scholarly journals Structural and hemodynamic properties of murine pulmonary arterial networks under hypoxia-induced pulmonary hypertension

2020 ◽  
Vol 234 (11) ◽  
pp. 1312-1329 ◽  
Author(s):  
Megan J Chambers ◽  
Mitchel J Colebank ◽  
M Umar Qureshi ◽  
Rachel Clipp ◽  
Mette S Olufsen
Keyword(s):  
Fluid Dynamics ◽  
Blood Pressure ◽  
Pulmonary Hypertension ◽  
Pulmonary Artery ◽  
Main Pulmonary Artery ◽  
Branching Ratio ◽  
Microcomputed Tomography ◽  
Imaging Data ◽  
One Dimensional ◽  
Computed Tomography Images

Detection and monitoring of patients with pulmonary hypertension, defined as a mean blood pressure in the main pulmonary artery above 25 mmHg, requires a combination of imaging and hemodynamic measurements. This study demonstrates how to combine imaging data from microcomputed tomography images with hemodynamic pressure and flow waveforms from control and hypertensive mice. Specific attention is devoted to developing a tool that processes computed tomography images, generating subject-specific arterial networks in which one-dimensional fluid dynamics modeling is used to predict blood pressure and flow. Each arterial network is modeled as a directed graph representing vessels along the principal pathway to ensure perfusion of all lobes. The one-dimensional model couples these networks with structured tree boundary conditions representing the small arteries and arterioles. Fluid dynamics equations are solved in this network and compared to measurements of pressure in the main pulmonary artery. Analysis of microcomputed tomography images reveals that the branching ratio is the same in the control and hypertensive animals, but that the vessel length-to-radius ratio is significantly lower in the hypertensive animals. Fluid dynamics predictions show that in addition to changed network geometry, vessel stiffness is higher in the hypertensive animal models than in the control models.

scholarly journals DECISION MAKING FOR DEVICE CLOSURE IN ADULTS WITH ‘HYPERTENSIVE PDA’–NON-INVASIVE CRITERIA: IMMEDIATE RESULTS

2021 ◽  
Vol 70 (Suppl-4) ◽  
pp. S762-67
Author(s):  
Ahsan Beg ◽  
Abdul Malik ◽  
Amjad Mahmood ◽  
M Younas ◽  
Fakher -e- Fayaz
Keyword(s):  
Pulmonary Hypertension ◽  
Retrospective Study ◽  
Pulmonary Artery ◽  
Main Pulmonary Artery ◽  
Tertiary Care ◽  
Referral Hospital ◽  
Device Closure ◽  
X Ray ◽  
Non Invasive ◽  
The Mean

Objective: To find the mean pulmonary artery pressures (PAP) in adults (>12 years) Patent Ductus Arteriosus (PDA) with ‘reversible pulmonary hypertension’ after the device closure. Residual PDA and immediate complications (embolization, pulse loss, obstruction in the aorta or pulmonary artery) are to be reported. Study Design: Retrospective study. Place and Duration of Study: Tertiary Care Referral Hospital, from Aug 2007 to Jun 2020. Methodology: This retrospective study is descriptive. Data collected by convenience sampling from 3 tertiary care referral hospital. 981 patients were undergone PDA device closure during the period from Aug 2007 to June 2020. After informed consent, an initial assessment was done by history, clinical examination, x-ray chest PA view, electrocardiography (ECG), and transthoracic echocardiography (TTE). Reversible pulmonary hypertension was labeled based on non-invasive criteria including room air saturation >93% and cardiomegaly on x-ray chest. Patients who had <93% and normal heart size on x-ray chest were excluded. The lower limit for age was 12 years. Results: Nine Hundred Eighty One patients had undergone PDA device closure. 32 (n=32/981 3.3%) had fulfilled our inclusion criteria. The mean age was 22 ± 9 (13–45) years. Mean weight was 41 ± 11 (25-66) kg. Successful device closure was done in 30 patients (93.7%). Mean diameter of PDA was 7 ± 0.1 (4.5-13 mm. Mean PAP decreased from 59 ± 13 mmHg to 38 ± 19 mmHg (p<0.05). Commonest device used was Shasma duct occluder (n=16/32 50%) followed by Occlutech Duct Occluder (n=7/32 21.9%), while 2 had muscular VSD device (n=5/32 15.6%). In 2 patients, there was an underestimation of the size of PDA so the device was retrieved and replaced with another larger one successfully. Two patients had the device fully dropped into the main pulmonary artery before it was released. Larger size device was not available at that time so the patients were referred for surgery. None of our patients had device embolization or residual shunt on echo performed next day to the procedure. Neither any patient had residual pulmonary hypertension on echocardiography. There was no significant obstruction in the aorta in any patients. Two patients had mild left pulmonary artery obstruction. There was no significant obstruction in the aorta in any of our patients. There was pulse loss in 3 patients which were treated successfully with heparin infusion with no residual damage. Conclusion: Device closure is a feasible option in adults with hypertensive PDA while the decision of reversibility is based on non-invasive criteria.

