The causes of development of pulmonary hypertension under obesity

2016 ◽  
Vol 22 (2) ◽  
pp. 66-69
Author(s):  
Veronika S. Pshennova ◽  
O. V Aleksandrov
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Pulmonary Hypertension ◽  
Pulmonary Artery ◽  
Body Mass ◽  
Main Group ◽  
Control Group ◽  
Average Blood Pressure ◽  
Males And Females

The article presents the results of study demonstrating that though evident symptoms of pulmonary hypertension were absent (maximal systolic tension was within standards both in males and females of main group) reliable increasing of blood pressure in pulmonary artery in comparison with control group under increasing of body mass index, waist volume and index waist/hips. At that, in males of main group under obesity degree I and II average blood pressure exceeded limits of standards.

scholarly journals CHARACTERISTICS OF METABOLIC PROCESSES IN THE FORMATION OF MENSTRUAL FUNCTION DISORDERS IN ADOLESCENT GIRLS WITH OBESITY

2021 ◽  
Vol 11 (4(42)) ◽  
pp. 28-33
Author(s):  
A. Borshuliak ◽  
O. Andriets ◽  
A. Andriets ◽  
A. Semeniak
Keyword(s):  
Insulin Resistance ◽  
Body Mass Index ◽  
Body Weight ◽  
Menstrual Cycle ◽  
Body Mass ◽  
Adolescent Girls ◽  
Main Group ◽  
Leptin Resistance ◽  
Control Group ◽  
Menstrual Dysfunction

Іntroduction. Today, a quarter of the population of economically developed countries has a body weight that is 15% larger than the norm. According to various authors, the timely onset of menarche in women with various forms of obesity and reproductive dysfunction is observed in 31% of cases only. Obesity results in insulin resistance, which in its turn results in hyperinsulinemia. The main reason of the connection of insulin resistance with reproductive function disorders consists in the specific influence of insulin on ovaries. Insulin suppresses apoptosis, binding to receptors of various growth factors that promotes long existence of atresizing follicles. In the pathogenesis of the metabolic syndrome, along with the development of hyperinsulinemia and insulin resistance, a significant role belongs to the imbalance of adipocytokines, one of which is adiponectin. The aim is to analyze metabolic processes in the formation of menstrual dysfunction in adolescent girls with obesity to improve diagnostic methods of menstrual disorders. Material and methods. Clinical and laboratory examination of adolescent girls aged 12-18 years was held, among which 79 had obesity and complaints about menstrual dysfunction (the main group); 31 with normal body weight and regular menstrual cycle (the control group). Research methods: general clinical, biochemical (indicators of lipid and carbohydrate metabolism were determined), instrumental (ultrasound), statistical. Results. It was found that 53.3% of the girls from the main group had the beginning of the first menstruation after 14 years, delayed menstruation from 42 days to 6 days, duration 2.1 ± 0.05 days, which was significantly shorter, the volume of 10.2 ± 0.05; 0.4 points (average 1-2 pads per day) was significantly lower (p <0.05). Ultrasound showed uterine hypoplasia in almost every second girl in the main group - 36 (45.46%). Hyperleptinemia and leptin resistance was found in obesity of the first degree 34.8 ± 1.75, in obesity of the second degree 37.15 ± 2.12, in obesity of the third degree 40.64 ± 2.0. It was 14.35 ng / ml in the control group, p<0,01. Hyperleptinemia in the main group was accompanied by hyperinsulinemia in 26% of cases and insulin resistance. The relationship between low values of adiponectin and elevated body mass index in patients of the main group was established, which was confirmed by the results of correlation analysis (adiponectin & body mass index: ρ = -0.74). Analysis of the results revealed a decrease of A/L level in the main group by 4.3 times. Based on our own results, the A/L and HOMA-AD models can be considered more accurate for determining insulin resistance. Conclusions. 1. Changes of the menstrual cycle in overweight girls were found. The association of adipokines secretion disorders is characterized by hyperleptinemia, leptin resistance, decreased Adiponectin / Leptin index and hypoadiponectinemia, which, in combination with insulin resistance, indicates the participation of adipokines in the genesis of oligomenorrhea. The algorithm of adolescents’ treatment with menstrual dysfunction on the background of obesity must include the calculation of Adiponectin/Leptin and HOMA-AD, which will make it possible to avoid overdiagnosis of insulin resistance.

scholarly journals Blood pressure circadian rhythm and obesity: Blood pressure variations and obesity

