCC mimicked MRONJ lesions. (2) Patients: Three patients undergoing amino-bisphosphonate treatment for osteoporosis presented with areas of intraorally exposed jawbone and unspecific radiological signs compatible with MRONJ. Due to the clinical suspicious of malignant lesion, incisional biopsy for histological examination was also performed. (3) Results: Histological examination of the tissue specimen revealed the presence of OSCC. All patients underwent cancer treatment. (4) Conclusions: Several signs and symptoms of OSCC may simulate, in patients with a history of anti-resorptive, MRONJ; for these reasons, it is important to perform histologic analysis when clinicians are facing a suspicious malignant lesion.

Unusual metastatic localization to the kidney of basaloid squamous cell carcinoma of the oropharynx

2018 ◽  
Vol 85 (4) ◽  
pp. 182-185
Author(s):  
Costantino Ricci ◽  
Martina S Rossi ◽  
Roberta De Stefano ◽  
Michelangelo Fiorentino ◽  
Francesco Vasuri
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Surgical Excision ◽  
Renal Lesion ◽  
Basaloid Squamous Cell Carcinoma ◽  
Case Presentation ◽  
History Of ◽  
Node Metastases ◽  
Basaloid Squamous

Case presentation: A 55-year-old man with a history of basaloid squamous cell carcinoma of the oropharynx with laterocervical lymph node metastases 6 years before (and treated with chemoradiation) presented with flank pain and hematuria. Computed tomography scan found a renal lesion, with radiological features more suspicious for primitive renal neoplasia. Histopathological and immunohistochemical examination after surgical excision revealed a basaloid squamous cell carcinoma involving renal parenchyma. Conclusion: Basaloid squamous cell carcinoma is a rare tumor but with a high percentage of distant metastasis, and it is mandatory, also for a general pathologist, to know this disease. Moreover, in a patient with renal metastases, any type of cancer should be taken into account, and this case is emblematic of why the previous medical history is crucial for differential diagnosis.

scholarly journals Ki-67 expression in human oral squamous cell carcinoma

2021 ◽  
Vol 8 (4) ◽  
pp. 473-477
Author(s):  
Harendra Kumar ◽  
Chandrakanta ◽  
Pooja Nagayach ◽  
Ritu Sonkar ◽  
Rajni Bharti
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Oral Mucosa ◽  
Tobacco Use ◽  
Squamous Cell ◽  
Ki 67 ◽  
Oral Cancers ◽  
Normal Oral Mucosa ◽  
History Of

Oral cancers are one of the 10 leading cancers in the world. However, in India, it is one of the most common cancers and constitutes a major public health problem. Oral squamous cell carcinoma is a well-known malignancy that accounts for more than 90% of all oral cancers. The study is carried out on 40 biopsy samples received on oral mucosa, in Department of Pathology of our institute. Maximum numbers of patients were from 3th to 6th decade in our study. 38 cases of oral squamous cell carcinoma were observed, out of which 31 (81.57%) were male, and 07 (18.42%) cases were female. The most common site was tongue (50%), followed by buccal mucosa (18.42%), 06 patients (15.78%) had lesion at palate. Thirty-five (92.10%) cases had a significant history of tobacco use/smoking, whereas 03 (7.89%) did not have any history of tobacco use. We observed Ki-67 LI for normal oral mucosa was 14 ± 5.6%. In well-differentiated carcinoma, the KI-67 LI was 28.52 ± 21.25%, which increased to 42.85 ± 18.2% in moderately differentiated carcinoma and 68.57 ± 17.6% in poorly differentiated carcinoma. Ki-67 acts as an excellent marker of cellular proliferation. There is a statistical difference in KI-67 overexpression between various grades of oral squamous cell carcinoma and normal oral mucosa (p value <0.05).

scholarly journals A history of allergies is associated with reduced risk of oral squamous cell carcinoma

2012 ◽  
Vol 23 (12) ◽  
pp. 1911-1919 ◽  
Author(s):  
Marni Stott-Miller ◽  
Chu Chen ◽  
David R. Doody ◽  
Joseph L. Carter ◽  
Denise A. Galloway ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
History Of ◽  
Reduced Risk

scholarly journals Oral Squamous Cell Carcinoma Arising in a Patient after Hematopoietic Stem Cell Transplantation with Bisphosphonate-Related Osteonecrosis of the Jaws

2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
Paolo G. Arduino ◽  
Crispian Scully ◽  
Luigi Chiusa ◽  
Roberto Broccoletti
Keyword(s):  
Squamous Cell Carcinoma ◽  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Oral Squamous Cell Carcinoma ◽  
Stem Cell Transplantation ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Hematopoietic Stem ◽  
Osteonecrosis Of The Jaws ◽  
History Of

A 55-year-old man with a history of acute myeloid leukaemia treated with hematopoietic stem cell transplantation and with a 5-year history of bisphosphonate-related osteonecrosis of the jaws, following 12 cycles of intravenous zoledronic acid therapy, presented in December 2009 with a history of increasingly severe unilateral lower jaw pain. Oral examination revealed, as previously, exposed bone in the left mandible, but also a new exophytic mass on the lower-left buccal mucosa. Biopsy confirmed a diagnosis of oral squamous cell carcinoma. To the best of our knowledge, this is the first report of an oral squamous cell carcinoma that appeared adjacent to an area of osteochemonecrosis.

scholarly journals Synchronous Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma and Metastatic Squamous Cell Carcinoma of the Cervix Involving the Coronary Arteries Leading to Acute Myocardial Infarction

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Michelle Bernshteyn ◽  
Alexandria Smith-Hannah ◽  
Amit S. Dhamoon
Keyword(s):  
Myocardial Infarction ◽  
Squamous Cell Carcinoma ◽  
Case Report ◽  
Chronic Lymphocytic Leukemia ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Lymphocytic Leukemia ◽  
Small Lymphocytic Lymphoma ◽  
Metastatic Squamous Cell Carcinoma ◽  
History Of

A 66-year-old woman presented to the hospital with a one-month history of shortness of breath, fatigue, and postmenopausal vaginal bleeding and a one-week history of chest pain. This case report discusses the rare synchronous occurrence of two different malignancies in the setting of non-ST segment elevation myocardial infarction and the relation between these unfortunate events. Besides the case presented in this report, there have been only 13 reported cases of synchronous chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) associated with metastatic squamous cell carcinoma. While it is well known that malignancy causes a hypercoagulable state, there are other mechanisms which may have contributed to the patient’s myocardial ischemia including external vascular compression, tumor lysis syndrome, and anemia. This case report discusses the rarity of synchronous malignancies but the importance of understanding and consideration of cardiac events in this population.

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