Two-dimensional hybrid analytical approach for the investigation of thermal aspects in human tissue undergoing regional hyperthermia therapy

2020 ◽  
Vol 234 (20) ◽  
pp. 3951-3966
Author(s):  
Jaideep Dutta ◽  
Balaram Kundu
Keyword(s):  
Heat Flux ◽  
Heat Conduction ◽  
Cancer Treatment ◽  
Thermal Response ◽  
Skin Tissue ◽  
Hyperbolic Heat Conduction ◽  
Two Dimensional ◽  
Regional Hyperthermia ◽  
Hyperthermia Therapy ◽  
The Impact

The formation of the present work is based on the development of the exact analytical solution of two-dimensional temperature response by employing the hyperbolic heat conduction bioheat model in a single-layered human skin tissue subjected to the regional hyperthermia therapy (RHT) for cancer treatment. The mathematical approach has been utilized as a hybrid form of ‘separation of variables’ and ‘finite integral transform’ method. Three kinds of surface heat fluxes (constant, sinusoidal and cosine) have been employed as an external heat source on the therapeutic surface of the square-shaped skin tissue of 100 mm × 100 mm. An innovative form of initial condition (spatially dependent) has been implemented in the present mathematical formulation as skin tissues are highly non-homogeneous and non-uniform in structure. The present research outcome indicates that cosine heat flux would be a suitable alternative for the sinusoidal heat flux. The impact of the relaxation time lag has been clearly noted in the thermal response with the waveform-like behaviour and it justifies the postulate of hyperbolic heat conduction. The two-dimensional temperature of the skin tissue has been observed in the range of 48.1 ℃–40 ℃ (in decreasing order). Estimated peak temperatures are in the proposed spectrum of hyperthermia therapy for an exposure time of 100 s, and this fact is true in an agreement with the medical protocol of the cancer treatment. The accuracy of the mathematical modelling and in-house computer codes are justified with the published numerical models and the maximum deviation of the thermal response has been noticed in order of 1.5–3%. The two-dimensional surface thermal contours have provided a glimpse of heat flow in the physical domain of skin tissue under different heating conditions and this research output may be beneficial to establish the theoretical standard of the regional hyperthermia treatment for cancer eradication.

Two-Dimensional Vibrating And Thermal Response of Skin Tissue To Different Types of Heat Sources Considering The Hyperbolic Heat Transfer Equation

2021 ◽  
Author(s):  
Mina Ghanbari ◽  
Ghader Rezazadeh
Keyword(s):  
Heat Transfer ◽  
Differential Equation ◽  
Heat Conduction ◽  
Boundary Conditions ◽  
Skin Tissue ◽  
Transient Temperature ◽  
Hyperbolic Heat Conduction ◽  
Two Dimensional ◽  
Thermomechanical Response ◽  
Different Types

Abstract Laser-induced thermal therapy, due to its applications in various clinical treatments, has become an efficient alternative, especially for skin ablation. In this work, the two-dimensional thermomechanical response of skin tissue subjected to different types of thermal loading is investigated. Considering the thermoelastic coupling term, the two-dimensional differential equation of heat conduction in the skin tissue based on the Cattaneo–Vernotte heat conduction law is presented. The two-dimensional differential equation of the tissue displacement coupled with the two-dimensional hyperbolic heat conduction equation of tissue is solved simultaneously to analyze the thermal and mechanical response of the skin tissue. The existence of mixed complicated boundary conditions makes the problem so complex and intricate. The Galerkin-based reduced-order model has been utilized to solve the two-sided coupled differential equations of skin displacement and heat transfer with accompanying complicated boundary conditions. The effect of various types of heating sources such as thermal shock, single and repetitive pulses, repeating sequence stairs, ramp-type, and harmonic-type heating, on the thermomechanical response of the tissue is investigated. The temperature distribution in the tissue along the depth and radial direction is also presented. The transient temperature and displacement response of tissue considering different relaxation times are studied, and the results are discussed in detail.

scholarly journals Thermo-vibrational analyses of skin tissue subjected to laser heating source in thermal therapy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mina Ghanbari ◽  
Ghader Rezazadeh
Keyword(s):  
Differential Equation ◽  
Heat Conduction ◽  
Boundary Conditions ◽  
Mechanical Response ◽  
Thermal Therapy ◽  
Skin Tissue ◽  
Transient Temperature ◽  
Hyperbolic Heat Conduction ◽  
Two Dimensional ◽  
Thermomechanical Response

AbstractLaser-induced thermal therapy, due to its applications in various clinical treatments, has become an efficient alternative, especially for skin ablation. In this work, the two-dimensional thermomechanical response of skin tissue subjected to different types of thermal loading is investigated. Considering the thermoelastic coupling term, the two-dimensional differential equation of heat conduction in the skin tissue based on the Cattaneo–Vernotte heat conduction law is presented. The two-dimensional differential equation of the tissue displacement coupled with the two-dimensional hyperbolic heat conduction equation in the tissue is solved simultaneously to analyze the thermal and mechanical response of the skin tissue. The existence of mixed complicated boundary conditions makes the problem so complex and intricate. The Galerkin-based reduced-order model has been utilized to solve the two-sided coupled differential equations of vibration and heat transfer in the tissue with accompanying complicated boundary conditions. The effect of various types of heating sources such as thermal shock, single and repetitive pulses, repeating sequence stairs, ramp-type, and harmonic-type heating, on the thermomechanical response of the tissue is investigated. The temperature distribution in the tissue along depth and radial direction is also presented. The transient temperature and displacement response of tissue considering different relaxation times are studied, and the results are discussed in detail.

