Asymptomatic urethral lymphogranuloma venereum: a case report

2018 ◽  
Vol 29 (8) ◽  
pp. 828-830
Author(s):  
Louise Charest ◽  
Judith Fafard ◽  
Zoë R Greenwald
Keyword(s):  
Risk Factors ◽  
Case Report ◽  
Chlamydia Trachomatis ◽  
North America ◽  
Urban Areas ◽  
Lymphogranuloma Venereum ◽  
Sex With Men ◽  
Current Guidelines

Since 2003, there has been a resurgence of lymphogranuloma venereum (LGV), a variant of Chlamydia trachomatis (CT), among men who have sex with men (MSM) in several urban areas of Europe and North America. LGV infection occurs most often at anal sites causing proctitis. Urethral and oropharyngeal infections are rare. In Quebec, LGV incidence has been increasing exponentially in recent years and the current guidelines support systematic LGV genotype testing among anorectal CT-positive samples only. This case report describes a patient with a urethral LGV infection, remarkable due to its prolonged asymptomatic development prior to the manifestation of an inguinal bubo. Physicians should be vigilant of potential cases of LGV and forward CT-positive samples occurring among individuals with LGV risk factors for genotype testing.

scholarly journals Lymphogranuloma venereum (LGV) in men who have sex with men (MSM): a re-emerging problem, Malta, 2018

2018 ◽  
Vol 23 (43) ◽  
Author(s):  
Alastair Donachie ◽  
Gianfranco Spiteri ◽  
Christopher Barbara ◽  
Tanya Melillo ◽  
Ronza Hadad ◽  
...  
Keyword(s):  
Risk Factors ◽  
Lymphogranuloma Venereum ◽  
Factors Associated ◽  
Sex Parties ◽  
Sex With Men ◽  
Group Sex

From 1 January to 30 June 2018, 11 cases of Lymphogranuloma venereum (LGV; all preserved samples (n = 4) genovar L2b) were identified at the Genitourinary Clinic (GUC), Mater Dei Hospital, Msida, Malta. All cases were diagnosed in men who have sex with men (MSM); six participated in three group-sex parties. Here, we describe the outbreak and risk factors associated with LGV diagnoses in MSM in Malta in 2018.

scholarly journals Analysis of 721 Chlamydia trachomatis-positive urogenital specimens from men and women using LGV L2-specific real-time PCR assay

2006 ◽  
Vol 11 (42) ◽  
Author(s):  
D Goldenberger ◽  
F Dutly ◽  
M Gebhardt
Keyword(s):  
Chlamydia Trachomatis ◽  
Real Time ◽  
Real Time Pcr ◽  
Western Europe ◽  
Lymphogranuloma Venereum ◽  
Pcr Assay ◽  
Men And Women ◽  
The World ◽  
Sex With Men

The epidemic of rectal lymphogranuloma venereum among men who have sex with men in western Europe and other parts of the world is ongoing

scholarly journals Lymphogranuloma Venereum in Australia: Anorectal Chlamydia trachomatis Serovar L2b in Men Who Have Sex with Men

2007 ◽  
Vol 45 (3) ◽  
pp. 1029-1031 ◽  
Author(s):  
D. Stark ◽  
S. van Hal ◽  
R. Hillman ◽  
J. Harkness ◽  
D. Marriott
Keyword(s):  
Chlamydia Trachomatis ◽  
Lymphogranuloma Venereum ◽  
Sex With Men

Lymphogranuloma venereum genovariants in men having sex with men in Italy

2020 ◽  
pp. sextrans-2020-054700
Author(s):  
Antonella Marangoni ◽  
Claudio Foschi ◽  
Federico Tartari ◽  
Valeria Gaspari ◽  
Maria Carla Re
Keyword(s):  
Chlamydia Trachomatis ◽  
Lymphogranuloma Venereum ◽  
Hiv Positive ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
High Burden ◽  
Total Prevalence ◽  
Sex With Men ◽  
Reference Strains ◽  
Over Time

ObjectivesLymphogranuloma venereum (LGV) is an STI caused by Chlamydia trachomatis serovars L1-L3. In Europe, the current epidemic is caused mainly by L2b genovariant, although increasing cases associated with other L2 variants have been reported. Here, we assessed the distribution of rectal LGV genovariants among men having sex with men (MSM) in Italy.MethodsFrom 2016 to 2020, all the anorectal swabs collected from MSM attending the STI Clinic of St. Orsola-Malpighi Hospital in Bologna and positive for C. trachomatis were stored. LGV infection was confirmed by a pmpH PCR, and, subsequently, a fragment of the ompA gene was amplified and sequenced. Sequences were aligned to reference strains representing different LGV variants.ResultsLGV cases accounted for one-third of all chlamydial rectal infections with a total prevalence of 4.1% (76/1852). Total number of LGV cases per year remained constant. LGV was mainly found in symptomatic patients (>65%), older than 30 years, with a high burden of other STIs (63.7% HIV-positive, 35.5% with concurrent rectal gonorrhoea, 19.7% with early syphilis). A decreasing trend in HIV-LGV co-infection was noticed over time. Three main LGV genovariants were detected (L2f, 46.1%; L2b, 23.0%; L2-L2b/D-Da, 16.9%), together with other known L2b variants (mainly L2bV2 and L2bV4). Two novel L2b ompA variants with non-synonymous single-nucleotide polymorphisms were found. Over time, the percentage of L2f cases dropped gradually, with a significant increase in L2-L2b/D-Da cases (p=0.04).ConclusionsIn our area, LGV is endemic among MSM with different circulating genovariants. Active surveillance and genotyping programmes are needed to reduce re-establishing of LGV infection.

