scholarly journals Gene Expression Profiles in Surgical Excision Margins Detected by Tissue Auto-Fluorescence (VELscope™) in Oral Potentially Malignant Disorders (OPMDs) and Oral Squamous Cell Carcinoma (OSCC)

Proceedings ◽  
2019 ◽  
Vol 35 (1) ◽  
pp. 81
Author(s):  
Buffone ◽  
Biamonte ◽  
Giudice
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Surgical Excision ◽  
Oral Potentially Malignant Disorders ◽  
Potentially Malignant ◽  
Auto Fluorescence

Oral squamous cell carcinoma (OSCC) is often. [...]

EXPRESSSION OF SERUM AND SALIVARY MMP-1 AND MMP-9 IN ORAL CANCER, ORAL POTENTIALLY MALIGNANT DISORDERS AND NORMALS.

2019 ◽  
Vol 8 (3) ◽  
Author(s):  
Sona Baburathinam ◽  
Vidyarani Shyamsundar ◽  
Aravindha Babu N ◽  
Karthika Nagarajan ◽  
Vijaylakshmi Ramshankar ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Expression Profiles ◽  
Control Group ◽  
Oral Tongue ◽  
Oral Potentially Malignant Disorders ◽  
Non Invasive ◽  
Potentially Malignant

Background: Matrix metalloproteinases (MMPs) have been implicated in aggressiveness, invasiveness and metastasis of many malignancies including oral squamous cell carcinoma. In the meta-analysis of microarray based Oral Tongue SCC gene expression profiles, MMP-1 and MMP-9 was highly up-regulated .Till date, non-invasive diagnostic aid to detect the malignant potential of OPML or the aggressiveness of OSCC is lacking. With this background we decided to see the level of MMP-1 and MMP- 9 in saliva and serum of OSCC patients with controls. Aim: To determine the level of MMP1 and MMP9 in serum and saliva of patients diagnosed with OSCC, OPML, normal and to correlate with the aggressiveness of the disease. Methodology: The epidemiologic data of the patients reporting to our dental college & Hospital  were obtained through an interview. After obtaining written consent from the patient, complete intra oral examination was done, blood, saliva was collected and stored using the standard protocol. ELISA was done on all the samples for MMP-1 and MMP9. Results: MMP-1 in serum and MMP-9 in saliva/ serum was up-regulated in OSCC, moderately up-regulated in OPML when compared to the control group. However MMP-1 in saliva was found to be very low or non detectable. Conclusion: The MMP-9 in saliva/serum and MMP-1 in serum was up-regulated in the OSCC. In future, may be these body fluids can be used to diagnose and to determine aggressiveness of OPML and OSCC by non-invasive techniques. Keywords:Enzyme-Linked Immunosorbent Assay (ELISA ), Matrix Metalloproteinase  (MMP),Oral Potentially Malignant Lesions (OPML), Oral Squamous Cell Carcinoma( OSCC), Oral Tongue Squamous Cell Carcinoma ( OTSCC).

scholarly journals Detection of Helicobacter pylori in Patients with Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders at a Tertiary Care Centre in Gujarat: A Case-Control Study

2021 ◽  
Author(s):  
Himani Bhardwaj Pandya ◽  
Shivangi Patel ◽  
Rajvi Patel ◽  
Urvi Patel ◽  
Sheel Patel ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Helicobacter Pylori ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Case Control ◽  
Oral Potentially Malignant Disorders ◽  
Potentially Malignant Disorders ◽  
Potentially Malignant ◽  
H Pylori

Introduction: Oral squamous cell carcinoma (OSCC) contribute to 90% of cancer cases in head and neck region and entails remarkable morbidity and mortality inspite of immense research and advances. Amongst other causes, infection with Helicobacter pylori is an emerging cause of OSCC. There is still perplexity in the exact etiopathogenesis of H. pylori related oral cancer. Aim: In order to explore this much unattended area, present study was aimed to find out the association between H. pylori in premalignant disorders and OSCC. Materials and methods: A Prospective case-control Pilot study of 35 patients (11 confirmed cases of Oral squamous cell carcinoma and 24 with oral potentially malignant disorders along with 15 age and sex matched healthy control) from June 2018 - September 2018 was conducted in the Department of Microbiology, Smt. B. K. Shah Medical Institute, Piparia, Gujarat. H. pylori was detected by methods like Rapid urease test, Gram’s staining and Serology. Results: H. pylori was detected in five cases with OSCC with male predominance and mean age 45.6 yrs. All the five positive patients were severely addicted to tobacco and betel quid since decades. Tobacco was found to be the major risk of OSCC with the OD of 16.19, followed by betel quid (OD-4.56) and H. pylori infection (OD-0.83). Conclusion: The results of this pilot study do not establish a definite causal relationship between H. pylori and OSCC due to the low sample size. Study definitely offers an avenue for further work on larger populations to confirm this possible association.

scholarly journals Detection of Human Papilloma Virus in Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma

2021 ◽  
Vol 17 (3) ◽  
pp. 279-285
Author(s):  
Snehashish Ghosh ◽  
Sartaj Singh Wazir ◽  
Rajesh Shah ◽  
Manoj Kumar Upadhyay ◽  
Rahul Gupta ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Human Papilloma Virus ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Oral Potentially Malignant Disorders ◽  
Hpv 16 ◽  
Papilloma Virus ◽  
Potentially Malignant ◽  
Human Papilloma Virus 16

Introduction: Human Papilloma Virus 16 and 18 affects the keratinocytes of oral mucosa and skin and can lead to the development of dysplastic lesions and ultimately into invasive oral squamous cell carcinoma. The objective of the present study was to evaluate the presence of human Papilloma virus 16 and 18 DNA in already diagnosed oral potentially malignant disorders and oral squamous cell carcinoma. Methods: 200 biopsy specimens (50 each) of already diagnosed leukoplakia, oral lichen planus (OLP), oral submucous fibrosis (OSMF) and oral squamous cell carcinoma was included for the study. A total 50 control tissue sections, which were obtained during removal of impacted teeth were also included in the study. All 250 specimens were subjected to polymerase chain reaction (PCR) for the identification of HPV 16 and 18. The results are analyzed using Statistical Package of Social Sciences (SPSS) version 16 software and Pearson’s chi square test was used for statistical analysis. Results: HPV 16 and 18 was noted in all the OPMDS and oral cancer specimens but the results were not statistically significant. However, not even a single case of control tissue showed the presence of HPV 16 and 18. Conclusions: The results of the present study shows HPV 16 and 18 is present in oral cancer as well as OPMDS, therefore it could be implicated in the pathogenesis of the above mentioned conditions.

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