2002 ◽  
Vol 55 (9-10) ◽  
pp. 419-421 ◽  
Author(s):  
Nebojsa Despotovic
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Circadian Rhythm ◽  
Arterial Hypertension ◽  
Systolic Blood Pressure ◽  
Body Mass ◽  
Pathophysiological Mechanism ◽  
Obese People ◽  
Pressure Pattern ◽  
Average Blood Pressure

Introduction The association between obesity and arterial hypertension has been established in a great number of studies. Our objective was to investigate whether circadian rhythm of blood pressure is disturbed among obese people. Material and methods In this cross-sectional, randomized study, Schiller BR-102 device was used for ambulatory blood pressure monitoring. One hundred and twenty outpatients were divided into three randomized groups: obese body mass index 30 kg/m2 (52 patients), overweight (28 patients), with body mass index 25,0-29,9 kg/m2 and normal weight (control group) (48 patients), with body mass index 18,5-24,9 kg/m2. In all patients we investigated the following blood pressure parameters: average blood pressure (total, day-time and night-time), maximal blood pressure and dipping or non-dipping blood pressure pattern during night (for systolic and diastolic blood pressure, respectively). Results In body mass index beyond 30 kg/m2 only systolic blood pressure parameters were significantly higher - average blood pressure - during daytime (P=0.034) and during night (P=0.014); maximal blood pressure (P=0.001). In body mass index beyond 30 kg/m2, absence of normal blood pressure during night was significantly more often registered (P=0.007). Discussion and Conclusion The non-dipping blood pressure pattern and increase of systolic blood pressure only reveal hyper activation of sympathetic nervous system as a leading pathophysiological mechanism causing arterial hypertension in obese patients.

scholarly journals Right ventricular failure and pulmonary hypertension at recurrent thromboembolism of small branches of the pulmonary artery in cancer patients

2015 ◽  
Vol 96 (4) ◽  
pp. 492-497
Author(s):  
I A Kamalov ◽  
M G Tukhbatullin
Keyword(s):  
Heart Failure ◽  
Pulmonary Hypertension ◽  
Pulmonary Artery ◽  
Venous Thrombosis ◽  
Malignant Tumors ◽  
Vena Cava ◽  
Right Heart Failure ◽  
Main Group ◽  
Control Group ◽  
Right Heart

Aim. Develop new approaches to the diagnosis of right heart failure and pulmonary hypertension in recurrent thromboembolism of small branches of the pulmonary artery in patients with malignant tumors. Methods. 83 patients with malignant tumors of various localizations were examined and followed-up. The main group included 49 patients with malignant tumors of various localizations and related venous thrombosis. The control group included 34 patients who did not have venous thrombosis. Patients in both groups underwent ultrasonography of inferior vena cava system veins and echocardiography at intervals of 3-4 days during the diagnosis and treatment of malignant tumors. Right ventricle ejection fraction and systolic pressure in the pulmonary artery were calculated at echocardiography. Results. No signs of inferior vena cava system veins thromboses, right heart failure, pulmonary hypertension were identified in patients of the control group while setting up the diagnosis and treatment of malignancies. In 38 out of 49 patients of the main group, right ventricular failure and pulmonary hypertension of varying severity were detected. The condition of 46 patients of the main group gradually improved after treating with anticoagulants. Conclusion. Recanalization of venous thrombosis is accompanied by frequent rejection of micro thrombi and embolization of small branches of pulmonary artery, causing right heart failure and pulmonary hypertension, which can be promptly detected by repeated echocardiography.

scholarly journals Risk factors and AGTR1 gene polymorphism (1166A>C) in patients with essential hypertension

2020 ◽  
Vol 24 (4 (96)) ◽  
pp. 99-104
Author(s):  
M. Semianiv
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Body Mass Index ◽  
Essential Hypertension ◽  
Diastolic Blood Pressure ◽  
Body Mass ◽  
Control Group ◽  
Blood Pressure Elevation ◽  
A1166c Polymorphism ◽  
Gender And Age

