Lymphogranuloma venereum genovariants in men having sex with men in Italy

2020 ◽  
pp. sextrans-2020-054700
Author(s):  
Antonella Marangoni ◽  
Claudio Foschi ◽  
Federico Tartari ◽  
Valeria Gaspari ◽  
Maria Carla Re
Keyword(s):  
Chlamydia Trachomatis ◽  
Lymphogranuloma Venereum ◽  
Hiv Positive ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
High Burden ◽  
Total Prevalence ◽  
Sex With Men ◽  
Reference Strains ◽  
Over Time

ObjectivesLymphogranuloma venereum (LGV) is an STI caused by Chlamydia trachomatis serovars L1-L3. In Europe, the current epidemic is caused mainly by L2b genovariant, although increasing cases associated with other L2 variants have been reported. Here, we assessed the distribution of rectal LGV genovariants among men having sex with men (MSM) in Italy.MethodsFrom 2016 to 2020, all the anorectal swabs collected from MSM attending the STI Clinic of St. Orsola-Malpighi Hospital in Bologna and positive for C. trachomatis were stored. LGV infection was confirmed by a pmpH PCR, and, subsequently, a fragment of the ompA gene was amplified and sequenced. Sequences were aligned to reference strains representing different LGV variants.ResultsLGV cases accounted for one-third of all chlamydial rectal infections with a total prevalence of 4.1% (76/1852). Total number of LGV cases per year remained constant. LGV was mainly found in symptomatic patients (>65%), older than 30 years, with a high burden of other STIs (63.7% HIV-positive, 35.5% with concurrent rectal gonorrhoea, 19.7% with early syphilis). A decreasing trend in HIV-LGV co-infection was noticed over time. Three main LGV genovariants were detected (L2f, 46.1%; L2b, 23.0%; L2-L2b/D-Da, 16.9%), together with other known L2b variants (mainly L2bV2 and L2bV4). Two novel L2b ompA variants with non-synonymous single-nucleotide polymorphisms were found. Over time, the percentage of L2f cases dropped gradually, with a significant increase in L2-L2b/D-Da cases (p=0.04).ConclusionsIn our area, LGV is endemic among MSM with different circulating genovariants. Active surveillance and genotyping programmes are needed to reduce re-establishing of LGV infection.

Prevalence and predictors of lymphogranuloma venereum among men who have sex with men at a Sydney metropolitan sexual health clinic

Sexual Health ◽  
2013 ◽  
Vol 10 (2) ◽  
pp. 190 ◽  
Author(s):  
David J. Templeton ◽  
Nicola Sharp ◽  
Sophie Gryllis ◽  
Catherine C. O'Connor ◽  
Sally M. Dubedat
Keyword(s):  
Chlamydia Trachomatis ◽  
Confidence Interval ◽  
Sexual Health ◽  
Lymphogranuloma Venereum ◽  
Health Clinic ◽  
Hiv Positive ◽  
Sex With Men

During an 18-month period to June 2012, 1732 anal chlamydia (Chlamydia trachomatis) tests were performed among men who have sex with men (MSM) at RPA Sexual Health in Sydney’s inner west. Positive anal chlamydia samples were subsequently tested for lymphogranuloma venereum (LGV). Seventy-five (4.3%) anal samples were positive for chlamydia among 67 men during the study period. Anal symptoms were reported for 16 out of 75 (21.3%) of anal chlamydia episodes overall. Three episodes of LGV (all serovar L2b) were identified, all three of whom reported anal symptoms (100%, 95% confidence interval (CI): 29.2–100%). In contrast, only 13/72 (18.1%, 95% CI: 10.0–28.9%) of those with non-LGV anal chlamydia reported anal symptoms. LGV was not identified in any of 59 episodes of asymptomatic anal chlamydia (0%, 95% CI: 0–6.1%). Of those with LGV, two were known to be HIV-positive and one subsequently seroconverted to HIV within a year of the LGV diagnosis. Our findings suggest that routine LGV testing among MSM is not warranted, except among those with anal symptoms.

scholarly journals Analysis of 721 Chlamydia trachomatis-positive urogenital specimens from men and women using LGV L2-specific real-time PCR assay

2006 ◽  
Vol 11 (42) ◽  
Author(s):  
D Goldenberger ◽  
F Dutly ◽  
M Gebhardt
Keyword(s):  
Chlamydia Trachomatis ◽  
Real Time ◽  
Real Time Pcr ◽  
Western Europe ◽  
Lymphogranuloma Venereum ◽  
Pcr Assay ◽  
Men And Women ◽  
The World ◽  
Sex With Men

The epidemic of rectal lymphogranuloma venereum among men who have sex with men in western Europe and other parts of the world is ongoing

scholarly journals Lymphogranuloma Venereum in Australia: Anorectal Chlamydia trachomatis Serovar L2b in Men Who Have Sex with Men

2007 ◽  
Vol 45 (3) ◽  
pp. 1029-1031 ◽  
Author(s):  
D. Stark ◽  
S. van Hal ◽  
R. Hillman ◽  
J. Harkness ◽  
D. Marriott
Keyword(s):  
Chlamydia Trachomatis ◽  
Lymphogranuloma Venereum ◽  
Sex With Men

scholarly journals Asymptomatic Lymphogranuloma Venereum among Nigerian Men who have Sex with Men

