scholarly journals Asymptomatic Lymphogranuloma Venereum among Nigerian Men who have Sex with Men

2017 ◽  
Vol 4 (suppl_1) ◽  
pp. S69-S70
Author(s):  
Trevor Crowell ◽  
Justin Hardick ◽  
Kara Lombardi ◽  
Senate Amusu ◽  
Sunday Odeyemi ◽  
...  
Keyword(s):  
Chlamydia Trachomatis ◽  
Rectal Swab ◽  
Lymphogranuloma Venereum ◽  
Rectal Pain ◽  
Sexually Transmitted ◽  
Oropharyngeal Swab ◽  
Rapid Tests ◽  
Sex With Men ◽  
Incident Cases

Abstract Background Among men who have sex with men (MSM), lymphogranuloma venereum (LGV) has been associated with proctocolitis that can lead to chronic complications and requires a longer course of antibiotic therapy than is recommended for infections due to other serovars of Chlamydia trachomatis (CT). We describe the prevalence and clinical features of LGV among Nigerian MSM diagnosed with anorectal CT. Methods MSM were recruited into the ongoing RV368 cohort in Lagos, Nigeria, using respondent-driven sampling. Participants were screened for HIV and bacterial sexually transmitted infections (STIs) every three months for up to 18 months. HIV was diagnosed using a parallel algorithm of rapid tests on fingerstick blood samples. PCR testing for Neisseria gonorrheae and CTwas performed on voided urine, oropharyngeal swab, and rectal swab specimens. For this analysis, prevalent and incident cases of rectal CT infection underwent additional testing to identify LGV serovars utilizing novel real-time PCR assays specific for the L serovars of CT Chlamydia trachomatis. Results From 28 April 2014–19 July 2016, 420 men underwent screening for rectal STIs, including 66 (15.7%) who had prevalent rectal infection with CT. An additional 68 participants developed incident infections during 208 person-years of follow-up. Of 134 eligible rectal swab specimens, 128 underwent further testing for LGV serovars. Seven (5.5%) of the tested samples were identified as LGV serovars of CT. None of the seven participants with LGV reported any symptoms such as fever or rectal pain. Two of the participants with LGV were simultaneously co-infected with rectal gonorrhea. HIV co-infection was common among participants with both LGV and non-LGV serovars of CT (71% and 77%, respectively, P = 0.74). Conclusion LGV was uncommon but present among Nigerian MSM in this study. LGV needs to be considered even in asymptomatic cases, particularly if anorectal CT infection fails to respond to the usual course of therapy. Consistent screening for L serovars of CT, or empiric treatment for LGV in cases with a high suspicion for this diagnosis, could potentially improve patient outcomes and decrease transmission. Disclosures All authors: No reported disclosures.

scholarly journals Outbreak of lymphogranuloma venereum among men who have sex with men in Barcelona 2007/08 – an opportunity to debate sexual health at the EuroGames 2008

2008 ◽  
Vol 13 (25) ◽  
Author(s):  
M Vall Mayans ◽  
E Caballero ◽  
P Garcia de Olalla ◽  
P Armengol ◽  
MG Codina ◽  
...  
Keyword(s):  
Chlamydia Trachomatis ◽  
Sexual Health ◽  
Sexually Transmitted Infection ◽  
Western Europe ◽  
Lymphogranuloma Venereum ◽  
Transmitted Infection ◽  
Sexually Transmitted ◽  
First Case ◽  
Sex With Men

Lymphogranuloma venereum (LGV) is a systemic sexually transmitted infection (STI) caused by Chlamydia trachomatis (L serovars L1, L2 or L3). Since 2003, several outbreaks of rectal LGV affecting men who have sex with men (MSM) have occurred in western Europe [1]. The first case in Spain was confirmed in Barcelona in 2005 [2], but no further cases have been detected in this city since until September 2007. We briefly summarise the characteristics of the LGV cases diagnosed at the outpatient STI clinic in Barcelona between September 2007 and April 2008.

scholarly journals Chlamydia trachomatis, Mycoplasma genitalium, Mycoplasma hominis, and Ureaplasma spp. Coinfection in an HIV-Positive Homosexual Man

2021 ◽  
Author(s):  
Swati Khullar ◽  
Jyoti Rawre ◽  
Deepika Yadav ◽  
Neena Khanna ◽  
Benu Dhawan
Keyword(s):  
Chlamydia Trachomatis ◽  
Mycoplasma Hominis ◽  
Mycoplasma Genitalium ◽  
Hiv Positive ◽  
Sexually Transmitted ◽  
Immunodeficiency Virus ◽  
Oropharyngeal Swab ◽  
Sex With Men ◽  
Multiple Male ◽  
Ureaplasma Spp

AbstractA 21-year-old human immunodeficiency virus-positive male patient presented with complaints of multiple hyperpigmented verrucous papules over his perianal area. He reported having unprotected anal and oral sex with multiple male partners. On examination, superficial ill-defined perianal erosions were present. A first void urine sample and clinician-collected rectal and oropharyngeal swabs were sent for the detection of Chlamydia trachomatis, Mycoplasma genitalium, Mycoplasma hominis, and Ureaplasma spp. Rectal swab tested positive for all the four pathogens. Oropharyngeal swab and urine samples tested positive for C. trachomatis. The patient was treated with doxycycline and moxifloxacin. This case underscores the importance of screening of men who have sex with men for possible coinfections with multiple sexually transmitted pathogens.