Objective – to analyze the association of risk factors with the 1666 A>C polymorphism of the AGTR1 gene in patients with essential hypertension.Material and methods. 100 patients were screened, 72 of whom were genotyped. The control group consisted of 48 healthy individuals who did not differ in gender and age, and with the group of patients.Results. The obtained data confirmed that the level of blood pressure elevation is associated, to some extent, with modified (diabetes mellitus 2, smoking, body mass index) and unmodified factors (family history, gender) the risk of essential hypertension. The results of the analysis of blood pressure levels considering the A1166C polymorphism of the AGTR1 gene showed that the values of systolic and diastolic blood pressure in the group of patients with C-allele carriers were higher than in carriers of AA genotype: SBP – by 5.38% (p<0.05), DBP – by 5.15% (p<0.05). Conclusions. The level of blood pressure in patients with essential hypertension depends on body mass index and smoking. In carriers of the C-allele of the AGTR1 gene (A1166C), the level of systolic and diastolic blood pressure exceeds the ones of the carriers of the AA genotype. The presence of the C-allele of the AGTR1 gene (A1166C) almost doubles the risk of severe essential hypertension [OR = 2.75; p = 0.037].

scholarly journals Efek suplementasi kalsium terhadap kebugaran dan profil kesehatan pada atlet Tarung Derajat

2020 ◽  
Vol 8 (1) ◽  
Author(s):  
Yusni Yusni ◽  
Amiruddin Amiruddin
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Physical Fitness ◽  
Body Mass ◽  
Female Athletes ◽  
Sports Injuries ◽  
Calcium Supplementation ◽  
Control Group ◽  
Control Group Design ◽  
Blood Calcium

Calcium is the main mineral that is needed by athletes for bone strength, joint, and muscle contraction during exercise. Strenuous and prolonged exercise will progressively increase calcium requirements. This inadequate calcium intake is having an impact on hypocalcemia and increasing the risk of sports injuries. The purpose of the study was to analyze the effect of calcium supplementation on fitness and health in Tarung Derajat athletes. The research design was experimental (pretest-posttest without control group design). A total of 21 Tarung Derajat athletes, aged 18-25 years, male and female were the subjects. The examination was physical fitness, anthropometric values, and blood pressure to determine the health profile, and blood calcium. The intervention was a calcium tablet, a dose of 1x1000 mg/day, given after dinner, and for 35 days. The results found that the number of female athletes with hypocalcemia decreased by 50%, from 44.44% (before) to 22.22% after calcium therapy. Physical fitness increased (p<0.05), but there was no change in weight (p>0.05), body mass index (BMI) (p>0.05), blood pressure (BP) (p>0.05) ) and calcium levels (p>0.05) after calcium supplementation. Conclusions: supplementation of calcium tablets decreased the amount of hypocalcemia in Tarung Derajat female athletes, increases physical fitness, does not significantly increase calcium levels but otherwise does not affect anthropometry (body weight and body mass index), and blood pressure in Tarung Derajat athletes.

scholarly journals Circulating ErbB3/HER3 Levels are Associated with Increased Risk of Hypertension with Overweight: A Cross-Sectional Study

2020 ◽  
Author(s):  
Lijun Zhu ◽  
Zhengmei Fang ◽  
Yuelong Jin ◽  
Weiwei Chang ◽  
Mengyun Huang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Body Mass Index ◽  
Body Mass ◽  
Conditional Logistic Regression ◽  
Cross Sectional Study ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Cross Sectional ◽  
Increased Risk

Abstract Background: Hypertension and overweight are both independent risk factors for cardiovascular disease，and being overweight can more likely to develop high blood pressure. Recent research has shown that ErbB3/HER3 played a considerable role in the development of cardiovascular disease. However, ErbB3 levels effects in the hypertensive overweight patients are unknown. This study aimed to assess the association between ErbB3 levels and hypertension with overweight in Chinese population. Methods: 128 Chinese adults aged 33-79 years, both sexes, underwent evaluation of height and weight, blood pressure, biochemical indicators and ErbB3 levels. Plasma ErbB3 levels was assessed by the Enzyme-linked immunosorbent assay (ELISA), and body mass index (BMI) was calculated as body weight divided by height squared. Participants were allocated in three groups according to blood pressure and BMI: healthy control group (CNT; n = 31; normotensive and nonoverweight), hypertension group (HT; n = 33; hypertension and nonoverweight) and hypertension with overweight group (HTO; n = 64; hypertension and overweight). A 2-tailed P<0.05 was defined to be statistically significant. Results: The difference in mean of ErbB3 levels in three groups was not significant, but had a linear decrease in males, in CNT (1.13±0.36), HT (1.03±0.36) and HTO (0.84±0.26) ng/ml, with P was 0.007. In drinking population, the ErbB3 was significantly reduced in the HTO group as compared with the CNT and HT groups (0.76±0.23 versus 1.18±0.37 and 1.20±0.30, respectively). ErbB3 levels was negatively correlated with DBP in males(r=-0.293, P=0.012), in smoking populations (r=-0.47, P=0.004) and drinking populations (r=-0.387, P=0.008). Besides, BMI in males and in drinking populations and UA in males presented negatively correlations with ErbB3 (p＜0.05). The multivariate conditional logistic regression showed that plasma ErbB3 levels was associated with reduced risk for HTO in males (OR 0.054; 95% CI: 0.007-0.412) and drink group(OR 0.002; 95% CI: 0.000-0.101). Conclusions：The apparent association between lower ErbB3 levels and overweight hypertensive patients suggested that ErbB3 may contribute to the pathogenesis to hypertension with overweight, with BMI, gender, and drinking all potentially modulating the process.Keywords: ErbB3; Hypertension; Overweight; Body mass index.