Diameter of the dilated main pulmonary artery in patients with pulmonary hypertension decreases after lung transplantation

Surgery Today ◽  
2019 ◽  
Vol 50 (3) ◽  
pp. 275-283
Author(s):  
Hidenao Kayawake ◽  
Akihiro Aoyama ◽  
Hideyuki Kinoshita ◽  
Tomoya Yoneda ◽  
Shiro Baba ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Pulmonary Artery ◽  
Lung Transplantation ◽  
Main Pulmonary Artery

Hypoxia-Induced Changes in the Mechanical Properties of the Mouse Pulmonary Artery

2003 ◽  
Author(s):  
Ryan W. Kobs ◽  
Nidal E. Muvarak ◽  
Naomi C. Chesler
Keyword(s):  
Mechanical Properties ◽  
Pulmonary Hypertension ◽  
Pulmonary Artery ◽  
Vascular Remodeling ◽  
Hypobaric Hypoxia ◽  
Vessel Wall ◽  
Main Pulmonary Artery ◽  
Collagen Content ◽  
Pulmonary Vascular Remodeling ◽  
Induced Changes

Hypobaric hypoxia produces pulmonary hypertension in mice which causes pulmonary vascular remodeling. To study the biomechanics of this process, mice were exposed to hypoxia for 0-(control), 10-, and 15-days. Using a pressurized arteriograph system, mechanical properties of the main pulmonary artery were measured and compared to the biological changes in the vessel wall measured histologically. 10- and 15-day hypoxic vessels were significantly stiffer when compared to 0-day vessels. This stiffness correlated with greater elastin and collagen content in the vessel wall.

scholarly journals A Case of Primary Pulmonary Hypertension Associated with Thrombus of The Right Main Pulmonary Artery

1960 ◽  
Vol 24 (5) ◽  
pp. 501-507
Author(s):  
MAGOJIRO MAEKAWA ◽  
YUTAKA OGATA ◽  
SHOZO IGUCHI ◽  
MIKIO SAKAI ◽  
CHUICHI KAWAI ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Pulmonary Artery ◽  
Primary Pulmonary Hypertension ◽  
Main Pulmonary Artery ◽  
The Right

The causes of development of pulmonary hypertension under obesity

2016 ◽  
Vol 22 (2) ◽  
pp. 66-69
Author(s):  
Veronika S. Pshennova ◽  
O. V Aleksandrov
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Pulmonary Hypertension ◽  
Pulmonary Artery ◽  
Body Mass ◽  
Main Group ◽  
Control Group ◽  
Average Blood Pressure ◽  
Males And Females

The article presents the results of study demonstrating that though evident symptoms of pulmonary hypertension were absent (maximal systolic tension was within standards both in males and females of main group) reliable increasing of blood pressure in pulmonary artery in comparison with control group under increasing of body mass index, waist volume and index waist/hips. At that, in males of main group under obesity degree I and II average blood pressure exceeded limits of standards.

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