scholarly journals Asymptomatic lymphogranuloma venereum among Nigerian men who have sex with men

2018 ◽  
Vol 94 (8) ◽  
pp. 578-581 ◽  
Author(s):  
Trevor A Crowell ◽  
Justin Hardick ◽  
Kara Lombardi ◽  
Zahra Parker ◽  
Afoke Kokogho ◽  
...  
Keyword(s):  
Lymphogranuloma Venereum ◽  
Nucleic Acid Amplification ◽  
Presumptive Treatment ◽  
Hiv Coinfection ◽  
Prevalent Disease ◽  
Observational Cohort ◽  
Sex With Men ◽  
Incident Cases ◽  
Improve Patient

ObjectivesRecent outbreaks of anorectal lymphogranuloma venereum (LGV) among men who have sex with men (MSM) have been characterised by proctocolitis requiring extended antibiotic treatment compared with infections caused by other serovars of Chlamydia trachomatis (CT). We describe the prevalence and clinical features of LGV among Nigerian MSM diagnosed with anorectal CT.MethodsMSM were recruited for this observational cohort in Lagos, Nigeria, using respondent-driven sampling and screened for HIV and bacterial STIs every three months for up to 18 months. Nucleic acid amplification tests for CT were performed on rectal swab specimens. Prevalent and incident cases of anorectal CT underwent additional testing to identify LGV using novel real-time PCR assays specific for the L-serovars of CT.ResultsFrom April 2014 to July 2016, 420 MSM underwent testing for rectal STIs, of whom 66 (15.7%) had prevalent anorectal CT. Among those without prevalent disease, 68 developed incident infections during 208 person-years of follow-up. Of 134 prevalent and incident cases of anorectal CT, 7 (5.2%) were identified as LGV. None of the seven participants with LGV reported any symptoms. Two of the participants with LGV were simultaneously coinfected with rectal gonorrhoea. HIV coinfection was common among participants with both LGV (n=5, 71%) and non-LGV (n=98, 77%) serovars of CT (P=0.66).ConclusionsAnorectal LGV was uncommon but present among Nigerian MSM in this study. Consistent screening for L-serovars of CT, or presumptive treatment for LGV in cases with a high suspicion for this diagnosis, could potentially improve patient outcomes and decrease transmission.

scholarly journals Lymphogranuloma venereum emerging in men who have sex with men in Germany

2006 ◽  
Vol 11 (9) ◽  
pp. 5-6 ◽  
Author(s):  
V Bremer ◽  
T Meyer ◽  
U Marcus ◽  
O Hamouda
Keyword(s):  
Lymphogranuloma Venereum ◽  
European Countries ◽  
Health Concern ◽  
Probable Case ◽  
Sexually Transmitted ◽  
Lymph Node Swelling ◽  
Male Patients ◽  
Sex With Men ◽  
Omp1 Gene ◽  
Great Public Health

A resurgence of lymphogranuloma venereum (LGV) has been observed in several European countries. LGV is not a mandatorily notifiable disease in Germany. Reports of LGV cases have actively been collected by the Robert Koch-Institut since 2004 to describe the outbreak and estimate the extent of the LGV problem in Germany. Updates on the LGV outbreak were published in the German national epidemiological bulletin. Physicians were asked to send their samples to a laboratory for genotyping. A possible case was defined as a person with symptoms of proctitis and/or inguinal lymph node swelling and a positive chlamydia serology. A probable case had in addition a positive chlamydia rectal or urinary PCR test. A case was confirmed if the genotype L1-L3 was identified based on sequence analysis of omp1 gene sequences. Since 2003, LGV has been reported in 78 male patients in Germany. Of these, 61 patients were confirmed as genotype L2. Fifty eight out of 78 patients (74%) are known to be men who have sex with men (MSM). Fifty five patients (71%) had rectal symptoms and 49 (63%) knew they were HIV positive. Sixty two (79%) of the patients were residents of Berlin or Hamburg. LGV has emerged in MSM in Germany at the same time as in other European countries. It is thought that LGV may become endemic in the MSM community in German metropolitan areas, because the number of reported patients with LGV continues to increase. The increase in the number of LGV cases and the high HIV prevalence in LGV patients are of great public health concern. Clinicians and MSM may not be sufficiently aware of the disease, and existing efforts to promote awareness and prevention of sexually transmitted infections and HIV need to be strengthened.

scholarly journals Analysis of 721 Chlamydia trachomatis-positive urogenital specimens from men and women using LGV L2-specific real-time PCR assay

2006 ◽  
Vol 11 (42) ◽  
Author(s):  
D Goldenberger ◽  
F Dutly ◽  
M Gebhardt
Keyword(s):  
Chlamydia Trachomatis ◽  
Real Time ◽  
Real Time Pcr ◽  
Western Europe ◽  
Lymphogranuloma Venereum ◽  
Pcr Assay ◽  
Men And Women ◽  
The World ◽  
Sex With Men