Investigation of Effect on Glycosylated Hemoglobin, Blood Pressure, and Body Mass Index of Diabetes Intensive Education Program in Patients With Type 2 Diabetes Mellitus

2011 ◽  
Vol 5 (4) ◽  
pp. 351-357 ◽  
Author(s):  
Emel Beyazıt ◽  
Mukadder Mollaoğlu
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Body Mass ◽  
Education Program ◽  
Glycosylated Hemoglobin ◽  
Intervention Group ◽  
Control Group ◽  
Arterial Blood ◽  
Number Of Patients ◽  
Intensive Education

This study investigated the effects of a diabetes intensive education program (DIEP) on glycosylated hemoglobin (HbA1c), body mass index (BMI), and arterial blood pressure (BP). An 8-week randomized-controlled trial was conducted in Cumhuriyet University Hospital. Diabetes patients were randomized to control group (CG; n = 25) and intervention group (IG; n = 25) who received DIEP, including the factors affecting metabolic control and implementation of diabetes guidelines. Primary outcomes included HbA1c, BP, and BMI. After the 8 weeks, there was a significant decrease in HbA1c mean values for the intervention group. Also, BP significantly decreased from 143/87 to 130/80 mmHg in the IG as compared with an increase from 137/82 to 137/86 mmHg in the CG. In addition, the results demonstrated that DIEP improved the number of patients at goal for BP (130/80 mmHg). Baseline BMI did not change significantly in either group during the course of the study. These findings show that the DIEP may be effective in decreasing HbA1c levels and improving adherence to BP control.

Salusin-α levels are negatively correlated with diastolic blood pressure in children with obesity

2019 ◽  
Vol 29 (10) ◽  
pp. 1225-1229 ◽  
Author(s):  
Pınar Dervişoğlu ◽  
Bahri Elmas ◽  
Mustafa Kösecik ◽  
Şükriye P. İşgüven ◽  
Mustafa Büyükavcı ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Diastolic Blood Pressure ◽  
Body Mass ◽  
Negative Correlation ◽  
Predictive Value ◽  
Left Ventricular ◽  
Control Group ◽  
Healthy Children ◽  
Obese Children

AbstractSalusins have emerged as a new biomarker that reflects an increased inflammatory state, which is associated with cardiovascular risk. We investigated the predictive value and usefulness of salusins as an inflammatory biomarker in obese children. This prospective cohort study included 75 obese children and 101 healthy children (as a control group). Salusin-α, Salusin-β, and various cardiovascular parameters were assessed in both groups. Correlation analyses of Salusin-α and Salusin-β with body mass index standard deviation scores and inflammatory and cardiovascular markers were performed. The mean patient age was 11.9±2.4 years for the obese group and 12.5±2.1 years for the control group. The obese children had a significantly higher heart rate, systolic blood pressure, diastolic blood pressure, epicardial adipose tissue thickness, and left ventricular mass than did the children in the control group. There was no significant correlation between Salusin-α and Salusin-β and body mass index; however, there was a negative correlation between Salusin- α and diastolic blood pressure (r = 0.277, p = 0.004). Overall, there was no significant difference in the Salusin-α and Salusin-β levels between obese and healthy children. However, a negative correlation was found between Salusin-α and diastolic blood pressure. Although this result suggests that Salusin-α might be an early marker of cardiovascular involvement in obese children, further studies are needed to demonstrate the predictive value of salusins.

scholarly journals Association of body mass index and waist circumference with high blood pressure in older adults

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Wenli Zhang ◽  
Kun He ◽  
Hao Zhao ◽  
Xueqi Hu ◽  
Chunyu Yin ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Older Adults ◽  
Body Mass Index ◽  
Waist Circumference ◽  
Body Mass ◽  
High Blood Pressure ◽  
Cubic Spline ◽  
Additive Interaction ◽  
Males And Females ◽  
The Relationship

