Phthalate Esters, Cystic Kidney Disease in Animals and Possible Effects on Human Health: A Review
1990 ◽
Vol 9
(6)
◽
pp. 397-401
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1 Phthalate esters are known to cause hepatic peroxisome proliferation in rodents and, after prolonged administration, hepatocarcinogenesis. Peroxisome proliferators as a group are hepatocarcinogenic. The mechanism is not known but it does not appear to involve a direct genotoxic element. 2 DEHP and DBP have been shown to cause renal cysts in rodents and they also produce renal peroxisome proliferation. There are no data to causally link the two phenomena. 3 Although renal cysts have been noted in haemodialysis patients and haemodialysis is a route of exposure to DEHP, there are no data to suggest a cause and effect relationship. 4 More studies are needed on the mechanism of renal cystogenesis.
2021 ◽
Vol 15
◽
pp. 117955652199235
2021 ◽
Vol 118
(39)
◽
pp. e2106770118
Keyword(s):
2008 ◽
Vol 136
(Suppl. 4)
◽
pp. 340-347
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Keyword(s):
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