Finite Element Formulation for Two-Dimensional Inverse Heat Conduction Analysis

1992 ◽  
Vol 114 (3) ◽  
pp. 553-557 ◽  
Author(s):  
T. R. Hsu ◽  
N. S. Sun ◽  
G. G. Chen ◽  
Z. L. Gong
Keyword(s):  
Heat Flux ◽  
Finite Element ◽  
Heat Conduction ◽  
Surface Heat Flux ◽  
Surface Heat ◽  
Element Formulation ◽  
Two Dimensional ◽  
Inverse Heat Conduction ◽  
Discrete Point ◽  
Element Algorithm

This paper presents a finite element algorithm for two-dimensional nonlinear inverse heat conduction analysis. The proposed method is capable of handling both unknown surface heat flux and unknown surface temperature of solids using temperature histories measured at a few discrete point. The proposed algorithms were used in the study of the thermofracture behavior of leaking pipelines with experimental verifications.

Nonhomogeneous Dual-Phase-Lag Heat Conduction Problem: Analytical Solution and Select Case Studies

2017 ◽  
Vol 140 (3) ◽  
Author(s):  
Simon Julius ◽  
Boris Leizeronok ◽  
Beni Cukurel
Keyword(s):  
Heat Flux ◽  
Heat Conduction ◽  
Analytical Solution ◽  
Heat Generation ◽  
Integral Transform ◽  
Heat Conduction Problem ◽  
Relaxation Times ◽  
Hyperbolic Heat Conduction ◽  
Phase Lag ◽  
Dual Phase

Finite integral transform techniques are applied to solve the one-dimensional (1D) dual-phase heat conduction problem, and a comprehensive analysis is provided for general time-dependent heat generation and arbitrary combinations of various boundary conditions (Dirichlet, Neumann, and Robin). Through the dependence on the relative differences in heat flux and temperature relaxation times, this analytical solution effectively models both parabolic and hyperbolic heat conduction. In order to demonstrate several exemplary physical phenomena, four distinct cases that illustrate the wavelike heat conduction behavior are presented. In the first model, following an initial temperature spike in a slab, the thermal evolution portrays immediate dissipation in parabolic systems, whereas the dual-phase solution depicts wavelike temperature propagation—the intensity of which depends on the relaxation times. Next, the analysis of periodic surface heat flux at the slab boundaries provides evidence of interference patterns formed by temperature waves. In following, the study of Joule heating driven periodic generation inside the slab demonstrates that the steady-periodic parabolic temperature response depends on the ratio of pulsatile electrical excitation and the electrical resistivity of the slab. As for the dual-phase model, thermal resonance conditions are observed at distinct excitation frequencies. Building on findings of the other models, the case of moving constant-amplitude heat generation is considered, and the occurrences of thermal shock and thermal expansion waves are demonstrated at particular conditions.

Analysis of the Thermal Response in Micromachine under the Thermal Shock

2011 ◽  
Vol 464 ◽  
pp. 583-587
Author(s):  
Ying Ze Wang ◽  
Xin Nan Song
Keyword(s):  
Heat Conduction ◽  
Relaxation Times ◽  
Boundary Surface ◽  
Thermal Relaxation ◽  
Thermal Response ◽  
Heat Propagation ◽  
Hyperbolic Heat Conduction ◽  
Thermal Relaxation Times ◽  
Fourier Heat Conduction ◽  
Sudden Temperature Change

The thermal response for given micromachine with the boundary surface exposed to sudden temperature change is studied by deriving an analytical solution of the hyperbolic heat conduction equation. Using the obtained analytical expression, the temperature profiles at the outer surface and interior of the micro beam are evaluated for various thermal relaxation times. The behaviors of hyperbolic heat propagation in micro beam are analyzed and possible anomalies are discussed by comparing the thermal behaviors of Fourier heat conduction.

Generalized Solution for Two-Dimensional Transient Heat Conduction Problems With Partial Heating Near a Corner

2019 ◽  
Vol 141 (7) ◽  
Author(s):  
Robert L. McMasters ◽  
Filippo de Monte ◽  
James V. Beck
Keyword(s):  
Boundary Condition ◽  
Heat Flux ◽  
Heat Conduction ◽  
Steady State ◽  
Separation Of Variables ◽  
Transient Heat Conduction ◽  
Generalized Solution ◽  
Convective Heating ◽  
Two Dimensional ◽  
Partial Heating

A generalized solution for a two-dimensional (2D) transient heat conduction problem with a partial-heating boundary condition in rectangular coordinates is developed. The solution accommodates three kinds of boundary conditions: prescribed temperature, prescribed heat flux and convective. Also, the possibility of combining prescribed heat flux and convective heating/cooling on the same boundary is addressed. The means of dealing with these conditions involves adjusting the convection coefficient. Large convective coefficients such as 1010 effectively produce a prescribed-temperature boundary condition and small ones such as 10−10 produce an insulated boundary condition. This paper also presents three different methods to develop the computationally difficult steady-state component of the solution, as separation of variables (SOV) can be less efficient at the heated surface and another method (non-SOV) is more efficient there. Then, the use of the complementary transient part of the solution at early times is presented as a unique way to compute the steady-state solution. The solution method builds upon previous work done in generating analytical solutions in 2D problems with partial heating. But the generalized solution proposed here contains the possibility of hundreds or even thousands of individual solutions. An indexed numbering system is used in order to highlight these individual solutions. Heating along a variable length on the nonhomogeneous boundary is featured as part of the geometry and examples of the solution output are included in the results.

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