Abstract Background The relationship between obesity and prevalent high blood pressure in older adults has predominantly been estimated using categorical measures of body mass index (BMI) and waist circumference (WC), masking the shape of the dose-response relationship. We aimed to examine the precise relationship of BMI, WC with high blood pressure and to assess the appropriate level of BMI and WC for high blood pressure. Methods We examined data for 126,123 individuals in Xinzheng city aged ≥60 years from a population based study from January to December 2019. Logistic regression and restricted cubic spline models were applied to assess the relationship and the appropriate level of BMI and WC for high blood pressure. An additive interaction analysis was used to test synergistic effects between a higher BMI and WC for high blood pressure. Results The full-adjusted odds ratios (ORs) with 95% confidence intervals (CIs) of an increase of 1 kg/m2 in BMI and 1 cm in WC for high blood pressure were 1.084 (1.080–1.087) and 1.026(1.024–1.027), respectively. Multivariable adjusted restricted cubic spline analyses showed the nonlinear relationships of BMI and WC with high blood pressure in both men and women (all P < 0.001). The risk of high blood pressure increased steeply with increasing BMI from ≥25 kg/m2 and WC ≥ 88 cm or 86 cm for males and females, respectively. And we observed a significant additive interaction between a higher BMI and WC such that the prevalence of high blood pressure was significantly enhanced. Conclusion These findings suggest increased high blood pressure prevalence in the older adults with increased BMI and WC. BMI ≤ 25 kg/m2 and WC ≤ 88 cm or 86 cm for males and females may be the best suggestion with regard to primary prevention of high blood pressure in older adults.

Indicators of Obesity and Cardiovascular Parameters in Obese and Non-Obese Subjects

2021 ◽  
Vol 15 (10) ◽  
pp. 3413-3416
Author(s):  
Sana Majeed ◽  
Rabia Azhar ◽  
Aysha Mushtaq ◽  
Tooba Jamal ◽  
Sidra Ashfaq
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Body Mass ◽  
Pulse Rate ◽  
Obese Group ◽  
Control Group ◽  
Study Group ◽  
Cardiovascular Parameters ◽  
Level Of Significance ◽  
And Control

Background and Aim: Obesity is a worldwide epidemic that is endangering an increasing number healthy populations. Obesity is caused by a sedentary lifestyle and poor dietary habits. Although numerous studies on obesity effects on cardiovascular parameters (CVP) are existing, associations between obese and non-obese people are limited. Therefore, the present study aimed to evaluate the indicators for obesity and compared obese and non-obese association with cardiovascular parameters. Materials and Methods: This cross-sectional study was carried out on 80 subjects in the Department of Physiology, Islamic International Medical College, Rawalpindi in collaboration with Railway General Hospital, Rawalpindi for duration of six months i.e from January 2020 to June 2021. All the subjects were divided into obese group-I and non-obese group-II. Each group consisted of 40 subjects. Individuals with body mass index 18 to 25 Kg/m2 and >26 Kg/m2 were considered as obese and non-obese respectively. Informed consent and ethical approval were taken from each individual and hospital ethical committee respectively. All the subjects (BMI> 26 Kg/m2) with medical issues specifically cardio-respiratory and smokers were excluded. Quetelet’s index and Vernier Caliper was used for physical examination and triceps skinfold girth (TSG). SPSS version 23 was used for data analysis. Results: Of the total 80 subjects, the study and control group had 40 subjects each. The overall mean age was 41.31±2.3 years. The mean value of body mass index in the study and control group was 34.6±5 Kg/m2 and 23.4±1.2 Kg/m2 respectively. Mean weight, body mass index, waist circumference (WC), and triceps skin girth (TSG) were found significantly higher in the study group as compared to the control group whereas study group subjects had lower height than the control group (p<0.005). Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), pulse pressure (PP) were significantly higher in the study group as compared to control group subjects considering 0.0005 level of significance, however, pulse rate (PR) was insignificant in the study group (0.05). Cardiovascular parameters were found significant and positive in the study group only with a 0.05 level of significance on Pearson’s Correlation. Conclusion: Our study found that shorter height with accelerated pulse rate subjects was prone to cardiovascular diseases. Also, short height with a higher pulse rate is obesity's best indicator correlating in obese or study group. Additionally, obesity has a significant association with subject lipid profile which may elevate the potential risk for cardiovascular disease development. Keywords: Obesity; Cardiovascular Parameters, Obesity Indicators

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