2017 ◽  
Vol 4 (suppl_1) ◽  
pp. S69-S70
Author(s):  
Trevor Crowell ◽  
Justin Hardick ◽  
Kara Lombardi ◽  
Senate Amusu ◽  
Sunday Odeyemi ◽  
...  
Keyword(s):  
Chlamydia Trachomatis ◽  
Rectal Swab ◽  
Lymphogranuloma Venereum ◽  
Rectal Pain ◽  
Sexually Transmitted ◽  
Oropharyngeal Swab ◽  
Rapid Tests ◽  
Sex With Men ◽  
Incident Cases

Abstract Background Among men who have sex with men (MSM), lymphogranuloma venereum (LGV) has been associated with proctocolitis that can lead to chronic complications and requires a longer course of antibiotic therapy than is recommended for infections due to other serovars of Chlamydia trachomatis (CT). We describe the prevalence and clinical features of LGV among Nigerian MSM diagnosed with anorectal CT. Methods MSM were recruited into the ongoing RV368 cohort in Lagos, Nigeria, using respondent-driven sampling. Participants were screened for HIV and bacterial sexually transmitted infections (STIs) every three months for up to 18 months. HIV was diagnosed using a parallel algorithm of rapid tests on fingerstick blood samples. PCR testing for Neisseria gonorrheae and CTwas performed on voided urine, oropharyngeal swab, and rectal swab specimens. For this analysis, prevalent and incident cases of rectal CT infection underwent additional testing to identify LGV serovars utilizing novel real-time PCR assays specific for the L serovars of CT Chlamydia trachomatis. Results From 28 April 2014–19 July 2016, 420 men underwent screening for rectal STIs, including 66 (15.7%) who had prevalent rectal infection with CT. An additional 68 participants developed incident infections during 208 person-years of follow-up. Of 134 eligible rectal swab specimens, 128 underwent further testing for LGV serovars. Seven (5.5%) of the tested samples were identified as LGV serovars of CT. None of the seven participants with LGV reported any symptoms such as fever or rectal pain. Two of the participants with LGV were simultaneously co-infected with rectal gonorrhea. HIV co-infection was common among participants with both LGV and non-LGV serovars of CT (71% and 77%, respectively, P = 0.74). Conclusion LGV was uncommon but present among Nigerian MSM in this study. LGV needs to be considered even in asymptomatic cases, particularly if anorectal CT infection fails to respond to the usual course of therapy. Consistent screening for L serovars of CT, or empiric treatment for LGV in cases with a high suspicion for this diagnosis, could potentially improve patient outcomes and decrease transmission. Disclosures All authors: No reported disclosures.

scholarly journals Lymphogranuloma Venereum Prevalence in Sweden among Men Who Have Sex with Men and Characterization of Chlamydia trachomatis ompA Genotypes

2006 ◽  
Vol 44 (11) ◽  
pp. 4066-4071 ◽  
Author(s):  
M. Klint ◽  
M. Lofdahl ◽  
C. Ek ◽  
A. Airell ◽  
T. Berglund ◽  
...  
Keyword(s):  
Chlamydia Trachomatis ◽  
Lymphogranuloma Venereum ◽  
Sex With Men

Lymphogranuloma venereum in Barcelona, 2007–2012: the role of seroadaptation in men who have sex with men

2014 ◽  
Vol 143 (1) ◽  
pp. 184-188 ◽  
Author(s):  
J. M. REYES-URUEÑA ◽  
P. GARCIA DE OLALLA ◽  
M. VALL-MAYANS ◽  
M. ARANDO ◽  
E. CABALLERO ◽  
...  
Keyword(s):  
Risk Factor ◽  
Incidence Rate ◽  
Lymphogranuloma Venereum ◽  
Transmission Risk ◽  
Hiv Positive ◽  
Strategic Positioning ◽  
Sex With Men ◽  
Rate Ratios ◽  
Telephone Questionnaire

SUMMARYThis study describes the incidence rate of reported lymphogranuloma venereum (LGV) in men who have sex with men (MSM) in Barcelona from 2007 to 2012. Epidemiological, clinical and sexual behaviour characteristics of LGV cases are described. Seroadaptive behaviours as a transmission risk factor were assessed by a telephone questionnaire during 2012. Data were handled on a strictly confidential basis. LGV annual rate ratios in MSM were compared with cases from 2007. Differences were statistically analysed with a Poisson test. The incidence rate of LGV in MSM aged 15–69 years ranged from 32·1/105MSM per year in 2007 to 182·7/105MSM per year in 2012. In 2012, 31/51 LGV cases (61%) answered the telephone questionnaire, of which 84% (26/31) were HIV positive, 39% (12/31) reported having sex according to their partners’ serostatus and 7% (2/31) used strategic positioning. The incidence of LGV has increased since 2007 and mainly affects HIV-positive MSM. It is probable that seroadaptation has facilitated LGV transmission.

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