The epidemic of rectal lymphogranuloma venereum among men who have sex with men in western Europe and other parts of the world is ongoing

scholarly journals Men treated for syphilis in Białystok, Poland, 2014-2018

2019 ◽  
pp. 329-335
Author(s):  
Agnieszka Beata Serwin ◽  
Adriana Grochowska ◽  
Iwona Flisiak
Keyword(s):  
Urban Areas ◽  
Partner Notification ◽  
Secondary Syphilis ◽  
Contact Tracing ◽  
Professional Activity ◽  
Symptomatic Infection ◽  
Sexually Transmitted ◽  
Sexual Contacts ◽  
Sex With Men

INTRODUCTION. Incidence of syphilis is increasing in Europe in recent years, mainly due to high incidence in men, especially men who have sex with men (MSM). AIM. To analyse sociodemographic, epidemiological and clinical characteristics of men treated for syphilis in Bialystok in 2014 – 2018, to compare these of MSM and men who have sex with women (MSW). MATERIAL AND METHODS. Analysis of age, residency, professional activity, type of sexual contacts (steady vs. casual), marital status, stage of syphilis diagnosed, concomitant sexually transmitted infections (STIs), treatment, partner notification and follow-up attendance. RESULTS. Of 49 male patients with syphilis 26 (53.06%) were MSM and 23 (46.94%) – MSW. The average age was 33.67 and 35.87 years in MSM and MSW patients, respectively. Majority of patients in both groups were residents of urban areas. Tradesmen and those unemployed constituted the highest proportion in MSM and MSW group, respectively. MSM were in majority single and had only casual contacts while MSW, mostly married or engaged in steady relationship, had also casual contacts. Secondary syphilis was most frequently diagnosed in MSM and late latent syphilis - in MSW. Eight patients (16.32%) had concomitant HIV infection, in all diagnosed before syphilis. Contact tracing was successful in 26.92% of MSM and 39.13% of MSW. Follow-up was not done or not completed in half of MSM and more than half of MSW. CONCLUSIONS. Results confirm that MSM play a crucial role in the current epidemics of syphilis. They have mainly casual sexual contacts and have symptomatic infection. In both MSM and MSW contact tracing and follow-up attendance is suboptimal.

scholarly journals Lymphogranuloma Venereum in Australia: Anorectal Chlamydia trachomatis Serovar L2b in Men Who Have Sex with Men

2007 ◽  
Vol 45 (3) ◽  
pp. 1029-1031 ◽  
Author(s):  
D. Stark ◽  
S. van Hal ◽  
R. Hillman ◽  
J. Harkness ◽  
D. Marriott
Keyword(s):  
Chlamydia Trachomatis ◽  
Lymphogranuloma Venereum ◽  
Sex With Men

Lymphogranuloma venereum genovariants in men having sex with men in Italy

2020 ◽  
pp. sextrans-2020-054700
Author(s):  
Antonella Marangoni ◽  
Claudio Foschi ◽  
Federico Tartari ◽  
Valeria Gaspari ◽  
Maria Carla Re
Keyword(s):  
Chlamydia Trachomatis ◽  
Lymphogranuloma Venereum ◽  
Hiv Positive ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
High Burden ◽  
Total Prevalence ◽  
Sex With Men ◽  
Reference Strains ◽  
Over Time

ObjectivesLymphogranuloma venereum (LGV) is an STI caused by Chlamydia trachomatis serovars L1-L3. In Europe, the current epidemic is caused mainly by L2b genovariant, although increasing cases associated with other L2 variants have been reported. Here, we assessed the distribution of rectal LGV genovariants among men having sex with men (MSM) in Italy.MethodsFrom 2016 to 2020, all the anorectal swabs collected from MSM attending the STI Clinic of St. Orsola-Malpighi Hospital in Bologna and positive for C. trachomatis were stored. LGV infection was confirmed by a pmpH PCR, and, subsequently, a fragment of the ompA gene was amplified and sequenced. Sequences were aligned to reference strains representing different LGV variants.ResultsLGV cases accounted for one-third of all chlamydial rectal infections with a total prevalence of 4.1% (76/1852). Total number of LGV cases per year remained constant. LGV was mainly found in symptomatic patients (>65%), older than 30 years, with a high burden of other STIs (63.7% HIV-positive, 35.5% with concurrent rectal gonorrhoea, 19.7% with early syphilis). A decreasing trend in HIV-LGV co-infection was noticed over time. Three main LGV genovariants were detected (L2f, 46.1%; L2b, 23.0%; L2-L2b/D-Da, 16.9%), together with other known L2b variants (mainly L2bV2 and L2bV4). Two novel L2b ompA variants with non-synonymous single-nucleotide polymorphisms were found. Over time, the percentage of L2f cases dropped gradually, with a significant increase in L2-L2b/D-Da cases (p=0.04).ConclusionsIn our area, LGV is endemic among MSM with different circulating genovariants. Active surveillance and genotyping programmes are needed to reduce re-establishing of LGV infection.

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