Medical conditions of Omer Seyfettin (1884–1920), the father of Turkish short stories, enshrined as a mystery

2020 ◽  
pp. 096777202095896
Author(s):  
Halil Tekiner ◽  
Steven Howard Yale ◽  
Eileen Scott Yale ◽  
Mehmet Doganay
Keyword(s):  
Short Story ◽  
Medical Condition ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Septic Encephalopathy ◽  
Aureus Infection ◽  
Posterior Neck ◽  
Clinical Signs And Symptoms ◽  
Shed Light

Born in 1884 in Balıkesir, Turkey, Ömer Seyfettin was a leading figure among modern Turkish short story writers whose death in 1920 at the age of 36 led to long-term speculations about his fatal illness. In order to pay homage to his memory in the centennial of his death and to shed light on his later medical condition, this paper seeks to reexamine his last days from a medico-historical perspective. Our findings indicate that there was a notable decline in his health occurring after 1917 when he was confined to social isolation. A carbuncle was diagnosed in his posterior neck when he was 35-years of age and not satisfactorily treated. In late February 1920, he developed progressive symptoms over two weeks consisting initially of a headache, followed by fever, delirium, hallucinations, and diplopia. These clinical signs and symptoms are clinically suggestive of a septic encephalopathy presumably caused by staphylococcus aureus infection secondary to the carbuncle, or perhaps by one of the myriad causes of viral meningoencephalitis.

Neonatal Glucose Metabolism: Differential Diagnoses, Evaluation, and Treatment of Hypoglycemia

2002 ◽  
Vol 21 (4) ◽  
pp. 9-19 ◽  
Author(s):  
Richard Cowett ◽  
Jeffrey Loughead
Keyword(s):  
Glucose Metabolism ◽  
Neonatal Period ◽  
Clinical Care ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Differential Diagnoses ◽  
Neonatal Hypoglycemia ◽  
Birth Weight Neonate ◽  
Clinical Signs And Symptoms

Hypoglycemia is one of the most common clinical care issues facing the neonatal practitioner. Increasing evidence indicates that neonatal hypoglycemia may have long-term neurologic effects. Care is complicated by the lack of a clearly defined threshold for hypoglycemia in term and preterm infants, however, and by highly variable clinical signs and symptoms. Furthermore, many infants with low blood glucose measurements do not exhibit obvious signs of impairment. The complexity of neonatal glucose metabolism is illustrated by the variety of conditions producing or associated with both neonatal hypo- and hyperglycemia. Maintenance of euglycemia is especially challenging in the sick or low birth weight neonate. This article defines euglycemia by its range and reviews the differential diagnoses and etiology of hypoglycemia—as well as the principles of its management—in the neonatal period.

Amyloid in the Lung

2020 ◽  
Vol 41 (02) ◽  
pp. 299-310
Author(s):  
Misbah Baqir ◽  
Anja C. Roden ◽  
Teng Moua
Keyword(s):  
Clinical Signs ◽  
Signs And Symptoms ◽  
Amyloid Protein ◽  
Pulmonary Manifestations ◽  
Precursor Proteins ◽  
Multisystemic Disease ◽  
Clinical Signs And Symptoms ◽  
Long Term Prognosis ◽  
Secondary Diseases

AbstractAmyloidosis is the term given to abnormal deposition of misfolded precursor proteins at single or multiple sites, leading to organ dysfunction or clinical signs and symptoms. Pulmonary manifestations are nonspecific and may be associated with several amyloid protein subtypes, commonly AL (light chain) and AA (autoimmune) amyloids. Signs or symptoms of amyloid disease may often involve more of the clinical abnormalities of other affected organs than the lungs themselves. Radiologic pulmonary findings include septal and parenchymal ground glass or nodular infiltrates, multiple nodules, cysts, and focal tracheobronchial abnormalities. Lymphadenopathy with or without calcification and pleural effusions has also been reported. Directed therapy is initiated in response to clinical signs or symptoms often as a result of systemic or secondary diseases or conditions. Long-term prognosis is more dependent on the extent of organ involvement where morbidity is often the highest in those with multisystemic disease.

scholarly journals MON-327 Soluble Alpha Klotho and IGF-I Before Surgery as Prognostic Factors to Acromegaly Long-term Remission

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Junia Ribeiro de Oliveira Longo Schweizer ◽  
Katharina Schilbach ◽  
Michael Haenelt ◽  
Xiao Wang ◽  
Mariana Ferreira Bizzi ◽  
...  
Keyword(s):  
Medical Treatment ◽  
Surgical Outcome ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Somatostatin Analogues ◽  
Total N ◽  
Igf I ◽  
Treatment Naïve ◽  
Clinical Signs And Symptoms