Case report: lymphogranuloma venereum in New Zealand

Sexual Health ◽  
2008 ◽  
Vol 5 (4) ◽  
pp. 369 ◽  
Author(s):  
Anne Robertson ◽  
Sunita Azariah ◽  
Collette Bromhead ◽  
Sepehr Tabrizi ◽  
Timothy Blackmore
Keyword(s):  
Case Report ◽  
New Zealand ◽  
Lymphogranuloma Venereum ◽  
Sex With Men

We report New Zealand’s first two cases of anorectal lymphogranuloma venereum (LGV). Although infection in these cases was probably acquired off-shore, the cases are reported to demonstrate the need to be vigilant to the possibility of LGV when men who have sex with men present with symptoms of proctitis. Investigation and management of LGV is discussed.

scholarly journals Asymptomatic Lymphogranuloma Venereum among Nigerian Men who have Sex with Men

2017 ◽  
Vol 4 (suppl_1) ◽  
pp. S69-S70
Author(s):  
Trevor Crowell ◽  
Justin Hardick ◽  
Kara Lombardi ◽  
Senate Amusu ◽  
Sunday Odeyemi ◽  
...  
Keyword(s):  
Chlamydia Trachomatis ◽  
Rectal Swab ◽  
Lymphogranuloma Venereum ◽  
Rectal Pain ◽  
Sexually Transmitted ◽  
Oropharyngeal Swab ◽  
Rapid Tests ◽  
Sex With Men ◽  
Incident Cases

Abstract Background Among men who have sex with men (MSM), lymphogranuloma venereum (LGV) has been associated with proctocolitis that can lead to chronic complications and requires a longer course of antibiotic therapy than is recommended for infections due to other serovars of Chlamydia trachomatis (CT). We describe the prevalence and clinical features of LGV among Nigerian MSM diagnosed with anorectal CT. Methods MSM were recruited into the ongoing RV368 cohort in Lagos, Nigeria, using respondent-driven sampling. Participants were screened for HIV and bacterial sexually transmitted infections (STIs) every three months for up to 18 months. HIV was diagnosed using a parallel algorithm of rapid tests on fingerstick blood samples. PCR testing for Neisseria gonorrheae and CTwas performed on voided urine, oropharyngeal swab, and rectal swab specimens. For this analysis, prevalent and incident cases of rectal CT infection underwent additional testing to identify LGV serovars utilizing novel real-time PCR assays specific for the L serovars of CT Chlamydia trachomatis. Results From 28 April 2014–19 July 2016, 420 men underwent screening for rectal STIs, including 66 (15.7%) who had prevalent rectal infection with CT. An additional 68 participants developed incident infections during 208 person-years of follow-up. Of 134 eligible rectal swab specimens, 128 underwent further testing for LGV serovars. Seven (5.5%) of the tested samples were identified as LGV serovars of CT. None of the seven participants with LGV reported any symptoms such as fever or rectal pain. Two of the participants with LGV were simultaneously co-infected with rectal gonorrhea. HIV co-infection was common among participants with both LGV and non-LGV serovars of CT (71% and 77%, respectively, P = 0.74). Conclusion LGV was uncommon but present among Nigerian MSM in this study. LGV needs to be considered even in asymptomatic cases, particularly if anorectal CT infection fails to respond to the usual course of therapy. Consistent screening for L serovars of CT, or empiric treatment for LGV in cases with a high suspicion for this diagnosis, could potentially improve patient outcomes and decrease transmission. Disclosures All authors: No reported disclosures.

scholarly journals Lymphogranuloma Venereum Prevalence in Sweden among Men Who Have Sex with Men and Characterization of Chlamydia trachomatis ompA Genotypes

2006 ◽  
Vol 44 (11) ◽  
pp. 4066-4071 ◽  
Author(s):  
M. Klint ◽  
M. Lofdahl ◽  
C. Ek ◽  
A. Airell ◽  
T. Berglund ◽  
...  
Keyword(s):  
Chlamydia Trachomatis ◽  
Lymphogranuloma Venereum ◽  
Sex With Men
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