Abstract BACKGROUND: Transsphenoidal surgery is the cornerstone of acromegaly treatment. However, cure is obtained in only ~50% of the cases. Until today, no biochemical marker has been identified to preoperatively predict surgical outcome and long-term remission. Recently, soluble alpha klotho (αKL) was proposed as new biomarker for diagnosis and follow-up of acromegaly. Therefore, we aimed to evaluate the potential of pre-surgery αKL concentrations as a prognostic factor to predict remission by surgery alone. Methods: We measured αKL concentrations (IBL-ELISA) and classical biomarkers (IGF-I and GHrandom, both by IDS-iSYS, GHnadir measured by IDS-iSYS (n=13) or DiaSorin-Liaison® (n=7)) in samples from a prospective study in treatment-naïve patients with acromegaly (total n=25). Patients were then followed for at least 6 months after surgery (median (range) 30.1 (6–142) months). Outcome was evaluated and classified as non-remission (NR: IGF-I>1.2xULN (n=2) or continued need for medical treatment with somatostatin analogues (n=10)) or remission (R: improvement on clinical signs and symptoms and IGF-I<1.2xULN without medical treatment, n=13). Results: Before surgery, all patients had elevated IGF-I (>1.2xULN), GHnadir (>0.4 ng/mL) and GHrandom (>1.0 ng/mL). As expected, αKL (pg/mL) was also high (>1.2xULN) in 92% patients. Before surgery, αKL was significantly higher in NR compared to R [6648 (4408–13951) vs. 3389 (2132–6837); p<0.05), as was IGF-I (ng/mL) [NR: 879.7 (771.8–961.5) vs. R: 640.2 (448.6–862.6); p<0.05). There was no difference in GHnadir and GHrandom (ng/mL) [10.42 (6.35–16.40) vs. 5.19 (1.19–10.70) and 12.39 (8.24–24.87) vs. 8.94 (4.24–15.55); p>0.05 for both comparisons). ROC analysis indicated that concentrations of αKL>4470pg/mL (~3.5xULN) (75% specificity, 62% sensitivity, AUC=0.72) and IGF-I>3.8xULN (67% specificity, 85% sensitivity, AUC=0.79) indicate lack of long-term remission. Conclusion: High αKL (>4470pg/mL, ~3.5xULN) and IGF-I (>3.8xULN) concentrations before surgery are significantly associated with persistent disease activity after surgery. However, both biomarkers alone or in combination have insufficient specificity (though acceptable sensitivity) as predictors of surgical outcome.

scholarly journals Does Recurrence of Carpal Tunnel Syndrome (CTS) after Complete Division of the Transverse Ligament Really Exist?

2021 ◽  
Vol 10 (18) ◽  
pp. 4208
Author(s):  
Fatma Kilinc ◽  
Bedjan Behmanesh ◽  
Volker Seifert ◽  
Gerhard Marquardt
Keyword(s):  
Carpal Tunnel Syndrome ◽  
Carpal Tunnel ◽  
Surgical Intervention ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Long Term Results ◽  
Transverse Ligament ◽  
Tunnel Syndrome ◽  
Clinical Signs And Symptoms

The aim of this study was to evaluate whether recurrent carpal tunnel syndrome (CTS) after complete and sufficient division of the transverse ligament really exists. Another goal was to analyze the underlying reasons for recurrent CTS operated on in our department. Over an observation period of eleven years, 156 patients underwent surgical intervention due to CTS. The records of each patient were analyzed with respect to baseline data (age, gender, affected hand), as were clinical signs and symptoms pre- and postoperatively. To assess long-term results, standardized telephone interviews were performed using a structured questionnaire in which the patients were questioned about persisting symptoms, if any. Of the 156 patients, 128 underwent first surgical intervention due to CTS in our department. In long-term follow-up, two-thirds of these patients had no symptoms at all; one-third of the patients described mild persisting numbness. None of the patients experienced a recurrence of CTS. The 28 patients who received their first operation outside of our department were operated on for recurrent CTS. The cause of recurrence was incomplete division of the distal part of the transverse carpal ligament in all cases. The results suggest that recurrent CTS after complete and sufficient division of the transverse ligament is very unlikely.

CHILDHOOD HYPERTHYROIDISM

1966 ◽  
Vol 51 (3) ◽  
pp. 321-336 ◽  
Author(s):  
J. Mäenpää ◽  
H. Hiekkala ◽  
B.-A. Lamberg
Keyword(s):  
Surgical Approach ◽  
Thyroid Nodules ◽  
Radioactive Iodine ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Nodular Goitre ◽  
Close Observation ◽  
Conservative Attitude ◽  
Clinical Signs And Symptoms

ABSTRACT Thirty-nine patients with childhood hyperthyroidism were treated during the period 1950-1964, most of them after 1955. The youngest patient was 3 years old. Thyroid nodules occurred in 55 per cent of the cases. In 25 patients long-term anti-thyroid treatment was instituted. This therapy was considered as successful in 7 instances (29 per cent). Four patients (17 per cent) are still under treatment, while in 13 (54 per cent) operation was later regarded as advisable owing to unsuccessful anti-thyroid treatment. The failure of thyrostatic therapy may have had some connection with the presence or appearance of thyroid nodules. In eight instances operation was carried out, primarily owing to compressive and/or nodular goitre. The results of operation (21 cases in all) are that 10 patients are euthyroid (48%) and 4 hypothyroid (19%) whilst 7 had a relapse or persistence of the disease (33%) of whom 5 are still under treatment and two have subsequently been rendered euthyroid by reoperation in one case and radioactive iodine (at the age of 19) in another case. There also seems to be a small group of patients (6 cases in this series) in whom, in spite of evident »biochemical disease« although with slight clinical signs and symptoms, the condition seems to resolve spontaneously and nothing but close observation appears to be needed. A primarily conservative attitude seems advisable. The presence of nodules in the thyroid initially, however, seems to indicate that a surgical approach will be required later on.

scholarly journals Dementia and Major Neurocognitive Disorders: Some Lessons Learned One Century after the first Alois Alzheimer’s Clinical Notes

Geriatrics ◽  
2021 ◽  
Vol 6 (1) ◽  
pp. 5
Author(s):  
Donatella Rita Petretto ◽  
Gian Pietro Carrogu ◽  
Luca Gaviano ◽  
Lorenzo Pili ◽  
Roberto Pili
Keyword(s):  
Young Woman ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Neurocognitive Disorders ◽  
Lessons Learned ◽  
Alzheimer Dementia ◽  
Clinical Notes ◽  
Alois Alzheimer ◽  
Clinical Signs And Symptoms

Over 100 years ago, Alois Alzheimer presented the clinical signs and symptoms of what has been later called “Alzheimer Dementia” in a young woman whose name was Augustine Deter [...]

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